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William Thiel, PhD

Assistant Professor of Internal Medicine-Cardiovascular Medicine

Current Positions

  • Assistant Professor of Internal Medicine-Cardiovascular Medicine

Education

  • PhD, Pharmacology, Vanderbilt University, Nashville, Tennessee
  • Postdoctoral Fellow, Hematology/Oncology, University of Iowa Carver College of Mediicne, Iowa City, Iowa

Graduate Program Affiliations

Center, Program and Institute Affiliations

Research Interests

  • My laboratory strives to decipher the mechanisms of cardiovascular disease development and progression using cell-targeting ligands (aptamers) and to develop novel treatments with these reagents. Currently we are focused on three areas of research. First, we are using vascular smooth muscle-specific aptamers to understand the complex mechanisms of neointimal formation after vascular injury. Second, we are developing cardiac-specific aptamers to study the mechanisms of cardiovascular disease. Finally, we are developing novel aptamer bioinformatics algorithms and methods to support aptamer discovery and target discovery. Our research program is supported by funding through the National Heart, Lung, and Blood Institute and the American Heart Association.

Selected Publications

  • Urak, K. T., Blanco, G. N., Shubham, S., Lin, L. H., Dassie, J. P., Thiel, W. H., Chen, Y., Sonkar, V. K., Lei, B., Murthy, S., Gutierrez, W. R., Wilson, M. E., Stiber, J. A., Klesney-Tait, J., Dayal, S., Miller, Jr, F. J. & Giangrande, P. H. (2019). RNA INHIBITORS OF NUCLEAR PROTEINS RESPONSIBLE FOR MULTIPLE ORGAN DYSFUNCTION SYNDROME. NATURE COMMUNICATIONS 10 (1) 116. DOI: 10.1038/s41467-018-08030-y. PMID: 30631065. PMCID: PMC6328615.
  • Guo, A., Wang, Y., Chen, B., Wang, Y., Yuan, J., Zhang, L., Hall, D., Wu, J., Shi, Y., Zhu, Q., Chen, C., Thiel, W. H., Zhan, X., Weiss, R. M., Zhan, F., Musselman, C. A., Pufall, M., Zhu, W., Au, K. F., Hong, J., Anderson, M. E., Grueter, C. E. & Song, L. S. (2018). E-C COUPLING STRUCTURAL PROTEIN JUNCTOPHILIN-2 ENCODES A STRESS-ADAPTIVE TRANSCRIPTION REGULATOR. SCIENCE (NEW YORK, N.Y.) 362 (6421). DOI: 10.1126/science.aan3303. PMID: 30409805. PMCID: PMC6336677.
  • Meng, X., Yang, S., Li, Y., Li, Y., Devor, E. J., Bi, J., Wang, X., Umesalma, S., Quelle, D. E., Thiel, W. H., Thiel, K. W. & Leslie, K. K. (2018). COMBINATION OF PROTEASOME AND HISTONE DEACETYLASE INHIBITORS OVERCOMES THE IMPACT OF GAIN-OF-FUNCTION P53 MUTATIONS. DISEASE MARKERS 2018 3810108. DOI: 10.1155/2018/3810108. PMID: 30647797. PMCID: PMC6311857.
  • Ruiz Ciancio, D., Vargas, M. R., Thiel, W. H., Bruno, M. A., Giangrande, P. H. & Mestre, M. B. (2018). APTAMERS AS DIAGNOSTIC TOOLS IN CANCER. PHARMACEUTICALS (BASEL, SWITZERLAND) 11 (3). DOI: 10.3390/ph11030086. PMID: 30208607. PMCID: PMC6160954.
  • Nguyen, E. K., Koval, O. M., Noble, P., Broadhurst, K., Allamargot, C., Wu, M., Strack, S., Thiel, W. H. & Grumbach, I. M. (2018). CAMKII (CA2+/CALMODULIN-DEPENDENT KINASE II) IN MITOCHONDRIA OF SMOOTH MUSCLE CELLS CONTROLS MITOCHONDRIAL MOBILITY, MIGRATION, AND NEOINTIMA FORMATION. ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY 38 (6) 1333-1345. DOI: 10.1161/ATVBAHA.118.310951. PMID: 29599132. PMCID: PMC5970052.
  • Thiel, W. H. & Giangrande, P. H. (2016). AFBI ASSAY - APTAMER FLUORESCENCE BINDING AND INTERNALIZATION ASSAY FOR CULTURED ADHERENT CELLS. METHODS (SAN DIEGO, CALIF.) 103 180-7. DOI: 10.1016/j.ymeth.2016.03.005. PMID: 26972784. PMCID: PMC4921262.
  • Thiel, W. H., Esposito, C. L., Dickey, D. D., Dassie, J. P., Long, M. E., Adam, J., Streeter, J., Schickling, B., Takapoo, M., Flenker, K. S., Klesney-Tait, J., Franciscis Vd, Miller, Jr, F. J. & Giangrande, P. H. (2016). SMOOTH MUSCLE CELL-TARGETED RNA APTAMER INHIBITS NEOINTIMAL FORMATION. MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY 24 (4) 779-87. DOI: 10.1038/mt.2015.235. PMID: 26732878. PMCID: PMC4886937.
  • Thiel, W. H. & Giangrande, P. H. (2016). ANALYZING HT-SELEX DATA WITH THE GALAXY PROJECT TOOLS--A WEB BASED BIOINFORMATICS PLATFORM FOR BIOMEDICAL RESEARCH. METHODS (SAN DIEGO, CALIF.) 97 3-10. DOI: 10.1016/j.ymeth.2015.10.008. PMID: 26481156. PMCID: PMC4792767.
  • Thiel, W. H. (2016). GALAXY WORKFLOWS FOR WEB-BASED BIOINFORMATICS ANALYSIS OF APTAMER HIGH-THROUGHPUT SEQUENCING DATA. MOLECULAR THERAPY NUCLEIC ACIDS 5 e345. DOI: 10.1038/mtna.2016.54. PMID: 28131286. PMCID: PMC5023399.
  • Thiel, W. H., Thiel, K. W., Flenker, K. S., Bair, T., Dupuy, A. J., McNamara, 2nd, J. O., Miller, F. J. & Giangrande, P. H. (2015). CELL-INTERNALIZATION SELEX: METHOD FOR IDENTIFYING CELL-INTERNALIZING RNA APTAMERS FOR DELIVERING SIRNAS TO TARGET CELLS. METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) 1218 187-99. DOI: 10.1007/978-1-4939-1538-5_11. PMID: 25319652. PMCID: PMC4435695.