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The Iowa Research Network (IRENE) is a practice-based research network (PBRN) supported by the University of Iowa’s Department of Family Medicine and external research funding. IRENE was established in 2001, and in 2023, IRENE began expanding its membership to include nurse practitioners, physician assistants, and pharmacists. In addition, IRENE has a Patient Advisory Board and a Steering Committee.  The two groups provide a variety of perspectives and work together to identify and refine IRENE’s research agenda.