Stephen K. Hunter, MD, PhD

Portrait
Director
Professor of Obstetrics and Gynecology - Maternal Fetal Medicine
Professor of Biomedical Engineering (BME)

Contact Information

Primary Office: 31312 Pomerantz Family Pavilion
Iowa City, IA 52242
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Office:
319-356-1929

Education

BS, University of Utah
PhD, University of Utah
MD, University of Utah

Resident, Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
Fellow, Maternal-Fetal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa

Licensure and Certifications

Maternal-Fetal Medicine Subspecialty - American Board of Obstetrics and Gynecology
Obstetrics and Gynecology - American Board of Obstetrics and Gynecology

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Translational Biomedicine

Research Summary

Diabetes in pregnancy; Bioartificial Pancreas (BAP); Fetal Therapy; Neovascularization around hollow Fiber Based Bioartificial Organs Using Biologically Active Substances

Publications

Santillan, M., Santillan, D., Scroggins, S., Minn, J., Leslie, K., Hunter, S., Zamba, G., Gibson-Corley, K. & Grobe, J. (2015). Vasopressin secretion in human pregnancy predicts the development of preeclampsia as early as the sixth week of gestation. Pregnancy Hypertens, 5(1), 25-6. PMID: 25787398.

Adams, A., Hubb, A. J., Santillan, M. K., Nishimura, T. E., Rubac, R., Gravatt, L., Higdon, E., Schroeder, K., Conklin, J., Bender, R. M., Hunter, S. K. & Santillan, D. A. (2015). Adherence to the updated guidelines for the prevention of perinatal Group B streptococcal disease. Proc Obstet Gynecol, 4(3), 2 p.

Santillan, M. K., Pelham, C. J., Ketsawatsomkron, P., Santillan, D. A., Davis, D. R., Devor, E. J., Gibson-Corley, K. N., Scroggins, S. M., Grobe, J. L., Yang, B., Hunter, S. K. & Sigmund, C. D. (2015). Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiol Rep, 3(1), pii: e12257. PMID: 25602015.

Mhyre, J. M., D'Oria, R., Hameed, A. B., Lappen, J. R., Holley, S. L., Hunter, S. K., Jones, R. I., King, J. C. & D'Alton, M. E. (2014). The maternal early warning criteria: a proposal from the national partnership for maternal safety. J Obstet Gynecol Neonatal Nurs, 43(6), 771-9. PMID: 25203897.

Mhyre, J. M., D'Oria, R., Hammed, A. B., Lappen, J. R., Holley, S. L., Hunter, S. K., Jones, R. L., King, J. C. & D'Alton, M. E. (2014). The maternal early warning criteria: a proposal from the national partnership for maternal safety. Obstet. Gynecol., 124(4), 782-6. PMID: 25198266.

Santillan, M. K., Kowalski, J., Santillan, D. A., Fleener, D., Netz, R., Hunter, S. K. & Haynes, W. (2014). Determinants of Changes in Flow Mediated Dilation and Pulse Wave Analysis Throughout All Trimesters of Normal Pregnancies.

Santillan, M. K., Santillan, D. A., Scroggins, S. M., Min, J. Y., Sandgren, J. A., Pearson, N. A., Leslie, K. K., Hunter, S. K., Zamba, G. K., Gibson-Corley, K. N. & Grobe, J. L. (2014). Vasopressin in Preeclampsia: A Novel Very Early Human Pregnancy Biomarker and Clinically Relevant Mouse Model. Hypertension. PMID: 25001273.

Santillan, M. K., Leslie, K. K., Hamilton, W. S., Boese, B. J., Ahuja, M., Hunter, S. K. & Santillan, D. A. (2014). Collection of a lifetime: a practical approach to developing a longitudinal collection of women's healthcare biological samples. Eur J Obstet Gynecol Reprod Biol, 179, 94-9. PMID: 24965987.

Santillan, M. K., Ramachandram, S., Santillan, D. A., Hunter, S. K., Leslie, K. K. & Devor, E. (2014). Setting the Tone: Human Placenta microRNA expression is Established in Gestation. Submitted to Am J Obstet Gynecol.

Taylor, J., Conklin, J., Hunter, S. K., Empey, R., Tyler, E., Christensen, A., Talcott, K., Ballas, Z., Santillan, D. & Santillan, M. (2013). Defining normal IgG changes throughout pregnancy. Proc Obstet Gynecol, 3(2), 8.

Kowalski, J., Santillan, D. A., Netz, R., Sinkey, C. A., Fleener, D., Hunter, S. K. & Santillan, M. K. (2013). Flow mediated vasodilation predicts the development of gestational diabetes mellitus. Proc Obstet Gynecol, 3(3), 2 p.

Santillan, D. A., Hamilton, W., Christenson, A., Talcott, K., Gravatt, L., Santillan, M. K. & Hunter, S. K. (2013). The Effects of Preeclampsia on Signaling to Hematopoietic Progenitor Cells. S. Schwartz-Rogers , S. Schwartz-Rogers (Eds.) (Vols. 3). (1), pp. 3. Iowa City, IA: Proc Obstet Gynecol.

Empey, R., Santillan, D. A., Santillan, M. K., Tyler, E., Hunter, S. K., Smith, E. & Stegmann, B. (2012). The influence of fetal sex on patterns of change in anti-Mullerian hormone during pregnancy. S. Schwartz-Rogers , S. Schwartz-Rogers (Eds.) (Vols. 2). (3), pp. Article 4 [2 pages]. Iowa City, IA: Proc Obstet Gynecol.

Kyser, K. L., Lu, X., Santillan, D. A., Santillan, M. K., Hunter, S. K., Cahill, A. G. & Cram, P. (2012). The Association Between Hospital Obstetrical Volume and Maternal Postpartum Complications (Editor's Choice). Mosby Inc. , Mosby Inc. (Eds.) (Vols. 207). pp. 42.e1-17. Am J Obstet Gynecol. PMID: 22727347.

Santillan, M. K., Santillan, D. A., Fleener, D., Stegmann, B., Zamba, G., Hunter, S. K. & Yankowitz, J. (2012). Single umbilical artery: does side matter?. (Vols. 32). (3), pp. 201-208. Fetal Diagn Ther. PMID: 22678110.

Santillan, D. A., Rai, K. K., Santillan, M. K., Krishnamachari, Y., Salem, A. K. & Hunter, S. K. (2011). Efficacy of Polymeric Encapsulated C5a peptidase-based Group B Streptococcus Vaccines in a Murine Model. (Vols. 205). (3), pp. 249.e1-8. Am J Obstet Gynecol. PMID: 21802065.

Zhao, A., Hunter, S. K. & Rodgers, V. (2010). Theoretical Prediction of Induction Period from Transient Pore Evolvement in Polyester-Based Microparticles. J Pharma Sci, 99(11), 4477-4487. PMID: 20845447.

Santillan, D. A., Santillan, M. K. & Hunter, S. K. (2009). Cell encapsulation as a potential nondietary therapy for maternal phenylketonuria. (Vols. 201). (3), pp. 289.e1-289.e6. Am J Obstet Gynecol. PMID: 19631922.

Santillan, M. K., Santillan, D. A., Sigmund, C. D. & Hunter, S. K. (2009). From molecules to medicine: a future cure for preeclampsia?. Drug News Perspect, 22(9), 531-41. PMID: 20072730.

Santillan, M. K., Santillan, D. A., Sigmund, C. D. & Hunter, S. K. (2009). From molecules to medicine: A future cure for preeclampsia?. Drug News Perspect, 22(9), 531-541. PMID: 20072730.

Santillan, D. A., Andracki, M. E. & Hunter, S. K. (2008). Protective Immunization in Mice Against group B Streptococci Using Encapsulated C5a Peptidase. (Vols. 198). (1), pp. 114e1-114e6. Am J Obstet Gynecol. PMID: 17905172.

Hunter, S. K. (2008). The Rising Pre-term Delivery Rate in Iowa - Three things We Can Do Now. (Vols. 29). (1) The Iowa Perinatal Letter.

Santillan, M. K., Hunter, S. K. (2008). Preeclampsia/Eclampsia: An Immediate and Long Term Problem. (Vols. 29). (4) The Iowa Perinatal Letter.

Hunter, S. K. (2007). Obstetrical High Risk Legal Situations. (Vols. 28). (4) The Iowa Perinatal Letter.

Tilakaratne, H. K., Hunter, S. K., Andracki, M. E., Benda, J. A. & Rodgers, V. G. (2007). Characterizing short-term release and neovascularization potential of multi-protein growth supplement delivered via alginate hollow fiber devices. (Vols. 28). (1), pp. 89-98. Biomaterials. PMID: 16952396.

Tilakaratne, H. K., Yang, B., Hunter, S. K., Andracki, M. E. & Rodgers, V. G. (2007). Can myoglobin expression in pancreatic beta cells improve insulin secretion under hypoxia? An exploratory study with transgenic porcine islets. (Vols. 31). (7), pp. 521-531. Artif Organs. PMID: 17584476.

Facer, S. R., Zaharias, R. S., Andracki, M. E., Lafoon, J., Hunter, S. K. & Schneider, G. B. (2005). Rotary Culture Enhances Pre-osteoblast Aggregation and Mineralization. (Vols. 84). (6), pp. 542-547. J Dent Res. PMID: 15914592.

Goldner, W. S., Kraus, V. L., Sivitz, W. I., Hunter, S. K. & Dillon, J. S. (2004). Cyclic Changes in Glycemia Assessed By Continuous Glucose Monitoring System During Multiple Complete Menstrual Cycles in Women with Type I Diabetes. (Vols. 6). (4), pp. 473-480. Diabetes Technol Ther. PMID: 15321002.

Tran, N. D., Hunter, S. K. & Yankowitz, J. (2004). Oral hypoglycemic agents in pregnancy. Obstet Gynecol Surv, 59(6), 456-63. PMID: 15167767.

Tran, N. D., Hunter, S. K. & Yankowitz, J. (2004). Oral Hypoglycemic Agents in Pregnancy. Obstetrical & Gynecological Survey, 59(6), 456-463. DOI: 10.1097/00006254-200406000-00024.

Tilakaratne, H. K., Hunter, S. K. & Rodgers, V. G. (2002). Mathematical Modeling of Myoglobin Facilitated Transport of Oxygen in Devices Containing Myoglobin-Expressing Cells. (Vols. 176). (2), pp. 253-267. Math Biosci. PMID: 11916512.

Guthmiller, J. M., Hassebroek-Johnson, J. R., Weenig, D. R., Johnson, G. K., Kirchner, H. L., Kohout, F. J. & Hunter, S. K. (2001). Periodontal disease in pregnancy complicated by type 1 diabetes mellitus. (Vols. 72). (11), pp. 1485-1490. J Periodontal. PMID: 11759859.

Hunter, S. K., Krieg, A. M. & Andracki, M. E. (2001). Biodegradable Microspheres Containing Group B Streptococcus (GBS) Vaccine: Immune Response in Mice. (Vols. 185). (5), pp. 1174-1179. Am J Obstet Gynecol. PMID: 11717653.

Hunter, S. (2001). Gestational Diabetes: Questions and Answers. (Vols. 12). (4), pp. 14-16. The Iowa Perinatal Letter.

Hansen, W. F., Fretz, P., Hunter, S. K. & Yankowitz, J. (2001). Leukemia in pregnancy and fetal response to multiagent chemotherapy. (Vols. 97). (5 (Part 2)), pp. 809-812. Obstet Gynecol. PMID: 11336761.

Andrews, J. I., Diekema, D. J., Hunter, S. K., Rhomberg, P. R., Pfaller, M. A., Jones, R. N. & Doern, G. V. (2000). Group B streptococci causing neonatal bloodstream infection: antimicrobial susceptibility and serotyping results from SENTRY centers in the Western Hemisphere. (Vols. 183). (4), pp. 859-62. Am J Obstet Gynecol. PMID: 11035326.

Hunter, S. K. (2000). Present and future perspectives on the use of free or encapsulated pancreatic islet cell transplantation as a treatment of pregnancy complicated by type I diabetes. (Vols. 9). (1), pp. 46-51. J Matern Fetal Med. PMID: 10757435.

Hunter, S. K., Kao, J. M., Wang, Y., Benda, J. A. & Rodgers, V. G. (1999). Promotion of neovascularization around hollow fiber bioartificial organs using biologically active substances. (Vols. 45). (1), pp. 37-40. ASAIO J. PMID: 9952004.

Hunter, S. K., Wang, Y. & Rodgers, V. G. (1999). Bioartificial pancreas (BAP) use in diabetic pregnancy. (Vols. 45). (1), pp. 13-17. Am Soc Artif Int Organs. PMID: 9952000.

Peleg, D., Hunter, S. K. (1999). Perinatal management of women with immune thrombocytopenic purpura: survey of United States perinatologists. (Vols. 180). (3 Pt 1), pp. 645-9. Am J Obstet Gynecol. PMID: 10076142.

Kao, J. M., Rose, R., M, Y., Hunter, S. K. & Rodgers, V. G. (1999). In-vivo Biocompatibility Evaluation of Cibacron Blue-Agarose. (Vols. 47). (4), pp. 537-542. J Biomed Mater Res. PMID: 10497289.

Peleg, D., Kennedy, C. M. & Hunter, S. (1998). Intrauterine growth restriction: Identification and management. Am Family Physician, 58(2), 453-460, 446-447. PMID: 9713399.

Peleg, D., Kennedy, C. M. & Hunter, S. K. (1998). Intrauterine growth restriction: identification and management. (Vols. 58). (2), pp. 453-60, 466-7. Am Fam Physician. PMID: 9713399.

Hunter, S. (1997). Asthma in Pregnancy. (Vols. 18). (1) The Iowa Perinatal Letter.

Hunter, S. K., Wang, Y., Weiner, C. P. & Niebyl, J. (1997). Encapsulated beta-islet cells as a bioartificial pancreas to treat insulin-dependent diabetes during pregnancy. (Vols. 177). (4), pp. 746-52. Am J Obstet Gynecol. PMID: 9369813.

Hunter, S. (1996). Random blood glucose, glucose tolerance, "postprandial glucose" and urine glucose tests. In H. I. Wildschut , C. P. Weiner , T. Peters , H. I. Wildschut , C. P. Weiner , T. Peters (Eds.) When to Screen in Obstetrics and Gynecology. pp. 170-179. WB Saunders.

Hunter, S. K., Weiner, C. P. (1996). Obstetric Hemorrhage. In J. T. Repke , J. T. Repke (Eds.) Intrapartum Obstetrics. pp. 203-222. Churchill Livingstone.

Hunter, S., Yankowitz, J. (1996). Medical Fetal Therapy. In J. A. Kuller , N. C. Chescheir , R. C. Defalo , J. A. Kuller , N. C. Chescheir , R. C. Defalo (Eds.) Prenatal Diagnosis and reproductive Genetics. pp. 172-180. Mosby Yearbook Inc.

Merrill, D. C., Hunter, S. K. (1995). Use of oxytocin for induction and augmentation of labor. Postgraduate Obstetrics & Gynecology, 15(18), 1-7.

Hunter, S. K., Martin, M., Benda, J. A. & Zlatnik, F. J. (1995). Liver transplant after massive spontaneous hepatic rupture in pregnancy complicated by preeclampsia. (Vols. 85). (5 Pt 2), pp. 819-22. Obstet Gynecol. PMID: 7724124.

Hunter, S. K., Neeld, J. B., Scott, J. R., Olsen, D. B., Urry, R. L. & Cichocki, T. (1990). Developing an artificial fallopian tube: successful in vitro trials in mice. (Vols. 53). (6), pp. 1083-6. Fertil Steril. PMID: 2351231.

Hunter, S., Scott, J. R., Hull, D. & Urry, R. L. (1989). The gamete and embryo compatibility of various synthetic polymers. (Vols. 50). pp. 110-116. Fertil Steril. PMID: 3384103.

Gregonis, D. E., Buerger, D. E., Van Wagenen, R. A., Hunter, S. & Andrade, J. D. (1984). Poly (ethylene glycol) surfaces to minimize protein absorption. Abst 2nd World Cong Biomat.

Hunter, S. K., Gregonis, D. E., Coleman, D. L., Hanover, B., Stephan, R. L. & Jacobsen, S. C. (1983). Surface modification of polyurethane to promote long-term patency of peritoneal access devices. (Vols. 29). pp. 250-254. Trans Am Soc Artif Intern Organs. PMID: 6673234.

Hunter, S. K., Gregonis, D. E., Coleman, D. L., Andrade, J. D. & Kessler, T. (1982). Molecular weight characterization of pre-and post-implant artificial heart polyurethane materials. (Vols. 28). pp. 473-7. Trans Am Soc Artif Intern Organs. PMID: 7164284.