Wade Gutierrez, M6G
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MSTP Learning Community: Bean MSTP Entry Date: June 9, 2016 |
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PhD Program: Cancer Biology |
Mentor: Rebecca Dodd, PhD |
Epigenetic Combination Therapy Improves Survival in Soft Tissue Sarcoma by a Novel Mechanism
Thesis Defense: November 4, 2022
Committees:
2016-present - CCOM Medical School Ambassador
2016-present - Student Member, American Medical Association (AMA)
2017-present - CCOM Student Representative, Association of American Medical Colleges (AAMC) Organization of Student Representatives (OSR)
2018-present - Affiliate Member, University of Iowa Holden Comprehensive Cancer Center
2018-present - Associate Member, American Association for Cancer Research (AACR)
2018-present - Member, Sarcoma Foundation of America
2018-present - Full Member, American Physician Scientist Association (APSA)
2019-present - MSTP Student Panel Member, CCOM FUTURE in Biomedicine Program
2019-2020 - AAMC - Organization of Student Representatives
2016-2017 - MSTP Recruitment Committee
2016-2019 - MSTP Applicant Task Force
Awards:
2016 - Sloan Scholar, Alfred P. Sloan Foundation Minority PhD (MPHD) Program, Sloan Center for Exemplary Mentoring, University of Iowa
2018 - Fellowship appointment on the Pharmacological Sciences Training Program (NIH T32 GM067795), Department of Pharmacology, University of Iowa
2018 - HCCC Affiliate Member, Experimental Therapeutics
2019 - Fellowship re-appointment on the Pharmacological Sciences Training Program (NIH T32 GM067795)
2020 - HCCC Retreat winner for Clinical Trials & Cancer Outcomes: Epigenetic Combination Therapy Improves Survival in Soft Tissue Sarcoma by a Novel Immune-independent Mechanism
2020 - Midwest Tumor Microenvironment Meeting Young Investigator Award
2022 - 2nd Annual MSTP Leadership Award
Mentorship:
2018 & 2019 - Summer Undergraduate MSTP Research (SUMR) Program Student Mentor
2021 & 2022 - SUMR Program - Bean Community Student Advisor
Education:
2016 - BS, Psychology - Kansas State University
Publications:
Kruspe S, Dickey DD, Urak KT, Blanco GN, Miller MJ, Clark KC, Burghardt E, Gutierrez WR, Phadke SD, Kamboj S, Ginader T, Smith BJ, Grimm SK, Schappet J, Ozer H, Thomas A, McNamara JO 2nd, Chan CH, Giangrande PH. Rapid and Sensitive Detection of Breast Cancer Cells in Patient Blood with Nuclease-Activated Probe Technology. Mol Ther Nucleic Acids. 2017 Sep 15;8:542-557. doi: 10.1016/j.omtn.2017.08.004. Epub 2017 Aug 12. PMCID: PMC5577414.
Kerov V, Laird JG, Joiner ML, Knecht S, Soh D, Hagen J, Gardner SH, Gutierrez W, Yoshimatsu T, Bhattarai S, Puthussery T, Artemyev NO, Drack AV, Wong RO, Baker SA, Lee A. α(2)δ-4 Is Required for the Molecular and Structural Organization of Rod and Cone Photoreceptor Synapses. J Neurosci. 2018 Jul 4;38(27):6145-6160. doi: 10.1523/JNEUROSCI.3818-16.2018. Epub 2018 Jun 6. PMCID: PMC6031576.
Urak KT, Blanco GN, Shubham S, Lin LH, Dassie JP, Thiel WH, Chen Y, Sonkar VK, Lei B, Murthy S, Gutierrez WR, Wilson ME, Stiber JA, Klesney-Tait J, Dayal S, Miller FJ Jr, Giangrande PH. RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome. Nat Commun. 2019 Jan 10;10(1):116. doi: 10.1038/s41467-018-08030-y. PubMed PMID: 30631065; PMCID: PMC6328615.
Scherer A, Stephens VR, McGivney GR, Gutierrez WR, Laverty EA, Knepper-Adrian V, Dodd RD. Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs. Genes (Basel). 2020 May 23;11(5). doi: 10.3390/genes11050583. PubMed PMID: 32456131; PubMed Central PMCID: PMC7288323.
Dodd RD, Scherer A, Huang W, McGivney GR, Gutierrez WR, Laverty EA, Ashcraft KA, Stephens VR, Yousefpour P, Saha S, Knepper-Adrian V, Floyd W, Chen M, Ma Y, Mastria EM, Cardona DM, Eward WC, Chilkoti A, Kirsch DG. Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma. Clin Cancer Res. 2020 Sep 15;26(18):5036-5047. doi: 10.1158/1078-0432.CCR-19-2597. Epub 2020 Jul 27. PubMed PMID: 32718998; PubMed Central PMCID: PMC7641033.
Yong C, Moose DL, Bannick N, Gutierrez WR, Vanneste M, Svensson R, Breheny P, Brown JA, Dodd RD, Cohen MB, Henry MD. Locally invasive, castrate-resistant prostate cancer in a Pten/Trp53 double knockout mouse model of prostate cancer monitored with non-invasive bioluminescent imaging. PLoS One. 2020;15(9):e0232807. doi: 10.1371/journal.pone.0232807. eCollection 2020. PubMed PMID: 32986721; PubMed Central PMCID: PMC7521703.
Gutierrez WR, Scherer A, McGivney GR, Brockman QR, Knepper-Adrian V, Laverty EA, Roughton GA, Dodd RD. Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models. Sci Rep. 2021 Jan 13;11(1):1098. doi: 10.1038/s41598-020-80216-1. PMID: 33441747; PMCID: PMC7806664.
Kruspe S, Dickey DD, Urak KT, Blanco GN, Miller MJ, Clark KC, Burghardt E, Gutierrez WR, Phadke SD, Kamboj S, Ginader T, Smith BJ, Grimm SK, Schappet J, Ozer H, Thomas A, McNamara JO 2nd, Chan CH, Giangrande PH. Rapid and Sensitive Detection of Breast Cancer Cells in Patient Blood with Nuclease-Activated Probe Technology. Mol Ther Nucleic Acids. 2017 Sep 15;8:542-557. doi: 10.1016/j.omtn.2017.08.004. Epub 2017 Aug 12. PubMed PMID: 28918054; PubMed Central PMCID: PMC5577414.
Brockman QR, Scherer A, McGivney GR, Gutierrez WR, Voigt AP, Isaacson AL, Laverty EA, Roughton G, Knepper-Adrian V, Darbro B, Tanas MR, Stipp CS, Dodd RD. PRC2 loss drives MPNST metastasis and matrix remodeling. JCI Insight. 2022 Sep 6;. doi: 10.1172/jci.insight.157502. [Epub ahead of print] PubMed PMID: 36066973.
Gutierrez WR, Scherer A, Rytlewski JD, Laverty EA, Sheehan AP, McGivney GR, Brockman QR, Knepper-Adrian V, Roughton GA, Quelle DE, Gordon DJ, Monga V, Dodd RD. Augmenting chemotherapy with low-dose decitabine through an immune- independent mechanism. JCI Insight. 2022 Oct 13:e159419. doi: 10.1172/jci.insight.159419. Epub ahead of print. PMID: 36227698.