Terry A. Braun, BS, MS, PhD

Hansjoerg E. J. W. Kolder, MD, PhD, Professorship in Best Disease Research
Director, Coordinated Laboratory for Computational Genomics
Professor of Biomedical Engineering (BME)
Professor of Ophthalmology and Visual Sciences
Professor of Electrical and Computer Engineering (ECE)

Contact Information

Primary Office
5318 SC
Iowa City, IA 52242

5318 SC
Iowa City, IA 52242

Primary Office
5318 SC


BS, Electrical Engineering, University of Iowa
MS, Electrical and Computer Engineering, University of Iowa
PhD, Genetics, University of Iowa

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Genetics, Interdisciplinary Graduate Program in Informatics, Interdisciplinary Graduate Program in Neuroscience

Center, Program and Institute Affiliations

Carver Family Center for Macular Degeneration, Center for Bioinformatics and Computational Biology, Holden Comprehensive Cancer Center, Institute for Clinical and Translational Science, Institute for Vision Research, Iowa Institute of Human Genetics., John and Marcia Carver Nonprofit Genetic Testing Laboratory

Research Summary

Genetics; bioinformatics and computational genetics; macular degeneration.


Stone, E. M., Andorf, J. L., Whitmore, S. S., DeLuca, A. P., Giacalone, J. C., Streb, L. M., Braun, T. A., Mullins, R. F., Scheetz, T. E., Sheffield, V. C. & Tucker, B. A. (2017). Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease. Ophthalmology, 124(9), 1314-1331. PMID: 28559085.

Taylor, K. R., Booth, K. T., Azaiez, H., Sloan, C. M., Kolbe, D. L., Glanz, E. N., Shearer, A. E., DeLuca, A. P., Anand, V. N., Hildebrand, M. S., Simpson, A. C., Eppsteiner, R. W., Scheetz, T. E., Braun, T. A., Huygen, P. L., Smith, R. J. & Casavant, T. L. (2016). Audioprofile Surfaces: The 21st Century Audiogram. The Annals of otology, rhinology, and laryngology, 125(5), 361-8. PMID: 26530094.

Scheetz, T. E., Fingert, J. H., Wang, K., Kuehn, M. H., Knudtson, K. L., Alward, W. L., Boldt, H. C., Russell, S. R., Folk, J. C., Casavant, T. L., Braun, T. A., Clark, A. F., Stone, E. M. & Sheffield, V. C. (2013). A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci. PLoS One, 8(3), 358657. PMID: 23536807.00.

Mahajan, V. B., Skeie, J. M., Bassuk, A. G., Fingert, J. H., Braun, T. A., Daggett, H. T., Folk, J. C., Sheffield, V. C. & Stone, E. M. (2012). Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration. PLoS Genet, 8(10), e1003001. PMID: 23055945.00.

Carr, J. C., Boese, E. A., Spanheimer, P. M., Dahdaleh, F. S., Martin, M., Calva, D., Schafer, B., Thole, D. M., Braun, T., O'Dorisio, T. M., O'Dorisio, M. S. & Howe, J. R. (2012). Differentiation of small bowel and pancreatic neuroendocrine tumors by gene-expression profiling. Surgery, 152(6), 998-1007. PMID: 23158174.00.

Eppsteiner, R. W., Shearer, A. E., Hildebrand, M. S., Deluca, A. P., Ji, H., Dunn, C. C., Black-Ziegelbein, E. A., Casavant, T. L., Braun, T. A., Scheetz, T. E., Scherer, S. E., Hansen, M. R., Gantz, B. J. & Smith, R. J. (2012). Prediction of cochlear implant performance by genetic mutation: the spiral ganglion hypothesis. Hear Res, 292(1-2), 51-58. PMID: 22975204.00.

Eppsteiner, R. W., Schearer, A. E., Hildebrand, M. S., Taylor, K. R., Deluca, A. P., Scherer, S., Huygen, P., Scheetz, T. E., Braun, T. A., Casavant, T. L. & Smith, R. J. (2012). Using the phenome and genome to improve genetic diagnosis for deafness. Otolaryngol Head Neck Surg, 147(5), 975-977. PMID: 22785243.00.

Davis, L. K., Meyer, K. J., Schindler, E. I., Beck, J. S., Rudd, D. S., Grundstad, A. J., Scheetz, T. E., Braun, T. A., Fingert, J. H., Alward, W. L., Kwon, Y. H., Folk, J. C., Russell, S. R., Wassink, T. H., Sheffield, V. C. & Stone, E. M. (2011). Copy number variations and primary open-angle glaucoma. Invest Ophthalmol Vis Sci, 52(10), 7122-7133. PMID: 21310917.00.

Hildebrand, M. S., Morin, M., Meyer, N. C., Mayo, F., Modamio-Hoybjor, S., Mencia, A., Olavarrieta, L., Morales-Angulo, C., Nishimura, C. J., Workman, H., Deluca, A. P., del Castillo, I., Taylor, K. R., Tompkins, B., Goodman, C. W., Schrauwen, I., Wesemael, M. V., Lachlan, K., Shearer, A. E., Braun, T. A., Huygen, P. L., Kremer, H., Van Camp, G., Moreno, F., Casavant, T. L., Smith, R. J. & Moreno-Pelayo, M. A. (2011). DFNA8/12 caused by TECTA mutations is the most identified subtype of nonsyndromic autosomal dominant hearing loss. Hum Mutat, 32(7), 825-834. PMID: 21520338.00.

Meyer, K. J., Davis, L. K., Schindler, E. I., Beck, J. S., Rudd, D. S., Grundstad, A. J., Scheetz, T. E., Braun, T. A., Fingert, J. H., Alward, W. L., Kwon, Y. H., Folk, J. C., Russell, S. R., Wassink, T. H., Stone, E. M. & Sheffield, V. C. (2011). Genome-wide analysis of copy number variants in age-related macular degeneration. Hum Genet, 129(1), 91-100. PMID: 20981449.00.

Walters, J. D., Bair, T. B., Braun, T. A., Scheetz, T. E., Robinson, J. P. & Casavant, T. L. (2009). Multi-granularity Parallel Computing in a Genome-Scale Molecular Evolution Application. J Supercomput, 5698, 49-59.

O'Leary, B. M., Davis, S. G., Smith, M. F., Brown, B., Kemp, M. B., Almabrazi, H., Grundstad, J. A., Burns, T., Leontiev, V., Andorf, J., Clark, A. F., Sheffield, V. C., Casavant, T. L., Scheetz, T. E., Stone, E. M. & Braun, T. A. (2007). Transcript annotation prioritization and screening system (TrAPSS) for mutation screening. J Bioinform Comput Biol, 5(6), 1155-1172. DOI: 10.1142/S0219720007003132.

Bischof, J. M., Chiang, A. P., Scheetz, T. E., Stone, E. M., Casavant, T. L., Sheffield, V. C. & Braun, T. A. (2006). Genome-wide identification of pseudogenes capable of disease-causing gene conversion. Hum Mutat, 27(6), 545-552. PMID: 16671097.00.

Chang, A. P., Beck, J. S., Yen, H. J., Tayeh, M. K., Scheetz, T. E., Swiderski, R. E., Nishimura, D. Y., Braun, T. A., Kim, K. Y., Huang, J., Elbedour, K., Carmi, R., Slusarski, D. C., Casavant, T. L., Stone, E. M. & Sheffield, V. C. (2006). Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11). Proceedings of the National Academy of Sciences, 103(16), 6287-6292. PMID: 16606853.00.

Braun, T. A., Shankar, S. P., Davis, S., O'Leary, B., Scheetz, T. E., Clark, A. F., Sheffield, V. C., Casavant, T. L. & Stone, E. M. (2006). Prioritizing regions of candidate genes for efficient mutation screening. Hum Mutat, 27(2), 195-200. PMID: 16395665.00.

Steely, H. T., Dillow, G. W., Bian, L., Grundstad, J., Braun, T. A., Casavant, T. L., McCartney, M. D. & Clark, A. F. (2006). Protein expression in a transformed trabecular meshwork cell line: proteome analysis. Mol Vis, 12, 372-383. PMID: 16636656.00.

Scheetz, T. E., Kim, K. Y., Swiderski, R. E., Philp, A. R., Braun, T. A., Knudtson, K. L., Dorrance, A. M., DiBona, G. F., Huang, J., Casavant, T. L., Sheffield, V. C. & Stone, E. M. (2006). Regulation of gene expression in the mammalian eye and its relevance to eye disease. Proc Natl Acad Sci USA, 103(39), 14429-14434. PMID: 16983098.00.

Sibenaller, Z. A., Etame, A. B., Ali, M. M., Barua, M., Braun, T. A., Casavant, T. L. & Ryken, T. C. (2005). Genetic characterization of commonly used glioma cell lines in the rat animal model system. Neurosurg Focus, 19(4), E1. PMID: 16241103.00.

Stone, E. M., Braun, T. A., Russell, S. R., Kuehn, M. H., Lotery, A. J., Moore, P. A., Eastman, C. G., Casavant, T. L. & Sheffield, V. C. (2004). Missense variations in the fibulin 5 gene and age-related macular degeneration. N Engl J Med, 351(4), 346-353. PMID: 15269314.00.

Scheetz, T. E., Trivedi, N., Roberts, C. A., Kucaba, T., Berger, B., Robinson, N. L., Birkett, C. L., Gavin, A. J., O'Leary, B., Braun, T. A., Bonaldo, M. F., Robinson, J. P., Sheffield, V. C., Soares, M. B. & Casavant, T. L. (2003). ESTprep: preprocessing cDNA sequence reads. Bioinformatics, 19(11), 1318-1324. DOI: 10.1093/bioinformatics/btg159.

Gavin, A. J., Scheetz, T. E., Roberts, C. A., O'Leary, B., Braun, T., Sheffield, V. C., Soares, M. B., Robinson, J. P. & Casavant, T. L. (2002). Pooled library tissue tags for EST-based gene discovery. Bioinformatics, 18(9), 1162-6. PMID: 12217907.

Mykytyn, K., Nishimura, D. Y., Searby, C. C., Shastri, M., Yen, H. J., Beck, J. S., Braun, T., Streb, L. M., Cornier, A. S., Cox, G. F., Fulton, A. B., Carmi, R., Luleci, G., Chandrasekharappa, S. C., Collins, F. S., Jacobson, S. G., Heckenlively, J. R., Weleber, R. G., Stone, E. M. & Sheffield, V. C. (2002). Identification of the gene (BBS1) most commonly involved in Bardet-Biedl syndrome, a complex human obesity syndrome. Nature Genetics, 31(4), 435-438.

Barrett, S., Beck, J. C., Bernier, R., Bisson, E., Braun, T., Casavant, T. L., Childress, D., Folstein, S. E., Garcia, M., Gardiner, M. B., Gilman, S., Haines, J. L., Hopkins, K., Landa, R., Meyer, N. H., Mullane, J. A., Nishimura, D. Y., Palmer, P., Piven, J., Purdy, J., Santangelo, S. L., Searby, C., Sheffield, V., Singleton, J. & Slager, S. (1999). An autosomal genomic screen for autism. Collaborative linkage study of autism. Am J Med Genet, 88(6), 609-15. PMID: 10581478.