Lab Website: https://irani.lab.uiowa.edu/

My laboratory explores fundamental mechanisms that govern vascular function in health and disease with a special emphasis on the molecular underpinnings of reduction-oxidation (redox) mechanisms

1. Post-translational regulation of the aging protein p66shc which promote oxidative stress in the setting of diabetes, hypercholesterolemia. 2. Post-translational redox modifications that regulate the SIRTIUN1 (SIRT1) deacetylase. 3. Role of p66shc in redox-regulated platelet function 4. Transcriptional and epigenetic regulation of p66shc and SIRT1. 5. Micro-RNA-mediated mechanisms which govern vascular function and cholesterol metabolism that are modulated by the gut microbiome. 6. Micro-RNA-dependent redox pathways that are governed by the oxidative stress protein p66shc 7. SIRT1-mediated post-translational regulation of the cardiac sodium channel.

PubMed link

Department/Program Affiliations:
Internal Medicine
Molecular Medicine