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Josh Lingo

Address: 2-551 BSBJoshua Lingo photo
Phone: (319) 335-7663
Email: joshua-lingo@uiowa.edu

Mentor: Dawn Quelle, PhD

Undergraduate Institution: Kansas State University

Graduate Program: Cancer Biology

Research Description

Mechanisms of resistance to CDK4/6-MEK inhibitor therapy in MPNSTs

In the Quelle lab, we have justified the use of both CDK4/6 and MEK inhibitors in MPNSTs. Dual targeting of CDK4/6 and MEK induces tumor regression in a de novo mouse models. However, drug resistant tumors emerge in time. Our goal is to elucidate the mechanism that provides MPNSTs with resistance to CDK4/6-MEK inhibition.

Awards

  • Fellowship appointment on the Pharmacological Sciences Training Program (NIH T32 GM067795), University of Iowa, 2021-present