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Budd A. Tucker, PhD

Professor of Ophthalmology and Visual Sciences

Introduction

During my career I have had extensive experience and published several manuscripts/scientific abstracts relating to stem cell production, culture, isolation, differentiation and transplantation (via both cell injection and polymer scaffold mediated delivery).

Current Positions

  • Professor of Ophthalmology and Visual Sciences
  • Howard Ruby Chair for Regenerative Ophthalmology, Ophthalmology and Visual Sciences

Education

  • BAH in Psychology, Sir Wilfred Grenfell College, Memorial University of Newfoundland, Corner Brook, Newfoundland, Canada
  • PhD in Neuroscience, Memorial University of Newfoundland, Newfoundland, Canada
  • Fellow in Ophthalmology, Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts

Graduate Program Affiliations

Center, Program and Institute Affiliations

Research Interests

  • MAJOR RESEARCH INTERESTS
  • RESEARCH SUMMARY

Selected Publications

  • Lozano LP, Jensen R, Jennisch M, Pandala NG, Jamshidi F, Boldt HC, Tucker BA, Binkley EM. (2025). Genetics and Current Research Models of Mendelian Tumor Predisposition Syndromes with Ocular Involvement. Prog Retin Eye Res 22:101359. ONLINE AHEAD OF PRINT. DOI: 10.1016/j.preteyeres.2025.101359. PMID: 40274012.
  • Binkley E, Boldt HC, Haefeli L, Lozano LP, Meyering E, Wiley L, Tucker B. (2025). Transconjunctival Approach for Injection into the Rat Optic Nerve. J Vis Exp. 4:(218). DOI: 10.3791/68048. PMID: 40257928.
  • Mullin NK, Bohrer LR, Voigt AP, Lozano LP, Wright AT, Bonilha VL, Mullins RF, Stone EM, Tucker BA. (2024). NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development. J Clin Invest 134(11):e173892. DOI: 10.1172/JCI173892. PMID: 38652563. PMCID: PMC11142732.
  • Wendland RJ, Tucker BA, Worthington KS. (2024). Influence of Substrate Stiffness on iPSC-Derived Retinal Pigmented Epithelial Cells. Stem Cells Transl Med 13(6):582-592. DOI: 10.1093/stcltm/szae022. PMID: 38560893. PMCID: PMC11165161.
  • Burnight ER, Fenner BJ, Han IC, DeLuca AP, Whitmore SS, Bohrer LR, Andorf JL, Sohn EH, Mullins RF, Tucker BA, Stone EM. (2024). Demonstration of the pathogenicity of a common non-exomic mutation in ABCA4 using iPSC-derived retinal organoids and retrospective clinical data. Hum Mol Genet 33(16):1379-1390. DOI: 10.1093/hmg/ddad176. PMID: 37930186. PMCID: PMC11305681.
  • Tucker BA, Burnight ER, Cranston CM, Ulferts MJ, Luse MA, Westfall T, Scott CA, Marsden A, Gibson-Corley K, Wiley LA, Han IC, Slusarski DC, Mullins RF, Stone EM. (2022). Development and biological characterization of a clinical gene transfer vector for the treatment of MAK-associated retinitis pigmentosa. Gene Ther 29(5):259-288. DOI: 10.1038/s41434-021-00291-5. PMID: 34518651. PMCID: PMC9159943.
  • Han IC, Wiley LA, Ochoa D, Lang MJ, Harman BE, Sheehan KM, Mullins RF, Stone EM, Tucker BA. (2023). Characterization of a novel Pde6b-deficient rat model of retinal degeneration and treatment with adeno-associated virus (AAV) gene therapy. Gene Ther. Apr;30(3-4):362-368. DOI: 10.1038/s41434-022-00365-y. PMID: 36175490.
  • Wiley LA, Boyce TM, Meyering EE, Ochoa D, Sheehan KM, Stone EM, Mullins RF, Tucker BA, Han IC. (2023). The Degree of Adeno-Associated Virus-Induced Retinal Inflammation Varies Based on Serotype and Route of Delivery: Intravitreal, Subretinal, or Suprachoroidal. Hum Gene Ther 34(11-12):530-539. DOI: 10.1089/hum.2022.222. PMID: 36793189. PMCID: PMC10282814.
  • Burnight ER, Wiley LA, Mullin NK, Adur MK, Lang MJ, Cranston CM, Jiao C, Russell SR, Sohn EH, Han IC, Ross JW, Stone EM, Mullins RF, Tucker BA. (2023). CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa. CRISPR J 6(6):502-513. DOI: 10.1089/crispr.2023.0039. PMID: 38108516. PMCID: PMC11304754.
  • Wiley LA, Kaalberg EE, Penticoff JA, Mullins RF, Stone EM, Tucker BA. (2016). Expression of the retina-specific flippase, ABCA4, in epidermal keratinocytes. F1000Research 5:193. DOI: 10.12688/f1000research.8089.1.