Yi Huang, MD, PhD
Associate Professor of Internal Medicine-Hematology, Oncology, and Blood and Marrow Transplantation
Current Positions
- Associate Professor of Internal Medicine-Hematology, Oncology, and Blood and Marrow Transplantation
Education
- MD, Nanjing Medical University, Nanjing, China
- PhD, Pathology & Lab Medicine, Medical University of South Carolina, Charleston, South Carolina
- Resident, Surgery, Affiliated Hospital of Medical College of Nanjing University, Nanjing, China
- Fellow, Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
Graduate Program Affiliations
Selected Publications
- Gu T, Vasilatos SN, Yin J, Qin Y, Zhang L, Davidson NE, Huang Y. Restoration of TFPI2 by LSD1 inhibition suppresses tumor progression and potentiates antitumor immunity in breast cancer. Cancer Lett. 2024; 600: 217182. PMID: 39154703
- Yin J, Gu T, Chaudhry N, Davidson NE, Huang Y. Epigenetic modulation of antitumor immunity and immunotherapy response in breast cancer: biological mechanisms and clinical implications. Front Immunol. 2024 Jan 10;14:1325615. doi: 10.3389/fimmu.2023.1325615. PMID: 38268926; PMCID: PMC10806158.
- Tong J, Tan X, Song X, Gao M, Risnik D, Hao S, Ermine K, Wang P, Li H, Huang Y, Yu J, Zhang L. CDK4/6 inhibition induces DR5 via p73 to potentiate antitumor and immunogenic effects. Cancer Res., 2022; 82 (7): 1340–1352. PMID: 35149588.
- Lizardo DY, Kuang C, Hao S, Yu J, Huang Y, Zhang L. Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: from bench to bedside. Biochim Biophys Acta Rev Cancer. 2020; 1874(2):188447. PMID: 33035640.
- Zhou Z, Zhou H, Ponzoni L, Luo A, Zhu R, He M, Huang Y, Guan K, Bahar I, Liu Z, Wan Y. EIF3H orchestrates Hippo pathway-mediated oncogenesis via catalytic control of YAP stability. Cancer Res. 2020; 80(12):2550-2563. PMID: 32269044.
- Ma W, Sun J, Xu J, Luo Z, Diao D, Zhang Z, Oberly PJ, Minnigh MB, Xie W, Poloyac SM, Huang Y, Li S. Sensitizing triple negative breast cancer to tamoxifen chemotherapy via a redox-responsive vorinostat-containing polymeric prodrug nanocarrier. Theranostics. 2020; 10(6): 2463-2478. PMID: 32194813.
- Qin Y, Vasilatos SN, Chen L, Wu H, Cao Z, Fu Y, Huang M, Vlad AM, Lu B, Oesterreich S, Davidson NE, Huang Y. Inhibition of histone lysine-specific demethylase 1 elicits breast tumor immunity and enhances antitumor efficacy of immune checkpoint blockade. Oncogene. 2019; 38(3):390-405. PMID: 30111819.
- Asan A, Skoko JJ, Woodcock CC, Wingert BM, Woodcock SR, Normolle D, Huang Y, Stark JM, Camacho CJ, Freeman BA, Neumann CA. Electrophilic fatty acids impair RAD51 function and potentiate the effects of DNA-damaging agents on growth of triple-negative breast cells. J Biol Chem. 2019; 294(2):397-404. PMID: 30478172.
- Xu J, Ma H, Jin J, Uttam S, Fu R, Huang Y, Liu Y. Super-resolution imaging of higher-order chromatin structures at different epigenomic states in single mammalian cells. Cell Rep. 2018; 24(4):873-882. PMID: 30044984.
- Cao C, Wu H, Vasilatos SN, Chandran U, Qin Y, Wan Y, Oesterreich S, Davidson NE, Huang Y. HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells. Int J Cancer. 2018; 143(6):1388-1401. PMID: 29633255.