Benjamin J. Miller, MD, MS
Professor of Orthopedics and Rehabilitation
Introduction
My research interests are focused on improving the outcomes and ultimate function and quality-of-life after surgical removal of sarcoma. This includes participation in a number of clinical trials, both as a collaborator and primary investigator. I lead the Musculoskeletal Tumor Registry (MsTR), a national registry to record oncologic and functional outcomes in patients with sarcoma and metastatic disease of bone. I also collaborate with our biomechanics laboratory in development of a finite-element model of metastatic disease to bone.
Current Positions
- Professor of Orthopedics and Rehabilitation
- Holden Comprehensive Cancer Center Sarcoma Multidisciplinary Oncology Group
- Vice Chair for Faculty Affairs
- Staff Physician, Department of Veterans Affairs
Education
- BS in Chemical Engineering with Bioengineering Concentration, Cornell University, Ithaca, New York
- MD in Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
- MS in Clinical Investigation, University of Iowa, Iowa City, Iowa
- Internship in General surgery, Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois
- Resident in Orthopaedic surgery, Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois
- Fellow in Orthopaedic oncology, University of Florida, Gainesville, Florida
Center, Program and Institute Affiliations
Research Interests
- Large database analysis to determine risk factors for adverse outcomes in sarcoma.
- Prospective clinical trials in sarcoma
- Patient-reported outcomes, function, and quality-of-life after surgical treatment of sarcoma
- Biomechanical analysis and development of a finite element model for metastatic bone disease to the proximal femur
- Multi-institutional collaborative research in orthopaedic oncology
- Use of TcO2 to predict wound complications in preoperative radiation for soft tissue sarcoma
- University of Iowa Holden Comprehensive Cancer Center Sarcoma Multidisciplinary Oncology Group
- Musculoskeletal Oncology Research Initiative (MORI)
Licenses & Certifications
- American Board of Orthopaedic Surgery, Step 2
- American Board of Orthopaedic Surgery, Step 1
- State Medical License, Iowa
Selected Publications
- Russell M, Leary S, Saxby NE, Glass N, Miller BJ. A pilot study of nutritional supplementation in soft tissue sarcoma patients. Iowa Orthop J. 2023 Dec;43(2):45-51. (PMID: 38213865)
- Lee CY, Petronek MS, Monga V, Miller BJ, Milhem MM, Magnotta VA, Allen BG. T2* imaging assessment of neoadjuvant radiation therapy combined with pharmacological ascorbate in extremity soft-tissue sarcomas: a pilot study. Iowa Orthop J. 2023 Dec;43(2):60-69. (PMID: 38213860)
- Johnson JE, Figueroa AV, Brouillette MJ, Miller BJ, Goetz JE. Mechanical gains associated with virtual prophylactic intramedullary nail fixation in femurs with metastatic disease. Iowa Orthop J. 2023 Dec;43(2):70-78. (PMID: 38213856)
- Gulbrandsen TR, Skalitzky MK, Russell MD, An Q, Hasan O, Miller BJ. Characteristics and long-term outcome of surgically managed high-grade extremity chondrosarcoma. Iowa Orthop J. 2023;43(1):71-75. (PMID: 37383872)
- Sakyi MY, Miller BJ, Coleman MC, Rodman SN, Brouillette MJ, Johnson JE, Fredericks DC, Goetz JE. Effects of radiotherapy upon bone structure-strength relationships vary with sex and fractionation of dosing. Iowa Orthop J. 2023;43(1):77-86. (PMID: 37383848)
- Johnson JE, Brouillette MJ, Miller BJ, Goetz JE. Finite element model-computed mechanical behavior of femurs with metastatic disease varies between physiologic and idealized loading simulations. Biomed Eng Comput Biol. 2023 Mar 31;14. (PMID: 37020922).
- Operative Standards for Cancer Surgery, Vol 3: Sarcoma, adrenal, neuroendocrine, peritoneal malignancies, urothelial, hepatobiliary. American College of Surgeons, Wolters Kluwer
- Herbach EL, McDowell BD, Charlton M, Miller BJ. Adjuvant treatment of surgically treated bone metastasis patients: association with hospital characteristics and trends over time. Med Oncol. 2023 Feb 24;40(4):107. doi: 10.1007/s12032-023-01961-7. PMID: 36826717.
- Keung EZ, Krause KJ, Maxwell J, Morris CD, Crago AM, Houdek MT, Kane J, Lewis V, Callegaro D, Miller B, Lazar AJ, Gladdy R, Raut CP, Fabbri N, Al-Refaie W, Fairweather M, Wong SL, Roland CL. Sentinel Lymph Node Biopsy for Extremity and Truncal Soft Tissue Sarcomas: A Systematic Review of the Literature. Ann Surg Oncol. 2023 Feb;30(2):958-967. doi: 10.1245/s10434-022-12688-6. Epub 2022 Oct 28. PMID: 36307665.
- Johnson JE, Goetz JE, Brouillette MJ, Miller BJ. Finite element analysis potentially identifies nonessential prophylactic stabilization in femurs with metastatic disease. Proc Inst Mech Eng H. 2022 Sep;236(9):1297-1308. doi: 10.1177/09544119221109740. Epub 2022 Jul 5. PMID: 35787214.