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Isabella Grumbach, MD, PhD

Internal Medicine

Office: 4336 PBDB
Office Phone: 319-384-4610

Lab: 4336 PBDB

Lab Website: https://grumbach.lab.uiowa.edu/

Vascular smooth muscle and endothelial biology in hypertension and vascular injury

My lab studies how the calcium-/calmodulin-depednent kinase II (CaMKII) regulates vascular physiology and pathology. We are focusing on CaMKII-dependent smooth muscle phenotypes such as calcium handling, contraction, proliferation, migration and apoptosis. We are investigating the effect of CaMKII on blood pressure regulation and on the response to vascular injury in vivo.

The multifunctional Ca2+/calmodulin-dependent kinase II regulates vascular smooth muscle migration through matrix metalloproteinase 9.

PubMed link

Department/Program Affiliations:
Internal Medicine
Molecular Medicine