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Scott Tyler

Mentor: John Engelhardt, Ph.D.
Lab Room: 1-111 BSB
Lab Phone: 319-335-9613

Taking an integrated wet-bench and bioinformatic approach to better understand the basic biology of cystic fibrosis

I'm working to assemble the ferret genome and discover orthologous genes. I am also working to identify and functionally validate a gene in cystic fibrosis mice that provides dominant protection against gut obstruction.

Keiser NW, Birket SE, Evans IA, Tyler SR, Crooke AK, Sun X, Zhou W, Nellis JR, Stroebele EK, Chu KK, Tearney GJ, Stevens MJ, Harris JK, Rowe SM, Engelhardt JF. Defective Innate Immunity and Hyper-Inflammation in Newborn CFTR-Knockout Ferret Lungs. Am J Respir Cell Mol Biol. 2014 Oct 15. [Epub ahead of print] PubMed PMID:25317669.

Sun X, Olivier AK, Yi Y, Pope CE, Hayden HS, Liang B, Sui H, Zhou W, Hager KR, Zhang Y, Liu X, Yan Z, Fisher JT, Keiser NW, Song Y, Tyler SR, Goeken JA, Kinyon JM, Radey MC, Fligg D, Wang X, Xie W, Lynch TJ, Kaminsky PM, Brittnacher MJ, Miller SI, Parekh K, Meyerholz DK, Hoffman LR, Frana T, Stewart ZA, Engelhardt JF. Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets. Am J Pathol. 2014 May;184(5):1309-22. doi: 10.1016/j.ajpath.2014.01.035. Epub 2014 Mar 15. PubMed PMID: 24637292; PubMed Central PMCID: PMC4005986.

Xie W, Lynch TJ, Liu X, Tyler SR, Yu S, Zhou X, Luo M, Kusner DM, Sun X, Yi Y, Zhang Y, Goodheart MJ, Parekh KR, Wells JM, Xue HH, Pevny LH, Engelhardt JF. Sox2 modulates Lef-1 expression during airway submucosal gland development. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L645-60. doi:10.1152/ajplung.00157.2013. Epub 2014 Jan 31. PubMed PMID: 24487391; PubMed Central PMCID: PMC3962629.

Sun X, Olivier AK, Liang B, Yi Y, Sui H, Evans TI, Zhang Y, Zhou W, Tyler SR, Fisher JT, Keiser NW, Liu X, Yan Z, Song Y, Goeken JA, Kinyon JM, Fligg D, Wang X, Xie W, Lynch TJ, Kaminsky PM, Stewart ZA, Pope RM, Frana T, Meyerholz DK, Parekh K, Engelhardt JF. Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets. Am J Respir Cell Mol Biol. 2014 Mar;50(3):502-12. doi: 10.1165/rcmb.2013-0261OC. PubMed PMID: 24074402;PubMed Central PMCID: PMC4068938.

Yan Z, Sun X, Evans IA, Tyler SR, Song Y, Liu X, Sui H, Engelhardt JF. Postentry processing of recombinant adeno-associated virus type 1 and transduction of the ferret lung are altered by a factor in airway secretions. Hum Gene Ther. 2013 Sep;24(9):786-96. doi: 10.1089/hum.2013.137. PubMed PMID:23948055; PubMed Central PMCID: PMC3768237.

Fisher JT, Tyler SR, Zhang Y, Lee BJ, Liu X, Sun X, Sui H, Liang B, Luo M, Xie W, Yi Y, Zhou W, Song Y, Keiser N, Wang K, de Jonge HR, Engelhardt JF. Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets. Am J Respir Cell Mol Biol. 2013 Nov;49(5):837-44. doi: 10.1165/rcmb.2012-0433OC. PubMed PMID: 23782101; PubMed Central PMCID: PMC3931095.

Sui H, Olivier AK, Klesney-Tait JA, Brooks L, Tyler SR, Sun X, Skopec A, Kline J, Sanchez PG, Meyerholz DK, Zavazava N, Iannettoni M, Engelhardt JF, Parekh KR. Ferret lung transplant: an orthotopic model of obliterative bronchiolitis. Am J Transplant. 2013 Feb;13(2):467-73. doi: 10.1111/j.1600-6143.2012.04337.x. Epub 2012 Dec 3. PubMed PMID: 23205765; PubMed Central PMCID: PMC3638989.