University of Iowa Department of Ophthalmology and Visual Sciences | Presentations and Posters at ARVO 2021

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Saturday, May 1

• 3:45 PM - 4:00 PM
• Live Paper Discussion
• Live Discussion: Retinal Organoids: Cell Diversity and New Strategies. Budd Tucker, PhD

Monday, May 3

• 10:15 AM - 11:45 AM
• Paper Session: Regulating Endothelial Cell Homeostasis
• Local CFH synthesis protects choroidal endothelial cells from membrane attack complex formation.  Kelly Mulfaul¹ , Nathaniel K. Mullin¹ , Joseph C. Giacalone¹ , Arwin Shrestha¹ , Heather T. Daggett¹ , Edwin M. Stone¹ , Budd A. Tucker¹ , Robert F. Mullins¹

• 10:15 AM - 12:00 PM
• Poster Session: Drug Delivery and Gene Therapy
• Subretinal gene replacement rescues retinal phenotype in BBS10 mouse. Arlene V. Drack^1,3 , Angela Mahoney^1,3 , Sajag Bhattarai^1,3 , Sara Mayer^1,3 , Jacintha Thomas^1,3 , Poppy Datta^1,3 , Ying Hsu^1,3 , Janelle Garrison^1,3 , Elise Heon² , Charles Searby^1,3 , Luk H. Vandenberghe^5,4 , Seongjin Seo^1,3 , Val Sheffield^1,3

• Poster Session: Gene Editing and Ocular Therapies
• Developing a CRISPR-mediated safe harbor strategy to correct patient-derived induced pluripotent stem cells. Erin R. Burnight¹ , Laura R. Bohrer¹ , Jessica A. Cooke¹ , Dalyz Ochoa¹ , Christy L. Ralston¹ , Elizabeth L. Geary¹ , Megan A. Luse¹ , Robert F. Mullins¹ , Edwin M. Stone¹ , Budd A. Tucker¹

• Poster Session: Drug Delivery and Gene Therapy
• Evaluating the tropism of chimeric helper-dependent adenoviral vectors for delivery of large genes. Luke A. Wiley¹ , Erin R. Burnight¹ , Dalyz Ochoa¹ , Malia M. Collins¹ , Katayoun Varzavand¹ , Edwin M. Stone¹ , Robert F. Mullins¹ , Budd A. Tucker¹ , Ian Han¹

• 3:30 PM - 5:15 PM
• Poster Session: Visual Impairment - Assessment and Measurement
• Five-Year Post-Injection Results of the Phase 3 Trial of Voretigene Neparvovec-ryzl in Biallelic RPE65 Mutation-Associated Inherited Retinal Disease. Jean Bennett^1,2 , Stephen R. Russell³ , Katherine A. High⁴ , Arlene V. Drack³ , Zi-Fan Yu⁵ , Daniel C. Chung⁶ , Kathy Reape⁴ , Albert M. Maguire^1,2

• Poster Session: Metabolism and Protein Processing: Retina, Photoreceptors and RPE
• Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance. Seongjin Seo^1,2 , Poppy Datta^1,2 , J T. Cribbs^1,2

Tuesday, May 4

• 9:15 AM - 11:00 AM
• Poster Session: Corneal Endothelium
• Examining the relationship between injector lumen diameter and exposed endothelial surface area and tissue conformation of DMEK tissue scrolls. Yong Kam² , Gregory Schmidt¹ , Mark A. Greiner^2,1 , Jennifer Ling^2,1 , Christopher Sales^2,1

• 1:15 PM - 2:45 PM
• Paper Session: Gene Therapy In Ocular Diseases
• Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa. Budd A. Tucker¹ , Erin R. Burnight¹ , Cathryn M. Cranston¹ , Jessica L. Fick¹ , Austin J. Reutzel¹ , Melette R. Devore¹ , Trudi Westfall² , C. Anthony Scott² , Autumn Marsden² , Katherine N. Gibson-Corley³ , Luke A. Wiley¹ , Ian Han¹ , Diane Slusarski² , Robert F. Mullins¹ , Edwin M. Stone¹

• 1:15 PM - 4:00 PM
• Poster Session: AMD and Retinal Disease Epidemiology
• ​BBS10 knockout mouse exhibits developmental lack of cone function and recapitulates retinal degeneration. Sara Mayer^1,2 , Jacintha Thomas^1,2 , Angela Mahoney^1,2 , Sajag Bhattarai^1,2 , Qihong Zhang^1,2 , Elliot Stalter^1,2 , Poppy Datta^1,2 , Ying Hsu^1,2 , Janelle Garrison^1,2 , Charles Searby^1,2 , Seongjin Seo^1,2 , Val Sheffield^1,2 , Arlene V. Drack^1,2

Wednesday, May 5

• 4:00 PM - 5:30 PM
• Special Interest Group.
• Is the Current Staging System for Diabetic Retinal Disease still relevant in 2021? Michael Abramoff, MD, PhD

• Special Interest Group.
• Deciphering the molecular landscape of retinal regeneration and degeneration using single cell genomics. Robert Mullins, MS, PhD

Thursday, May 6

• 3:10 PM - 3:25 PM
• Minisymposium.
• Central neuropathic contributors to ocular surface pain. Randy Kardon, MD, PhD

• 3:12 PM - 3:26 PM
• Minisymposium.
• Transcriptomic heterogeneity of choroidal cells in aging and disease. Robert Mullins, MS, PhD

• 4:15 PM - 5:45 PM
• Paper Session: Genetics of Retinal Dystrophies
• Mutational burden of mt3243G in blood correlates with the age of onset of retinal symptoms. Nathaniel K. Mullin¹ , Kristin R. Anfinson¹ , Louisa M. Affatigato¹ , Jeaneen L. Andorf¹ , Megan J. Riker¹ , Robert F. Mullins¹ , Edwin M. Stone¹ , Budd A. Tucker¹

• Paper Session: Stem Cells/Gene Therapy/Transplantation
• Safety and efficacy of sepofarsen in the second treated eye in a Ph1b/2 extension trial in Leber Congenital Amaurosis type 10 (LCA10). Stephen R. Russell¹ , Arlene V. Drack¹ , Artur V. Cideciyan^2,3 , Samuel G. Jacobson^2,3 , Bart Leroy^4,5 , Allen Ho⁶ , Caroline Van Cauwenbergh⁴ , Arun k. Krishnan^2,3 , Wilhelmina R. den Hollender⁷ , Adriana Hollestein-Havelaar⁷ , Mike Schwartz⁷ , Aniz Girach⁷

Friday, May 7

• 1:15 PM - 4:45 PM
• Paper Session: Applications of Single-Cell RNA-SEQ and Transcriptome Studies to Retinal Cell Biology
• Single-cell RNA sequencing identifies unique gene expression patterns in the foveal and perifoveal human retina. Andrew P. Voigt¹ , Nathaniel K. Mullin¹ , S S. Whitmore¹ , Todd E. Scheetz¹ , Edwin M. Stone¹ , Budd A. Tucker¹ , Robert F. Mullins¹