Bradley J. Van Voorhis, MD

Portrait
Professor of Obstetrics and Gynecology - Reproductive Endocrinology and Infertility
Acting Division Director for Gynecology Oncology
Executive Vice Chair, Department of Obstetrics & Gynecology
Director, In Vitro Fertilization Program
Director, Division of Reproductive Endocrinology and Infertility

Contact Information

Office
31335 PFP
Iowa City, IA 52242
319-356-4536

Education

BS, Pre-Medicine, Iowa State University
MD, Medicine, University of Iowa College of Medicine
Resident, Obstetrics & Gynecology, Medical College of Virginia
Fellow, Reproductive Endocrinology, Brigham & Women's Hospital - Harvard Medical School

Licensure and Certifications

Board Certified Reproductive Endocrinology - American Board of Obstetrics & Gynecology
Diplomate, American Board of Obstetrics & Gynecology - American Board of Obstetrics & Gynecology

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Translational Biomedicine

Research Summary

Dr. Van Voorhis' research focuses on evaluation and treatment of the infertile couple. He is interested in outcomes research including cost-effectiveness studies. He has published on birth defects following in vitro fertilization which appear to be slightly increased by this treatment. He is currently exploring the possible mechanisms of this finding. In addition, he is interested in reducing complications from infertility treatment, including reducing the rates of multiple gestations. Other areas of interest include novel ovulation induction techniques and evaluation of benign uterine conditions including endometrial polyps and fibroids and their effect on fertility.

Publications

Klenov, V. E., Boulet, S. L., Mejia, R. B., Kissin, D. M., Munch, E., Mancuso, A. & Van Voorhis, B. J. (2018). Live birth and multiple birth rates in US in vitro fertilization treatment using donor oocytes: a comparison of single-embryo transfer and double-embryo transfer. J Assist Reprod Genet. PMID: 29931407.

Klenov, V. E., Boulet, S. L., Mejia, R. B., Kissin, D. M., Munch, E., Mancuso, A. & Van Voorhis, B. J. (In Press). Live birth and multiple birth rates in US in vitro fertilization treatment using donor oocytes: a comparison of single-embryo transfer and double-embryo transfer. Fertil Steril [Epub ahead of print].

New, E. P., Mallen, A. R., Mancuso, A. & Van Voorhis, B. J. (2018). Adnexal torsion in a patient with Mullerian agenesis undergoing ovarian stimulation: a case report. POG, Article 1 [ 6 p. ].

Meldrum, D. R., Adashi, E. Y., Garzo, V. G., Gleicher, N., Parinaud, J., Pinborg, A. & Van Voorhis, B. (2018). Prevention of in vitro fertilization twins should focus on maximizing single embryo transfer versus twins are an acceptable complication of in vitro fertilization. Fertil Steril, 109(2), 223-229. PMID: 29446716.

Garzo, G., Adashi, E. Y., Garzo, V. G., Gleicher, N., Perinaud, J., Pinborg, A. & Van Voorhis, B. (2018). Prevention of in vitro fertilization twins should focus on maximizing single embryo transfer versus twins are an acceptable complication of in vitro fertilization. Fertil Steril, 109(2), 223-229. PMID: 29447664.

Van Voorhis, B., Mejia, R. B. (2017). Single-embryo transfer point-it is the way forward. Fertility and Sterility, 108(5), 757. PMID: 29102001.

Klenov, V., Boulet, S., Mejia, R., Kissin, D. M., Munch, E., Mancuso, A. & Van Voorhis, B. (2017). O-238: Live Birth and Multiple Birth Rates in Donor Oocyte Cycles Using Elective Single Embryo Transfer Versus Double Embryo Transfer in United States In-Vitro Fertilization Clinics. ASRM Abstracts, 103(3), Supplement e98.

Klenov, V., Boulet, S., Mejia, R., Kissin, D. M. & Van Voorhis, B. (2017). O-239: Medical Costs of Live Births from Elective Single Embryo Transfer Versus Double Embryo Transfer in Donor Oocyte Cycles. ASRM Abstracts, 103(3), Supplement e99.

Ryan, G., Thoma, M., Stern, J. E., Mengeling, M., O'Shea, A., Syrop, C. H., Stewart, K., Torner, J. & Van Voorhis, B. (2017). Reproductive Health Risk Due to Sexual and Combat-Related Trauma in US Veterans. Fertility and Sterility, 108(3), Supplement e2-e3. DOI: https://doi.org/10.1016/j.fertnstert.2017.07.025.

Van Voorhis, B., Mejia, R. B. (2017). Single-embryo transfer point - it is the way forward. Fertil Steril. DOI: 10.1016/j.fertnstert.2017.08.030.

Brachova, P., Alvarez, N. S., Van Voorhis, B. J. & Christenson, L. K. (2017). Cytidine deaminase Apobec3a induction in fallopian epithelium after exposure to follicular fluid. Gynecol Oncol, 145(3), 577-583. PMID: 28215840.

Munch, E. M., Sparks, A. E., Zimmerman, M. B., Van Voorhis, B. J. & Duran, E. H. (2017). High FSH Dosing is Associated with Reduced Live Birth Rate in Fresh but not Subsequent Frozen embryo Transfers. Hum Reprod, Oxford University Press. PMID: 28472321.

Klenov, V. E., Van Voorhis, B. J. (2017). Ultrasound in Infertility Treatments. Clin Obstet Gynecol, 60(1), 108-120. PMID: 28059846.

Klenov, V., Van Voorhis, B. J. (2016). State Mandated IVF Coverage Decreases Multiple Gestation Rates - Helpful but Not Enough. Obstet Gynecol, 128(6), 1201-1202. PMID: 27824764.

Shah, D. K., Van Voorhis, B. J., Vitonis, A. F. & Missmer, S. A. (2016). Association Between Body Mass Index, Uterine Size, and Operative Morbidity in Women Undergoing Minimally Invasive Hysterectomy. J Minim Invasive Gynecol, 23(7), 1113-112. PMID: 27523922.

Mancuso, A. C., Boulet, S. L., Duran, E., Munch, E., Kissin, D. M. & Van Voorhis, B. J. (2016). Elective single embryo transfer in women less than age 38 years reduces multiple birth rates, but not live birth rates, in United States fertility clinics. Fertil Steril, 106(5), 1107-1114. PMID: 27376458.

Toner, J. P., Coddington, C. C., Doody, K., Van Voorhis, B., Seifer, D. B., Ball, G. D., Luke, B. & Wantman, E. (2016). Society for Assisted Reproductive Technology and assisted reproductive technology in the United States: a 2016 update. Fertil Steril, 106(3), 541-6. PMID: 27301796.

Munch, E. M., Sparks, A. E., Gonzalez Bosquet, J., Christenson, L. K., Devor, E. J. & Van Voorhis, B. J. (2016). Differentially expressed genes in preimplantation human embryos: potential candidate genes for blastocyst formation and implantation. J Assist Reprod Genet, 33(8), 1017-25. PMID: 27241529.

Kapfhamer, J., Van Voorhis, B. J. (2016). Gestational surrogacy: a call for safer practice. Fertil Steril, 106(2), 270-1. PMID: 27181925.

Luke, B., Brown, M. B., Wantman, E., Baker, V. L., Stern, J. E., Widra, E., Coddington, C. C., Gibbons, W. E., Van Voorhis, B. J. & Ball, G. D. (2016). Hysterectomy Risk in Premenopausal-Aged Military Veterans - Associations with Sexual Assault and Gynecologic Symptoms. Am J Obstet Gynecol, 214(3), 352.e1-352e.13. PMID: 26475424.

Klenov, V., Van Voorhis, B. (In Press). Use of Ultrasound in Infertility. In Clinical Obstetrics and Gynecology.

Munch, E. M., Sparks, A. E., Duran, E. H. & Van Voorhis, B. J. (2015). Lack of carbon filtration impact early embryo development. J Assist Reprod Genet, 32(7), 1009-17. PMID: 26003657.

Van Voorhis, B. J. (2015). Guest Editor, Best practices in in vitro fertilization. (2), pp. 63-4. Sem Reprod Med.

Cookingham, L. M., Van Voorhis, B. J. & Ascoli, M. (2015). Do alterations in follicular fluid proteases contribute to human infertility?. J Assist Reprod Genet, 32(5), 737-45.

Van Voorhis, B. J. (2015). Ultrasound assessment of ovarian reserve. In , R. M. Botros , B. Rizk , E. E. Puscheck (Eds.) Ultrasonography in Infertility, Chapter 27. pp. 260-3. Cambridge, United Kingdom: Cambridge University Press.

Van Voorhis, B. J., Duran, E. H. & Ryan, G. L. (2014). Insights on managing the older couple with unexplained infertility and normal ovarian reserve. Fertil Steril, 101(6), 1586-7.

Kresowik, J. D., Devor, E., Van Voorhis, B. J. & Leslie, K. K. (2014). MicroRNA-31 is significantly elevated in both human endometrium and serum during the window of implantation: A potential biomarker for optimum receptivity. Biol Reprod, Elsevier Publishing Co. PMID: 24855107.

Rosenbluth, E. M., Shelton, D. N., Wells, L. M., Sparks, A. E. & Van Voorhis, B. J. (2014). Human embryos secrete microRNAs into culture media--a potential biomarker for implantation. Fertil Steril, Elsevier Publishing Co, 101(5), 1493-500. PMID: 24786747.

Eppsteiner, E. E., Sparks, A. E., Liu, D. & Van Voorhis, B. J. (2014). Change in oocyte yield in repeat IVF cycles: Effect of ovarian reserve. Fertil Steril, Elsevier Publishing Co., 101(2), 399-402. PMID: 24331835.

Ball, D., Coddington, C., Doody, K., Schattman, G. L., Toner, J., Van Voorhis, B. J. & Williams, R. S. (2014). The playing field is changing . . . (Vols. 101). (4), pp. e29. Fertil Steril, Elsevier Publishing Co.

Levens, E. D., Van Voorhis, B. J. & Hill, M. J. (2013). Should single-embryo transfer be mandatory in patients undergoing IVF?. Contemp OBGYN, 58(11), 70-2.

Rosenbluth, E. M., Shelton, D. N., Sparks, A. E., Devor, E., Christenson, L. & Van Voorhis, B. J. (2013). MicroRNA Expression in the Human Blastocyst. Fertil Steril, Published by Elsevier Inc, 99(3), 855-61. PMID: 23211712.

Kresowik, J. D., Sparks, A. E. & Van Voorhis, B. J. (2013). Clinical factors associated with live birth after single embryo transfer. Obstet Gynecol, 68(3), 207-8.

Moolenaar, L., Mol, B. & Van Voorhis, B. J. (2013). Cost-effectiveness of intrauterine insemination. In B. Cohlen , W. Ombelet (Eds.) Intrauterine Insemination: An Evidence-Based Guideline for Daily Practice.

Lemos, E., Zhang, D., Van Voorhis, B. J. & Hu, X. H. (2013). Healthcare expenses associated with multiple vs. singleton pregnancies in the United States. Am J Obstet Gynecol, 209(6), 586.e1 - 586.e11. PMID: 24238479.

Kresowik, J. D., Sparks, A. E. & Van Voorhis, B. J. (2012). Clinical Factors Associated with Live Birth after Single Embryo Transfer. Fertil Steril, Published by Elsevier Inc, 98(5), 1152-6. PMID: 22959461.

Kresowik, J. D., Syrop, C. H., Van Voorhis, B. J. & Ryan, G. L. (2012). Ultrasound is the optimal choice for guidance in difficult hysteroscopy. Ultrasound Obstet Gynecol, John Wiley & Sons Publishers, 39(6), 715-8. PMID: 22173892.

Schultz, K., Santillan, M. K., Stegmann, B. J., Santillan, D. A., Smith, E. M. & Van Voorhis, B. J. (2012). Anti-Müllerian Hormone concentration levels in maternal plasma during the first, second and third trimester of pregnancy. Proc Obstet Gynecol, Published by the University of Iowa College of Medicine, Dept of OB-GYN, 2(3).

Rosenbluth, E. M., Van Voorhis, B. J. (2011). Evolving role of assisted reproductive technologies. In H. Hatasla (Eds.) Clinical Obstetrics & Gynecology. (4) PMID: 22031263.

Kresowik, J. D., Stegmann, B. J., Sparks, A. E., Ryan, G. L. & Van Voorhis, B. J. (2011). Five years of a mandatory Single Embryo Transfer (mSET) policy dramatically reduces twinning rate without lowering pregnancy rates. Fertil Steril, 96(6), 1367-9. PMID: 21962964.

Martini, S., Van Voorhis, B. J., Stegmann, B. J., Sparks, A. E., Shochet, T., Zimmerman, M. B. & Ryan, G. L. (2011). In vitro fertilization patients support a single blastocyst transfer policy. Fertil Steril, 96(4), 993-7. PMID: 21868000.

Mains, L. M., Christenson, L., Yang, B., Sparks, A. E., Mathur, S. & Van Voorhis, B. J. (2011). Identification of apolipoprotein A1 in the human embryonic secretome. Fertility and sterility, 96(2), 422-427.e2. PMID: 21676393.

Shamshirsaz, A. A., Shamshirsaz, A. A., Vibhakar, J. L., Broadwell, C. & Van Voorhis, B. J. (2011). Laparoscopic management of chemical peritonitis caused by dermoid cyst spillage. JSLS, 15(3), 403-5. PMID: 21985734.

Duran, E. H., Van Voorhis, B. J. (2011). Ultrasound-guided embryo transfer. In G. T. Kovacs (Eds.) How to improve your ART success rates: An evidence-based review of Adjunts to IVF. pp. 161-4. Cambridge University Press..

Van Voorhis, B. J. (2011). What should the urologist know about female infertility?. Cambridge University Press, 134-8.

Mains, L., Zimmerman, M., Blaine, J., Stegmann, B., Sparks, A., Ansley, T. & Van Voorhis, B. (2010). Achievement test performance in children conceived by IVF. Human reproduction (Oxford, England), 25(10), 2605-11. PMID: 20716561.

Bagegni, N., Blaine, J., Van Voorhis, B. J. & Dokras, A. (2010). Risk of Early and Late Obstetric Complications in Women with IVF-Conceived Pregnancies and Polycystic Ovary Syndrome. Proc Obstet Gynecol, Published by the University of Iowa, Dept of OB-GYN, 1(2), Article 2.

Berdahl, D. M., Blaine, J., Van Voorhis, B. & Dokras, A. (2010). Detection of enlarged yolk sac on early ultrasound is associated with adverse pregnancy outcomes. Fertility and sterility, 94(4), 1535-7. PMID: 20153855.

Van Voorhis, B. J., Thomas, M. R., Surrey, E. S. & Sparks, A. E. (2010). What do Consistently High-Performing In Vitro Fertilization Programs in the United States Do?. Fertil Steril, Elsevier Publishing Co, 94(4), 1346-9. PMID: 20674899.

Mains, L., Van Voorhis, B. J. (2010). Optimizing the technique of embryo transfer. Fertility and sterility, 94(3), 785-90. PMID: 20409543.

Thomas, M. R., Sparks, A. E., Ryan, G. L. & Van Voorhis, B. J. (2010). Clinical predictors of human blastocyst formation and pregnancy after extended embryo culture and transfer. Fertil Steril, Elsevier Ltd Publishing Co, 94(2), 543-8. PMID: 19409548.

Van Voorhis, B. J., Ryan, G. L. (2010). Ethical Obligation for restricting the number of embryos transferred to women: combating the multiple-birth epidemic for IVF. In M. V. Sauer (Eds.) Semin Reprod Med. (4), pp. 287-94. Theime Medical Publishers. PMID: 20683792.

Van Voorhis, B. J., Ryan, G. L. (2010). Ethical obligation for restricting the number of embryos transferred to women: combating the multiple-birth epidemic from in vitro fertilization. Seminars in reproductive medicine, 28(4), 287-94. PMID: 20683792.

King, J. L., Yang, B., Sparks, A. E., Murray, J. & Van Voorhis, B. J. (2010). Skewed X Inactivation and IVF-Conceived Infants. (Vols. 20). (5), pp. 660-3. Reprod Biomed Online, published by Elsevier Ltd. PMID: 20207584.

Sipe, C. S., Thomas, M. R., Stegmann, B. J. & Van Voorhis, B. J. (2010). Effects of exogenous testosterone supplementation in gonadotrophin stimulated cycles. Human reproduction (Oxford, England), 25(3), 690-6. PMID: 20031956.

Van Voorhis, B. J. (2010). AIUM practice guideline for the performance of pelvic ultrasound examinations. J Ultrasound Med, 29(1), 166-72.

Van Voorhis, B. J. (2010). Cost-effectiveness of IVF compared to other infertility treatments; a United States perspective. F V & V in ObGyn, Monograph 1-5, 29-31.

Sipe, C. S., Thomas, M. R. & Van Voorhis, B. J. (2010). Effects of Exogenous Testosterone Supplementation in Gonadotropin Stimulated Cycles. Hum Reprod, 25(3), 690-6. PMID: 20031956.

Mains, L., Van Voorhis, B. J. (2010). Embryo transfer in IVF: Evidence-Based Clinical Practice. In Carrell , Peterson (Eds.) Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice. pp. 677-87. New York: Springer.

Van Voorhis, B. J. (2010). Endometriosis. In 2004-2009 Research Online: Disease-Oriented Testing, UPC Medical Diagnosis Series, University Pathology Consortium. University of Iowa College of Medicine: Disease-Oriented Testing, UPC Medical Diagnosis Series, University Pathology Consortium by AC Eichholz - ?2010.

Van Voorhis, B. J. (2010). Hirsutism. In 2004-2009 Research Online: Disease-Oriented Testing, UPC Medical Diagnosis Series, University Pathology Consortium by AC Eichholz - ?2010. University of Iowa College of Medicine: Disease-Oriented Testing, UPC Medical Diagnosis Series, University Pathology Consortium by AC Eichholz - 2010.

Berdahl, D. M., Blaine, J., Van Voorhis, B. J. & Dokras, A. (2009). Detection of enlarged yolk sac on early ultrasound is associated with adverse pregnancy outcomes. Fertil Steril, published by Elsevier Ltd, 301(1), 82-3. PMID: 19409548.

Van Voorhis, B. J., Santoro, N., Harlow, S. & Crawford, S. L. (2009). The relationship of bleeding patterns to daily reproductive hormones in women approaching menopause. Obstet Gynecol, 112(1), 101-8. PMID: 18591314.

Mains, L., Ryan, G. L., Sparks, A. E. & Van Voorhis, B. J. (2009). Sextuplets: an unusual complication of single embryo transfer. Fertil Steril, 91(3), 932.e1-2. PMID: 18973900.

Van Voorhis, B. J. (2009). A 41-year-old woman with menorrhagia, anemia, and fibroids: review of treatment of uterine fibroids. JAMA, 301(1), 82-93. PMID: 19050179.

Van Voorhis, B. J. (2009). AIUM practice guideline for ultrasonography in reproductive medicine. Ultrasound Med, 28(1), 128-37.

Van Voorhis, B. J. (2009). Biennial Review of Infertility. D. T. Carrell , C. Racowsky , B. V. Schlegel , B. J. Van Voorhis (Eds.) (Vols. 1). Human Press.

Van Voorhis, B. J., Santoro, N., Harlow, S., Crawford, S. L. & Randolph, J. (2008). The relationship of bleeding patterns to daily reproductive hormones in women approaching menopause. Obstetrics and gynecology, 112(1), 101-8. PMID: 18591314.

Van Voorhis, B. J. (2008). Ultrasound assessment of the ovary in the infertile woman. (3), pp. 217-22. Semin Reprod Med, Thieme Medical Publishers. PMID: 18504696.

Kresowik, J. D., Ryan, G. L. & Van Voorhis, B. J. (2008). Progression of atypical endometrial hyperplasia to adenocarcinoma despite intrauterine progesterone treatment with LNG-IUS. Obstet Gynecol, 111(2 (Pt 2)), 547-9. PMID: 18239018.

Van Voorhis, B. J., Dokras, A. (2008). Delayed blastocyst transfer; is the window shutting?. Fertil Steril, 89(1), 31-2. PMID: 17511991.

Shroff, R., Syrop, C. H., Davis, W. A. & Van Voorhis, B. J. (2007). A risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria. Fertil Steril, 88(5), 1389-95. PMID: 17462641.

Thomas, M. R., Van Voorhis, B. J. (2007). Gynecologic Ultrasound. In R. S. Gibbs , B. Y. Karlan , A. F. Haney , I. E. Nygaard (Eds.) Danforth's Obstetrics & Gynecology, 10th Edition. pp. 540-54. Lippincott, Williams and Wilkins, Philadelphia, PA.

Ryan, G. L., Sparks, A. E., Sipe, C. S., Syrop, C. H., Van Voorhis, B. J. & Dokras, A. (2007). A mandatory single blastocyst transfer policy with educational campaign in a United States IVF program reduces multiple gestation rates without sacrificing pregnancy rates. Fertil Steril, 88(2), 354-60. PMID: 17490657.

Ryan, G. L., Feng, X., d'Alva, C. B., Zhang, M., Van Voorhis, B. J., Pinto, E. M., Kubias, A. E., Antonini, S. R., Latronico, A. C. & Segaloff, D. L. (2007). Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism. J Clin Endocrinol Metabol, 92(6), 2312-7. PMID: 17356048.

Hollinrake, E., Abreu, A., Maifeld, M., Van Voorhis, B. J. & Dokras, A. (2007). Increased risk of depressive disorders in women with polycystic ovary syndrome. Fertil Steril, 87(6), 1369-76. PMID: 17397839.

Sipe, C. S., Van Voorhis, B. J. (2007). Testosterone patch improves ovarian response to gonadotropin stimulation in a patient with Kallmann’s Syndrome. Hum Reprod, Oxford, England, 22(5), 1380-3. PMID: 17341590.

Ryan, G. L., Kresowik, J., Austin, C. & Van Voorhis, B. J. (2007). Ultrasound- assisted repair of a unique case of distal vaginal agenesis. Fertil Steril, Elsevier Publishing Co, 87(4), 976.e9-12. PMID: 17239874.

Van Voorhis, B. J. (2007). In Vitro Fertilization. NEJM, 356, 379-86.

Van Voorhis, B. J. (2007). Clinical practice. In vitro fertilization. The New England journal of medicine, 356(4), 379-86. PMID: 17251534.

Ryan, G. L., Feng, X., d'Alva, C. B., Van Voorhis, B. J. & Zhang, M. (2007). Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism. J Clin Endocrinol Metabol, 92(6), 2312-21. PMID: 17356048.

Sipe, C. S., Maifeld, M., Davis, W. A. & Van Voorhis, B. J. (2006). A prospective randomized trial comparing anastrozole and clomiphene citrate in an ovulation induction protocol utilizing gonadotropins. Fertil Steril, 86(6), 1676-81. PMID: 1700784.

Dokras, A., Jagasia, D. H., Maifeld, M., Sinkey, C. A., Van Voorhis, B. J. & Haynes, W. G. (2006). Obesity and insulin resistance but not hyperandrogenism mediates vascular dysfunction in women with polycystic ovary syndrome. Fertil Steril, 86(6), 1702-9. PMID: 17067587.

Sipe, C. S., Maifeld, M., Davis, W. A. & Van Voorhis, B. J. (2006). Testosterone patch improves ovarian response to gonadotropin stimulation in a patient with Kallmann’s Syndrome. Feril Steril, Elsevier Publishing Co, 86(6), 1676-81. PMID: 17007849.

Ryan, G. L., Stolpen, A. & Van Voorhis, B. J. (2006). An Unusual Cause of Adolescent Dysmenorrhea. Obstet Gynecol, 108(4), 1017-22. PMID: 17012466.

Stewart, E. A., Segars, J. H. & Van Voorhis, B. J. (2006). Fibroids: Something old, something new. (1) ACOG Update.

Dokras, A., Baredziak, L., Blaine, J., Syrop, C. H., Van Voorhis, B. J. & Sparks, A. E. (2006). Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet Gynecol, 108(1), 61-9. PMID: 16816057.

Silberstein, T., Saphier, O., Van Voorhis, B. J. & Plosker, S. M. (2006). Endometrial polyps in reproductive-age fertile and infertile women. ISR Med Assoc J, 8(3), 192-5. PMID: 16599056.

Van Voorhis, B. J. (2006). Outcomes of assisted reproductive technology. Obstet Gynecol, 107(1).

Van Voorhis, B. J. (2005). Genitourinary symptoms in the menopause transition. Am J Med, 118(Suppl 12B), 47-53. PMID: 16414326.

Ryan, G. L., Moss, V. A., Davis, W. A., Sparks, A. E., Van Voorhis, B. J. & Dokras, A. (2005). Oral ovulation induction agents combined with low-dose gonadotropin injections and IUI: cost an gonadotropins and IUI: cost and clinical effectiveness. J Reprod Med, 50(12), 943-50. PMID: 16444896.

Olson, C. K., Keppler-Noreuil, K. M., Romitti, P. A., Budelier, W. T., Ryan, G. L., Sparks, A. E. & Van Voorhis, B. J. (2005). In vitro fertilization is associated with an increase in major birth defects. Fertil Steril, 84(5), 1038-15. PMID: 16275219.

Wald, M., Sparks, A. E., Sandlow, J. L., Van Voorhis, B. J., Syrop, C. H. & Niederberger, C. S. (2005). Computational models for prediction of IVF/ICSI outcomes with surgically retrieved spermatozoa. (Vols. 11). (3), pp. 325-31. Reprod BioMed Online. PMID: 16176672.

Dokras, A., Bochner, M., Hollinrake, E., Markham, S., Van Voorhis, B. J. & Jagaisa, D. (2005). Screening women with polycystic ovarian syndrome for metabolic syndrome. Obstet Gynecol, 106(1), 131-7. PMID: 15994628.

Ryan, G. L., Syrop, C. H. & Van Voorhis, B. J. (2005). Role, epidemiology, and natural history of benign uterine mass lesions. Clinical obstetrics and gynecology, 48(2), 312-24. PMID: 15805789.

Van Voorhis, B. J., Greensmith, J. E., Dokras, A., Sparks, A. E. & Simmons, S. T. (2005). Hyperbaric oxygen and ovarian follicular simulation for in vitro fertilization: a pilot study. Fertil Steril, 83(1), 226-8. PMID: 15652917.

Ryan, G. L., Syrop, C. H. & Van Voorhis, B. J. (2005). Role, Epidemiology and Natural History of Benign Uterine Mass Lesions. In M. Gibson (Eds.) Clinical Obstetrics & Gynecology. (2), pp. 312-24.

Van Weert, J., Repping, S., Van Voorhis, B. J., van der Veen, F., Bussuyt, P. M. & Mol, B. W. (2004). Performance of the postwash total motile sperm count as a predictor of pregnancy at the time of intrauterine insemination: a meta-analysis. Fertil Steril, 82(3), 612-20. PMID: 15374704.

Ryan, G. L., Van Voorhis, B. J. (2004). The desire of infertile patients for multiple gestations-do they know the risks?. Fertil Steril, 81(3), 526. PMID: 15037390.

Eicholz, A. C., Van Voorhis, B. J., Sorosky, J. I., Smith, B. J. & Sood, A. K. (2004). Operative note dictation: should it be taught routinely in residency programs?. Obstet Gynecol, 103(2), 342-6. PMID: 14754706.

Gross, J. N., Clay, D. L., Harper, D. C., Stockman, A. & Van Voorhis, B. J. (2004). Assisted reproductive technology: counseling and disclosure with children. Children's Healthcare, 33(2), 123-31.

Van Voorhis, B. J., Santoro, N. & Montgomery-Rice, V. (2004). The Menopause Transition. In ACOG Update. (2)

Van Voorhis, B. J. (2003). Tubal ligation a risk factor for hysterectomy. ACOG Clinical Review, 7.

Van Voorhis, B. J. (2003). Evaluating economic studies in reproductive medicine. Seminars in reproductive medicine, 21(1), 85-93. PMID: 12806563.

Armstrong, V., Hanson, W. F., Van Voorhis, B. J. & Syrop, C. H. (2003). Detection of cesarean scars by transvaginal ultrasound. Obstet Gynecol, 101(1), 61-5. PMID: 12517646.

Van Voorhis, B. J. (2003). Evaluating Economic Studies in Reproductive Medicine. In Seminars in Reproductive Medicine. (1), pp. 85-93.

Van Voorhis, B. J. (2003). Previous tubal ligation is a risk factor for hysterectomy after rollerball endometrial ablation. (Vols. 101). pp. 818-9. Obstet Gynecol.

Van Voorhis, B. J. (2003). Use of Ultrasound to Predict and Optimize Outcomes of Ovulation Induction. In Infert Reprod Med Clin N Am. pp. 269-91.

Mall, A., Shirk, G. & Van Voorhis, B. J. (2002). Previous tubal ligation is a risk factor for hysterectomy following rollerball endometrial ablation. Obstet Gynecol, 100(4), 659-64. PMID: 12383530.

Van Voorhis, B. J., Romitti, P. A. & Jones, M. P. (2002). Family history as a risk factor for development of uterine fibroids – results of pilot study and literature review. J Reprod Med, 47(8), 663-9. PMID: 12216434.

DeWaay, D. J., Syrop, C. H., Nygaard, I. E., Davis, W. A. & Van Voorhis, B. J. (2002). Natural history of uterine polyps and fibroids. Obstet Gynecol, 100(1), 3-7. PMID: 12100797.

Van Voorhis, B. J. (2002). Endocrine Assays. In American College of Obstetrics & Gynecology Precis. 2nd Edition. pp. 8-18.

Van Voorhis, B. J. (2002). Epidemiology of Uterine Fibroids. In Infert Reprod Med Clin N Am. pp. 271-81.

Van Voorhis, B. J. (2002). "So many studies - so little insight": Editorial regarding lead article in Obstet Gynecol (Natural history of uterine polyps and leiomyomata). Obstet Gynecol, 100(1), 1-2.

Van Voorhis, B. J., Sparks, A. E. & Syrop, C. H. (2001). Decision to do IUI or IVF-sperm count?. (Vols. 76). (5), pp. 1086-7. Fertil Steril, Elsevier Publishing Co. PMID: 11704154.

Van Voorhis, B. J. (2001). Guest editor of "Management Options for Uterine Fibroids". Lippincott Williams & Wilkins, 22(2).

Van Voorhis, B. J., Barnett, M., Sparks, A. E., Syrop, C. H., Rosenthal, G. E. & Dawson, J. (2001). Effect of the total motile sperm count on the efficacy and cost-effectiveness of infertility treatments. Fertil Steril, 75(4), 661-8. PMID: 11287015.

Zhang, M., Shi, H., Segaloff, D. L. & Van Voorhis, B. J. (2001). Expression and localization of the luteinizing hormone receptor in the female mouse reproductive tract. Biol Reprod, 64(1), 179-87. PMID: 11133673.

Van Voorhis, B. J., Syrop, C. H. (2000). Cost-effective treatment for the Couple with Infertility. In R. M. Pitkin , J. R. Scott (Eds.) Clinical Obstetrics and Gynecology. Lippincott-Raven Publishers, Philadelphia, PA.

Tjarks, M., Van Voorhis, B. J. (2000). Treatment of benign endometrial polyps. Obstet Gynecol, 96(6), 886-9. PMID: 11084172.

Van Voorhis, B. J., Dokras, A. A. & Syrop, C. H. (2000). Bilateral undescended ovaries: association with infertility and treatment with in vitro fertilization. Fertil Steril, 74(5), 1041-3. PMID: 11056257.

Van Voorhis, B. J. (2000). A Comparison of Tubal Ligation Reversal Procedures. In R. M. Pitkin , J. R. Scott (Eds.) Clinical Obstetrics and Gynecology. Lippincott-Raven Publishers, Philadelphia, PA.

Van Voorhis, B. J. (2000). Comparison of tubal ligation reversal procedures. Clinical obstetrics and gynecology, 43(3), 641-9. PMID: 10949765.

Stovall, D. W., Van Voorhis, B. J. (1999). Immunologic tests and treatments in patients with unexplained infertility, IVF-ET, and recurrent pregnancy loss. Clinical obstetrics and gynecology, 42(4), 979-1000. PMID: 10572710.

Van Voorhis, B. J., Sparks, A. E. (1999). Semen analysis: what tests are clinically useful?. Clinical obstetrics and gynecology, 42(4), 957-71. PMID: 10572708.

Stovall, D. W., Allen, B. D., Sparks, A. E., Syrop, C. H., Saunders, R. D. & Van Voorhis, B. J. (1999). The cost of infertility evaluation and therapy: findings of a self-insured healthcare plan. Fertil Steril, 72(5), 778-84. PMID: 10560977.

Clevenger-Hoeft, M., Syrop, C. H., Stovall, D. W. & Van Voorhis, B. J. (1999). Sonohysterography in premenopausal women with and without abnormal bleeding. Obstet Gynecol, 94(4), 516-20. PMID: 10511351.

Syrop, C. H., Dawson, J. D., Husman, K. J., Sparks, A. E. & Van Voorhis, B. J. (1999). Ovarian volume may predict assisted reproductive outcomes better than follicle stimulating hormone concentration on day 3. Hum Reprod, 14(7), 1752-6. PMID: 10402382.

Van Voorhis, B. J. (1999). Donation of cryopreserved embryos is ethical. Modern Medicine.

Erickson, S. S., Van Voorhis, B. J. (1999). Intermenstrual bleeding secondary to cesarean scar diverticula: report of three cases. Obstet Gynecol, 93(5), 802-5. PMID: 10912399.

Van Voorhis, B. J., Grinstead, D. M., Sparks, A. E., Gerard, J. L. & Weir, R. F. (1999). Establishment of a successful donor embryo program: medical, ethical and policy issues. Fertil Steril, 71(4). PMID: 10202866.

Van Voorhis, B. J. (1999). Intrauterine insemination more cost-effective than IVF for some couples. Modern Medicine.

Lallas, T. A., Mehaffey, P. C., Lager, D. J., Van Voorhis, B. J. & Sorosky, J. L. (1999). Malignant cervical schwannoma: an unusual pelvic tumor. (Vols. 72). (2), pp. 238-42. Gynecol Oncol. PMID: 10021307.

Stewart, E. A., Sahakian, M., Rhoades, A., Van Voorhis, B. J. & Nowak, R. A. (1999). Messenger ribonucleic acid for the gonadal luteinizing hormone/human chorionic gonadotropin receptor is not present in human endometrium. Fertil Steril, 71(2), 368-72. PMID: 9988413.

Stovall, D. W., Van Voorhis, B. J. (1999). Autoantibodies and Reproductive Failure: A critical Review. In R. M. Pitkin , J. R. Scott (Eds.) Clinical Obstetrics and Gynecology. Lippincott-Raven Publishers.

Van Voorhis, B. J. (1999). Book review for "Principles of Oocyte and Embryo Donation". New York: Springer-Verlag, 72, 569.

Van Voorhis, B. J. (1999). Control of Follicular Development. In E. Knobil , J. Neill (Eds.) Encyclopedia of Reproduction. pp. 389-95. Academic Press.

Van Voorhis, B. J. (1999). Follicular Steroidogenesis. In E. Knobil , J. Neill (Eds.) Encyclopedia of Reproduction. pp. 376-89. Academic Press.

Van Voorhis, B. J., Syrop, C. H. (1999). RE: Cost effective treatment of infertility patients. (Vols. 72). pp. 562-3. Fertil Steril.

Steward, E. A., Van Voorhis, B. J. & Nowak, R. A. (1999). RE: mRNA for the LH/hCG receptor in human endometrium. (Vols. 72). pp. 374-5. Fertil Steril.

Van Voorhis, B. J., Sparks, A. E. (1999). Semen Analysis. What Tests are Clinically Useful?. In , R. M. Pitkin , J. R. Scott (Eds.) Clinical Obstetrics and Gynecology. Lippincott-Raven Publishers, Philadelphia, PA.

Van Voorhis, B. J., Stovall, D. W. & Allen, B. D. (1998). Cost-effective treatment of the infertile couple. Fertil Steril, 70(6), 1995-1005. PMID: 9848285.

Stovall, D. W., Van Voorhis, B. J., Sparks, A. E., Syrop, C. H. & Adams, L. M. (1998). Selective early elimination of luteal support in assisted reproduction cycles using a gonadotropin-releasing hormone agonist during ovarian stimulation. Fertil Steril, 70(6), 20-9. PMID: 9848295.

Van Voorhis, B. J., Sparks, A. E., Syrop, C. H. & Stovall, D. W. (1998). Ultrasound-guided aspiration of hydrosalpinges is associated with improved pregnancy and implantation rates after in vitro fertilization cycles. Hum Reprod, 13(3). PMID: 9572444.

Van Voorhis, B. J. (1998). Cost-effective Infertility Care. OB/GYN News.

Van Voorhis, B. J. (1998). Infertility treatment: What is a cost-effective approach?. (Vols. 10). pp. 20-9. Drug Benefit Trends.

Stovall, D. W., Parrish, S. B., Van Voorhis, B. J., Hahn, S. J., Sparks, A. E. & Syrop, C. H. (1998). Uterine leiomyomas reduce the efficacy of assisted reproduction cycles: results of a matched follow-up study. Human Reprod, 13(1), 192-7. PMID: 9512256.

Van Voorhis, B. J., Stovall, D. W. (1997). Autoantibodies and infertility; a review of the literature. J Reprod Immunol, 33(3), 329-56. PMID: 9255726.

Van Voorhis, B. J., Sparks, A. E., Allen, B., Stovall, D. W., Syrop, C. H. & Chapler, F. K. (1997). Cost-effectiveness of infertility treatment: a cohort study. Fertil Steril, 67(5), 830-6. PMID: 9130886.

Van Voorhis, B. J., Dawson, J., Stovall, D., Sparks, A. E. & Syrop, C. H. (1997). Smoking effects on fertility.

Van Voorhis, B. J. (1997). Cigarette smoking impairs ovarian function and reduces pregnancy rates in assisted reproduction cycles. Reprod Review, 2, 1-4.

Van Voorhis, B. J. (1997). Nitric oxide and ovarian steroidogenesis. In Workshop 21; Ernst Schering Research Foundation. pp. 117-39. Ernst Schering Research Foundation.

Van Voorhis, B. J., Dawson, J. D., Stovall, D. W., Sparks, A. E. & Syrop, C. H. (1996). The effects of smoking on ovarian function and fertility during assisted reproduction cycles. Obstet Gynecol, 88(5), 785-91. PMID: 8885914.

Stovall, D. W., Van Voorhis, B. J., Mattingly, K. L., Sparks, A. E., Chapler, F. K. & Syrop, C. H. (1996). The effectiveness of sublingual progesterone administration during cryopreserved embryo transfer cycles: results of a matched follow-up study. Fertil Steril, 65(5), 986-91. PMID: 8612862.

Snyder, G. D., Holmes, R. W., Bates, J. N. & Van Voorhis, B. J. (1996). Nitric oxide inhibits aromatase activity: mechanisms of action. J Steroid Bichem and Mol Biol, 58(1), 63-9. PMID: 8809186.

Sandlow, J., Donovan, J., Sparks, A., Syrop, C., Van Voorhis, B. & Stovall, D. (1996). Microsurgical epididymal sperm aspiration. Iowa Medicine: Journal of the Iowa Medical Society, 86(9), 367-8. PMID: 8961632.

Van Voorhis, B. J., Moore, K., Strijbos, P., Nelson, S., Baylis, S., Grzybicki, D. & Weiner, C. P. (1995). Expression and localization of inducible and endothelial nitric oxide synthase in the rat ovary: effects of gonadotropin stimulation in vivo. J Clin Invest, 96(6), 2719-26. PMID: 8675639.

Syrop, C. H., Willhoite, A. & Van Voorhis, B. J. (1995). Ovarian volume: a novel predictor for assisted reproduction. Fertil Steril, 64(6), 1167-71. PMID: 7589671.

Weiner, C. P., Thompson, L. P. & Van Voorhis, B. J. (1995). The role of nitric oxide in female reproduction. Fetal and Maternal Medicine Review, 7(4), 175-205.

Van Voorhis, B. J., Syrop, C. H., Allen, B. D., Sparks, A. E. & Stovall, D. W. (1995). The efficacy and cost effectiveness of embryo cryopreservation compared with other assisted reproductive techniques. Fertil Steril, 64(3), 647-50. PMID: 7641925.

Van Voorhis, B. J., Syrop, C. H., Vincent, R. & Sparks, A. E. (1995). Tubal versus uterine transfer of cryopreserved embryos: a prospective, randomized trial. Fertil Steril, 63(3), 578-83.

Vincent, Jr., R. D., Syrop, C. H., Van Voorhis, B. J., Chestnut, D. H., Sparks, A. E., McGrath, J. M., Choi, W. W., Bates, J. N. & Penning, J. N. (1995). An evaluation of the effect of anesthetic technique on reproductive success after laparoscopic pronuclear stage transfer (PROST): propofol-nitrous oxide versus isoflurane-nitrous oxide. Anesthesiology, 82(2), 352-8. PMID: 7856893.

Van Voorhis, B. J., Dunn, M. S., Snyder, G. D. & Weiner, C. P. (1994). Nitric oxide: an autocrine regulator of human granulosa-luteal cell steroidogenesis. Endocrinology, 135(5), 1799-806. PMID: 7525252.

Van Voorhis, B. J., Neff, T. W., Syrop, C. H. & Chapler, F. K. (1994). Primary hypothyroidism associated with multicystic ovaries and ovarian torsion in an adult. Obset Gynecol, 83(5), 885-7. PMID: 8159386.

Wenstrom, K. D., Syrop, C. H., Hammitt, D. G. & Van Voorhis, B. J. (1993). Increased risk of monozygotic twinning associated with assisted reproduction. Fertil Steril, 60(3), 510-14. PMID: 8375535.

Van Voorhis, B. J., Dunn, M. S., Falck, J. R., Bhatt, R. K., VanRollins, M. & Snyder, G. D. (1993). Metabolism of arachidonic acid to epoxyeicosatrienoic acids by human granulosa cells may mediate steroidogenesis. The Journal of clinical endocrinology and metabolism, 76(6), 1555-9. PMID: 8388882.

Van Voorhis, B. J., Dawson, J., Stovall, D., Sparks, A. E. & Syrop, C. H. (1993). Effects of smoking on ovulation induction for assisted reproductive techniques. Obstetric & Gynecological Survey, 48(5), 349.

Hammitt, D. G., Syrop, C. H., Van Voorhis, B. J., Walker, D. L., Miller, T. L. & Barud, K. M. (1993). Maturational asynchrony between oocytes-cumulus morphology and nuclear maturity in GnRH-a stimulations. Fertil Steril, 59(2), 375-81. PMID: 8425634.

Van Voorhis, B. J., Donovan, J. F. (1993). Legal issues in operative laparoscopy. Contemporary OB-GYN, 38(8), 31-7.

Van Voorhis, B. J., Syrop, C. H., Hammitt, D. G., Dunn, M. S. & Snyder, G. D. (1992). Effects of smoking on ovulation induction for assisted reproductive techniques. Fertility and sterility, 58(5), 981-5. PMID: 1426386.

Hammitt, D. G., Syrop, C. H., Van Voorhis, B. J., Walker, D. L., Miller, T. M., Barud, K. M. & Hood, C. C. (1992). Prediction of nuclear maturity from cumulus-coronal morphology: influence of embryologist experience. J Asst Reprod and Genetics, 9(5), 439-46. PMID: 1482838.

Van Voorhis, B. J., Schwaiger, J., Syrop, C. H. & Chapler, F. K. (1992). Early diagnosis of ovarian torsion by color doppler ultrasonography. Fertility & Sterility, 58(1), 215-17. PMID: 1624012.

Van Voorhis, B. J., Williamson, R. A., Gerard, J. L., Hammitt, D. G. & Syrop, C. H. (1992). Use of oocytes from anonymous, matched fertile donors for prevention of inheritable genetic diseases. J Med Genetics, 29(6), 398-9. PMID: 1619634.

Van Voorhis, B. J., Snyder, G. & Longo, J. (1992). Effects of quinacrine on egg activation: a possible role for phospholipase A2 in sea urchin fertilization. Invertebrate Reproduction and Development, 21, 33-41.

Hammitt, D. G., Syrop, C. H., Van Voorhis, B. J., Walker, D. L., Miller, T. M., Barud, K. M. & Hood, C. C. (1992). Metabolism of arachidonic acid to epoxyeicosatrienoic acids by human granulosa cells may mediate steroidogenesis. J Asst Reprod and Genetics, 9, 439-46.

Anderson, D. J., Politch, J. A., Martinez, A., Van Voorhis, B. J., Padian, N. S. & O'Brien, T. R. (1991). White blood cells and HIV-1 in semen from vasectomized seropositive men. Lancet, 338(8766), 573. PMID: 1678827.

Van Voorhis, B. J., Martinez, A., Mayer, K. & Anderson, D. (1991). Detection of human immuno-deficiency virus Type I in blood and semen by the polymerase chain reaction DNA amplification technique. Fertility & Sterility (Reviewed in Science News 138;18:286), 55(3), 588-94.

Van Voorhis, B. J., Huettner, P., Clark, M. & Hill, J. (1990). Immunohistochemical localization of prostaglandin H synthase in the female reproductive tract and in endometriosis. American Journal of Obstetrics & Gynecology, 163(1), 57-62. PMID: 1695815.

Stomper, P. C., Van Voorhis, B. J., Ravnikar, V. A. & Meyer, J. E. (1990). Mammographic changes associated with postmenopausal hormone replacement therapy: a longitudinal study. Radiology, 174(2), 487-90. PMID: 2136958.

Van Voorhis, B., Matt, D. W., Tedeschi, M. L. & Steingold, K. A. (1989). Comparison of in vivo bioavailability of progestational agents into the rat uterus and liver and the effect of plasma protein binding. American Journal of Obstetrics and Gynecology, 161(6 Pt 1), 1698-703. PMID: 2603929.

Van Voorhis, B. J., Anderson, D. J. & Hill, J. A. (1989). The effects of RU 486 on immune function and steroid-induced immunosuppression in vitro. The Journal of Clinical Endocrinology and Metabolism, 69(6), 1195-9. PMID: 2584354.

Van Voorhis, B., Cruikshank, D. P. (1989). Colon carcinoma complicating pregnancy. A report of two cases. The Journal of Reproductive Medicine, 34(11), 923-7. PMID: 2685290.