Edward F. Linton, MD
Assistant Professor of Ophthalmology and Visual Sciences
Introduction
Dr. Linton completed his undergraduate and medical school at the University of Pennsylvania in Philadelphia. He then did his residency training in Ophthalmology at Vanderbilt in Nashville TN. He came to Iowa city in 2021 for a clinical neuro-ophthalmology fellowship, and then completed an additional year of research fellowship. His primary research interests are in structural and functional assessment of the visual system including new approaches to perimetry to improve reliability and access, integration of different imaging modalities including blood flow and OCT imaging, and deep learning approaches to image analysis.
Current Positions
- Assistant Professor - Ophthalmology and Visual Sciences
Education
- Research Fellow in Neuro-Ophthalmology, University of Iowa Hospitals & Clinics, Iowa City, Iowa
- Fellow in Neuro-Ophthalmology, University of Iowa Hospitals & Clinics, Iowa City, Iowa
- Resident in Ophthalmology, Vanderbilt University, Nashville, TN
- MD in Medicine, Perelman School of Medicine, University of Pennsylvania, PA
Research Interests
- Smartphone perimetry without eye tracking
- Laser Speckle Flowgraphy in Carotid Cavernous Fistula
Selected Publications
- Capper EN, Linton EF, Anders JJ, Kardon RH, Gramlich OW. (2025). MOG35 - 55-induced EAE model of optic nerve inflammation compared to MS, MOGAD and NMOSD related subtypes of human optic neuritis. J Neuroinflammation 22(1):102. DOI: 10.1186/s12974-025-03424-4. PMID: 40197321. PMCID: PMC11977933.
- Wang JR, Linton EF, Johnson BA, Kupersmith MJ, Garvin MK, Kardon RH. (2024). Visualization of Optic Nerve Structural Patterns in Papilledema Using Deep Learning Variational Autoencoders. Transl Vis Sci Technol 13(1):13. DOI: 10.1167/tvst.13.1.13. PMID: 38231498. PMCID: PMC10795546.
- Chen Z, Zhang H, Linton EF, Johnson BA, Choi YJ, Kupersmith MJ, Sonka M, Garvin MK, Kardon RH, Wang JK. (2024). Hybrid deep learning and optimal graph search method for optical coherence tomography layer segmentation in diseases affecting the optic nerve. Biomed Opt Express 15(6):3681-3698. DOI: 10.1364/BOE.516045. PMID: 38867777. PMCID: PMC11166436.
- Pruett JK, Linton EF, Donahue SP, Groth SL. (2024). Accuracy and Reproducibility of Virtual Reality Perimetry in Children. J Pediatr Ophthalmol Strabismus 61(4):262-266. DOI: 10.3928/01913913-20240118-03. PMID: 38380937.
- Wang JK, Johnson BA, Chen Z, Zhang H, Szanto D, Woods B, Wall M, Kwon YH, Linton EF, Pouw A, Kupersmith MJ, Garvin MK, Kardon RH. (2025). Quantifying the spatial patterns of retinal ganglion cell loss and progression in optic neuropathy by applying a deep learning variational autoencoder approach to optical coherence tomography. Front Ophthalmol 4:1497848. DOI: 10.3389/fopht.2024.1497848. PMID: 39963427. PMCID: PMC11830743.
- Linton EF, Ahmad NU, Filister R, Wang JK, Sohn EH, Kardon R. (2025). Laser speckle flowgraphy reveals widespread reductions in ocular blood flow in non-exudative age-related macular degeneration. Am J Ophthalmol 273:92-106. DOI: 10.1016/j.ajo.2025.01.012. PMID: 39892803.
- Linton E, Ahmad NUS, Filister R, Wang JK, Sohn EH, Kardon RH. (2024). Laster speckle flowgraphy reveals widespread reductions in ocular blood flow in non-exudative age-related macular degeneration independent of ocular perfusion pressure. Inves. Ophth. & Vis. Sci. 65(7):5705.
- Schepers J, Heinzman Z, Wijayagunaratne A, Marin-Franch I, Wall M, Linton E. (2024). Feasibility of size-modulation as a strategy to improve smartphone perimetry. Inves. Ophth. & Vis. Sci. 65(7):1873.
- Wang JK, Chen Z, Zhang HH, Woods B, Szanto D, Johnson B, Linton E, Sonka M, Kupersmith MJ, Garvin MK, Kardon RH. (2024). Textural Analysis of OCT En -Face Images Predicts Spatial Patterns of Retinal Neuronal Loss at the Macula. Inves. Ophth. & Vis. Sci. 65(7):6180.
- Ahmad NUS, Nellis J, Wang JK, Takahashi N, Linton E, Kardon RH. (2024). Ocular Blood Flow Decreases During Hemodialysis. Inves. Ophth. & Vis. Sci. 65(7):2820.