Lab Website: https://medicine.uiowa.edu/pediatrics/profile/janice-staber

Neuro-outcomes in hemophilia A

My research explores the effects of cerebral microbleeds and neuroinflammation on brain structure and behavior changes in hemophilia A. We utilize piggyBac-mediated non-viral gene therapy to determine if we can correct these changes. My research focuses on three key knowledge gaps in hemophilia: 1) mechanisms leading to decreased brain volumes in hemophilia A, 2) defining the executive dysfunction and behavior changes in hemophilia A, and 3) neuroinflammatory biomarkers and cell signaling to predict changes in the brain.

PubMed link

Department/Program Affiliations:
Iowa Neuroscience Institute
Pediatrics