Seongjin Seo, PhD
Associate Professor of Ophthalmology and Visual Sciences
Office
Lab
4171 Medical Education Research Facility
Iowa City, IA 52242
Current Positions
- Associate Professor of Ophthalmology and Visual Sciences
Education
- BS in Biology Education, Seoul National University, Seoul, Korea
- Biology, Seoul National University, Seoul, Korea
- PhD in Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri, United States
Graduate Program Affiliations
Center, Program and Institute Affiliations
Research Interests
- Proteomic characterization of retinitis pigmentosa
- Molecular mechanisms of protein trafficking to the primary cilia and photoreceptor outer segment
- Analysis of protein-protein interaction network (interactome) in cilia biology
- Disease mechanisms of retinitis pigmentosa, obesity, and cystic kidney disease associated with ciliary defects
Selected Publications
- Seo S, Datta P, Do Rhee K, Staudt RJ, Thompson J, Hsu Y, Hassan S, Rankin T, Drack AV. (2024). Delivering large genes using adeno-associated virus (AAV) and the CRE-lox DNA recombination system. Inves. Ophth. & Vis. Sci. 65(7):1030.
- Burnight ER, Wiley LA, Ochoa D, Varzavand K, Seo S, Han IC, Mullins RF, Stone EM, Tucker BA. (2024). A dual AAV vector approach for the treatment of ABCA4-associated retinal disease. Invest. Ophthalmol. Vis. Sci. 65(7):1540.
- Datta P, Rhee KD, Staudt RJ, Thompson JM, Hsu Y, Hassan S, Drack AV, Seo S. (2024). Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system. Hum Mol Genet. ONLINE AHEAD OF PRINT. DOI: 10.1093/hmg/ddae144. PMID: 39393808.
- Datta, P., Hendrickson, B., Brendalen, S., Ruffcorn, A. & Seo, S. (2019). The myosin-tail homology domain of centrosomal protein 290 is essential for protein confinement between the inner and outer segments in photoreceptors. The Journal of biological chemistry 294 (50) 19119-19136. DOI: 10.1074/jbc.RA119.009712. PMID: 31694913. PMCID: PMC6916492.
- Weihbrecht, K., Goar, W. A., Carter, C. S., Sheffield, V. C. & Seo, S. (2018). Genotypic and phenotypic characterization of the Sdccag8Tn(sb-Tyr)2161B.CA1C2Ove mouse model. PloS one 13 (2) e0192755. DOI: 10.1371/journal.pone.0192755. PMID: 29444170. PMCID: PMC5812623.
- Hsu, Y., Garrison, J. E., Kim, G., Schmitz, A. R., Searby, C. C., Zhang, Q., Datta, P., Nishimura, D. Y., Seo, S. & Sheffield, V. C. (2017). BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment. PLoS genetics 13 (10) e1007057. DOI: 10.1371/journal.pgen.1007057. PMID: 29049287.
- Seo, S. & Datta, P. (2017). Photoreceptor outer segment as a sink for membrane proteins: hypothesis and implications in retinal ciliopathies. Human Molecular Genetics 26 (R1) R75-R82. DOI: 10.1093/hmg/ddx163. PMID: 28453661.
- Dutta, N. & Seo, S. (2016). RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner. Biology Open 5 (9) 1283-1289. DOI: 10.1242/bio.020461. PMID: 27493202. PMCID: PMC5051646.
- Bullard, S. A., Seo, S., Schilling, B., Dyle, M. C., Dierdorff, J. M., Ebert, S. M., DeLau, A. D., Gibson, B. W. & Adams, C. M. (2016). Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4. The Journal of biological chemistry 291 (34) 17496-17509. DOI: 10.1074/jbc.M116.740308. PMID: 27358404. PMCID: PMC5016147.
- Biswal, M. R., Ildefonso, C. J., Mao, H., Seo, S. J., Wang, Z., Li, H., Le, Y. Z. & Lewin, A. S. (2016). Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration. Advances in experimental medicine and biology 854 31-37. DOI: 10.1007/978-3-319-17121-0_5. PMID: 26427390.