Drew Voigt, M6G
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MSTP Learning Community: Boulware MSTP Entry Date: June 20, 2016 |
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PhD Program: Molecular Medicine |
Mentors: Robert Mullins, PhDTodd Scheetz, PhD |
Single-cell Transcriptomics of the Human Retina: Regional Specialization, Endothelial Degeneration & Bioinformatic Visualization
Thesis Defense: September 21, 2021
Committees:
2019-present - Founder & Chair, Spectrum Soccer (CCOM)
Awards:
2017 - The John Stokes Award for Research in Internal Medicine, Medical Student Research Day, Sept 15
2019 - UI Carver College of Medicine Trainee Scholar Travel Award ("Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing")
2020 - CCOM Medicine Trainee Scholar Virtual Event Award for article published in Cells
2020 - NIH NRSA Predoctoral Fellowship (F30 EY031923)
Individual Funding Awards:
07/21/2020 - 07/20/2024
F30 EY 031923 - (National Eye Institute)
The Membrane Attack Complex and the Choriocapillaris in Health and Age-Related Macular Degeneration
Teaching:
2017 Fall - Human Gross Anatomy Tutor
2018 Spring - Mechanisms of Health and Disease III Tutor
2020 Spring - Computational Genomics TA
Education:
2014 - BA, Mathematics - St. Olaf College
Publications:
Voigt AP, Whitmore SS, Flamme-Wiese MJ, Riker MJ, Wiley LA, Tucker BA, Stone EM, Mullins RF, Scheetz TE. Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing. Exp Eye Res. 2019 Jul;184:234-242. doi: 10.1016/j.exer.2019.05.001. Epub 2019 May 8. PubMed PMID: 31075224; PubMed Central PMCID: PMC6596422.
Borcherding N, Voigt AP, Liu V, Link BK, Zhang W, Jabbari A. Single-Cell Profiling of Cutaneous T-Cell Lymphoma Reveals Underlying Heterogeneity Associated with Disease Progression. Clin Cancer Res. 2019 May 15;25(10):2996-3005. doi: 10.1158/1078-0432.CCR-18-3309. Epub 2019 Feb 4. PMID: 30718356; PMCID: PMC6659117.
Borcherding N, Bormann NL, Voigt AP, Zhang W. TRGAted: A web tool for survival analysis using protein data in the Cancer Genome Atlas. Version 2. F1000Res. 2018 Aug 10 [revised 2018 Jan 1];7:1235. doi: 10.12688/f1000research.15789.2. eCollection 2018. PMCID: PMC6173115.
Feddersen CR, Wadsworth LS, Zhu EY, Vaughn HR, Voigt AP, Riordan JD, Dupuy AJ. A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells. BMC Genomics. 2019 Jun 17;20(1):497. doi: 10.1186/s12864-019-5888-6. PubMed PMID: 31208320; PubMed Central PMCID: PMC6580595.
Feddersen CR, Schillo JL, Varzavand A, Vaughn HR, Wadsworth LS, Voigt AP, Zhu EY, Jennings BM, Mullen SA, Bobera J, Riordan JD, Stipp CS, Dupuy AJ. Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma. Cancer Res. 2019 Oct 1;79(19):5074-5087. doi: 10.1158/0008-5472.CAN-19-0244. Epub 2019 Aug 15. PMID: 31416844; PMCID: PMC6774858.
Voigt AP, Mulfaul K, Mullin NK, Flamme-Wiese MJ, Giacalone JC, Stone EM, Tucker BA, Scheetz TE, Mullins RF. Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24100-24107. doi: 10.1073/pnas.1914143116. Epub 2019 Nov 11. PubMed PMID: 31712411; PubMed Central PMCID: PMC6883845.
Voigt AP, Binkley E, Flamme-Wiese MJ, Zeng S, DeLuca AP, Scheetz TE, Tucker BA, Mullins RF, Stone EM. Single-Cell RNA Sequencing in Human Retinal Degeneration Reveals Distinct Glial Cell Populations. Cells. 2020 Feb 13;9(2). doi: 10.3390/cells9020438. PubMed PMID: 32069977; PubMed Central PMCID: PMC7072666.
Voigt AP, Whitmore SS, Mulfaul K, Chirco KR, Giacalone JC, Flamme-Wiese MJ, Stockman A, Stone EM, Tucker BA, Scheetz TE, Mullins RF. Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype. Microvasc Res. 2020 Sep;131:104031. doi: 10.1016/j.mvr.2020.104031. Epub 2020 Jun 9. PubMed PMID: 32531351; PubMed Central PMCID: PMC7396301.
Mulfaul K, Giacalone JC, Voigt AP, Riker MJ, Ochoa D, Han IC, Stone EM, Mullins RF, Tucker BA. Stepwise differentiation and functional characterization of human induced pluripotent stem cell-derived choroidal endothelial cells. Stem Cell Res Ther. 2020 Sep 23;11(1):409. doi: 10.1186/s13287-020-01903-4. PubMed PMID: 32967716; PubMed Central PMCID: PMC7510078.
Voigt AP, Whitmore SS, Lessing ND, DeLuca AP, Tucker BA, Stone EM, Mullins RF, Scheetz TE. Spectacle: An interactive resource for ocular single-cell RNA sequencing data analysis. Exp Eye Res. 2020 Nov;200:108204. doi: 10.1016/j.exer.2020.108204. Epub 2020 Sep 7. PubMed PMID: 32910939; PubMed Central PMCID: PMC7655596.
Stone NE, Voigt AP, Cooke JA, Giacalone JC, Hanasoge S, Mullins RF, Tucker BA, Sulchek T. Label-free microfluidic enrichment of photoreceptor cells. Exp Eye Res. 2020 Oct;199:108166. doi: 10.1016/j.exer.2020.108166. Epub 2020 Aug 6. PubMed PMID: 32771499.
Mullin NK, Voigt AP, Cooke JA, Bohrer LR, Burnight ER, Stone EM, Mullins RF, Tucker BA. Patient derived stem cells for discovery and validation of novel pathogenic variants in inherited retinal disease. Prog Retin Eye Res. 2021 Jul;83:100918. doi: 10.1016/j.preteyeres.2020.100918. Epub 2020 Oct 29. Review. PubMed PMID: 33130253; PubMed Central PMCID: PMC8559964..
Borcherding N, Vishwakarma A, Voigt AP, Bellizzi A, Kaplan J, Nepple K, Salem AK, Jenkins RW, Zakharia Y, Zhang W. Mapping the immune environment in clear cell renal carcinoma by single-cell genomics. Commun Biol. 2021 Jan 27;4(1):122. doi: 10.1038/s42003-020-01625-6. PubMed PMID: 33504936; PubMed Central PMCID: PMC7840906.
Voigt AP, Mullin NK, Stone EM, Tucker BA, Scheetz TE, Mullins RF. Single-cell RNA sequencing in vision research: Insights into human retinal health and disease. Prog Retin Eye Res. 2021 Jul;83:100934. doi: 10.1016/j.preteyeres.2020.100934. Epub 2020 Dec 28. Review. PubMed PMID: 33383180; PubMed Central PMCID: PMC8236499.
Sabree SA, Voigt AP, Blackwell SE, Vishwakarma A, Chimenti MS, Salem AK, Weiner GJ. Direct and indirect immune effects of CMP-001, a virus-like particle containing a TLR9 agonist. J Immunother Cancer. 2021 Jun;9(6). doi: 10.1136/jitc-2021-002484. PubMed PMID: 34083419; PubMed Central PMCID: PMC8183212.
Voigt AP, Mullin NK, Whitmore SS, DeLuca AP, Burnight ER, Liu X, Tucker BA, Scheetz TE, Stone EM, Mullins RF. Human photoreceptor cells from different macular subregions have distinct transcriptional profiles. Hum Mol Genet. 2021 Jul 28;30(16):1543-1558. doi: 10.1093/hmg/ddab140. PubMed PMID: 34014299; PubMed Central PMCID: PMC8330894.
Stone NE, Voigt AP, Mullins RF, Sulchek T, Tucker BA. Microfluidic processing of stem cells for autologous cell replacement. Stem Cells Transl Med. 2021 Oct;10(10):1384-1393. doi: 10.1002/sctm.21-0080. Epub 2021 Jun 22. Review. PubMed PMID: 34156760; PubMed Central PMCID: PMC8459636.
Kim MC, Borcherding N, Ahmed KK, Voigt AP, Vishwakarma A, Kolb R, Kluz PN, Pandey G, De U, Drashansky T, Helm EY, Zhang X, Gibson-Corley KN, Klesney-Tait J, Zhu Y, Lu J, Lu J, Huang X, Xiang H, Cheng J, Wang D, Wang Z, Tang J, Hu J, Wang Z, Liu H, Li M, Zhuang H, Avram D, Zhou D, Bacher R, Zheng SG, Wu X, Zakharia Y, Zhang W. CD177 modulates the function and homeostasis of tumor- infiltrating regulatory T cells. Nat Commun. 2021 Oct 1;12(1):5764. doi: 10.1038/s41467-021-26091-4. PubMed PMID: 34599187; PubMed Central PMCID: PMC8486774
Mulfaul K, Mullin NK, Giacalone JC, Voigt AP, DeVore M, Stone EM, Tucker BA, Mullins RF. Local Factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration. J Pathol. 2022 Jan 17. doi: 10.1002/path.5867. Epub ahead of print. PMID: 35038170.
Voigt AP, Mullin NK, Mulfaul K, Lozano LP, Wiley LA, Flamme-Wiese MJ, Boese EA, Han IC, Scheetz TE, Stone EM, Tucker BA, Mullins RF. Choroidal Endothelial and Macrophage Gene Expression in Atrophic and Neovascular Macular Degeneration. Hum Mol Genet. 2022 Feb 19:ddac043. doi: 10.1093/hmg/ddac043. Epub ahead of print. PMID: 35181781.
Brockman QR, Scherer A, McGivney GR, Gutierrez WR, Voigt AP, Isaacson AL, Laverty EA, Roughton G, Knepper-Adrian V, Darbro B, Tanas MR, Stipp CS, Dodd RD. PRC2 loss drives MPNST metastasis and matrix remodeling. JCI Insight. 2022 Sep 6;. doi: 10.1172/jci.insight.157502. [Epub ahead of print] PubMed PMID: 36066973.
Mulfaul K, Russell JF, Voigt AP, Stone EM, Tucker BA, Mullins RF. The Essential Role of the Choriocapillaris in Vision: Novel Insights from Imaging and Molecular Biology. Annu Rev Vis Sci. 2022 Sep 15;8:33-52. doi: 10.1146/annurev-vision-100820-085958. PMID: 36108103.
den Hollander AI, Mullins RF, Orozco LD, Voigt AP, Chen HH, Strunz T, Grassmann F, Haines JL, Kuiper JJW, Tumminia SJ, Allikmets R, Hageman GS, Stambolian D, Klaver CCW, Boeke JD, Chen H, Honigberg L, Katti S, Frazer KA, Weber BHF, Gorin MB. Systems genomics in age-related macular degeneration. Exp Eye Res. 2022 Sep 12:109248. doi: 10.1016/j.exer.2022.109248. Epub ahead of print. PMID: 36108770.
Lehmann GL, Ginsberg M, Nolan DJ, Rodríguez C, Martínez-González J, Zeng S, Voigt AP, Mullins RF, Rafii S, Rodriguez-Boulan E, Benedicto I. Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells. Cells. 2022 Sep 24;11(19). doi: 10.3390/cells11192975. PubMed PMID: 36230937.