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Ian Han, MD

Associate Professor of Ophthalmology and Visual Sciences

Introduction

I work with a highly collaborative team in the Institute for Vision Research whose mission is to cure blindness by elucidating key pathways of retinal disease and developing breakthrough treatments. My research involves a multidisciplinary approach that synthesizes insights from advanced retinal imaging and translational models. Current treatments in development use cutting-edge technologies such as viral vector-mediated gene therapy, sustained drug delivery with nanoparticles and 3D-printed biomaterials, and retinal cell replacement with patient-derived autologous induced pluripotent stem cell grafts. I also lead a Retinal Imaging and Modeling (RIM) Lab that uses computational methods for analyzing multimodal imaging data toward improved understanding of pathophysiologic mechanisms and guiding clinical trial design. Synergistic to these efforts is my practice as a vitreoretinal surgeon which informs and motivates scientific pursuits from the clinic to the lab and back.

Current Positions

  • Associate Professor of Ophthalmology and Visual Sciences
  • Service Director, Vitreoretinal Diseases and Surgery

Education

  • BS in Biology with Concentration in Cell and Molecular Biology, Duke University Trinity College of Arts and Sciences, Durham, NC
  • MD, Duke University School of Medicine, Durham, NC
  • Internship in Internal Medicine, University of North Carolina Hospitals, Chapel Hill, NC
  • Resident in Ophthalmology, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD
  • Fellow in Advanced Specialty Training Program in Medical and Surgical Retina, Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD

Research Interests

  • Advanced retinal imaging for insights into the pathophysiology of vitreoretinal disease
  • Molecular mechanisms of inherited, inflammatory, and age-related retinal degeneration
  • Translational (in vitro and in vivo) models of retinal disease
  • Ocular drug delivery, including via nanoparticles and viral vectors
  • Retinal stem cell therapy, including scaffold-supported induced pluripotent stem cell grafts
  • Preclinical and clinical trial design and execution for emerging therapies

Licenses & Certifications

  • Medical License, Iowa Board of Medicine, IA
  • ABO Certification, American Board of Ophthalmology

Selected Publications

  • Whitmore SS, Critser DB, Stone EM, Han IC. (2025). Retinal thickness and visual acuity in early-onset Stargardt disease follow a non-linear progression curve: implications for clinical trials. Ophthalmic Genet 25:1-7. ONLINE AHEAD OF PRINT. DOI: 10.1080/13816810.2025.2470212. PMID: 40000365.
  • Boyce TM, Han IC. (2025). Hyperacute Outer Retinal Dysfunction-A Retina on Fire. JAMA Ophthalmol. ONLINE AHEAD OF PRINT. DOI: 10.1001/jamaophthalmol.2024.6488. PMID: 39946122.
  • Somisetty A, Doston AD, Han IC. (2023). Pigmented Paravenous Retinochoroidal Atrophy. EyeRounds.org. December 5, 2023. Available from: https://eyerounds.org/cases/348-pigmented-paravenous-retinochoroidal-atrophy.htm#gsc.tab=0
  • Dangremond TE, Ramirez DA, Han IC. (2020). Charles Bonnet Syndrome. EyeRounds.org. September 17, 2020. Available from https://EyeRounds.org/cases/302-chares-bonnet-syndrome.htm
  • Yom KH, Diel RJ, Stiff HA, Johnson AT, Han IC. (2020). Paracentral Acute Middle Maculopathy (PAMM). EyeRounds.org. June 10, 2020; Available from: http://EyeRounds.org/cases/299-PAMM.htm
  • Quist TS, Hendricks TM, Han IC. (2020). Central Serous Chorioretinopathy. EyeRounds.org. January 28, 2020. Available from: https://webeye.ophth.uiowa.edu/eyeforum/cases/291-central-serous-chorioretinopathy.htm
  • Binkley EB, Critser DB, Abramoff MD, Han IC, Folk JC. (2017). Imaging Vitreous Cell Using Cirrus OCT. Presented at Annual Meeting, American Academy of Ophthalmology
  • Scott AW, Han IC. (2016). Ultra-wide-field Retinal Imaging in the Staging and Management of Sickle Cell Retinopathy. Presented at Annual Meeting, American Society of Retina Specialists
  • Scott AW, Tadarati M, Pacheco KD, Han IC. (2016). Evaluation of macular vascular abnormalities identified with optical coherence tomography angiography in patients with various sickle cell genotypes. Presented at Annual Meeting, American Society of Retina Specialists
  • Medearis SA, Han IC, Yang P, Zhang N, Peairs JJ, Jaffe GJ. (2010). The Critical Role of Bcl-xL in Mouse Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci 51(13):471.