colten-lankford@uiowa.edu
Mentor: Sheila Baker, Ph.D.
Lab Room: 4-411 BSB
Lab Phone: 319-335-6516

Uncovering mechanisms of HCN1 regulation

Hyperpolarization activated cyclic nucleotide-gated channel 1 (HCN1) is a sodium/potassium channel expressed throughout the brain. HCN1 functions in regulating excitability in brain neurons and acts to temporally limit the duration of light activated signaling in rod and cone photoreceptors. My research focuses on investigating the mechanisms, both in terms of channel biogenesis and degradation, that control the concentration of HCN1 at the plasma membrane.

Inamdar SM, Lankford CK, Laird JG, Novbatova G, Tatro N, Whitmore SS, Scheetz TE, Baker SA. Analysis of 14-3-3 isoforms expressed in photoreceptors. Exp Eye Res. 2018 May;170:108-116. doi: 10.1016/j.exer.2018.02.022. Epub 2018 Feb 24. PubMed PMID: 29486162; PubMed Central PMCID: PMC5924652.