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Matthew M. Harper, PhD

Portrait
Assistant Professor of Ophthalmology and Visual Sciences

Contact Information

Office
Bldg 42 VAMC
Iowa City, IA 52242
319-338-0581

Education

BS, Biology, Iowa State University
PhD, Neuroscience Graduate Program, Iowa State University
Postdoctoral Fellow, Neuroscience, Iowa State University

Center, Program and Institute Affiliations

Institute for Vision Research

Research Summary

The overall goal of my research program is to understand the effects of traumatic brain injury on the visual system. My lab has chosen to examine the visual system because of its highly accessible nature and the ability to examine retinal structure and function over time, which provides longitudinal information that is not possible to examine in the brain. Using animal models we have found that retinal ganglion cells in the eye are highly susceptible to blast-mediated traumatic brain injury, and that this damage is variable based on genetic background. Understanding the physiology of retinal ganglion cells after injury has allowed us to begin to define the molecular pathways by which these cells become dysfunctional and subsequently die after injury. We are currently developing and testing novel therapies to prevent and rehabilitate damage to the visual system after TBI. We are hopeful that these therapies can be extended to treat other diseases affecting retinal ganglion cells and the optic nerve.

Publications

Evans, L. P., Woll, A. W., Wu, S., Todd, B. P., Hehr, N., Hedberg-Buenz, A., Anderson, M. G., Newell, E. A., Ferguson, P. J., Mahajan, V. B., Harper, M. M. & Bassuk, A. G. (2020). Modulation of Post-Traumatic Immune Response Using the IL-1 Receptor Antagonist Anakinra for Improved Visual Outcomes. Journal of neurotrauma. PMID: 32056479.

Harper, M. M., Rudd, D., Meyer, K. J., Kanthasamy, A. G., Anantharam, V., Pieper, A. A., Vázquez-Rosa, E., Shin, M. K., Chaubey, K., Koh, Y., Evans, L. P., Bassuk, A. G., Anderson, M. G., Dutca, L., Kudva, I. T. & John, M. (2020). Identification of chronic brain protein changes and protein targets of serum auto-antibodies after blast-mediated traumatic brain injury. Heliyon, 6(2), e03374. PMID: 32099918.

Harper, M. M., Woll, A. W., Evans, L. P., Delcau, M., Akurathi, A., Hedberg-Buenz, A., Soukup, D. A., Boehme, N., Hefti, M. M., Dutca, L. M., Anderson, M. G. & Bassuk, A. G. (2019). Blast Preconditioning Protects Retinal Ganglion Cells and Reveals Targets for Prevention of Neurodegeneration Following Blast-Mediated Traumatic Brian Injury. Investigative ophthalmology & visual science, 60(13), 4159-4170. PMID: 31598627.

Babicky, M. L., Harper, M. M., Chakedis, J., Cazes, A., Mose, E. S., Jaquish, D. V., French, R. P., Childers, B., Alakus, H., Schmid, M. C., Foubert, P., Miyamoto, J., Holman, P. J., Walterscheid, Z. J., Tang, C. M., Varki, N., Sicklick, J. K., Messer, K., Varner, J. A., Waltz, S. E. & Lowy, A. M. (2019). MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages. Oncogene, 38(28), 5599-5611. PMID: 30967626.

Harper, M. M., Hedberg-Buenz, A., Herlein, J., Abrahamson, E. E., Anderson, M. G., Kuehn, M. H., Kardon, R. H., Poolman, P. & Ikonomovic, M. D. (2019). Blast-Mediated Traumatic Brain Injury Exacerbates Retinal Damage and Amyloidosis in the APPswePSENd19e Mouse Model of Alzheimer's Disease. Investigative ophthalmology & visual science, 60(7), 2716-2725. PMID: 31247112.

Brega, A. G., Henderson, W. G., Harper, M. M., Thomas, J. F., Manson, S. M., Batliner, T. S., Braun, P. A., Quissell, D. O., Wilson, A., Tiwari, T. & Albino, J. (2019). Association of Ethnic Identity with Oral Health Knowledge, Attitudes, Behavior, and Outcomes on the Navajo Nation. Journal of health care for the poor and underserved, 30(1), 143-160. PMID: 30827975.

Keenan, T. D., Agrón, E., Domalpally, A., Clemons, T. E., van Asten, F., Wong, W. T., Danis, R. G., Sadda, S., Rosenfeld, P. J., Klein, M. L., Ratnapriya, R., Swaroop, A., Ferris, 3rd, F. L. & Chew, E. Y. (2018). Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16. Ophthalmology, 125(12), 1913-1928. PMID: 30060980.

Batliner, T. S., Tiwari, T., Henderson, W. G., Wilson, A. R., Gregorich, S. E., Fehringer, K. A., Brega, A. G., Swyers, E., Zacher, T., Harper, M. M., Plunkett, K., Santo, W., Cheng, N. F., Shain, S., Rasmussen, M., Manson, S. M. & Albino, J. (2018). Randomized Trial of Motivational Interviewing to Prevent Early Childhood Caries in American Indian Children. JDR clinical and translational research, 3(4), 366-375. PMID: 30238061.

Genova, R. M., Meyer, K. J., Anderson, M. G., Harper, M. M. & Pieper, A. A. (2018). Neprilysin inhibition promotes corneal wound healing. Scientific reports, 8(1), 14385. PMID: 30258206.

Wert, K. J., Velez, G., Cross, M. R., Wagner, B. A., Teoh-Fitzgerald, M. L., Buettner, G. R., McAnany, J. J., Olivier, A., Tsang, S. H., Harper, M. M., Domann, F. E., Bassuk, A. G. & Mahajan, V. B. (2018). Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface. Free radical biology & medicine, 124, 408-419. PMID: 29940351.

Wilson, A. R., Fehringer, K. A., Henderson, W. G., Venner, K., Thomas, J., Harper, M. M., Batliner, T. S. & Albino, J. (2018). Fidelity of motivational interviewing in an American Indian oral health intervention. Community dentistry and oral epidemiology, 46(3), 310-316. PMID: 29461622.

Harper, M. M., Connolly, M. L., Goldie, L., Irvine, E. J., Shaw, J. E., Jayawarna, V., Richardson, S. M., Dalby, M. J., Lightbody, D. & Ulijn, R. V. (2018). Biogelx: Cell Culture on Self-Assembling Peptide Gels. Methods in molecular biology (Clifton, N.J.), 1777, 283-303. PMID: 29744843.

Isaacs RCA,, Harper, M. M. & Miller, E. C. (2017). Analytical challenges in the confirmative identification of dipyrone as an adulterant in illicit drug samples. Forensic science international, 270, 185-192. PMID: 27823839.

Yin, T. C., Voorhees, J. R., Genova, R. M., Davis, K. C., Madison, A. M., Britt, J. K., Cintrón-Pérez, C. J., McDaniel, L., Harper, M. M. & Pieper, A. A. (2016). Acute Axonal Degeneration Drives Development of Cognitive, Motor, and Visual Deficits after Blast-Mediated Traumatic Brain Injury in Mice. eNeuro, 3(5). PMID: 27822499.

Russell, A., Galvin, K. M., Harper, M. M. & Clayman, M. L. (2016). A comparison of heterosexual and LGBTQ cancer survivors' outlooks on relationships, family building, possible infertility, and patient-doctor fertility risk communication. Journal of cancer survivorship : research and practice, 10(5), 935-42. PMID: 26887847.

Russell, A. M., Galvin, K. M., Harper, M. M. & Clayman, M. L. (2016). Erratum to: A comparison of heterosexual and LGBTQ cancer survivors' outlooks on relationships, family building, possible infertility, and patient-doctor fertility risk communication. (Vols. 10). (5), pp. 943. Journal of cancer survivorship : research and practice. PMID: 26961488.

Helmers, R. A., Gabrielson, S. R. & Harper, M. M. (2016). DEVELOPING A NEW GOVERNANCE STRUCTURE: THE MAYO CLINIC EXPERIENCE. Physician leadership journal, 3(3), 40-5. PMID: 27295745.

Hedberg-Buenz, A., Christopher, M. A., Lewis, C. J., Meyer, K. J., Rudd, D. S., Dutca, L. M., Wang, K., Garvin, M. K., Scheetz, T. E., Abràmoff, M. D., Harper, M. M. & Anderson, M. G. (2015). RetFM-J, an ImageJ-based module for automated counting and quantifying features of nuclei in retinal whole-mounts. Experimental eye research. PMID: 26283021.

Shevalye, H., Yorek, M. S., Coppey, L. J., Holmes, A., Harper, M. M., Kardon, R. H. & Yorek, M. A. (2015). Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. Journal of neurophysiology, 114(1), 199-208. PMID: 25925322.

Yorek, M. S., Obrosov, A., Shevalye, H., Holmes, A., Harper, M. M., Kardon, R. H. & Yorek, M. A. (2015). Effect of diet-induced obesity or type 1 or type 2 diabetes on corneal nerves and peripheral neuropathy in C57Bl/6J mice. Journal of the peripheral nervous system: JPNS, 20(1), 24-31. PMID: 25858759.

Dutca, L. M., Stasheff, S. F., Hedberg-Buenz, A., Rudd, D. S., Batra, N., Blodi, F. R., Yorek, M. S., Yin, T., Shankar, M., Herlein, J. A., Naidoo, J., Morlock, L., Williams, N., Kardon, R. H., Anderson, M. G., Pieper, A. A. & Harper, M. M. (2014). Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243. Investigative ophthalmology & visual science, 55(12), 8330-41. PMID: 25468886.

Yin, T. C., Britt, J. K., De Jesús-Cortés, H., Lu, Y., Genova, R. M., Khan, M. Z., Voorhees, J. R., Shao, J., Katzman, A. C., Huntington, P. J., Wassink, C., McDaniel, L., Newell, E. A., Dutca, L. M., Naidoo, J., Cui, H., Bassuk, A. G., Harper, M. M., McKnight, S. L., Ready, J. M. & Pieper, A. A. (2014). P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury. Cell reports, 8(6), 1731-40. PMID: 25220467.

Yorek, M. S., Obrosov, A., Shevalye, H., Lupachyk, S., Harper, M. M., Kardon, R. H. & Yorek, M. A. (2014). Effect of glycemic control on corneal nerves and peripheral neuropathy in streptozotocin-induced diabetic C57Bl/6J mice. Journal of the peripheral nervous system: JPNS, 19(3), 205-17. PMID: 25403729.

Harper, M. M. (2014). Author response: Pressure wave dosimetry for "Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury". Investigative ophthalmology & visual science, 55(3), 1350-1. PMID: 24603601.

Clayman, M. L., Harper, M. M., Quinn, G. P., Reinecke, J. & Shah, S. (2013). Oncofertility resources at NCI-designated comprehensive cancer centers. Journal of the National Comprehensive Cancer Network : JNCCN, 11(12), 1504-9. PMID: 24335685.

Wang, Q., Grozdanic, S. D., Harper, M. M., Hamouche, K., Hamouche, N., Kecova, H., Lazic, T., Hernandez-Merino, E. & Yu, C. (2013). Detection and characterization of glaucoma-like canine retinal tissues using Raman spectroscopy. Journal of biomedical optics, 18(6), 067008. PMID: 23804216.

Mohan, K., Kecova, H., Hernandez-Merino, E., Kardon, R. H. & Harper, M. M. (2013). Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury. Investigative ophthalmology & visual science, 54(5), 3440-50. PMID: 23620426.

Harper, M. M., McKeating, K. S. & Faulds, K. (2013). Recent developments and future directions in SERS for bioanalysis. Physical chemistry chemical physics : PCCP, 15(15), 5312-28. PMID: 23318580.

Antony, B. J., Abràmoff, M. D., Harper, M. M., Jeong, W., Sohn, E. H., Kwon, Y. H., Kardon, R. & Garvin, M. K. (2013). A combined machine-learning and graph-based framework for the segmentation of retinal surfaces in SD-OCT volumes. Biomedical optics express, 4(12), 2712-28. PMID: 24409375.

Harper, M. M. (2013). Visual Function and its management in mTBI. IN: New Information Learned from experimental blast TBI. Smith-Kettlewell Eye Research Institute Press.

Harper, M. M., Robertson, B., Ricketts, A. & Faulds, K. (2012). Specific detection of DNA through coupling of a TaqMan assay with surface enhanced Raman scattering (SERS). Chemical communications (Cambridge, England), 48(75), 9412-4. PMID: 22889872.

Mohan, K., Harper, M. M., Kecova, H., Ye, E. A., Lazic, T., Sakaguchi, D. S., Kardon, R. H. & Grozdanic, S. D. (2012). Characterization of structure and function of the mouse retina using pattern electroretinography, pupil light reflex, and optical coherence tomography. Veterinary ophthalmology, 15 Suppl 2, 94-104. PMID: 22642927.

Clayman, M. L., Makoul, G., Harper, M. M., Koby, D. G. & Williams, A. R. (2012). Development of a shared decision making coding system for analysis of patient-healthcare provider encounters. Patient education and counseling, 88(3), 367-72. PMID: 22784391.

Mohan, K., Kecova, H., Hernandez-Merino, E., Kardon, R. H. & Harper, M. M. (2012). Retinal ganglion cell damage in an experimental rodent model of blast-mediated traumatic brain injury. Invest Ophthalmol Vis Sci, 54(5), 3340-50. PMID: 23620426.

Harper, M. M., Dougan, J. A., Shand, N. C., Graham, D. & Faulds, K. (2012). Detection of SERS active labelled DNA based on surface affinity to silver nanoparticles. The Analyst, 137(9), 2063-8. PMID: 22434199.

Harper, M. M., Mohan, K., Kecova, H., Hernandez-Merino, E. & Kardon, R. H. (2012). Experimental blast-mediated TBI results in a biphasic loss of visual function. 5th military vision symposium on Ocular and Vision Injury.

Wang, Q., Grozdanic, S. D., Harper, M. M., Hamouche, N., Kecova, H., Lazic, T. & Yu, C. (2011). Exploring Raman spectroscopy for the evaluation of glaucomatous retinal changes. Journal of Biomedical Optics, 16(10), 107006. PMID: 22029368.

Wang, Q., Grozdanic, S. D., Harper, M. M., Hamouche, N., Kecova, H., Lazic, T. & Yu, C. (2011). Exploring Raman spectroscopy for the evaluation of glaucomatous retinal changes. Journal of biomedical optics, 16(10), 107006. PMID: 22029368.

Harper, M. M., Grozdanic, S. D., Blits, B., Kuehn, M. H., Zamzow, D., Buss, J. E., Kardon, R. H. & Sakaguchi, D. S. (2011). Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes. Invest Ophthalmol Vis Sci, 52(7), 4506-15. PMID: 21498611.

Harper, M. M., Grozdanic, S. D., Blits, B., Kuehn, M. H., Zamzow, D., Buss, J. E., Kardon, R. H. & Sakaguchi, D. S. (2011). Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes. Investigative ophthalmology & visual science, 52(7), 4506-15. PMID: 21498611.

Jiang, B., Harper, M. M., Kecova, H., Adamus, G., Kardon, R. H., Grozdanic, S. D. & Kuehn, M. H. (2010). Neuroinflammation in advanced canine glaucoma. Mol Vis, 16, 2092-108. PMID: 21042562.

Grozdanic, S. D., Lazic, T., Kuehn, M. H., Harper, M. M., Kardon, R. H., Kwon, Y. H., Lavik, E. B. & Sakaguchi, D. S. (2010). Exogenous modulation of intrinsic optic nerve neuroprotective activity. Graefes Arch Clin Exp Ophthalmol, 248(8), 1105-16. PMID: 20229104.

Grozdanic, S. D., Lazic, T., Kuehn, M. H., Harper, M. M., Kardon, R. H., Kwon, Y. H., Lavik, E. B. & Sakaguchi, D. S. (2010). Exogenous modulation of intrinsic optic nerve neuroprotective activity. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 248(8), 1105-16. PMID: 20229104.

Harper, M. M., Ye, E. A., Blong, C. C., Jacobson, M. L. & Sakaguchi, D. S. (2010). Integrins contribute to initial morphological development and process outgrowth in rat adult hippocampal progenitor cells. Journal of molecular neuroscience : MN, 40(3), 269-83. PMID: 19499350.

Grozdanic, S. D., Kecova, H., Harper, M. M., Nilaweera, W., Kuehn, M. H. & Kardon, R. H. (2010). Functional and structural changes in a canine model of hereditary primary angle-closure glaucoma. Invest Ophthalmol Vis Sci, 51(1), 255-63. PMID: 19661222.

Grozdanic, S. D., Kecova, H., Harper, M. M., Nilaweera, W., Kuehn, M. H. & Kardon, R. H. (2010). Functional and structural changes in a canine model of hereditary primary angle-closure glaucoma. Investigative ophthalmology & visual science, 51(1), 255-63. PMID: 19661222.

Harper, M. M., Adamson, L., Blits, B., Bunge, M. B., Grozdanic, S. D. & Sakaguchi, D. S. (2009). Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells. Exp Eye Res, 89(4), 538-48. PMID: 19524566.

Harper, M. M., Adamson, L., Blits, B., Bunge, M. B., Grozdanic, S. D. & Sakaguchi, D. S. (2009). Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells. Experimental eye research, 89(4), 538-48. PMID: 19524566.

Harper, M. M., Ye, E. A., Blong, E. A., Jacobson, M. L. & Sakaguchi, D. S. (2009). Integrins contribute to initial morphological development and process outgrowth in rat adult hippocampal progenitor cells. J Mol Neurosci, 40(3), 269-83. PMID: 19499350.

Grozdanic, S. D., Harper, M. M. & Kecova, H. (2008). Antibody-mediated retinopathies in canine patients: mechanism, diagnosis, and treatment modalities. Vet Clin North Am Small Anim Pract, 38(2), 361-87. PMID: 18299012.

Grozdanic, S. D., Harper, M. M. & Kecova, H. (2008). Antibody-mediated retinopathies in canine patients: mechanism, diagnosis, and treatment modalities. The Veterinary clinics of North America. Small animal practice, 38(2), 361-87, vii. PMID: 18299012.

Sakaguchi, D. S., Hoffelen, S. V., Greenlee, M. H., Harper, M. M. & Au, D. T. (2008). Cell birth and death in the developing retina of the Brazilian opossum, Monodelphis domestica. Brain Res, 1195, 28-42. PMID: 18191114.

Sakaguchi, D. S., Hoffelen, S. V., Greenlee, M. H., Harper, M. M. & Au, D. T. (2008). Cell birth and death in the developing retina of the Brazilian opossum, Monodelphis domestica. Brain research, 1195, 28-42. PMID: 18191114.

Sakaguchi, D. S., Van Hoffelen, S. J., Theusch, E., Parker, E., Orasky, J., Harper, M. M., Benediktsson, A. & Young, M. J. (2004). Transplantation of neural progenitor cells into the developing retina of the Brazilian opossum: an in vivo system for studying stem/progenitor cell plasticity. Dev Neurosci, 26(5-6), 336-45. PMID: 15855762.

Sakaguchi, D. S., Van Hoffelen, S. J., Theusch, E., Parker, E., Orasky, J., Harper, M. M., Benediktsson, A. & Young, M. J. (2004). Transplantation of neural progenitor cells into the developing retina of the Brazilian opossum: an in vivo system for studying stem/progenitor cell plasticity. Developmental neuroscience, 26(5-6), 336-45. PMID: 15855762.

Dansky, H. M., Charlton, S. A., Harper, M. M. & Smith, J. D. (1997). T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse. Proceedings of the National Academy of Sciences of the United States of America, 94(9), 4642-6. PMID: 9114044.

Sills, E. S., Baum, J. D., Ling, X., Harper, M. M., Levy, D. P. & Lockwood, C. J. (1997). [Average length of spontaneous labor in Chinese primigravidas]. Journal de gynecologie, obstetrique et biologie de la reproduction, 26(7), 704-10. PMID: 9471433.

Amit, A. G., Harper, M. M., Mariuzza, R. A., Saludjian, P., Poljak, R. J., Lamoyi, E. & Nisonoff, A. (1983). Preliminary crystallographic study of the Fab fragment of a monoclonal anti-phenylarsonate antibody. Journal of molecular biology, 165(2), 415-7. PMID: 6842607.