Wallace L. Alward, MD

Portrait
Frederick C. Blodi Chair in Ophthalmology
Vice-Chair, Ophthalmology
Director, Glaucoma Service
Professor of Ophthalmology and Visual Sciences

Contact Information

Primary Office: 11190C PFP
Iowa City, IA 52242
319-356-2228

Education

AB, Biology, Kenyon College
MD, Medicine, Ohio State University

Internship, General Surgery, University Hospitals of Pittsburgh
Resident, Chief Resident, Ophthalmology, University of Louisville
Resident, Ophthalmology, University of Louisville
Fellow, Glaucoma, Bascom Palmer Eye Institute, University of Miami

Licensure and Certifications

ABO Certification - American Board of Ophthalmology
State of Florida Medical License (inactive)
State of Kentucky Medical License (inactive)
State of Alaska Medical License (Inactive)
NBME Diplomate - National Board of Medical Examiners

Center, Program and Institute Affiliations

Carver Family Center for Macular Degeneration, Institute for Vision Research

Research Summary

Dr. Alward is primarily a glaucoma clinician. His areas of research interest include pigmentary glaucoma, combined glaucoma and cataract surgery, normal tension glaucoma, and gonioscopy. The major focus of his research over the last many years has been the molecular genetics of glaucoma. In collaboration with Edwin Stone and Val Sheffield, Dr. Alward was part of the team that described the first gene for primary open angle glaucoma. He was involved in the the discovery of the myocilin gene for primary open angle glaucoma, the PITX2 and FOXC1 genes for Axenfeld-Rieger syndrome and the TBK1 gene for normal tension glaucoma.

Publications

Alward, W. L. (2017). Sunshine Has Darkened my Worldview. (Vols. 175). pp. xii-xiii. American journal of ophthalmology. PMID: 28088286.

Provencher, L. M., Carter, P. C. & Alward WLM, (2017). Idiopathic Bilateral Profound Hypotony in an Unknown Progressive Neurodegenerative Disorder. Journal of glaucoma, 26(5), e168-e170. PMID: 28221333.

DeLuca, A. P., Alward, W. L., Liebmann, J., Ritch, R., Kawase, K., Kwon, Y. H., Robin, A. L., Stone, E. M., Scheetz, T. E. & Fingert, J. H. (2017). Genomic Organization of TBK1 Copy Number Variations in Glaucoma Patients. Journal of glaucoma, 26(12), 1063-1067. PMID: 28984711.

Guo, Z., Kwon, Y. H., Lee, K., Wang, K., Wahle, A., Alward, W. L., Fingert, J. H., Bettis, D. I., Johnson, C. A., Garvin, M. K., Sonka, M. & Abràmoff, M. D. (2017). Optical Coherence Tomography Analysis Based Prediction of Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma. Investigative ophthalmology & visual science, 58(10), 3975-3985. PMID: 28796875.

Lewis, C., Hedberg-Buenz, A., DeLuca, A. P., Stone, E. M., Alward WLM, & Fingert, J. H. (2017). Primary Congenital and Developmental Glaucomas. Human molecular genetics, 26(R1), R28-R36. PMID: 28549150.

Wang, X., Mudie, L. I., Baskaran, M., Cheng, C. Y., Alward, W. L., Friedman, D. S. & Brady, C. J. (2017). Crowdsourcing to Evaluate Fundus Photographs for the Presence of Glaucoma. Journal of glaucoma, 26(6), 505-510. PMID: 28319525.

Provencher, L. M., Carter, K. D., Nerad, J. A. & Alward, W. L. (2017). Upper Eyelid Splitting to Facilitate the Insertion of Glaucoma Drainage Devices. Journal of glaucoma, 26(11), e249-e251. PMID: 28930886.

Provencher, L. M., Shriver, E. M. & Alward, W. L. (2017). Ptosis Masquerading as Progression of Severe Glaucoma. JAMA ophthalmology, 135(9), e172788. PMID: 28910451.

Simpson, A., Avdic, A., Roos, B. R., DeLuca, A., Miller, K., Schnieders, M. J., Scheetz, T. E., Alward, W. L. & Fingert, J. H. (2017). LADD syndrome with glaucoma is caused by a novel gene. Molecular vision, 23, 179-184. PMID: 28400699.

Aponte, E. P., Ball, D. C. & Alward, W. L. (2016). Iridocorneal Endothelial Syndrome in a 14-Year-Old Male. Journal of Glaucoma, 25(2), e115-e116. PMID: 26035422.

Clark, T. J., Rao, K., Quinn, C. D., Batlle, J. F., Alward, W. L., Wester, S. T. & Shriver, E. M. (2016). A Vector Force Model of Upper Eyelid Position in the Setting of a Trabeculectomy Bleb. Ophthalmic Plastic & Reconstructive Surgery, 32(2), 127-32. PMID: 25794022.

Haugsdal, J. M., Goins, K. M., Greiner, M. A., Kwon, Y. H., Alward, W. L. & Wagoner, M. D. (2016). Boston type 1 keratoprosthesis for primary congenital glaucoma. British Journal of Ophthalmology, 100(3), 328-31. PMID: 26206789.

Scheetz, T. E., Roos, B. R., Solivan-Timpe, F., Miller, K., DeLuca, A. P., Stone, E. M., Kwon, Y. H., Alward, W. L., Wang, K. & Fingert, J. H. (2016). SQSTM1 Mutations and Glaucoma. PloS one, 11(6), e0156001. PMID: 27275741.

Fingert, J. H., Robin, A. L., Scheetz, T. E., Kwon, Y. H., Liebmann, J. M., Ritch, R. & Alward, W. L. (2016). Tank-Binding Kinase 1 (TBK1) Gene and Open-Angle Glaucomas (An American Ophthalmological Society Thesis). Transactions of the American Ophthalmological Society, 114, T6. PMID: 27881886.

Alward, W. L. (2016). The Red Badge. Ophthalmology, 123(9), S30-S31. DOI: 10.1016/j.ophtha.2016.06.013.

Elshatory, Y. M., Gauger, E. H., Kwon, Y. H., Alward, W. L., Boldt, H. C., Russell, S. R. & Mahajan, V. B. (2016). Management of Pediatric Aphakic Glaucoma With Vitrectomy and Tube Shunts. Journal of pediatric ophthalmology and strabismus, 53(6), 339-343. PMID: 27668871.

Risma, J. M., Tehrani, S., Wang, K., Fingert, J. H., Alward, W. L. & Kwon, Y. H. (2016). The Utility of Diaton Tonometer Measurements in Patients With Ocular Hypertension, Glaucoma, and Glaucoma Tube Shunts. Journal of Glaucoma, 25(8), 643-647. PMID: 26950582.

Goins, K. M., Kitzmann, A. S., Greiner, M. A., Kwon, Y. H., Alward, W. L., Ledolter, J. & Wagoner, M. D. (2016). Boston Type 1 Keratoprosthesis: Visual Outcomes, Device Retention, and Complications. Cornea, 35(9), 1165-74. PMID: 27191675.

Phillips, D. L., Goins, K. M., Greiner, M. A., Alward, W. L., Kwon, Y. H. & Wagoner, M. D. (2015). Boston Type 1 Keratoprosthesis for Iridocorneal Endothelial Syndromes. Cornea, 34(11), 1383-6. PMID: 26398156.

Alward, W. L., Longmuir, S. Q., Miri, M. S., Garvin, M. K. & Kwon, Y. H. (2015). Movement of Retinal Vessels to Optic Nerve Head with Intraocular Pressure Elevation in a Child. Ophthalmology, 122(7), 1532-4. PMID: 25726092.

Aung, T., Ozaki, M., Mizoguchi, T., Allingham, R. R., Li, Z., Haripriya, A., Nakano, S., Uebe, S., Harder, J. M., Chan, A. S., Lee, M. C., Burdon, K. P., Astakhov, Y. S., Abu-Amero, K. K., Zenteno, J. C., Nilgün, Y., Zarnowski, T., Pakravan, M., Safieh, L. A., Jia, L., Wang, Y. X., Williams, S., Paoli, D., Schlottmann, P. G., Huang, L., Sim, K. S., Foo, J. N., Nakano, M., Ikeda, Y., Kumar, R. S., Ueno, M., Manabe, S., Hayashi, K., Kazama, S., Ideta, R., Mori, Y., Miyata, K., Sugiyama, K., Higashide, T., Chihara, E., Inoue, K., Ishiko, S., Yoshida, A., Yanagi, M., Kiuchi, Y., Aihara, M., Ohashi, T., Sakurai, T., Sugimoto, T., Chuman, H., Matsuda, F., Yamashiro, K., Gotoh, N., Miyake, M., Astakhov, S. Y., Osman, E. A., Al-Obeidan, S. A., Owaidhah, O., Al-Jasim, L., Shahwan, S. A., Fogarty, R. A., Leo, P., Yetkin, Y., Oguz, Ç., Kanavi, M. R., Beni, A. N., Yazdani, S., Akopov, E. L., Toh, K. Y., Howell, G. R., Orr, A. C., Goh, Y., Meah, W. Y., Peh, S. Q., Kosior-Jarecka, E., Lukasik, U., Krumbiegel, M., Vithana, E. N., Wong, T. Y., Liu, Y., Koch, A. E., Challa, P., Rautenbach, R. M., Mackey, D. A., Hewitt, A. W., Mitchell, P., Wang, J. J., Ziskind, A., Carmichael, T., Ramakrishnan, R., Narendran, K., Venkatesh, R., Vijayan, S., Zhao, P., Chen, X., Guadarrama-Vallejo, D., Cheng, C. Y., Perera, S. A., Husain, R., Ho, S. L., Welge-Luessen, U. C., Mardin, C., Schloetzer-Schrehardt, U., Hillmer, A. M., Herms, S., Moebus, S., Nöthen, M. M., Weisschuh, N., Shetty, R., Ghosh, A., Teo, Y. Y., Brown, M. A., Lischinsky, I., Crowston, J. G., Coote, M., Zhao, B., Sang, J., Zhang, N., You, Q., Vysochinskaya, V., Founti, P., Chatzikyriakidou, A., Lambropoulos, A., Anastasopoulos, E., Coleman, A. L., Wilson, M. R., Rhee, D. J., Kang, J. H., May-Bolchakova, I., Heegaard, S., Mori, K., Alward, W. L., Jonas, J. B., Xu, L., Liebmann, J. M., Chowbay, B., Schaeffeler, E., Schwab, M., Lerner, F., Wang, N., Yang, Z., Frezzotti, P., Kinoshita, S., Fingert, J. H., Inatani, M., Tashiro, K., Reis, A., Edward, D. P., Pasquale, L. R., Kubota, T., Wiggs, J. L., Pasutto, F., Topouzis, F., Dubina, M., Craig, J. E., Yoshimura, N., Sundaresan, P., John, S. W., Ritch, R., Hauser, M. A. & Khor, C. C. (2015). Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. (Vols. 47). (6), pp. 689. Nature genetics. PMID: 26018902.

Hazlewood, R. J., Roos, B. R., Solivan-Timpe, F., Honkanen, R. A., Jampol, L. M., Gieser, S. C., Meyer, K. J., Mullins, R. F., Kuehn, M. H., Scheetz, T. E., Kwon, Y. H., Alward, W. L., Stone, E. M. & Fingert, J. H. (2015). Heterozygous triplication of upstream regulatory sequences leads to dysregulation of matrix metalloproteinase 19 in patients with cavitary optic disc anomaly. Human mutation, 36(3), 369-78. PMID: 25581579.

Tandon, A., Alward, W. L. (2015). The centennial of modern gonioscopy. Ophthalmologica, 233(1), 58-9. PMID: 25427974.

Alward, W. L. (2015). Iowa Glaucoma Curriculum.

Aung, T., Ozaki, M., Mizoguchi, T., Allingham, R. R., Li, Z., Haripriya, A., Nakano, S., Uebe, S., Harder, J. M., Chan, A. S., Lee, M. C., Burdon, K. P., Astakhov, Y. S., Abu-Amero, K. K., Zenteno, J. C., Nilgün, Y., Zarnowski, T., Pakravan, M., Safieh, L. A., Jia, L., Wang, Y. X., Williams, S., Paoli, D., Schlottmann, P. G., Huang, L., Sim, K. S., Foo, J. N., Nakano, M., Ikeda, Y., Kumar, R. S., Ueno, M., Manabe, S., Hayashi, K., Kazama, S., Ideta, R., Mori, Y., Miyata, K., Sugiyama, K., Higashide, T., Chihara, E., Inoue, K., Ishiko, S., Yoshida, A., Yanagi, M., Kiuchi, Y., Aihara, M., Ohashi, T., Sakurai, T., Sugimoto, T., Chuman, H., Matsuda, F., Yamashiro, K., Gotoh, N., Miyake, M., Astakhov, S. Y., Osman, E. A., Al-Obeidan, S. A., Owaidhah, O., Al-Jasim, L., Al Shahwan, S., Fogarty, R. A., Leo, P., Yetkin, Y., Oguz, Ç., Kanavi, M. R., Beni, A. N., Yazdani, S., Akopov, E. L., Toh, K. Y., Howell, G. R., Orr, A. C., Goh, Y., Meah, W. Y., Peh, S. Q., Kosior-Jarecka, E., Lukasik, U., Krumbiegel, M., Vithana, E. N., Wong, T. Y., Liu, Y., Koch, A. E., Challa, P., Rautenbach, R. M., Mackey, D. A., Hewitt, A. W., Mitchell, P., Wang, J. J., Ziskind, A., Carmichael, T., Ramakrishnan, R., Narendran, K., Venkatesh, R., Vijayan, S., Zhao, P., Chen, X., Guadarrama-Vallejo, D., Cheng, C. Y., Perera, S. A., Husain, R., Ho, S. L., Welge-Luessen, U. C., Mardin, C., Schloetzer-Schrehardt, U., Hillmer, A. M., Herms, S., Moebus, S., Nöthen, M. M., Weisschuh, N., Shetty, R., Ghosh, A., Teo, Y. Y., Brown, M. A., Lischinsky, I., Crowston, J. G., Coote, M., Zhao, B., Sang, J., Zhang, N., You, Q., Vysochinskaya, V., Founti, P., Chatzikyriakidou, A., Lambropoulos, A., Anastasopoulos, E., Coleman, A. L., Wilson, M. R., Rhee, D. J., Kang, J. H., May-Bolchakova, I., Heegaard, S., Mori, K., Alward, W. L., Jonas, J. B., Xu, L., Liebmann, J. M., Chowbay, B., Schaeffeler, E., Schwab, M., Lerner, F., Wang, N., Yang, Z., Frezzotti, P., Kinoshita, S., Fingert, J. H., Inatani, M., Tashiro, K., Reis, A., Edward, D. P., Pasquale, L. R., Kubota, T., Wiggs, J. L., Pasutto, F., Topouzis, F., Dubina, M., Craig, J. E., Yoshimura, N., Sundaresan, P., John, S. W., Ritch, R., Hauser, M. A. & Khor, C. C. (2015). A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. Nature genetics, 47(4), 387-92. PMID: 25706626.

Alward, W. L. (2015). Gonioscopy.org – A website to teach gonioscopy through the use of videography.

Khorram, D., Choi, M., Roos, B. R., Stone, E. M., Kopel, T., Allen, R., Alward, W. L., Scheetz, T. E. & Fingert, J. H. (2015). Novel TMEM98 mutations in pedigrees with autosomal dominant nanophthalmos. Molecular vision, 21, 1017-23. PMID: 26392740.

Ahram, D. F., Alward, W. L. & Kuehn, M. H. (2015). The genetic mechanisms of primary angle closure glaucoma. Eye (London, England), 29(10), 1251-9. PMID: 26206529.

Ward, M. S., Goins, K. M., Greiner, M. A., Kitzmann, A. S., Sutphin, J. E., Alward, W. L., Greenlee, E. C., Kwon, Y. H., Zimmerman, M. B. & Wagoner, M. D. (2014). Graft Survival Versus Glaucoma Treatment After Penetrating or Descemet Stripping Automated Endothelial Keratoplasty. Cornea, 33(8), 785-89. PMID: 24915017.

Tandon, A., Tehrani, S., Greiner, M. A., Fingert, J. H. & Alward, W. L. (2014). Thin Central Corneal Thickness and Early-Onset Glaucoma in Lacrimo-auriculo-dento-digital Syndrome. JAMA ophthalmology, 132(6), 782-84. PMID: 24921174.

Shareef, S., Alward, W., Crandall, A., Vold, S. & Ahmed, I. (2014). Intra-operative gonioscopy: a key to successful angle surgery. Expert Review of Ophthalmology, 9(6), 515-527. DOI: 10.1586/17469899.2014.973022.

Risma, T. B., Alward, W. L. (2014). Successful Long-term Management of Iris Flocculi and Miosis in a Patient With a Strong Family History of Thoracic Aortic Aneurysms and Dissections Associated With an MYH11 Mutation. JAMA ophthalmology, 132(6), 778-80. PMID: 24921172.

Alward, W. L. (2013). An Artist's Perspective on the Eye - Paintings by J. McGuinness Myers. American Journal of Ophthalmology, 155(2), 412.e3. DOI: 10.1016/j.ajo.2012.12.002.

Hong, E. S., Burden, J. H. & Alward, W. L. (2013). Intralesional ethanol for an unresectable epithelial inclusion cyst. JAMA Ophthlamol, 131(2), 262-3. PMID: 23411902.

Fingert, J. H., Burden, J. H., Wang, K., Kwon, Y. H., Alward, W. L. & Anderson, M. G. (2013). Circumferential Iris Transillumination Defects in Exfoliation Syndrome. Journal of glaucoma, 22(7), 555-8. PMID: 22525123.

Seo, S., Solivan-Timple, F., Roos, B. R., Robin, A. L., Stone, E. M., Young, Y. H., Alward, W. L. & Fingert, J. H. (2013). Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma. Curr Eye Res, 38(2), 310-5. PMID: 23286385.

Scheetz, T. E., Fingert, J. H., Wang, K., Kuehn, M. H., Knudtson, K. L., Alward, W. L., Boldt, H. C., Russell, S. R., Folk, J. C., Casavant, T. L., Braun, T. A., Clark, A. F., Stone, E. M. & Sheffield, V. C. (2013). A genome-wide association study for primary open angle glaucoma and macular degeneration reveals novel Loci. PLoS One, 8(3), e58657. PMID: 23536807.

Wandling, G. R., Rauen, M. P., Goins, K. M., Kitzmann, A. S., Sutphin, J. E., Kwon, Y. H., Alward, W. L. & Wagoner, M. D. (2012). Glaucoma therapy escalation in eyes with pseudophakic corneal edema after penetrating keratoplasty and Descemet's stripping automated endothelial keratoplasty. International ophthalmology, 32(1), 14-Sep. PMID: 22246622.

Fingert, J. H., Roos, B. R., Solivan-Timpe, F., Miller, K. A., Oetting, T. A., Wang, K., Kwon, Y. H., Scheetz, T. E., Stone, E. M. & Alward, W. L. (2012). Analysis of ASB10 variants in open angle glaucoma. Human molecular genetics, 21(20), 4543-8. PMID: 22798626.

Mao, M., Solivan-Timpe, F., Roos, B. R., Mullins, R. F., Oetting, T. A., Kwon, Y. H., Brzeskiewicz, P. M., Stone, E. M., Alward, W. L., Anderson, M. G. & Fingert, J. H. (2012). Localization of SH3PXD2B in human eyes and detection of rare variants in patients with anterior segment diseases and glaucoma. Molecular vision, 18, 705-13. PMID: 22509100.

Alward, W. L. (2011). A history of gonioscopy. Optometry and vision science, 88(1), 29-35. PMID: 20966801.

Tang, L., Garvin, M. K., Lee, K., Alward, W. L., Kwon, Y. H. & Abramoff, M. D. (2011). Robust multiscale stereo matching from fundus images with radiometric differences. IEEE Transactions on Pattern Analysis and Machine Intelligence, 33(11), 2245-2258. DOI: 10.1109/TPAMI.2011.69.

Kuehn, M. H., Wang, K., Roos, B., Stone, E. M., Kwon, Y. H., Alward, W. L., Mullins, R. F. & Fingert, J. H. (2011). Chromosome 7q31 POAG locus: ocular expression of caveolins and lack of association with POAG in a US cohort. Mol Vis, 17, 430-5. PMID: 21321670.

Davis, L. K., Meyer, K. J., Schindler, E. I., Beck, J. S., Rudd, D. S., Grundstad, A. J., Scheetz, T. E., Braun, T. A., Fingert, J. H., Alward, W. L., Kwon, Y. H., Folk, J. C., Russell, S. R., Wassink, T. H., Sheffield, V. C. & Stone, E. M. (2011). Copy number variations and primary open-angle glaucoma. Investigative ophthalmology & visual science, 52(10), 7122-33. PMID: 21310917.

Meyer, K. J., Davis, L. K., Schindler, E. I., Beck, J. S., Rudd, D. S., Grundstad, A. J., Scheetz, T. E., Braun, T. A., Fingert, J. H., Alward, W. L., Kwon, Y. H., Folk, J. C., Russell, S. R., Wassink, T. H., Stone, E. M. & Sheffield, V. C. (2011). Genome-wide analysis of copy number variants in age-related macular degeneration. Human genetics, 129(1), 91-100. PMID: 20981449.

Fingert, J. H., Robin, A. L., Stone, J. L., Roos, B. R., Davis, L. K., Scheetz, T. E., Bennett, S. R., Wassink, T. H., Kwon, Y. H., Alward, W. L., Mullins, R. F., Sheffield, V. C. & Stone, E. M. (2011). Copy number variations on chromosome 12q14 in patients with normal tension glaucoma. Human molecular genetics, 20(12), 2482-94. PMID: 21447600.

Fingert, J. H., Alward, W. L., Wang, K., Yorio, T. & Clark, A. F. (2010). Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders. Molecular vision, 16, 596-601. PMID: 20376328.

Parikh, M., Alward, W. (2010). Axenfeld-Rieger Syndrome and Peters anomaly (Chapter 58). In J. H. Krachmer , M. Mannis , E. J. Holland (Eds.) Cornea. (3rd ed), pp. 655-65. St Louis, MO: Mosby.

Tang, L., Kwon, Y. H., Alward, W. L., Greenlee, E. C., Lee, K., Garvin, M. K. & Abramoff, M. D. (2010). 3D reconstruction of the optic nerve head using stereo fundus images for computer-aided diagnosis of glaucoma. Proceedings of the SPIE, 7624, 76243D.

Wandling, G. R., Parikh, M., Robinson, C., Pramanik, S. N., Goins, K. M., Sutphin, J. E., Alward, W. L., Greenlee, E. C., Kwon, Y. H. & Wagoner, M. D. (2010). Escalation of glaucoma therapy after deep lamellar endothelial keratoplasty. Cornea, 29(9), 991-5. PMID: 20520533.

Kwon, Y. H., Fingert, J. H., Kuehn, M. H. & Alward, W. L. (2009). Primary open-angle glaucoma. The New England journal of medicine, 360(11), 1113-24. PMID: 19279343.

Longmuir, R. A., Fingert, J. H. & Alward, W. (2009). Inflammatory Glaucoma (Chapter 54D). In W. Tasman , A. F. Jacqer (Eds.) Duane's Clinical Ophthalmology. Philadelphia, PA: Lippincott Williams & Wilkins.

Kwon, Y. H., Adix, M., Zimmerman, M. B., Piette, S., Greenlee, E. C., Alward, W. L. & AbrÌÊmoff, M. D. (2009). Variance owing to observer, repeat imaging, and fundus camera type on cup-to-disc ratio estimates by stereo planimetry. Journal of glaucoma, 18(4), 305-10. PMID: 19365196.

AbrÌÊmoff, M. D., Lee, K., Niemeijer, M., Alward, W. L., Greenlee, E. C., Garvin, M. K., Sonka, M. & Kwon, Y. H. (2009). Automated segmentation of the cup and rim from spectral domain OCT of the optic nerve head. Investigative Opthalmology & Visual Science, 50(12), 5778-84. PMID: 19608531.

Alward, W. L. (2009). How I choose a prostaglandin analogue. American journal of ophthalmology, 147(1), 1-2. PMID: 19100349.

Trantow, C. M., Mao, M., Petersen, G. E., Alward, E. M., Alward, W. L., Fingert, J. H. & Anderson, M. G. (2009). LYST mutation in mice recapitulates iris defects of human exfoliation syndrome. Investigative ophthalmology & visual science, 50(3), 1205-14. PMID: 19029039.

Honkanen, R. A., Jampol, L. M., Fingert, J. H., Moore, M. D., Taylor, C. M., Stone, E. M. & Alward, W. L. (2007). Familial cavitary optic disk anomalies: clinical features of a large family with examples of progressive optic nerve head cupping. American journal of ophthalmology, 143(5), 788-794. PMID: 17362864.

Fingert, J. H., Alward, W. L., Kwon, Y. H., Wang, K., Streb, L. M., Sheffield, V. C. & Stone, E. M. (2007). LOXL1 mutations are associated with exfoliation syndrome in patients from the midwestern United States. American journal of ophthalmology, 144(6), 974-975. PMID: 18036875.

Hewitt, A. W., Poulsen, J. P., Alward, W. L., Bennett, S. L., Budde, W. M., Cooper, R. L., Craig, J. E., Fingert, J. H., Foster, P. J. & Garway-Heath, D. F. (2007). Heritable features of the optic disc: a novel twin method for determining genetic significance. Investigative ophthalmology & visual science, 48(6), 2469-75. PMID: 17525172.

AbrÌÊmoff, M. D., Alward, W. L., Greenlee, E. C., Shuba, L., Kim, C. Y., Fingert, J. H. & Kwon, Y. H. (2007). Automated segmentation of the optic disc from stereo color photographs using physiologically plausible features. Investigative Ophthalmology & Visual Science, 48(4), 1665-73. PMID: 17389498.

Dinn, R. B., Zimmerman, M. B., Shuba, L. M., Doan, A. P., Maley, M. K., Greenlee, E. C., Alward, W. L. & Kwon, Y. H. (2007). Concordance of diurnal intraocular pressure between fellow eyes in primary open-angle glaucoma. Ophthalmology, 114(5), 915-20. PMID: 17467528.

Fingert, J. H., Alward, W. L., Kwon, Y. H., Shankar, S. P., Andorf, J. L., Mackey, D. A., Sheffield, V. C. & Stone, E. M. (2007). No association between variations in the WDR36 gene and primary open-angle glaucoma. Archives of ophthalmology, 125(3), 434-6. PMID: 17353431.

Shuba, L. M., Doan, A. P., Maley, M. K., Zimmerman, M. B., Dinn, R. B., Greenlee, E. C., Alward, W. L. & Kwon, Y. H. (2007). Diurnal fluctuation and concordance of intraocular pressure in glaucoma suspects and normal tension glaucoma patients. Journal of glaucoma, 16(3), 307-12. PMID: 17438425.

Honkanen, R., Alward, W. L. & Cossari, A. J. (2006). Progressive iris changes in a case of Axenfeld-Rieger syndrome. Archives of ophthalmology, 124(12), 1793. PMID: 17159049.

Kuehn, M. H., Kim, C. Y., Ostojic, J., Bellin, M., Alward, W. L., Stone, E. M., Sakaguchi, D. S., Grozdanic, S. D. & Kwon, Y. H. (2006). Retinal synthesis and deposition of complement components induced by ocular hypertension. Experimental eye research, 83(3), 620-8. PMID: 16677633.

Fingert, J. H., Kwon, Y. H., Moore, P. A., Johnston, R. M., Kim, K. Y., Sheffield, V. C., Alward, W. L. & Stone, E. M. (2006). The C677T variant in the methylenetetrahydrofolate reductase gene is not associated with disease in cohorts of pseudoexfoliation glaucoma and primary open-angle glaucoma patients from Iowa. Ophthalmic genetics, 27(2), 39-41. PMID: 16754204.

Maciolek, N. L., Alward, W. L., Murray, J. C., Semina, E. V. & McNally, M. T. (2006). Analysis of RNA splicing defects in PITX2 mutants supports a gene dosage model of Axenfeld-Rieger syndrome. BMC medical genetics, 7, 59. PMID: 16834779.

Alward, W. (2005). Axenfeld-Rieger Syndrome and Peters anomaly (Chapter 63). In J. H. Krachmer , M. Mannis , E. H. Holland (Eds.) Cornea. (2nd ed) St Louis, MO: Mosby.

Reistad, C. E., Shields, M. B., Campbell & et al (2005). The influence of peripheral iridotomy on the intraocular pressure course of patients with pigmentary glaucoma. Journal of Glaucoma, 14, 255-259. PMID: 15990602.

Alward, W. L. (2004). Macular degeneration and glaucoma-like optic nerve head cupping. American journal of ophthalmology, 138(1), 135-6. PMID: 15234293.

Grassi, M. A., Alward, W. L., Verdick, R. L., Langlow, E. P. & Kwon, Y. H. (2004). Atypical pigment dispersion syndrome in a child. American journal of ophthalmology, 137(4), 753-6. PMID: 15059719.

Alward, W. (2004). Should glaucoma patients undergo genetic testing?. In R. Susanna (Eds.) Important Questions About Glaucoma. Sao Paolo: Cultura Medica.

Anderson, D. R., Drance, S. M., Schulzer, M. (2003). Factors that predict the benefit of lowering intraocular pressure in normal tension glaucoma. American Journal of Ophthalmology, 136, 820-829.

Alward, W. L., Kwon, Y. H., Kawase, K., Craig, J. E., Hayreh, S. S., Johnson, A. T., Khanna, C. L., Yamamoto, T., Mackey, D. A. & Roos, B. R. (2003). Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma. American journal of ophthalmology, 136(5), 904-10. PMID: 14597044.

Alward, W. L. (2003). The OPA1 gene and optic neuropathy. British Journal of Ophthalmology, 87, 2-3. PMID: 12488251.

Honkanen, R. A., Nishimura, D. Y., Swiderski, R. E., Bennett, S. R., Hong, S., Kwon, Y. H., Stone, E. M., Sheffield, V. C. & Alward, W. L. (2003). A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene. American journal of ophthalmology, 135(3), 368-75. PMID: 12614756.

Kwon, Y. H., Kim, Y. I., Pereira, M. L., Montague, P. R., Zimmerman, M. B. & Alward, W. L. (2003). Rate of optic disc cup progression in treated primary open-angle glaucoma. Journal of glaucoma, 12(5), 409-16. PMID: 14520149.

Alward, W. L. (2003). Biomedicine. A new angle on ocular development. Science (New York, N.Y.), 299, 1527-1528. PMID: 12624251.

Borges, A. S., Susanna, R., Carani, J. C., Betinjane, A. J., Alward, W. L., Stone, E. M., Sheffield, V. C. & Nishimura, D. Y. (2002). Genetic analysis of PITX2 and FOXC1 in Rieger Syndrome patients from Brazil. Journal of glaucoma, 11(1), 51-6. PMID: 11821690.

Bruno, C. A., Alward, W. L. (2002). Gonioscopy in primary angle closure glaucoma. Seminars in ophthalmology, 17(2), 59-68. PMID: 15513458.

Graul, T. A., Kim, C. S., Alward, W. L. & Kwon, Y. H. (2002). Progressive axial myopia in a juvenile patient with traumatic glaucoma. American journal of ophthalmology, 133(5), 700-2. PMID: 11992870.

Graul, T. A., Kwon, Y. H., Zimmerman, M. B., Kim, C. S., Sheffield, V. C., Stone, E. M. & Alward, W. L. (2002). A case-control comparison of the clinical characteristics of glaucoma and ocular hypertensive patients with and without the myocilin Gln368Stop mutation. American journal of ophthalmology, 134(6), 884-90. PMID: 12470758.

Pereira, M. L., Kim, C. S., Zimmerman, M. B., Alward, W. L., Hayreh, S. S. & Kwon, Y. H. (2002). Rate and pattern of visual field decline in primary open-angle glaucoma. Ophthalmology, 109(12), 2232-40. PMID: 12466164.

Fingert, J. H., Stone, E. M., Sheffield, V. C. & Alward, W. L. (2002). Myocilin glaucoma. Survey of ophthalmology, 47(6), 547-61. PMID: 12504739.

Alward, W. L., Kwon, Y. H., Khanna, C. L., Johnson, A. T., Hayreh, S. S., Zimmerman, M. B., Narkiewicz, J., Andorf, J. L., Moore, P. A. & Fingert, J. H. (2002). Variations in the myocilin gene in patients with open-angle glaucoma. Archives of ophthalmology, 120(9), 1189-97. PMID: 12215093.

Drance, S., Anderson, D. R., Schulzer, M. (2001). Risk factors for progression of visual field abnormalities in normal-tension glaucoma. American Journal of Ophthalmology, 131, 699-708.

Graul, T. D., Alward, W. (2001). Uveitic Glaucoma (Chapter 54D). In W. Tasman , A. F. Jacqer (Eds.) Duane's Clinical Ophthalmology (in 6 volumes). Philadelphia, PA: Lippincott Williams & Wilkins.

Sheffield, V. C., Alward, W. & Stone, E. M. (2001). The Glaucomas. In C. R. Scriver , A. L. Beauder & S. S. Sly , D. Valle (Eds.) The Metabolic and Molecular Bases of Inherited Disease (in 4 volumes). (8th ed) New York: McGraw-Hill.

Nishimura, D. Y., Searby, C. C., Alward, W. L., Walton, D., Craig, J. E., Mackey, D. A., Kawase, K., Kanis, A. B., Patil, S. R. & Stone, E. M. (2001). A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye. American journal of human genetics, 68(2), 364-72. PMID: 11170889.

Alward, W. L. (2001). Additive efficacy of unoprostone isopropyl 0.12% (rescula) to latanoprost 0.005%. American journal of ophthalmology, 132(3), 449-51. PMID: 11554384.

Clark, A. F., Kawase, K., English-Wright, S., Lane, D., Steely, H. T., Yamamoto, T., Kitazawa, Y., Kwon, Y. H., Fingert, J. H., Swiderski, R. E., Mullins, R. F., Hageman, G. S., Alward, W. L., Sheffield, V. & Stone, E. M. (2001). Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(7), 1251-3. PMID: 11344104.

Kwon, Y. H., Kim, C. S., Zimmerman, M. B., Alward, W. L. & Hayreh, S. S. (2001). Rate of visual field loss and long-term visual outcome in primary open-angle glaucoma. American journal of ophthalmology, 132(1), 47-56. PMID: 11438053.

Collaborative Normal-Tension Glaucoma Study Group, (2001). Natural History of Normal-Tension Glaucoma (Collaborative Normal-Tension Glaucoma Study). Ophthalmology, 108(2). PMID: 11158794.

Kawase, C., Kawase, K., Taniguchi, T., Sugiyama, K., Yamamoto, T., Kitazawa, Y., Alward, W. L., Stone, E. M., Nishimura, D. Y. & Sheffield, V. C. (2001). Screening for mutations of Axenfeld-Rieger syndrome caused by FOXC1 gene in Japanese patients. Journal of glaucoma, 10(6), 477-82. PMID: 11740218.

Kwon, Y. H., Taylor, J. M., Hong, S., Honkanen, R. A., Zimmerman, M. B., Alward, W. L. & Sutphin, J. E. (2001). Long-term results of eyes with penetrating keratoplasty and glaucoma drainage tube implant. Ophthalmology, 108(2), 272-8. PMID: 11158798.

Fingert, J. H., Clark, A. F., Craig, J. E., Alward, W. L., Snibson, G. R., McLaughlin, M., Tuttle, L., Mackey, D. A., Sheffield, V. C. & Stone, E. M. (2001). Evaluation of the myocilin (MYOC) glaucoma gene in monkey and human steroid-induced ocular hypertension. Investigative ophthalmology & visual science, 42(1), 145-52. PMID: 11133859.

Parrish, R. K., Schiffman, J. C., Feuer, W. J., Heuer, D. K. (2001). Prognosis and risk factors for early postoperative wound leaks after trabeculectomy with and without fluorouracil. American Journal of Ophthalmology, 132, 633-640.

Jacobson, N., Andrews, M., Shepard, A. R., Nishimura, D., Searby, C., Fingert, J. H., Hageman, G., Mullins, R., Davidson, B. L., Kwon, Y. H., Alward, W. L., Stone, E. M. & Sheffield, V. (2001). Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor. Human molecular genetics, 10(2), 117-25. PMID: 11152659.

Alward, W., Fingert, J. H., Kwon, Y. H., Johnson, A. T., Hayreh, S. S., Sheffield, V. C. & Stone, E. M. (2000). Characterization of a large family with adult-onset primary open-angle glaucoma caused by a mutation in the GLC1A gene. In G. K. Krieglstein (Eds.) Glaucoma Update VI, Chapter 7. Berlin, Heidelberg: Springer-Verlag.

Alward, W. L. (2000). Frequency doubling technology perimetry for the detection of glaucomatous visual field loss. American journal of ophthalmology, 129(3), 376-8. PMID: 10755955.

Kwon, Y. H., Hong, S., Honkanen, R. A. & Alward, W. L. (2000). Correlation of automated visual field parameters and peripapillary nerve fiber layer thickness as measured by scanning laser polarimetry. Journal of glaucoma, 9(4), 281-8. PMID: 10958600.

Alward, W. L. (2000). Axenfeld-Rieger syndrome in the age of molecular genetics. American journal of ophthalmology, 130(1), 107-15. PMID: 11004268.

Alward, W. L. (2000). Glaucoma, The Requisites in Ophthalmology. St. Louis: Mosby, Inc..

Amendt, B. A., Semina, E. V. & Alward, W. L. (2000). Rieger syndrome: a clinical, molecular, and biochemical analysis. Cellular and molecular life sciences : CMLS, 57(11), 1652-66. PMID: 11092457.

Swiderski, R. E., Ross, J. L., Fingert, J. H., Clark, A. F., Alward, W. L., Stone, E. M. & Sheffield, V. C. (2000). Localization of MYOC transcripts in human eye and optic nerve by in situ hybridization. Investigative ophthalmology & visual science, 41(11), 3420-8. PMID: 11006234.

Alward, W. L. (2000). The genetics of open-angle glaucoma: the story of GLC1A and myocilin. Eye (London, England), 14 ( Pt 3B), 429-36. PMID: 11026970.

Smith, R. S., Zabaleta, A., Kume, T., Savinova, O. V., Kidson, S. H., Martin, J. E., Nishimura, D. Y., Alward, W. L., Hogan, B. L. & John, S. W. (2000). Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. Human molecular genetics, 9(7), 1021-32. PMID: 10767326.

Fingert, J. H., HÌ©on, E., Liebmann, J. M., Yamamoto, T., Craig, J. E., Rait, J., Kawase, K., Hoh, S. T., Buys, Y. M., Dickinson, J., Hockey, R. R., Williams-Lyn, D., Trope, G., Kitazawa, Y., Ritch, R., Mackey, D. A., Alward, W. L. & Sheffield, V. C. (1999). Analysis of myocilin mutations in 1703 glaucoma patients from five different populations. Human molecular genetics, 8(5), 899-905. PMID: 10196380.

Oh, K. T., Alward, W. L. & Kardon, R. H. (1999). Myositis associated with a Baerveldt glaucoma implant. American journal of ophthalmology, 128(3), 375-6. PMID: 10511042.

Swiderski, R. E., Reiter, R. S., Nishimura, D. Y., Alward, W. L., Kalenak, J. W., Searby, C. S., Stone, E. M., Sheffield, V. C. & Lin, J. J. (1999). Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects. Developmental dynamics : an official publication of the American Association of Anatomists, 216(1), 16-27. PMID: 10474162.

Haynes, W. L., Alward, W. L. (1999). Control of intraocular pressure after trabeculectomy. Survey of ophthalmology, 43(4), 345-55. PMID: 10025517.

Haynes, W. L., Alward, W. L. (1999). Combination of autologous blood injection and bleb compression sutures to treat hypotony maculopathy. Journal of glaucoma, 8(6), 384-7. PMID: 10604298.

Swiderski, R. E., Ying, L., Cassell, M. D., Alward, W. L., Stone, E. M. & Sheffield, V. C. (1999). Expression pattern and in situ localization of the mouse homologue of the human MYOC (GLC1A) gene in adult brain. Brain Research. Molecular Brain Research, 68(42737), 64-72. PMID: 10320784.

Fingert, J. H., Ying, L., Swiderski, R., Arbour, N., Nystuen, A., Alward, W., Sheffield, V. C. & Stone, E. M. (1998). Comparison and characterization of the human GLC1A glaucoma gene and its mouse orthologue. Investigative Ophthalmology and Visual Science, 39(Supp), S512.

Nishimura, D. Y., Swiderski, R. E., Alward, W. L., Searby, C. C., Patil, S. R., Bennet, S. R., Kanis, A. B., Gastier, J. M., Stone, E. M. & Sheffield, V. C. (1998). The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25. Nature genetics, 19(2), 140-7. PMID: 9620769.

Fingert, J. H., Ying, L., Swiderski, R. E., Nystuen, A. M., Arbour, N. C., Alward, W. L., Sheffield, V. C. & Stone, E. M. (1998). Characterization and comparison of the human and mouse GLC1A glaucoma genes. Genome research, 8(4), 377-84. PMID: 9548973.

Alward, W. L., Semina, E. V., Kalenak, J. W., HÌ©on, E., Sheth, B. P., Stone, E. M. & Murray, J. C. (1998). Autosomal dominant iris hypoplasia is caused by a mutation in the Rieger syndrome (RIEG/PITX2) gene. American journal of ophthalmology, 125(1), 98-100. PMID: 9437321.

Alward, W. L. (1998). Medical Management of Glaucoma. New England Journal, 339, 1298-1307. PMID: 9791148.

Collaborative Normal-Tension Glaucoma Study Group (1998). Comparison of Glaucomatous Progression between Untreated Patients with Normal-Tension Glaucoma and Patients with Therapeutically Reduced Intraocular Pressues. American Journal of Ophthalmology, 126(4), 487-497.

Semina, E. V., Reiter, R. & Leysens, N. J. (1998). Cloning and Characterizatio of a Novel Bicoid-Related Homeobox Transcription Factor Gene, REIG, Involved in Rieger Syndrome. Natural Geneticfs, 14(4), 498-505.

Collaborative Normal-Tension Glaucoma Study (1998). The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. American Journal of Ophthalmology, 126(4), 498-505. PMID: 9780094.

Semina, E. V., Ferrell, R. E., Mintz-Hittner, H. A., Bitoun, P., Alward, W. L., Reiter, R. S., Funkhauser, C., Daack-Hirsch, S. & Murray, J. C. (1998). A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD. Nature genetics, 19(2), 167-70. PMID: 9620774.

Alward, W. L., Fingert, J. H. & Coote, M. A. (1998). Clinical Features Associated with Mutations in the Chromosome 1 Open-Angle Glaucoma Gene (GLC1A). New England Journal of Medicine, 338(15), 1022-1027. PMID: 9535666.

McKinney, J. K., Alward, W. L. (1997). Unilateral pigment dispersion and glaucoma caused by angle recession. Archives of ophthalmology, 115(11), 1478-9. PMID: 9366689.

Alward, W. (1997). Molecular genetics of glaucoma: Effects on the future of disease classification (Chapter 9). E. M. Van Buskirk , M. B. Shields (Eds.) Philadelphia, PA: Lippincott-Raven 100 Years of Progress in Glaucoma.

Carlson, D. W., Alward, W. L., Barad, J. P., Zimmerman, M. B. & Carney, B. L. (1997). A randomized study of mitomycin augmentation in combined phacoemulsification and trabeculectomy. Ophthalmology, 104(4), 719-24. PMID: 9111269.

Hayreh, S. S., Zimmerman, M. B., Podhajsky, P. & Alward, W. L. (1997). Nonarteritic anterior ischemic optic neuropathy: role of nocturnal arterial hypotension. Archives of ophthalmology, 115(7), 942-5. PMID: 9230848.

Stone, E. M., Fingert, J. H., Alward, W. L., Polansky, J. R., Nguyen, T. D., Sunden, S. L., Nishimura, D., Clark, A. F., Nystuen, A. & Nichols, B. E. (1997). Identification of a gene that causes primary open angle glaucoma. Science (New York, N.Y.), 275(5300), 668-70. PMID: 9005853.

Johnson, A. T., Alward, W., Sheffield, V. C. & Stone, E. M. (1996). Genetics and Glaucoma (Chapter 2). In R. Ritch , M. B. Shields , T. Krupin (Eds.) The Glaucomas. (2nd ed) St Louis: CV Mosby.

Alward, W. L., Ossoinig, K. C. (1996). Pigment dispersion secondary to cysts of the iris pigment epithelium. Chinese edition of Archives of Ophthalmology, 5, 98-99.

The Fluorouracil Filtering Surgery Study Group (1996). Five-year follow-up of the Fluorouracil Filtering Surgery Study. American Journal of Ophthalmology, 121(4), 349-366. PMID: 8604728.

Alward, W. L., Johnson, A. T., Nishimura, D. Y., Sheffield, V. C. & Stone, E. M. (1996). Molecular genetics of glaucoma: current status. Journal of glaucoma, 5(4), 276-84. PMID: 8795774.

Sunden, S. L., Alward, W. L., Nichols, B. E., Rokhlina, T. R., Nystuen, A., Stone, E. M. & Sheffield, V. C. (1996). Fine mapping of the autosomal dominant juvenile open angle glaucoma (GLC1A) region and evaluation of candidate genes. Genome research, 6(9), 862-9. PMID: 8889553.

(1996). Five-year follow-up of the Fluorouracil Filtering Surgery Study (letter). (Vols. 122). pp. 751. American Journal of Ophthalmology.

Alward, W. L. (1996). Marked intraocular pressure rise following autologous blood injection into a filtering bleb. Spanish edition of Archives of Ophthalmology, 7(88-89).

Semina, E. V., Reiter, R., Leysens, N. J., Alward, W. L., Small, K. W., Datson, N. A., Siegel-Bartelt, J., Bierke-Nelson, D., Bitoun, P. & Zabel, B. U. (1996). Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome. Nature genetics, 14(4), 392-399. PMID: 8944018.

Carlson, D. W., Alward, W. L. & Folberg, R. (1995). Aggressive nevus of the iris with secondary glaucoma in a child. American journal of ophthalmology, 119(3), 367-8. PMID: 7872400.

Haynes, W. L., Alward, W. L. (1995). Rapid visual recovery and long-term intraocular pressure control after donor scleral patch grafting for trabeculectomy-induced hypotony maculopathy. Journal of glaucoma, 4(3), 200-1. PMID: 19920669.

Campagna, J. A., Munden, P. M. & Alward, W. L. (1995). Tenon's cyst formation after trabeculectomy with mitomycin C. Ophthalmic surgery, 26(1), 57-60. PMID: 7746627.

Haynes, W. L., Thompson, H. S., Johnson, A. T. & Alward, W. L. (1995). Comparison of the miotic effects of dapiprazole and dilute pilocarpine in patients with the pigment dispersion syndrome. Journal of glaucoma, 4(6), 379-85. PMID: 19920703.

Alward, W. L., Ossoinig, K. C. (1995). Pigment dispersion secondary to cysts of the iris pigmenjt epithelium. Archives of Ophthalmology, 113, 1574-1575. PMID: 7487635.

Alward, W. L. (1995). Linkage of posterior polymorphous corneal dystrophy to 20q11. Human Molecular Genetics, 4, 485-588. PMID: 7795607.

L, H. W., Alward, W. L., Tello, C., Liebmann, J. M. & Ritch, R. (1995). Incomplete elimination of exercise-induced pigment dispersion by laser iridotomy in pigment dispersion syndrome. Ophthalmic surgery and lasers, 26(5), 484-6. PMID: 8963864.

Munden, P. M., Alward, W. L. (1995). Combined phacoemulsification, posterior chamber intraocular lens implantation, and trabeculectomy with mitomycin C. American journal of ophthalmology, 119(1), 20-9. PMID: 7825686.

HÌ©on, E., Sheth, B. P., Kalenak, J. W., Sunden, S. L., Streb, L. M., Taylor, C. M., Alward, W. L., Sheffield, V. C. & Stone, E. M. (1995). Linkage of autosomal dominant iris hypoplasia to the region of the Rieger syndrome locus (4q25). Human Molecular Genetics, 4(8), 1435-9. PMID: 7581385.

Alward, W. L. (1995). Marked intraocular pressure rise following blood injection into a filtering bleb. Archives of ophthalmology, 113(10), 1232-3. PMID: 7575250.

Alward, W., Murray, J. C. (1994). Axenfeld-Rieger Syndrome. In J. Wiggs (Eds.) Molecular Genetics of Ocular Disorders. New York, NY: Wiley-Liss.

Hayreh, S. S., Zimmerman, M. B., Podhajsky, P. & Alward, W. L. (1994). Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. American journal of ophthalmology, 117(5), 603-24. PMID: 8172267.

Alward, W. L. (1994). Color Atlas of Gonioscopy. London: Mosby-Yearbook Europe.

Haynes, W. L., Alward, W. L. & Thompson, H. S. (1994). Distortion of the pupil in patients with the pigment dispersion syndrome. Journal of glaucoma, 3(4), 329-32. PMID: 19920618.

Haynes, W. L., Alward, W. L. & McKinney, J. K. (1994). Low-energy argon laser suture lysis after trabeculectomy. American journal of ophthalmology, 117(6), 800-1. PMID: 8198165.

Collaborative Normal-Tension Glaucoma Study Group (1994). Errors in the Diagnosis of Visual-Field Progression in Normal-Tension Glaucoma. Ophthalmology, 101(9), 1589-1594.

Alward, A. L. (1994). Slide Atlas of Gonioscopy. London: Wolfe Slide Atlases.

Haynes, W. L., Alward, W. L., McKinney, J. K., Munden, P. M. & Verdick, R. (1994). Quantitation of iris transillumination defects in eyes of patients with pigmentary glaucoma. Journal of glaucoma, 3(2), 106-13. PMID: 19920562.

The Fluorouracil Filtering Surgery Study (1993). Three-Year Follow-up of the Fluorouracil Filtering Study Group. American Journal of Ophthalmology, 115(1), 82-92. PMID: 8420383.

Ritch, R., Alward, W. L. (1993). Asymmetric pigmentary glaucoma caused by unilateral angle recession. American journal of ophthalmology, 116(6), 765-6. PMID: 8250082.

Farrell, T. A., Alward, W. L. (1993). Fundamental of Slit Lamp Biomicroscopy. American Academy of Ophthalmology.

Johnson, A. T., Drack, A. V., Kwitek, A. E., Cannon, R. L., Stone, E. M. & Alward, W. L. (1993). Clinical features and linkage analysis of a family with autosomal dominant juvenile glaucoma. Ophthalmology, 100(4), 524-9. PMID: 8479711.

Joos, K. M., Alward, W. L. & Folberg, R. (1993). Experimental endoscopic goniotomy. A potential treatment for primary infantile glaucoma. Ophthalmology, 100(7), 1066-70. PMID: 8321530.

Sheffield, V. C., Stone, E. M., Alward, W. L., Drack, A. V., Johnson, A. T., Streb, L. M. & Nichols, B. E. (1993). Genetic linkage of familial open angle glaucoma to chromosome 1q21-q31. Nature genetics, 4(1), 47-50. PMID: 8513321.

Schulzer, M. (1992). Intraocular pressure reduction in normal-tension glaucoma patients. Ophthalmology, 99, 1468-1470.

Haynes, W. L., Johnson, A. T. & Alward, W. L. (1992). Effects of jogging exercise on patients with the pigmentary dispersion syndrome and pigmentary glaucoma. Ophthalmology, 99(7), 1096-103. PMID: 1495789.

(1992). Risk factors for suprachoroidal hemorrhage after filtering surgery. American Journal of Ophthalmology, 113(5), 501-507. PMID: 1575223.

Murray, J. C., Bennett, S. R., Kwitek, A. E., Small, K. W., Schinzel, A., Alward, W. L., Weber, J. L., Bell, G. I. & Buetow, K. H. (1992). Linkage of Rieger syndrome to the region of the epidermal growth factor gene on chromosome 4. Nature genetics, 2(1), 46-9. PMID: 1303248.

Lam, B. L., Alward, W. L. & Kolder, H. E. (1991). Effect of cataract on automated perimetry. Ophthalmology, 98(7), 1066-70. PMID: 1891215.

Haynes, W. L., Thompson, H. S., Kardon, R. H. & Alward, W. L. (1991). Asymmetric pigmentary dispersion syndrome mimicking Horner's syndrome. American journal of ophthalmology, 112(4), 463-4. PMID: 1928256.

Joos, K. M., Brown, D. M. & Alward, W. L. (1991). A multilens case. Archives of ophthalmology, 109(10), 1343-4. PMID: 1929910.

Alward, W. (1991). Laser cyclophotocoagulation (Chapter 14). In S. R. Sneed , T. A. Weingeist (Eds.) Practical Applications of Laser Surgery in Ophthalmology. Nowalk, CT: Appleton & Lange.

Alward, W. (1991). Review of End Note Plus. American Journal of Ophthalmology, 111(6), 780-781.

Wolf, M. D., Alward, W. L. & Folk, J. C. (1991). Long-term visual function in acute posterior multifocal placoid pigment epitheliopathy. Archives of ophthalmology, 109(6), 800-3. PMID: 2043067.

Alward, W. (1991). Laser iridotomy (Chapter 12). In S. R. Sneed , T. A. Weingeist (Eds.) Practical Applications of Laser Surgery in Ophthalmology. Norwalk, CT: Appleton & Lange.

Carlson, D. W., Alward, W. L. (1991). A placebo for mitomycin C. Ophthalmology, 100, 1343-1344. PMID: 8459992.

Alward, W. L., Krasnow, M. A., Keech, R. V., Pulido, J. S. & Sutton, G. L. (1991). Persistent hyperplastic primary vitreous with glaucoma presenting in infancy. Archives of Ophthalmology, 109, 1063-1064. PMID: 1867540.

Alward, W. (1991). Argon laser trabeculoplasty (Chapter 13). In S. R. Sneed , T. A. Weingeist (Eds.) Practical Applications of Laser Surgery in Ophthalmology. Norwalk, CT: Appleton & Lange.

Alward, W. L., Krachmer, J. H. & Macsai, M. S. (1990). Arthrogryposis multiplex congenita with Peter's anomaly. Journal of pediatric ophthalmology and strabismus, 27(6), 329. PMID: 2099778.

Haynes, W. L., Johnson, A. T. & Alward, W. L. (1990). Inhibition of exercise-induced pigment dispersion in a patient with the pigmentary dispersion syndrome. American journal of ophthalmology, 109(5), 601-2. PMID: 2139759.

Alward, W. L., Munden, P. M., Verdick, R. E., Perell, H. R. & Thompson, H. S. (1990). Use of infrared videography to detect and record iris transillumination defects. Archives of ophthalmology, 108(5), 748-50. PMID: 2334336.

Alward, W. (1990). Review of Laser Microsurgery of Glaucoma by L Buratto, A Ricci, and D Vitali. American Journal of Ophthalmology, 109(4), 493.

Alward, W. (1989). Review of Manual of Glaucoma Diagnosis and Management by Theodore Krupin. American Journal of Ophthalmology, 107(4), 443.

Alward, W. L., Byrne, S. F., Hughes, J. R. & Hodapp, E. A. (1989). Dislocated lens nuclei simulating choroidal melanomas. Archieves of Ophthalmology, 107, 1463-1464.

Bennett, S. R., Alward, W. L. & Folberg, R. (1989). An autosomal dominant form of low-tension glaucoma. American journal of ophthalmology, 108(3), 238-44. PMID: 2774031.

Anderson, D. R., Feuer, W. J., Alward, W. L. & Skuta, G. L. (1989). Threshold equivalence between perimeters. American journal of ophthalmology, 107(5), 493-505. PMID: 2712132.

(1989). Fluorouracil filtering surgery study one-year follow-up. American Journal of Ophthalmology, 108(6), 625-635. PMID: 2688428.

Alward, W. (1989). Uveitic Glaucoma (Chapter 54D). In T. D. Duane , J. Ed (Eds.) Clinical Ophthalmology. Philadelphia: Harper and Row.

Alward, W. (1989). Review of Perspectives in Glaucoma by MB Shields, IP Pollack, and AE Kolker. Ophthalmologica, 199, 173.

Relf, S. J., Gharagozloo, N. Z., Skuta, G. L., Alward, W. L., Anderson, D. R. & Brubaker, R. F. (1988). Thymoxamine reverses phenylephrine-induced mydriasis. American journal of ophthalmology, 106(3), 251-5. PMID: 2971321.

Alward, W. L., Hodapp, E. A., Parel, J. M. & Anderson, D. R. (1988). Argon laser endophotocoagulator closure of cyclodialysis clefts. American journal of ophthalmology, 106(6), 748-9. PMID: 3195659.

Hall, D. B., McMahon, B. J., Alward, W. & Heyward, W. L. (1986). Re-evaluation of the association between sex, age, and acute infection with hepatitis B virus in Yupik Eskimos. (Vols. 153). pp. 1180-1181. Journal of Infectious Diseases.

Alward, W. L., Hall, D. B. & Heyward, W. L. (1986). The hepatitis B carrier state in the development of primary hepatocellular carcinoma. Journal of Infectious Diseases, 153, 171-172. PMID: 3001192.

Heyward, W. L., Bender, T. R., McMahon, B. J., Hall, D. B., Francis, D. P., Lanier, A. P., Alward, W., Ahton, J. L., Murphy, B. L. & Maynard, J. E. (1985). Use of hepatitis B vaccine in a population hyperendemic for hepatitis B virus infection. American Journal of Epidemiology, 21, 914-923. PMID: 3160233.

Ireland, B., Knutson, L., Alward, W. & Hall, D. B. (1985). Pertussis: A study of incidence and mortality in a Yukon-Kuskokwim Delta epidemic. In R. Fortuine (Eds.) Circumpolar Health 84. pp. 229-234. Seattle: University of Washington Press.

McMahon, B. J., Alward, W. L., Hall, D. B., Heyward, W. L., Bender, T. R., Francis, D. P. & Maynard, J. E. (1985). Acute hepatitis B virus infection: relation of age to the clinical expression of disease and subsequent development of the carrier state. The Journal of infectious diseases, 151(4), 599-603. PMID: 3973412.

Heyward, W. L., Bender, T. R., McMahon, B. J., Hall, D. B., Francis, D. P., Lanier, A. P., Alward, W. L., Ahtone, J. L., Murphy, B. L. & Maynard, J. E. (1985). The control of hepatitis B virus infection with vaccine in Yupik Eskimos. Demonstration of safety, immunogenicity, and efficacy under field conditions. American journal of epidemiology, 121(6), 914-23. PMID: 3160233.

Alward, W. L., Bender, T. R., Demske, J. A. & Hall, D. B. (1985). High prevalence of myopia among young adult Yupik Eskimos. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 20(7), 241-5. PMID: 4092169.

Alward, W. L., McMahon, B. J., Hall, D. B., Heyward, W. L., Francis, D. P. & Bender, T. R. (1985). The long-term serological course of asymptomatic hepatitis B virus carriers and the development of primary hepatocellular carcinoma. The Journal of infectious diseases, 151(4), 604-9. PMID: 2982971.

Alward, W., McMahon, B. J., Hall, D. B., Heyward, W. L., Francis, D. P. & Bender, T. R. (1985). The Long-Term Serological Course of Asymptomatic Hepatitis B Virus Carriers and the Development of Primary Hepatocellular Carcinoma. Journal of Infectious Diseases, 151, 604-609.

Silimperi, D. R., Alward, W. L. (1984). Microbiologic investigation of the Barrow frozen bodies. Artic Anthropology, 21, 117-121.

Alward, W. L. (1982). Suspect botulism - Hooper Bay Alaska (CDC). Morbidity and Mortality Weekly Report.