CURRENT STUDENTS:
Emma Croushore
Koppenhafer SL, Goss KL, Voigt E, Croushore E, Terry WW, Ostergaard J, Gordon PM, Gordon DJ. Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma. Oncogene. 2022 May;41(20):2873-2884. doi: 10.1038/s41388-022-02310-0. Epub 2022 Apr 14. PubMed PMID: 35422476; PubMed Central PMCID: PMC9107507.
Joshua Lingo
Kohlmeyer JL, Kaemmer CA, Lingo JJ, Voigt E, Leidinger MR, McGivney GR, Scherer A, Koppenhafer SL, Gordon DJ, Breheny P, Meyerholz DK, Tanas MR, Dodd RD, Quelle DE. Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo. Neurooncol Adv. 2022 Jan-Dec;4(1):vdac047. doi: 10.1093/noajnl/vdac047. eCollection 2022 Jan-Dec. PubMed PMID: 35571990; PubMed Central PMCID: PMC9092646.
Ellen Voigt
Koppenhafer SL, Goss KL, Voigt E, Croushore E, Terry WW, Ostergaard J, Gordon PM, Gordon DJ. Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma. Oncogene. 2022 May;41(20):2873-2884. doi: 10.1038/s41388-022-02310-0. Epub 2022 Apr 14. PubMed PMID: 35422476; PubMed Central PMCID: PMC9107507.
Kohlmeyer JL, Kaemmer CA, Lingo JJ, Voigt E, Leidinger MR, McGivney GR, Scherer A, Koppenhafer SL, Gordon DJ, Breheny P, Meyerholz DK, Tanas MR, Dodd RD, Quelle DE. Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo. Neurooncol Adv. 2022 Jan-Dec;4(1):vdac047. doi: 10.1093/noajnl/vdac047. eCollection 2022 Jan-Dec. PubMed PMID: 35571990; PubMed Central PMCID: PMC9092646.
Voigt E, Wallenburg M, Wollenzien H, Thompson E, Kumar K, Feiner J, McNally M, Friesen H, Mukherjee M, Afeworki Y, Kareta MS. Sox2 Is an Oncogenic Driver of Small-Cell Lung Cancer and Promotes the Classic Neuroendocrine Subtype. Mol Cancer Res. 2021 Dec;19(12):2015-2025. doi: 10.1158/1541-7786.MCR-20-1006. Epub 2021 Sep 30. PubMed PMID: 34593608; PubMed Central PMCID: PMC8642303.
Voigt EM, Adili R, Bormann JL, Foss KN, Hurley LJ, Meyer ES, Veldman AJ, Mast KA, West JL, Whiteheart SW, Holinstat M, Larson MK. In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi. Platelets. 2019;30(2):271-279. doi: 10.1080/09537104.2017.1420154. Epub 2017 Dec 29. PubMed PMID: 29286871; PubMed Central PMCID: PMC6146071.
Voigt E, Wollenzien H, Kareta MS. Somatic Pluripotent Genes in Tissue Repair, Developmental Disease, and Cancer. SPG Biomed. 2018;1(2). doi: 10.32392/biomed.18. Epub 2018 Oct 28. PubMed PMID: 31172135; PubMed Central PMCID: PMC6548517.
Gavin McGivney
Kohlmeyer JL, Kaemmer CA, Lingo JJ, Voigt E, Leidinger MR, McGivney GR, Scherer A, Koppenhafer SL, Gordon DJ, Breheny P, Meyerholz DK, Tanas MR, Dodd RD, Quelle DE. Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo. Neurooncol Adv. 2022 Jan-Dec;4(1):vdac047. doi: 10.1093/noajnl/vdac047. eCollection 2022 Jan-Dec. PubMed PMID: 35571990; PubMed Central PMCID: PMC9092646.
Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs. Scherer A, Stephens VR, McGivney GR, Gutierrez WR, Laverty EA, Knepper-Adrian V, Dodd RD. Genes (Basel). 2020 May 23;11(5):583. doi: 10.3390/genes11050583.PMID: 32456131
Tumor subtype determines therapeutic response to chimeric polypeptide nanoparticle-based chemotherapy in Pten-deleted mouse models of sarcoma. Dodd RD, Scherer A, Huang W, McGivney GR, Gutierrez WR, Laverty E, Ashcraft KA, Stephens VR, Yousefpour P, Saha S, Knepper-Adrian VL, Floyd W, Chen M, Ma Y, Mastria EM, Cardona DM, Eward WC, Chilkoti A, Kirsch DG. Clin Cancer Res. 2020 Jul 27:clincanres.2597.2019. doi: 10.1158/1078-0432.CCR-19-2597. Online ahead of print.PMID: 32718998
PAST STUDENTS:
Nick Borcherding
TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex. Merritt N, Garcia K, Rajendran D, Lin Z-Y, Zhang X, Mitchell KA, Borcherding N, Fullenkamp C, Chimenti MS, Gingras A-C, Harvey KF, Tanas MR. Elife. 2021 Apr 29;10:e62857. PMC8143797
Mapping the immune environment in clear cell renal carcinoma by single-cell genomics. Borcherding N*, Vishwakarma A*, Voigt AP. et al. Commun Biol 4, 122 (2021). doi: 10.1038/s42003-020-01625-6. PMID: 33504936.
Metadherin enhances vulnerability of cancer cells to ferroptosis. Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner BA, Buettner GR, Spitz DR, Leslie KK, Zhang J, Meng X. Cell Death Dis. 2019 Sep 17;10(10):682. doi: 10.1038/s41419-019-1897-2. PMID: 31527591 PMC6746770
Single-Cell Profiling of Cutaneous T-Cell Lymphoma Reveals Underlying Heterogeneity Associated with Disease Progression. Borcherding N, Voigt AP, Liu V, Link BK, Zhang W, Jabbari A. Clin Cancer Res. 2019 May 15;25(10):2996-3005. doi: 10.1158/1078-0432.CCR-18-3309. Epub 2019 Feb 4.PMID: 30718356. PMC6659117.
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, Liu LZ, Ge X, Jiang BH, Gibson-Corley K, Klingelhutz A, Tan NS, Zhu Y, Sutterwala FS, Shen X, Zhang W. Oncogene. 2019 Mar;38(13):2351-2363. doi: 10.1038/s41388-018-0592-6. Epub 2018 Dec 5. PMID: 30518876
The clinical promise of immunotherapy in triple-negative breast cancer. Vikas P, Borcherding N, Zhang W. Cancer Manag Res. 2018 Dec 10;10:6823-6833. doi: 10.2147/CMAR.S185176. eCollection 2018.PMID: 30573992. PMC6292225
Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski AM, Xie Q, Markan KR, Li W, Potthoff MJ, Fuentes-Mattei E, Ellies LG, Knudson CM, Lee MH, Yeung SJ, Cassel SL, Sutterwala FS, Zhang W. Nat Commun. 2016 Oct 6;7:13007. PMID: 27708283 PMC5059727
Ajaykumar Vishwakarma
Direct and indirect immune effects of CMP-001, a virus-like particle containing a TLR9 agonist.Sabree SA, Voigt AP, Blackwell SE, Vishwakarma A, Chimenti MS, Salem AK, Weiner GJ. Journal for ImmunoTherapy of Cancer 9 (2021). PMID: 34083419. PMC8183212
Mapping the immune environment in clear cell renal carcinoma by single-cell genomics. Borcherding N*, Vishwakarma A*, Voigt AP. et al. Commun Biol 4, 122 (2021). doi: 10.1038/s42003-020-01625-6. PMID: 33504936.
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Kolb R, Kluz P, Tan ZW, Borcherding N, Bormann N, Vishwakarma A, Balcziak L, Zhu P, Davies BS, Gourronc F, Liu LZ, Ge X, Jiang BH, Gibson-Corley K, Klingelhutz A, Tan NS, Zhu Y, Sutterwala FS, Shen X, Zhang W. Oncogene. 2019 Mar;38(13):2351-2363. doi: 10.1038/s41388-018-0592-6. Epub 2018 Dec 5. PMID: 30518876
Vishwakarma, Ajaykumar and Karp, Jeffrey, eds. Biology and Engineering of Stem Cell Niches. Elsevier Academic Press, 2017.
Zhaoming Wang
T cells, particularly activated CD4+ cells, maintain anti-CD20-mediated NK cell viability and antibody dependent cellular cytotoxicity. Wang Z, Chimenti MS, Strouse C, Wiener GJ. Cancer Immunol Immunother. 2021 Jun 10. doi: 10.1007/s00262-021-02976-7.
A genetic screen to identify gain- and loss-of-function modifications that enhance T-cell infiltration into tumors.Rogers LM, Wang Z, Mott SL, Dupuy AJ, Weiner GJ. Cancer Immunol Res. 2020 Jul 1:canimm.0056.2020. doi: 10.1158/2326-6066.CIR-20-0056. Online ahead of print. PMID: 32611665
Immune checkpoint markers and anti-CD20-mediated NK cell activation. Wang Z, Weiner GJ. J Leukoc Biol. 2020 Dec 8;10.1002/JLB.5A0620-365R. doi: 10.1002/JLB.5A0620-365R
In situ immunization of a TLR9 agonist virus-like particle enhances anti-PD1 therapy. Cheng Y, Lemke-Miltner CD, Wongpattaraworkul W, Wang Z, Chan CHF, Salem AK, Weiner GJ, Simons AL. J Immunother Cancer. 2020 Oct;8(2):e000940. doi: 10.1136/jitc-2020-000940.
Provisional intellectual patent No. 63/159,276; Inventors: George Weiner, Zhaoming Wang
Wade Gutierrez
Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs. Scherer A, Stephens VR, McGivney GR, Gutierrez WR, Laverty EA, Knepper-Adrian V, Dodd RD.Genes (Basel). 2020 May 23;11(5):583. doi: 10.3390/genes11050583.PMID: 32456131
Tumor subtype determines therapeutic response to chimeric polypeptide nanoparticle-based chemotherapy in Pten-deleted mouse models of sarcoma. Dodd RD, Scherer A, Huang W, McGivney GR, Gutierrez WR, Laverty E, Ashcraft KA, Stephens VR, Yousefpour P, Saha S, Knepper-Adrian VL, Floyd W, Chen M, Ma Y, Mastria EM, Cardona DM, Eward WC, Chilkoti A, Kirsch DG. Clin Cancer Res. 2020 Jul 27:clincanres.2597.2019. doi: 10.1158/1078-0432.CCR-19-2597. Online ahead of print. PMID: 32718998
RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome. Urak K, Blanco GN, Shubham S, Lin LH, Dassie JP, Thiel WH, Chen Y, Sonkar VK, Lei B, Murthy S, Gutierrez WR, Wilson ME, Stilber JA, Klesney-Tait J, Dayal S, Miller FJ Jr, Giangrande PH. Nat Commun 2019 Jan 10; 10(1) doi: 10.1038/s41467-018-08030y. PMID: 30631065 PMC6328615
Devon Moose
Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation. Moose DL, Krog BL, Kim TH, Zhao L, Williams-Perez S, Burke G, Rhodes L, Vanneste M, Breheny P, Milhem M, Stipp CS, Rowat AC, Henry MD. Cell Rep. 2020 Mar 17;30(11):3864-3874.e6. doi:10.1016/j.celrep.2020.02.080. PMID: 32187555. PMC7219793
High content screening identifies monensin as an EMT-selective cytotoxic compound. Vanneste M, Huang Q, Li M, Moose D, Zhao L, Stamnes MA, Schultz M, Wu M, Henry MD.Sci Rep. 2019 Feb 4;9(1):1200. doi: 10.1038/s41598-018-38019-y.PMID: 30718715 PMC6361972
A model for the detection of pancreatic ductal adenocarcinoma circulating tumor cells. Alexander MS, O'Leary BR, Moose D, Du J, Henry MD, Cullen JJ. J Biol Methods. 2018 Sep 5;5(3):e97. doi: 10.14440/jbm.2018.250. eCollection 2018. PMID: 31453247 PMC6706145
The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity. Moose DL, Haase SJ, Aldrich BT, Lear BC. Front Cell Neurosci. 2017 Jun 6;11:159. doi: 10.3389/fncel.2017.00159. eCollection 2017. PMID: 28634443 PMC5459923.
A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. Buchakjian MR, Merritt NM, Moose DL, Dupuy AJ, Tanas MR, Henry MD.PLoS One. 2017 Aug 25;12(8):e0183469. doi: 10.1371/journal.pone.0183469. eCollection 2017.PMID: 28841687 PMC5571905
Eliot Zhu
Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis. Vanneste M, Feddersen CR, Varzavand A, Zhu EY, Foley T, Zhao L, Holt KH, Milhem M, Piper R, Stipp CS, Dupuy AJ, Henry MD. Front Oncol. 2020 Apr 3;10:442. doi: 10.3389/fonc.2020.00442. eCollection 2020. PMID: 32346533
A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells. Feddersen CR, Wadsworth LS, Zhu EY, Vaughn HR, Voigt AP, Riordan JD, Dupuy AJ.BMC Genomics. 2019 Jun 17;20(1):497. doi: 10.1186/s12864-019-5888-6.PMID: 31208320. PMC6580595
Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma. Feddersen CR, Schillo JL, Varzavand A, Vaughn HR, Wadsworth LS, Voigt AP, Zhu EY, Jennings BM, Mullen SA, Bobera J, Riordan JD, Stipp CS, Dupuy AJ. Cancer Res. 2019 Oct 1;79(19):5074-5087. PMID: 31416844
Keith Garcia
Photodynamic Therapy Using Hippo Pathway Inhibitor Verteporfin: A Potential Dual Mechanistic Approach in Treatment of Soft Tissue Sarcomas. Rytewski JD, Scalora N, Garcia K, Tanas M, Toor F, Miller B, Allen B, Milhem M, Monga V. Cancers (Basel). 2021 Feb 8; 13(4): 675. PMC7915813
TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex. Merritt N, Garcia K, Rajendran D, Lin Z-Y, Zhang X, Mitchell KA, Borcherding N, Fullenkamp C, Chimenti MS, Gingras A-C, Harvey KF, Tanas MR. Elife. 2021 Apr 29;10:e62857. PMC8143797