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Mitchell Lefebvre, M6G

mitchell-lefebvre@uiowa.edu

 

MSTP Learning Community:  McCowen

MSTP Entry Date:  June 1, 2016

PhD Program:

Immunology

Mentor:

John Harty, PhD


Fleet-footed soldiers: circulating memory CD8 T cells quickly enter the fray during malarial and bacterial infection of the liver

Thesis Defense:  December 6, 2021


Committees:

  • 2015 Fall - MOHD Medical Student Liaison Committee
  • 2015-2017 - MSTP RAGBRAI Planning Team
  • 2017-2018 - APSA Midwest Regional Meeting Planning Committee
  • 2018-2019 - MSTP Monday Committee

Awards:

  • 2019 - Graduate College Post-Comprehensive Research Fellowship Award, University of Iowa
  • 2020 - Immunology T32 Training Grant Recipient

Teaching:

  • 2017 Fall - Step 1 tutor
  • 2018 Fall - Step 1 tutor
  • 2018 Fall - Medical Student Microbiology TA
  • 2019 Spring - MOHD II Tutor

Education:

2015 - BS, Microbiology / Bacteriology - University of Alabama

Publications:

ORCiD:  0000-0002-7641-7043

Martin MD, Jensen IJ, Ishizuka AS, Lefebvre M, Shan Q, Xue HH, Harty JT, Seder RA, Badovinac VP. Bystander responses impact accurate detection of murine and human antigen-specific CD8 T cells. J Clin Invest. 2019 Jun 20;129(9):3894-3908. doi: 10.1172/JCI124443. PubMed PMID: 31219804; PubMed Central PMCID: PMC6715387.

Lefebvre MN, Harty JT. You Shall Not Pass: Memory CD8 T Cells in Liver-Stage Malaria. Trends Parasitol. 2020 Feb;36(2):147-157. doi: 10.1016/j.pt.2019.11.004. Epub 2019 Dec 13. Review. PubMed PMID: 31843536; PubMed Central PMCID: PMC6937381.

Jensen IJ, McGonagill PW, Lefebvre MN, Griffith TS, Harty JT, Badovinac VP. Worry and FRET: ROS Production Leads to Fluorochrome Tandem Degradation and impairs Interpretation of Flow Cytometric Results. Immunity. 2020 Mar 17;52(3):419-421. doi: 10.1016/j.immuni.2020.02.003. PubMed PMID: 32187510; PubMed Central PMCID: PMC7251922.

Lefebvre MN, Harty JT. γδ T cells burst malaria's bubble. Nat Immunol. 2021 Feb 5. doi: 10.1038/s41590-021-00879-4. Epub ahead of print. PMID: 33547458.

Lefebvre MN, Surette FA, Anthony SM, Vijay R, Jensen IJ, Pewe LL, Hancox LS, Van Braeckel-Budimir N, van de Wall S, Urban SL, Mix MR, Kurup SP, Badovinac VP, Butler NS, Harty JT.  Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell Rep. 2021 Nov 2;37(5):109956. doi: 10.1016/j.celrep.2021.109956. PubMed PMID: 34731605; PubMed Central PMCID: PMC8628427.

Lefebvre MN, Drewry LL, Pewe LL, Hancox LS, Reyes-Sandoval A, Harty JT.  Cutting Edge: Subunit Booster Vaccination Confers Sterilizing Immunity against Liver-Stage Malaria in Mice Initially Primed with a Weight-Normalized Dose of Radiation-Attenuated Sporozoites. J Immunol. 2021 Dec
1;207(11):2631-2635. doi: 10.4049/jimmunol.2100818. Epub 2021 Oct 29. PubMed PMID: 34716185; PubMed Central PMCID: PMC8612975.