Eliot Zhu, M6G
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MSTP Learning Community: Flocks MSTP Entry Date: June 3, 2015 |
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PhD Program: Cancer Biology |
Mentor: Adam Dupuy, PhD |
Phenotype-specific drivers of adaptive resistance to MAPKi in BRAFV600E/K melanomas
Thesis Defense: January 7, 2022
Awards:
2015 - Medical Student Research Day - Edward Heath Award (outstanding communication of laboratory achievements)
Individual Funding Awards:
12/01/2019 - 11/30/2023
F30CA247102 - (National Cancer Institute)
Drivers of MAPK redundant mechanisms of resistance to BRAF inhibition in melanoma
02/01/2020 - 01/01/2021
American Skin Association Cohen Family Medical Student Grant
Targetable Drivers of Drug Resistance to BRAF Inhibitors in Melanoma
02/01/2019 - 02/01/2020
Melanoma Research Foundation Grant
Identification of Src family kinases that drive resistance to mutant BRAF inhibition
Teaching:
2019 Spring - MOHD II Tutor
2019 Spring - MOHD III Tutor
Education:
2012 - BS, Systems Biology - Case Western Reserve University
Publications:
Feddersen CR, Wadsworth LS, Zhu EY, Vaughn HR, Voigt AP, Riordan JD, Dupuy AJ. A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells. BMC Genomics. 2019 Jun 17;20(1):497. doi: 10.1186/s12864-019-5888-6. PubMed PMID: 31208320; PubMed Central PMCID: PMC6580595.
Feddersen CR, Schillo JL, Varzavand A, Vaughn HR, Wadsworth LS, Voigt AP, Zhu EY, Jennings BM, Mullen SA, Bobera J, Riordan JD, Stipp CS, Dupuy AJ. Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma. Cancer Res. 2019 Oct 1;79(19):5074-5087. doi: 10.1158/0008-5472.CAN-19-0244. Epub 2019 Aug 15. PMID: 31416844; PMCID: PMC6774858.
Feddersen CR, Wadsworth LS, Zhu EY, Vaughn HR, Voigt AP, Riordan JD, Dupuy AJ. A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells. BMC Genomics. 2019 Jun 17;20(1):497. doi: 10.1186/s12864-019-5888-6. PubMed PMID: 31208320; PubMed Central PMCID: PMC6580595.
Vanneste M, Feddersen CR, Varzavand A, Zhu EY, Foley T, Zhao L, Holt KH, Milhem M, Piper R, Stipp CS, Dupuy AJ, Henry MD. Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis. Front Oncol. 2020 Apr 3;10:442. doi: 10.3389/fonc.2020.00442. eCollection 2020. PubMed PMID: 32346533; PubMed Central PMCID: PMC7169429.
Zhu EY, Dupuy AJ. Machine learning approach informs biology of cancer drug response. BMC Bioinformatics. 2022 May 17;23(1):184. doi: 10.1186/s12859-022-04720-z. PMID: 35581546; PMCID: PMC9112473.
Zhu EY, Riordan JD, Vanneste M, Henry MD, Stipp CS, Dupuy AJ. SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas. NPJ Precis Oncol. 2022 Oct 21;6(1):74. doi: 10.1038/s41698-022-00310-7. PubMed PMID: 36271142; PubMed Central PMCID: PMC9587254.