sarah-sapouckey@uiowa.edu
Mentor: Justin Grobe, Ph.D., FAHA
Lab Room: 2-300 BSB
Lab Phone: 319-353-5803

Leptin-Angiotensin Interaction in Hypothalamic Control of Metabolism

Obesity represents an enormous biomedical, economic and social burden worldwide, and development of new therapeutic approaches depends upon understanding the molecular mechanisms that control energy balance. Leptin is a well-known circulating hormone that contributes to energy homeostasis in part through the control of resting metabolic rate, and our team has demonstrated that the renin-angiotensin system within the arcuate nucleus of the hypothalamus mediates this control. My ongoing work is focused on understanding the molecular connections that mediate this leptin-angiotensin cross-talk within the brain.

Hill CE, Sapouckey SA, Suvorov A, Vandenberg LN (2017). "Developmental exposures to bisphenol S, a BPA replacement, alter estrogen-responsiveness of the female reproductive tract: a pilot study." Cogent Medicine 0(0).

Sapouckey SA, Kassotis CD, Nagel SC, Vandenberg LN. Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice. Endocrinology. 2018 Mar 1;159(3):1277-1289. doi: 10.1210/en.2017-00866. PubMed PMID: 29425295; PubMed Central PMCID: PMC5809159.

Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Angiotensin AT(1A) Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin. Am J Physiol Regul Integr Comp Physiol. 2018 Jan 24. doi: 10.1152/ajpregu.00435.2017. [Epub ahead of print] PubMed PMID: 29364700.

Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism. Physiol Genomics. 2017 Dec 1;49(12):722-732. doi: 10.1152/physiolgenomics.00087.2017. Epub 2017 Oct 6. Review. PubMed PMID: 28986397; PubMed Central PMCID: PMC5814669.