lucas-bondurant@uiowa.edu
Mentor: Matthew Potthoff, Ph.D.
Lab Room: 3322 PBDB
Lab Phone: 319-335-7660

Studying the pharmalogical effects of FGF21 in metabolic syndrome

FGF21 is liver-derived hormone that shows great promise in treating diabetes. While FGF21 increases insulin sensitivity, the mechanism by which it does this is still not clear. By using diverse genetic mouse models we seek to delineate the tissues and signaling pathway that FGF21 acts upon in order to increase glucose uptake and insulin sensitivity. In addition, I have previously worked on a project investigating how FGF21 regulates sweet preference and sugar intake.

BonDurant LD, Ameka M, Naber MC, Markan KR, Idiga SO, Acevedo MR, Walsh SA, Ornitz DM, Potthoff MJ. FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms. Cell Metab. 2017 Apr 4;25(4):935-944.e4. doi: 10.1016/j.cmet.2017.03.005. PubMed PMID: 28380381; PubMed Central PMCID:PMC5494834.

von Holstein-Rathlou S, BonDurant LD, Peltekian L, Naber MC, Yin TC, Claflin KE, Urizar AI, Madsen AN, Ratner C, Holst B, Karstoft K, Vandenbeuch A, Anderson CB, Cassell MD, Thompson AP, Solomon TP, Rahmouni K, Kinnamon SC, Pieper AA, Gillum MP, Potthoff MJ. FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver. Cell Metab. 2016 Feb 9;23(2):335-43. doi: 10.1016/j.cmet.2015.12.003. Epub 2015 Dec 24. PubMed PMID: 26724858; PubMed Central PMCID: PMC4756759.