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About the Project

Project PREVENT is a test-negative case-control study of health care personnel (HCP) in 16 US academic medical centers with the following objectives:

  1. To evaluate post-introduction effectiveness of a complete schedule of SARS-CoV-2 vaccine in preventing laboratory-confirmed symptomatic COVID-19 among HCP (primary objective);
  2. To estimate the post-introduction effectiveness of SARS-CoV-2 vaccines in preventing severe disease among those with laboratory-confirmed symptomatic COVID-19;
  3. To identify differences in vaccine effectiveness by age group and comorbidity categories;
  4. To evaluate vaccine effectiveness in various job categories and clinical practice settings;
  5. To estimate the comparative effectiveness of different SARS-CoV-2 vaccines or,  for vaccines with 2-dose schedules, 1 vs. 2-doses;
  6. To compare health care and COVID-19 testing practices of HCP within specific job groups;
  7. To describe quarantine, isolation, repeat testing, and return-to-work practices among vaccinated and unvaccinated HCP tested for COVID-19;
  8. To identify factors associated with the decision to be vaccinated for SARS-CoV-2; and
  9. To evaluate provider behavior changes, use of infection mitigation strategies, and decision-making in response to COVID-19 vaccination.

These questions will be answered by enrolling HCP in participating sites who develop symptoms of COVID-19. After COVID-19 testing, we will define:

Cases: HCP who test positive for COVID-19, and

Controls: HCP who test negative for COVID-19.

Study sites are selected to be high-volume academic centers with robust employee testing programs that participate in EMERGEncy ID NET, a CDC-funded emerging infectious disease network created for surveillance and research of emerging infections (PI: David Talan, MD).

Project PREVENT is being administered with the Clinical Coordinating Center at the Geffen School of Medicine at UCLA and the Data Coordinating Center at the University of Iowa.