Kyle Flippo, PhD

Address: 3310C PBDB
Phone: (319) 335-7660

Mentor: Matthew J. Potthoff, PhD

PhD Institution: University of Iowa, 2017

Research Description

Role of endocrine signaling in the CNS in regulating metabolism


  • Brain & Behavior Research Foundation (NARSAD) award, 1/15/20 - 1/14/22
  • Most Outstanding Postdoctoral Research Poster, Fraternal Order of Eagles Diabetes Research Center Research Day, 2019
  • Best Postdoctoral Poster Award, CCOM Health Science Research Week, 2018
  • Diabetes Research Training Program (T32 DK112751), 2017-present
  • Ranbir K. Bhatnagar Scholar Award, Department of Pharmacology, University of Iowa, 2017
  • Sally and Ken Mason Travel Grant, 2017
  • Ballard Seashore Dissertation Fellowship, 2017
  • Most Outstanding Research Poster, CCOM Health Sciences Research Week, 2014
  • Exemplary Senator Service Award, 2013
  • Interdisciplinary Training Program in Pain Research (T32 NS045549), 2012-2014


  1. Sobreira DR, Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, Claussnitzer M, Aneas I, Nóbrega, MA. Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5. Science.  2021 Jun 4;372(6546):1085-1091. doi: 10.1126/science.abf1008.
  2. Flippo KH, Lin Z, Dickey AS, Zhou X, Dhanesha NA, Walters GC, Liu Y, Merrill RA, Meller R, Simon RP, Chauhan AK, Usachev YM, Strack S.: Deletion of a Neuronal Drp1 Activator Protects against Cerebral Ischemia. J Neurosci 40(15):3119-3129, 2020.  PMID: 32144179; PMCID: PMC7141887
  3. Jensen-Cody SO*, Flippo KH*, Claflin KE, Yavuz Y, Sapouckey SA, Walters GC, Usachev YM, Atasoy D, Gillum MP, Potthoff MJ.:  FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake. *contributed equally.  Cell Metab. 32(2):273-286, 2020.  PMID: 32640184
  4. Flippo KH and Potthoff MJ.:  Chronicles of an FGF chimera: The odyssey continues. EBioMedicine 49:15-16, 2019.  PMCID: PMC6945278
  5. Flippo KH, Gnanasekaran A, Perkins GA, Ahmad A, Merrill RA, Dickey AS, Taylor SS, McKnight GS, Chauhan AK, Usachev YM, Strack S.: AKAP1 protects from cerebral ischemic stroke by inhibiting Drp1-dependent mitochondrial fission. J. Neurosci. 38(38):8233-8242, 2018. PMCID: PMC6146498
  6. Mapuskar KA, Flippo KH, Schoenfeld JD, Riley D, Strack S, Heljah TH, Furqan M, Domann FE, Buatti JM, Goswami PC, Spitz DR. and Allen BG.: Mitochondrial superoxide mediates age-associated increases in susceptibility of dermal fibroblasts to radiation and chemotherapy. Cancer Res. 77(18):5054-5067, 2017.  PMCID: PMC5600863
  7. Flippo KH, Strack S.:  An emerging role for mitochondrial dynamics in schizophrenia. Schizophr Res 187:26-32, 2017.  PMCID: PMC564380
  8. Flippo KH, Strack S.:  Mitochondrial dynamics in neuronal injury, development and plasticity. J Cell Sci 130(4):671-681, 2017.  PMCID: PMC5339882
  9. Slupe AM, Merrill RA, Flippo KH, Lobas MA, Houtman JC, Strack S.:  A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury. J Biol Chem 288(17):123353-65, 2013.  PMCID: PMC3636919


  1. Flippo KH, Potthoff MJ. Metabolic Messengers: FGF21. Nat Metab. 2021 Mar;3(3):309-317. doi: 10.1038/s42255-021-00354-2. Epub 2021 Mar 18.PMID: 33758421 Review. No abstract available.

Books / Chapters

  1. Merrill RA, Flippo KH and Strack S. Measuring mitochondrial shape with ImageJ.  In: Strack S. and Usachev YM. (eds) Techniques to Investigate Mitochondrial Function in Neurons, Vol. 123, Springer New York, New York. ISBN:978-1-4939-6888-6