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Guorui (Gary) Deng, PhD

Address: 2-300 BSB
Phone: (319) 384-3020
Email: guorui-deng@uiowa.edu

Mentor: Huxing Cui, PhD

PhD Institution: Wake Forest University

Research Description

Angiotensin and vasopressin receptor second-messenger cascades, and their modulation by Regulators of G-protein Signaling


  • American Heart Association Postdoctoral Fellowship (19POST34380239), 2019-present
  • Received an EB2019 Data Sciences International Physiological ‘Omics Training Research Excellence Award, 2019


  1. Deng Y, Deng G, Grobe JL, Cui H. Hypothalamic GPCR signaling pathways in cardiometabolic control. Front Physiol. 2021 Jun (accepted)
  2. Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL.: Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. Hypertension. 2020 Aug;76(2):589-597. doi: 10.1161/HYPERTENSIONAHA.120.15137. Epub 2020 Jun 8. PMID: 32507042
  3. Sapouckey SA, Morselli LL, Deng G, Patil CN, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL.: Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or agouti-related peptide. Am J Physiol Regul Integr Comp Physiol. 2020 May 1;318(5):R855-R869. doi: 10.1152/ajpregu.00297.2019. Epub 2020 Mar 18. PMID: 32186897
  4. Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL.: Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. Hypertension. 2020 Feb;75(2):569-579. doi: 10.1161/HYPERTENSIONAHA.119.14056. Epub 2019 Dec 23. PMID: 31865781
  5. Deng G and Grobe JL.:  The renin-angiotensin system in the arcuate nucleus controls resting metabolic rate. Curr Opin Nephrol Hypertens. 28(2):120-127, 2019.  PMCID: PMC6366639
  6. Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher, KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL: Arginine Vasopressin Infusion is Sufficient to Model Clinical Features of Preeclampsia in Mice. JCI Insight. 3(19), 2018. PMCID: PMC6237463
  7. Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL:  Regulators of G Protein Signaling in Cardiovascular Function during Pregnancy. Physiol Genomics. 50(8):590-604, 2018. PMCID: PMC6139632
  8. Sapouckey SA, Deng G, Sigmund CD, Grobe JL:  Potential Mechanisms of Hypothalamic Renin-angiotensin System Activation by Leptin and DOCA-salt for the Control of Resting Metabolism. Physiol Genomics. 49(12):722-32, 2017. PMCID: PMC5814669
  9. Gallagher PE, Arter AL, Deng G, Tallant EA.:  Angiotensin-(1-7): A Peptide Hormone with Anti-Cancer Activity. Current Medicinal Chemistry 21(21):2417-23, 2014.  PMID: 24524765
  10. Deng G, Sui G.:  Noncoding RNA in Oncogenesis: A New Era of Identifying Key Players. International Journal of Molecular Sciences 14(9):18319-49, 2013.  PMCID: PMC3794782