Chian Ju Jong, PhD

Address: 2-400 BSB
Phone:  (319) 384-4447

Mentor:  Stefan Strack, PhD

PhD Institution:  University of South Alabama

Research Description

De novo mutations in PP2A regulatory subunits in neurodevelopmental disorders


  • Pharmacological and Pharmaceutical Sciences Research Retreat Poster Award, 2018


  1. Schaffer SW, Ito T, Azuma J, Jong CJ, Kramer JH.: Mechanisms underlying development of taurine-deficient cardiomyopathy. Hearts. 1:86-98, 2020.
  2. Jong CJ, Merrill RA, Wilkerson EM, Herring LE, Graves LM, Strack S.: Reduction of protein phosphatase 2A (PP2A) complexity reveals cellular functions and dephosphorylation motifs of the PP2A/B'd holoenzyme. J Biol Chem. 295(17): 5654-5668, 2020. PMID:32156701
  3. Jong CJ, Yeung J, Tseung E, Karmazyn M.: Leptin-induced cardiomyocyte hypertrophy is associated with enhanced mitochondrial fission. Mol Cell Biochem. 454(1-2):33-44, 2019.  PMID: 30251118
  4. Schaffer S, Jong CJ, Shetewy A, Ramila KC, Ito T.: Impaired energy production contributes to development of failure in taurine deficient heart. Adv Exp Med Biol. 975 Pt 1:435-46, 2017. PMID: 28849473 
  5. Jong CJ, Ito T, Prentice H, Wu JY, Schaffer S.: Role of mitochondria and endoplasmic reticulum in taurine-deficiency-mediated apoptosis. Nutrients. 9(8):795, 2017. PMCID: PMC5579589
  6. Shetewy A, Shimada K, Warner D, Jong CJ, Al Mehdi AB, Alexeyev M, Schaffer SW.: Mitochondrial defects associated with β-alanine toxicity. Mol Cell Biochem 416(1-2):11-22, 2016.  PMCID: PMC5097872
  7. Schaffer SW, Shimada-Takaura K, Jong CJ, Ito T, Takahashi K.: Impaired energy metabolism of the taurine-deficient heart. Amino Acid. 48:549-558, 2016.  PMID: 26475290
  8. Jong CJ, Ito T, Schaffer S.: The ubiquitin-proteasome system and autophagy are defective in the taurine deficient heart. Amino Acids. 47:2609-2622, 2015.  PMID: 26193770
  9. Schaffer SW, Jong CJ.: Regulation of cardiac hypertrophy by T-type Ca2+-channel. In T-type Calcium Channels in Basic and Clinical Science. Ed. London: Springer Vienna, 73-84, 2015. Print.
  10. Schaffer SW, Ramila KC, Jong CJ, Shetewy A, Shimada K, Ito T, Azuma J, Cioffi E.: Does taurine prolong lifespan by improving heart function? Adv Exp Med Biol. 803:555-570, 2015.  PMID: 25833527
  11. Jong CJ, Takashi Ito, Azuma J, Schaffer S.: Taurine depletion decreases GRP78 and downregulates the unfolded protein response. Adv Exp Med Biol. 803:555-570, 2015.  PMID: 25833527
  12. Shimada K, Jong CJ, Takahashi K, Schaffer S.: Role of ROS production and turnover in the antioxidant activity of taurine. Adv Exp Med Biol 803:581-596, 2015.  PMID: 25833529
  13. KC Ramila, Jong CJ, Pastukh VM, Ito T, Azuma J, Schaffer SW.: Role of protein phosphorylation in excitation-contraction coupling in taurine deficient hearts. Am J Physiol Heart Circ Physiol 308:H232-239, 2015.  PMID: 25437920
  14. Schaffer SW, Jong CJ, Ito T, Azuma J.: Effect of taurine on ischemia-reperfusion injury. Amino Acids. 46:21-30, 2014.  PMID: 22936072
  15. Schaffer SW, Jong CJ, Ito T, Azuma J.: Role of taurine in the pathologies of MELAS and MERRF. Amino Acids. 46:47-56, 2014.  PMID: 23179085
  16. Schaffer SW, Shimada K, Jong CJ, Ito T, Azuma J, Takahashi K.: Effect of taurine and potential interactions with caffeine on cardiovascular function. Amino Acids. 46:1147-1157, 2014.  PMID: 24615238
  17. Isfort M, Stevens SC, Schaffer SW, Jong CJ, Wold LE.: Metabolic dysfunction in diabetic cardiomyopathy. Heart Failure Reviews. 19:35-48, 2014.  PMCID: PMC3683106
  18. Schaffer SW, Jong CJ, Warner D, Ito T, Azuma J.: Taurine deficiency and MELAS are closely related syndromes. Advances in Experimental Medicine and Biology. 776:153-165, 2013.  PMID: 23392880
  19. Ata H, Shrestha D, Oka M, Ochi R, Jong CJ, Gebb S, Benjamin J, Schaffer S, Hobart HH, Downey J, McMurtry I, Gupte R.: Down-regulation of replication factor C-40 (RFC40) causes chromosomal missegregation in neonatal and hypertrophic adult rat cardiac myocytes. PLoS One. 7:e39009, 2012.  PMCID: PMC3375256
  20. Schaffer SW, Jong CJ, Mozaffari M.: Role of oxidative stress in diabetes-mediated vascular dysfunction: unifying hypothesis of diabetes revisited. Vascular Pharmacol. 57:139-149, 2012.  PMID: 22480621
  21. Jong CJ, Azuma J, Schaffer S.: Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production. Amino Acids. 42:2223-2232, 2012.  PMID: 21691752
  22. Jong CJ, Azuma J, Schaffer SW.: Role of mitochondrial permeability transition in taurine deficiency-induced apoptosis. Experimental and Clinical Cardiology. 16:125-128, 2011.  PMCID: PMC3206105
  23. Schaffer SW, Jong CJ.: MELAS syndrome: mediated by impaired taurinomethyluridine synthesis. Genes and Cardiovascular Function. Part 3:93-100, 2011.
  24. Schaffer SW, Jong CJ, KC Ramila, Azuma J.: Physiological roles of taurine in heart and muscle. Journal of Biomedical Science. 17(Suppl 1):S2, 2010.  PMCID:  PMC2994395
  25. Jong CJ, Ito T, Mozaffari M, Azuma J, Schaffer S.: Effect of β-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content. Journal of Biomedical Science. 17(Suppl 1):S25, 2010.  PMCID: PMC2994391
  26. Pastukh P, Chen H, Wu S, Jong CJ, Alexeyev M, Schaffer S.: Effect of hypernatremia on injury caused by energy deficiency: role of T-type Ca2+ channel. American Journal of Physiology-Cell Physiology. 299:C289-C297, 2010.  PMCID: PMC2928636
  27. Ricci C, Jong CJ, Schaffer SW.: Proapoptotic and antiapoptotic effects of hyperglycemia: role of insulin signaling. Canadian Journal of Physiology and Pharmacology. 86(4):166-72, 2008.  PMID: 18418425