Lab Website: https://chauhan.lab.uiowa.edu

Thrombo-inflammation in context of stroke and atherosclerosis

Cardiovascular diseases (CVDs) and stroke remain one of the leading causes of mortality and morbidity worldwide. Of note, CVDs claim more lives than all form of cancers combined. Research in my laboratory is focused to better understand how metabolic reprogramming regulates platelet and leukocyte function and whether targeting enzymes involved in metabolic pathway can inhibit thrombosis and inflammation. If successful, this could be developed as a therapeutic strategy toward better management of patients at high risk for acute coronary events and stroke. My lab utilizes state-of-the-art imaging techniques like intravital microscopy, laser-speckle imaging and magnetic resonance imaging in order to study mechanistic role of thrombo-inflammation in the modulation of acute ischemic stroke, arterial thrombosis, and deep vein thrombosis. In addition, we are exploring novel pathways that contribute pathophysiology of atherothrombosis, atherosclerosis and plaque stability.

PubMed link

Department/Program Affiliations:
Internal Medicine
Molecular Medicine