Postdoctoral Research Fellow
Training Mentor: Ryan Boudreau
Email: jared-mclendon@uiowa.edu
Research Projects
Cardiac stress causes detrimental changes in gene expression. Overall, my research is focused on characterizing post-transcriptional responses and evaluating their relevance to therapeutic development for cardiovascular disease. RNA binding proteins (RBPs) contribute significantly to post-transcriptional regulation of gene expression; however, few studies have evaluated RBPs in cardiac stress. We aim to identify pathogenic and protective RNA binding proteins (RBPs) in heart and to evaluate whether modulation of their activities is effective to manipulate cardiac gene expression for therapeutic benefit.
T-32 Supported Publications and Presentations
- Spengler, R.M., Zhang, X., Cheng, C., McLendon, J.M., Skeie, J.M., Johnson, F.L., Davidson, B.L., and Boudreau, R.L., Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP. Nucleic Acids Res, 2016. 44(15): p. 7120-7131. PubMed ID: 27418678.
- McLendon JM, Zhang X, Boudreau RL. The RNA binding protein RBPMS2 is a novel regulator of cardiac stress. American Heart Association-Scientific Sessions 2016. Circulation. 2016;134:A20109.
Training Activities
- Served as an executive officer for the University of Iowa Postdoctoral Association (August 2016 - present) (secretary/treasurer).
- Training Courses Attended:
- "American Heart Association Scientific Sessions"
- "Writing an effective NIH biosketch"
- "Bioinformatics Summer Short Course "
- "Careers Outside the Academy"
- Meetings with Hosted Speakers
- Dr. Jeanne M. Nerbonne
- Dr. John Wemmie
- Dr. Vincent A. Magnotta.
- Trained two undergraduate students in general laboratory skills, mouse husbandry, and basic molecular biology.