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Laura Marquez Loza, M6G

laura-marquezloza@uiowa.edu

 

MSTP Learning Community:  Boulware

MSTP Entry Date:  June 8, 2015

PhD Program:

Molecular Medicine

Mentor:

Paul McCray, MD


Codon Optimization of Cystic Fibrosis Transmembrane Conductance Regulator to Enhance Therapeutic Gene Expression

Thesis Defense:  May 19, 2021


Committees:

  • 2015 Fall - MAS I Medical Student Liaison Committee
  • 2019 Fall-present - GPSG Grants Reviewing Committee
  • 2017-2018 - APSA Midwest Regional Meeting Planning Committee
  • 2019-present - MSTP Applicant Task Force
  • 2019-present - Retreat & I Heart Science Committee

Awards:

  • 2018 - American Physician Scientist Association Midwest Regional Meeting – Poster award
  • 2018 - Pediatric Research Day – Basic Science Poster Award
  • 2018 - Graduate College Underrepresentative Minory Pre-Comprehensive Mentored Summer Research Fellowship
  • 2019 - American Society for Gene and Cell Therapy – URM Travel Award
  • 2020 - American Society for Gene and Cell Therapy – URM Travel Award towards travel to next year’s meeting
  • 2020 - Fellowship Award F31HL1500-01

Individual Funding Awards:

07/10/2020 - 07/09/2024
F31 HL152500 - (National Heart, Lung & Blood Institute)
Advancing lentiviral gene therapy for cystic fibrosis

Teaching:

  • 2017-2019 - Step 1 Tutor group
  • 2019 Jan - UI Health Care STEM Night at the Iowa Children's Museum
  • 2019 Spring - TA for course MMED:6226 Cell Cycle Control
  • 2019 Spring - TA for course MMED:6227 Cell Fate and Decisions
  • 2019 Spring - TA for course MMED:6225 Growth Factor and Receptor Signaling

Education:

2008 - BS, Wood Science & Technology - Oregon State University

Publications:

ORCiD:  0000-0002-0149-2727

Cooney AL, Singh BK, Loza LM, Thornell IM, Hippee CE, Powers LS, Ostedgaard LS, Meyerholz DK, Wohlford-Lenane C, Stoltz DA, B McCray P Jr, Sinn PL. Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus. Nucleic Acids Res. 2018 Oct 12;46(18):9591-9600. doi: 10.1093/nar/gky773. PubMed PMID: 30165523; PubMed Central PMCID: PMC6182177

Marquez Loza LI, Yuen EC, McCray PB Jr. Lentiviral Vectors for the Treatment and Prevention of Cystic Fibrosis Lung Disease. Genes (Basel). 2019 Mar 14;10(3). Doi: 10.3390/genes10030218. Review. PubMed PMID: 30875857; PubMed Central PMCID: PMC6471883.

Marquez Loza LI, Cooney AL, Dong Q, Randak CO, Rivella S, Sinn PL, McCray PB Jr. Increased CFTR expression and function from an optimized lentiviral vector for cystic fibrosis gene therapy. Mol Ther Methods Clin Dev. 2021 Feb 27;21:94-106. doi: 10.1016/j.omtm.2021.02.020. PMID: 33768133; PMCID: PMC7973238.