E. Dale Abel, MD, PhD

Professor & Head
Internal Medicine

Office: 108 CMAB
Office Phone: 319-353-3050

Lab: 140 EMRB

Lab Website: https://abel.lab.uiowa.edu/

Cardiac metabolism, mitochondrial energetics and molecular mechanisms for cardiac dysfunction in diabetes.

Dr. Abel’s research is focused on elucidating the mechanisms that are responsible for cardiac dysfunction in obesity, diabetes and insulin resistant states. His studies have elucidated mechanisms that are responsible for mitochondrial dysfunction that characterizes the heart in insulin resistant states and has pioneered studies of insulin action and glucose metabolism in the heart. Recent studies have focused on: (1) The contribution of excessive myocardial insulin signaling in the myocardium in accelerating left ventricular remodeling in the hypertrophied and failing heart. (2) The regulation of myocardial autophagy by insulin signaling. (3) The mechanisms by which myocardial lipid overload alters autophagy in cardiac muscle (4) The role of altered mitochondrial dynamics in the pathophysiology of cardiac dysfunction in obesity and insulin resistant states. (5) Mechanisms for increased thrombosis in obesity and insulin resistant states.

PubMed link

Department/Program Affiliations:
Internal Medicine
Molecular Medicine