Lab Website: https://yang.lab.uiowa.edu

Our research aims to identify the molecular components of integration between organelle stress responses that are in play in obesity and diabetes at the cellular and organismic levels

We recently identified that autophagy is an important regulator of hepatic glucose metabolism and insulin signaling, and that loss of autophagy is a critical contributor to the defective ER function characteristic of obesity. We are specifically interested in identifying the physiological causes of defective hepatic autophagy in obesity, and defining the molecular mechanisms underlying how autophagy, as a catabolic pathway, controls energy homeostasis in obesity-associated metabolic disorders.

PubMed link

Department/Program Affiliations:
Anatomy and Cell Biology
Molecular Medicine