Seongjin Seo, PhD

Portrait
Associate Professor of Ophthalmology and Visual Sciences

Contact Information

Lab: 4171 MERF
Iowa City, IA 52242
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Office: 4135F MERF
Iowa City, IA 52242
319-353-4605

Education

BS, Biology Education, Seoul National University
Biology, Seoul National University
PhD, Molecular Biology and Pharmacology, Washington University School of Medicine

Center, Program and Institute Affiliations

Institute for Vision Research

Publications

Weihbrecht, K., Goar, W. A., Carter, C. S., Sheffield, V. C. & Seo, S. (2018). Genotypic and phenotypic characterization of the Sdccag8Tn(sb-Tyr)2161B.CA1C2Ove mouse model. PloS one, 13(2), e0192755. PMID: 29444170.

Hsu, Y., Garrison, J. E., Kim, G., Schmitz, A. R., Searby, C. C., Zhang, Q., Datta, P., Nishimura, D. Y., Seo, S. & Sheffield, V. C. (2017). BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment. PLoS genetics, 13(10), e1007057. PMID: 29049287.

Seo, S., Datta, P. (2017). Photoreceptor outer segment as a sink for membrane proteins: hypothesis and implications in retinal ciliopathies. Human Molecular Genetics, 26(R1), R75-R82. PMID: 28453661.

Dutta, N., Seo, S. (2016). RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner. Biology Open, 5(9), 1283-1289. PMID: 27493202.

Biswal, M. R., Ildefonso, C. J., Mao, H., Seo, S. J., Wang, Z., Li, H., Le, Y. Z. & Lewin, A. S. (2016). Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration. Advances in experimental medicine and biology, 854, 31-37. PMID: 26427390.

Bullard, S. A., Seo, S., Schilling, B., Dyle, M. C., Dierdorff, J. M., Ebert, S. M., DeLau, A. D., Gibson, B. W. & Adams, C. M. (2016). Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4. The Journal of biological chemistry, 291(34), 17496-17509. PMID: 27358404.

Lee, J. J., Seo, S. (2015). PDE6D binds to the C-terminus of RPGR in a prenylation-dependent manner. (Vols. 16). (12), pp. 1581-1582. EMBO reports. PMID: 26553938.

Plotnikova, O. V., Seo, S., Cottle, D. L., Conduit, S., Hakim, S., Dyson, J. M., Mitchell, C. A. & Smyth, I. M. (2015). INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability. Journal of cell science, 128(2), 364-372. PMID: 25395580.

Datta, P., Allamargot, C., Hudson, J. S., Andersen, E. K., Bhattarai, S., Drack, A. V., Sheffield, V. C. & Seo, S. (2015). Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome. Proceedings of the National Academy of Sciences of the United States of America, 112(32), E4400-E4409. PMID: 26216965.

Zhang, Y., Seo, S., Bhattarai, S., Bugge, K., Searby, C. C., Zhang, Q., Drack, A. V., Stone, E. M. & Sheffield, V. C. (2014). BBS mutations modify phenotypic expression of CEP290-related ciliopathies. Hum Mol Genet, 23(1), 40-51. PMID: 23943788.

Swiderski, R. E., Nakano, Y., Mullins, R. F., Seo, S. & Bánfi, B. (2014). A Mutation in the Mouse Ttc26 Gene Leads to Impaired Hedgehog Signaling. PLoS Genetics, 10(10), e1004689. PMID: 25340710.

Chamling, X., Seo, S., Searby, C. C., Kim, G., Slusarski, D. C. & Sheffield, V. C. (2014). The Centriolar Satellite Protein AZI1 Interacts with BBS4 and Regulates Ciliary Trafficking of the BBSome. PLoS Genet, 10(2), e1004083. PMID: 24550735.

Nelson, N. G., Skeie, J. M., Muradov, H., Rowell, H. A., Seo, S. & Mahajan, V. B. (2014). CAPN5 gene silencing by short hairpin RNA interference. BMC Res Notes, 7(1), 642.

Sinha, S., Belcastro, M., Datta, P., Seo, S. & Sokolov, M. (2014). Essential Role of the Chaperonin CCT in Rod Outer Segment Biogenesis. Invest Ophthalmol Vis Sci, 55(6), 3775-3785.

Seo, S., Mullins, R. F., Dumitrescu, A. V., Bhattarai, S., Gratie, D., Wang, K., Stone, E. M., Sheffield, V. & Drack, A. V. (2013). Subretinal gene therapy of mice with Bardet-Biedl syndrome type 1. Invest Ophthalmol Vis Sci, 54(9), 6118-32. PMID: 23900607.

Drack, A. V., Mullins, R. & Seo, S. (2013). Retinitis Pigmentosa Syndromes: Bardet-Biedl Syndrome. In M. E. Hartnett , M. Trese & A. Capone (Eds.) Pediatric Retina. pp. 259068. Philadelphia: Lippincott.

Chamling, X., Seo, S., Bugge, K., Searby, C., Guo, D. F., Drack, A. V., Rahmouni, K. & Sheffield, V. C. (2013). Ectopic expression of human BBS4 can rescue Bardet-Biedl syndrome phenotypes in Bbs4 null mice. PLoS One, 8(3), e59101. PMID: 23554981.

Seo, S., Solivan-Timpe, F., Roos, B. R., Robin, A. L., Stone, E. M., Kwon, Y. H., Alward, W. L. & Fingert, J. H. (2013). Identification of Proteins that Interact with TANK Binding Kinase 1 and Testing for Mutations Associated with Glaucoma. Curr. Eye. Res., 38(2), 310-5. PMID: 23286385.

Zhang, Q., Seo, S., Bugge, K., Stone, E. M. & Sheffield, V. C. (2012). BBS proteins interact genetically with the IFT pathway to influence SHH related phenotypes. Hum Mol Genet, 21(9), 1945-1953. PMID: 22228099.

Zhang, Q., Yu, D., Seo, S., Stone, E. M. & Sheffield, V. C. (2012). Intrinsic protein-protein interaction mediated and chaperonin assisted sequential assembly of a stable Bardet-Biedl syndrome protein complex, the BBSome. J Biol Chem, 287(24), 20625-20635. PMID: 22500027.

Humbert, M. C., Weihbrecht, K., Searby, C. C., Li, Y., Pope, R. M., Sheffield, V. C. & Seo, S. (2012). ARL13B, PDE6D and CEP164 form a functional network for INPP5E ciliary targeting. Proc. Natl. Acad. Sci. USA., 109(48), 19691-6. PMID: 23150559.

Carter, C. S., Vogel, T. W., Zhang, Q., Seo, S., Swiderski, R. E., Moninger, T. O., Cassell, M. D., Thedens, D. R., Keppler-Noreuil, K. M., Nopoulos, P., Nishimura, D. Y., Searby, C. C., Bugge, K. & Sheffield, V. C. (2012). Abnormal development of NG2+PDGFR-a+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model. Nat. Med., 18(12), 1797-804. PMID: 23160237.

Seo, S., Zhang, Q., Bugge, K., Breslow, D. K., Searby, C. C., Nachury, M. V. & Sheffield, V. C. (2011). A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. PLoS Genet, 7(11), e1002358. PMID: 22072986.

Sang, L., Miller, J. J., Corbit, K. C., Giles, R. H., Brauer, M. J., Otto, E. A., Baye, L. M., Wen, X., Scales, S. J., Kwong, M., Huntzicker, E. G., Sfakianos, M. K., Sandoval, W., Bazan, J. F., Kulkarmi, P., Giarcia-Gonzalo, F. R., Seol, A. D., O'Toole, J. F., Held, S., Reutter, H. M., Lane, W. S., Rafiq, M. A., Noor, A., Ansar, M., Devi, A. R., Sheffield, V. C., Slusarski, D. C., Vincent, J. B., Doherty, D. A., Hildebrandt, F., Reiter, J. F. & Jackson, P. K. (2011). Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways. Cell, 145(4), 513-28. PMID: 21565611.

Zhang, Q., Nishimura, D., Seo, S., Vogel, T., Morgan, D., Searby, C., Bugge, K., Stone, E., Rhamouni, K. & Sheffield, V. (2011). Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS associated phenotypes and Bbs3 unique phenotypes. Proc. Natl. Acad. Sci. USA., 108(51), 20678-20683. PMID: 22139371.

Seo, S., Baye, L. M., Schulz, N. P., Beck, J. S., Zhang, Q., Slusarski, D. C. & Sheffield, V. C. (2010). BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. Proc Natl Acad Sci U S A, 107(4), 1488-93. PMID: 20080638.

Seo, S., Guo, D. F., Bugge, K., Morgan, D. A., Rahmouni, K. & Sheffield, V. C. (2009). Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. Hum Mol Genet, 18(7), 1323-31. PMID: 19150989.

Rahmouni, K., Fath, M. A., Seo, S., Thedens, D. R., Berry, C. J., Weiss, R., Nishimura, D. Y. & Sheffield, V. C. (2008). Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome. J Clin Invest, 118(4), 1458-67. PMID: 18317593.

Seo, S., Lim, J. W., Yellajoshyula, D., Chang, L. W. & Kroll, K. L. (2007). Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. EMBO J, 26(24), 5093-108. PMID: 18007592.

Seo, S., Kroll, K. L. (2006). Geminin's double life: chromatin connections that regulate transcription at the transition from proliferation to differentiation. Cell Cycle, 5(4), 374-9. PMID: 16479171.

Seo, S., Richardson, G. A. & Kroll, K. L. (2005). The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD. Development, 132(1), 105-15. PMID: 15576411.

Seo, S., Herr, A., Lim, J. W., Richardson, G. A., Richardson, H. & Kroll, K. L. (2005). Geminin regulates neuronal differentiation by antagonizing Brg1 activity. Genes Dev, 19(14), 1723-34. PMID: 16024661.

Cho, G., Kang, S., Seo, S., Kim, Y. & Jung, G. (1997). The Transcriptional Repression of the Human Cu/Zn Superoxide Dismutase (sod1) Gene by the Anticancer Drug Mitomycin C (MMC). Biochem Mol Biol Int, 42(5), 949-956.

Seo, S., Kang, S. S., Cho, G., Rho, H. M. & Jung, G. (1997). C/EBP Alpha and C/EBP Beta Play Similar Roles in the Transcription of the Human Cu/Zn SOD Gene. Gene, 203(1), 11-15.

Seo, S., Kim, H. T., Cho, G., Rho, H. M. & Jung, G. (1996). Sp1 and C/EBP-Related Factor Regulate the Transcription of Human Cu/ZN SOD Gene. Gene, 178(1-2), 177-185.