Jae Kyoon Kim, PhD

Address: 2400 PBDBPhoto of Jae Kyoon Kim
Phone: (319) 353-4535
Email: jaekyoon-kim@uiowa.edu

Mentor: Ted Abel, PhD

PhD Institution: University of Wisconsin-Milwaukee

Research Description

Identifying the role of D1 or D2-SPN and the molecular mechanisms of sex-dependent behavioral alteration in a mouse model for neurodevelopmental disorders

Awards

  • James Spratt Scholar Award, 2019-2020
  • OSSD (Organization for the Study of Sex Difference), NIH-Sponsored Travel Award, 2018
  • Biomedical Postdoctoral Scholar Award, 2018

Publications

  1. Kim, J., Lee, S., Kim, J., Ham, S., Yoon Park, J.H., Han, S., Jung, Y.K., Shim, I., Han, J.S., Lee, K.W., Kim, J.: Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-β and tau in a mouse model of Alzheimer’s disease. Hum Mol Genet, 29(2):228-237, 2020. PMID: 31814000
  2. Kim, J., Schalk, J.C., Gremminger, R.L., Koss, W.A., Frick, K.M.: (2019) Dorsal Hippocampal Actin Polymerization Is Necessary for Activation of G-protein-Coupled Estrogen Receptor (GPER) to Increase CA1 Dendritic Spine Density and Enhance Memory Consolidation. J Neuro, 39(48):9598-9610, 2019.  PMCID: PMC6880457
  3. Hanson, A.M., Perera, I.S., Kim, J., Pandey, R.K., Sweeney, N., Lua, X., Imhoff, A., Mackinnon, A.C., Frick, K.M., Donaldson, W.A., Sem, D.S.:  A-C estrogens as potent and selective estrogen receptor-beta agonists (SERBAs) to enhance memory consolidation under low-estrogen conditions. J Med Chem, 61(11):4720-4738, 2018. PMID: 29741891
  4. Frick, K.M., Kim, J.:  Mechanisms underlying the rapid effects of estradiol and progesterone on hippocampal memory consolidation in female rodents. Horm Behav, 104:100-110, 2018.  PMCID: PMC6226372
  5. Frick, K.M., Kim, J., Koss, W.A.:  Estradiol and hippocampal memory in female and male rodents. Curr Opin Behav Sci, 23:65-74, 2018.  PMCID: PMC6191066
  6. Frick, K.M., Tuscher, J.J., Koss, W.A., Kim, J., Taxier, L.R.:  Estrogenic regulation of memory consolidation: A look beyond the hippocampus, ovaries, and females. Physiol Behav, 187:57-66, 2018.  PMCID: PMC5787049
  7. Kim, J., Frick, K.M.:  Distinct effects of estrogen receptor antagonism on object recognition and spatial memory consolidation in ovariectomized mice. Psychoneuroendocrinology, 85:110-114, 2017.  PMID: 28846921
  8. Kim, J., Szinte, J.S., Boulware, M.I., Frick, K.M.:  17β-Estradiol and agonism of G-protein-coupled estrogen receptor enhance hippocampal memory via different cell-signaling mechanisms. J Neuro, 36(11):3309-21, 2016.  PMCID: PMC4792941
  9. Frick, K.M., Kim, J., Tuscher, J.J., Fortress, A.M.:  Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents. Learn Mem, 22(9):472-93, 2015.  PMCID: PMC4561402
  10. Tuscher, J.J., Fortress, A.M., Kim, J., Frick, K.M.:  Regulation of object recognition and object placement by ovarian sex steroid hormones. Behav Brain Res, 285:140-57, 2015.  PMCID: PMC4329280
  11. Fortress, A.M., Kim, J., Poole, R.L., Gould, T.J., Frick, K.M.:  17β‐estradiol regulates histone alterations associated with memory consolidation and increases Bdnf promoter acetylation in middle‐aged female mice. Learn Mem, 21(9):457-67, 2014.  PMCID: PMC4138358
  12. Kim, H.W., Kim, J., Kim, J., Lee, S., Choi, B.R., Han, J.S., Lee, K.W., Lee, H.J.:  3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation. Toxicol Sci, 137(1):158-67, 2014.  PMID: 24162184
  13. Kim, J., Kim, J., Shim, J., Lee, C.Y., Lee, K.W., Lee, H.J.:  Cocoa phytochemicals: recent advances in molecular mechanisms on health. Crit Rev Food Sci Nutr, 54(11):1458-72, 2014.  PMID: 24580540
  14. Kim, J., Kim, J., Shim, J., Lee, S., Kim, J., Lim, S.S., Lee, K.W., Lee, H.J.:  Licorice-derived dehydroglyasperin C increases MKP-1 expression and suppresses inflammation-mediated neurodegeneration. Neurochem Int, 63(8), 732-740, 2013.  PMID: 24083986
  15. Kim, J., Lee, S., Shim, J., Kim, H.W., Kim, J., Jang, Y.J., Yang, H., Park, J., Choi, S.H., Yoon, J.H., Lee, K.W., & Lee, H.J.:  Caffeinated coffee, decaffeinated coffee, and the phenolic phytochemical chlorogenic acid up-regulate NQO1 expression and prevent H2O2-induced apoptosis in primary cortical neurons. Neurochem Int, 60(5), 466-474, 2012.  PMID: 22353630
  16. Jang, Y.J., Kim, J., Shim, J., Kim, J., Byun, S., Oak, M.H., Lee, K.W., & Lee, H.J.:  Kaempferol attenuates 4-hydroxynonenal-induced apoptosis in PC12 cells by directly inhibiting NADPH oxidase. J Pharmacol Exp Ther, 337(3), 747-754, 2011.  PMID: 21398514
  17. Koh, K.1, Kim, J.1, Jang, Y.J., Yoon, K., Cha, Y., & Lee, H.J.:  Transcription factor Nrf2 suppresses LPS-induced hyperactivation of BV-2 microglial cells. J Neuroimmunol, 233(1-2), 160-167, 2011. 1:co-first author.  PMID: 21349591

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