Clinical Trial Networks

SIREN (The Strategies to Innovate Emergency Care Clinical Trials Network)

SIREN is a clinical trials network that aims to identify effective early stage treatments to improve outcomes of patients with neurologic, cardiac, respiratory, and hematologic emergencies. SIREN is funded by the National Institute of Neurological Disorders and Stroke (NINDS), National Heart, Lung and Blood Institute (NHLBI), and National Center for Advancing Translational Sciences (NCATS). Andrew Nugent, MD serves as the site investigator for SIREN. 

As a member of SIREN, UI Hospitals & Clinics has the opportunity to collaborate on a variety of clinical trials. Currently, Nicholas Mohr, MD, MS serves as the site investigator for the Hyperbaric Oxygen Brain Injury Trial (HO2BIT). This trial seeks to determine the most effective dose schedule for hyperbaric oxygen (HBO) treatments in brain injury patients. The data collected during this study will also be used to plan future efficacy trials. 

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EMERGEncy ID NET is a research network that is funded by a cooperative grant through the Centers for Disease Control and Prevention. Over the past 25 years, this network has studied a wide range of emerging infectious diseases. Collaborating institutions continue to conduct research and surveillance to assess disease prevalence, risk factors, and management practices for acute presentations from the community to emergency departments. 

As part of EMERGEncy ID NET, UI Hospitals & Clinics Department of Emergency Medicine is an active collaborator on the project “Management of Diverticulitis in the Emergency Department” with Brett Faine, PharmD, serving as the site investigator. This study aims to identify clinical factors that are associated with the decision to either hospitalize or discharge diverticulitis patients who present to the emergency department. This data will be used to inform clinical decision making and to provide a foundation for a diagnostic algorithm to guide clinical practice. 

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