Lab Website: http://dayal.lab.uiowa.edu/

The focus of Dr. Dayal’s research is in delineating mechanisms of thrombosis associated with cardiovascular risk factors and cancer.

Thrombotic diseases such as myocardial infarction, stroke, deep vein thrombosis and pulmonary embolisms are the leading causes of morbidity and mortality worldwide. The primary focus of Dr. Dayal’s laboratory is to define the mechanisms of thrombosis using murine models and clinically-relevant human specimens. We are particularly interested in risk factors such as aging, hyperhomocysteinemia, and cancer. The ongoing projects examine: 1) role of oxidative pathways in platelet activation with aging, 2) the mediator of thrombosis in hyperhomocysteinemia with a special emphasis on role of sulphur metabolites, and 3) mechanism of thrombogenesis in pediatric acute lymphoblastic leukemia. A secondary interest is to investigate cognitive responses in aging and hyperhomocysteinemia. The Dayal laboratory is currently funded through a R01 from National Institute of Aging (NIA, NIH) as well as through other internal (Dance Marathon Grant) and external (DOD) collaborative research awards.

PubMed link

Department/Program Affiliations:
Internal Medicine
Molecular Medicine