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Benjamin J. Miller, MD, MS

Holden Comprehensive Cancer Center Sarcoma Multidisciplinary Oncology Group
Associate Professor of Orthopedics and Rehabilitation

Contact Information

Primary Office
01015 JPP
Iowa City, IA 52242


BS, Chemical Engineering with Bioengineering Concentration, Cornell University
MD, Medicine, University of Iowa Carver College of Medicine
MS, Clinical Investigation, University of Iowa
Internship, General surgery, Rush-Presbyterian-St. Luke’s Medical Center
Resident, Orthopaedic surgery, Rush-Presbyterian-St. Luke’s Medical Center
Fellow, Orthopaedic oncology, University of Florida

Licensure and Certifications

American Board of Orthopaedic Surgery, Step 2
American Board of Orthopaedic Surgery, Step 1

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Research Summary

My research interests are focused on improving the outcomes and ultimate function and quality-of-life after surgical removal of sarcoma. This includes participation in a number of clinical trials, both as a collaborator and primary investigator. I am also president of the Musculoskeletal Oncology Research Initiative, a consortium of orthopaedic oncologists with the common goal of improving care of sarcoma patients through collaborative research. I have experience with large database investigation of risk factors for adverse outcomes in sarcoma. Finally, I collaborate with our biomechanics laboratory in development of a finite-element model of metastatic disease to bone.


Ramkumar, D. B., Ramkumar, N., Miller, B. J. & Henderson, E. R. (2019). Risk factors for detectable metastatic disease at presentation in Ewing sarcoma – an analysis of the SEER registry. Cancer Epidemiol., 57, 134-139. PMID: 30412903.

Wendt, R., Gao, Y. & Miller, B. J. (2019). Rural patients are at risk for increased stage at presentation and diminished overall survival in osteosarcoma. Cancer Epidemiol.,(61), 119-123. PMID: 31212223.

Miller, B. J. (2019). Use of imaging prior to referral to a musculoskeletal oncologist. J Am Acad Orthop Surg. PMID: 31206439.

Mayo, Z., Kennedy, S., Gao, Y. & Miller, B. (2019). What is the clinical importance of incidental findings on staging CT scans in patients with sarcoma?. Clin Orthop Relat Res., 477(4), 730-737. PMID: 30601764.

Abarca, T., Gao, Y., Monga, V., Tanas, M. R., Milhem, M. M. & Miller, B. J. (2018). Improved survival for extremity soft tissue sarcoma treated in high-volume facilities. J Surg Oncol, 117(7), 1479-1486. PMID: 29633281.

Kohler, J., Glass, N., Noiseux, N. O., Callaghan, J. J. & Miller, B. J. (2018). Might doctors really “know best?”: Utilizing surgeon intuition to strengthen preoperative surgical risk assessment. Iowa Orthop J, 38, 203-208. PMID: 30104946.

Hasley, I., Blevins, A. E. & Miller, B. J. (2018). The significance of a “close” margin in extremity sarcoma: A systematic review. Iowa Orthop J, 38, 131-136. PMID: 30104934.

Kennedy, S., Mayo, Z., Gao, Y. & Miller, B. J. (2018). What are the results of surgical treatment of postoperative wound complications in soft tissue sarcoma? A retrospective, multi-center case series. Iowa Orthop J, 38, 123-130. PMID: 30104935.

Miller, B. J. (2018). CORR Insights: Neoadjuvant chemotherapy followed by delayed surgery: Is it necessary for all patients with nonmetastatic high-grade pelvic osteosarcoma?. Clin Orthop Relat Res. PMID: 30188347.

Reif, T. J., Strotman, P. K., Kliethermes, S. A., Miller, B. J. & Nystrom, L. M. (2018). No consensus on implant choice for oligometastatic disease of the femoral head and neck. J Bone Oncol, 12, 14-18. PMID: 29850399.

Miller, B. J., Gao, Y. & Duchman, K. R. (2017). Does surgery or radiation provide the best overall survival in Ewing’s sarcoma? A review of the NCDB. J Surg Oncol., 116(3), 384-390. PMID: 28420037.

Miller, B. J., Gao, Y. & Duchman, K. R. (2017). Socioeconomic measures influence survival in osteosarcoma: an analysis of the National Cancer Data Base. Cancer Epidemiology, 49, 112-117. PMID: 28601784.

Buchta, C. M., Boi, S. K., Miller, B. J., Milhem, M. M. & Norian, L. A. (2017). Obesity does not exacerbate the protumorgenic systemic environment in sarcoma subjects. Immunohorizons, 1(4), 20-28. PMID: 29202127.

Guseva, N. V., Jaber, O., Tanas, M. R., Stence, A. A., Sompallae, R., Schade, J., Fillman, A. N., Miller, B. J., Bossler, A. D. & Ma, D. (2017). Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novel USP6 fusions and upregulation of USP6 expression in aneurysmal bone cyst. Genes Chromosomes Cancer, 56(4), 266-77. PMID: 27910166.

Duchman, K. R., Miller, B. J. (2017). Are Recently Trained Tumor Fellows Performing Less Tumor Surgery? An Analysis of 10 Years of the ABOS Part II Database. Clin Orthop Relat Res., 475(1), 221-8. PMID: 27511202.

Miller, B. J. (2017). CORR Insights: Is it appropriate to treat sarcoma metastases with intramedullary nailing?. (Vols. 475). (1), pp. 218-220. Clinical Orthopaedics & Related Research. PMID: 27832412.

Miller, B. J. (2017). CORR Insights: Survival in Mesenchymal Chondrosarcoma Varies based on age and tumor location: A survival analysis of the SEER database. (Vols. 475). (3), pp. 806-7. Clinical Orthopaedics & Related Research. PMID: 27048221.

Miller, B. J. (2016). CORR Insights: Reliability and validity of a Japanese-language and culturally adapted version of the Musculoskeletal Tumor Society Scoring System for the lower extremity. (Vols. 474). (9), pp. 2053-4. Clinical Orthopaedics & Related Research. PMID: 27380281.

Ries, Z., Gibbs, C. P., Scarborough, M. T. & Miller, B. J. (2016). Pulmonary surveillance strategies following sarcoma excision vary among orthopedic oncologists: A survey of the Musculoskeletal Tumor Society. Iowa Orthop J., 36, 109-116. PMID: 27528846.

Nystrom, L., Miller, B. J. (2016). Transcutaneous oximetry may predict wound healing complications in preoperatively radiated soft tissue sarcoma. Iowa Orthop J., 36, 117-122. PMID: 27528847.

Fullenkamp, C. A., Hall, S. L., Jaber, I. I., Pakalniskis, B. L., Savage, E. C., Savage, J. M., Ofori-Amanfo, G. K., Lambertz, A. M., Ivins, S. D., Stipp, C. S., Miller, B. J., Milhem, M. M. & Tanas, M. R. (2016). TAZ and YAP are frequently activated oncoproteins in sarcomas. Oncotarget, 7(21), 30094-108. PMID: 27129148.

Holt, J., Miller, B. J., Callaghan, J., Clark, C., Willenborg, M. & Noiseux, N. (2016). Minimizing blood transfusion in total hip and knee arthroplasty through a multimodal approach. J Arthroplasty, 31(2), 378-82. PMID: 26391927.

Miller, B. J. (2016). Acing the Orthopedic Board Exam. Thorofare, NJ: SLACK, Inc.

Miller, B. J. (2015). CORR Insights: Should high-grade extraosseous osteosarcoma be treated with multimodality therapy like other soft tissue sarcomas?. (Vols. 473). (11), pp. 3612-4. Clinical Orthopaedics and Related Research. PMID: 26310679.

Miller, B. J. (2015). Parity Investigators. Prophylactic antibiotic regimens in tumor surgery (PARITY): a pilot multicenter randomized controlled trial. Bone Joint Res, 4(10), 163-9. PMID: 26450640.

Duchman, K. R., Gao, Y. & Miller, B. J. (2015). Prognostic factors for survival in patients with high-grade osteosarcoma using the surveillance, epidemiology, and end results (SEER) program database. Cancer Epidemiology, 39(4), 593-9. PMID: 26002013.

Hoang, K., Gao, Y. & Miller, B. J. (2015). The variability of surgical margin reporting in limb salvage surgery for sarcoma. Iowa Orthopaedic Journal, 35, 181-6. PMID: 26361463.

Duchman, K. R., Gao, Y. & Miller, B. J. (2015). Prognostic factors for survival in patients with Ewing's sarcoma using the surveillance, epidemiology, and end results (SEER) program database. Cancer Epidemiology, 39(2), 189-95. PMID: 25595632.

Miller, B. J., Avedian, R. S., Rajani, R., Leddy, L., White, J. R., Cummings, J., Balach, T. & MacDonald, K. (2015). What is the Use of Imaging Prior to Referral to an Orthopaedic Oncologist? A Prospective, Multi-Center Investigation. Clin Orthop Relat, 473(3), 868-74. PMID: 24777726.

Miller, B. J., Rajani, R., Leddy, L., Carmody Soni, E. E. & White, J. R. (2015). The Musculoskeletal Oncology Research Initiative. How Much Tumor Surgery Do Early-career Orthopaedic Oncologists Perform?. Clin Orthop Relat, 473(2), 695-702. PMID: 25224820.

Miller, B. J., Callaghan, J. J., Cram, P., Karam, M., Marsh, J. L. & Noiseux, N. O. (2014). Changing Trends in the Treatment of Femoral Neck Fractures: A Review of the American Board of Orthopaedic Surgery Database. Journal of Bone and Joint Surgery Am, 96(17), 149. PMID: 25187593.

Jerath, N. U., Chen, J. J., Miller, B. J. & Reddy, C. G. (2014). Teaching NeuroImages: Intraneural Ganglion Cyst of the Tibial Nerve. Neurology, 174-5. PMID: 24843041.

Duchman, K. R., Lynch, C. F., Buckwalter, J. A. & Miller, B. J. (2014). Estimated Cause-Specific Survival Continues to Improve Over Time in Patients with Chondrosarcoma. Clin Orthop Relat Res.. PMID: 24706044.

Miller, B. J. (2014). Population-Based registries are important in Sarcoma: An Editorial Regarding: "Incidence patterns of primary bone cancer in Taiwan". Ann Surg Oncol.. PMID: 24743911.

Miller, B. J., Lynch, C. F. & Buckwalter IV, J. A. (2013). Conditional Survival of Osteosarcoma and Ewing’s Sarcoma. Clinical Orthopaedics and Related Research, 471(11), 3398-404. PMID: 23821136.

Miller, B. J., Lu, X. & Cram, P. (2013). The Trends in Management of Femoral Neck Fractures in the Medicare Population from 1991-2008. Journal of Bone and Joint Surgery – Am, 95(18 e132), 1-8. PMID: 24048563.

Miller, B. J., Cram, P., Lynch, C. F. & Buckwalter, J. A. (2013). Risk Factors at Presentation for Metastatic Osteosarcoma: An Analysis of the SEER Database. Journal of Bone and Joint Surgery Am, 95(13), e89.

Otero, J. E., Graves, C. M., TeKippe, A., Buckwalter, J. A. & Miller, B. J. (2013). Factors affecting outcomes in patients treated surgically for upper extremity tumors and tumor-like lesions. Iowa Orthop J, 33, 119-29. PMID: 24027471.

Nystrom, L. M., Buckwalter, J. A., Syrbu, S. & Miller, B. J. (2013). Serum Protein Electrophoresis in the Evaluation of Lytic Bone Lesions. Iowa Orthop J,(33), 114-8. PMID: 27027470.

Carmody Soni, E. E., Miller, B. J., Scarborough, M. T. & Parker Gibbs, C. (2012). Functional outcomes and gait analysis of patients after periacetabular sarcoma resection with and without ischiofemoral arthrodesis. J Surg Oncol, 106(7), 844-9. PMID: 22549842.

Miller, B. J. (2012). Prereferral MRI use in patients with musculoskeletal tumors is not excessive. Clin Orthop Relat Res, 470(11), 3240-5. PMID: 22610528[.

Miller, B. J., Cai, X. & Cram, P. (2012). Mortality Rates are Similar After Hip Fracture in Rural and Urban Patients. Clin Orthop Relat Res, 470(6), 1763-70. PMID: 22016000.

Cram, P., Cai, X., Lu, X., Vaughan-Sarrazin, M. S. & Miller, B. J. (2012). Total Knee Arthroplasty Outcomes in Top-Ranked and Non-Top-Ranked Orthopaedic Hospitals: An Analysis of Medicare Administrative Data. Mayo Clin Proc, 87(4), 341-8. PMID: 22469347.

Miller, B. J., Carmody Soni, E. E., Reith, J. D., Gibbs, C. P. & Scarborough, M. T. (2012). CT Scans for Pulmonary Surveillance May Be Overused in Lower-Grade Sarcoma. Iowa Orthop J., 32, 28-34. PMID: 23576918.

Carmody Soni, E. E., Miller, B. J., Scarborough, M. T., Reith, J. & Gibbs, C. P. (2011). Cyclooxygenase-2 expression is not associated with clinical outcome in synovial sarcoma. Oncol Rep., 26(6), 1513-7. PMID: 21874258.

Gaskins III, R. B., Miller, B. J. & Scarborough, M. T. (2011). Charcot arthropathy of shoulder: a case report. Orthop Surg, 3(4), 268-70. PMID: 22021145.

Cram, P., Lu, X., Kates, S. L., Li, Y. & Miller, B. J. (2011). Outliers: Hospitals with Consistently Lower and Higher Than Predicted Joint Arthroplasty Readmission Rates. Geriatric Orthopaedic Surgery and Rehabilitation, 2(4), 135-147. PMID: 23569683.

Miller, B. J., Soni, E. E., Gibbs, C. P. & Scarborough, M. T. (2011). Intramedullary Nails for Long Bone Metastases: Why Do They Fail?. Orthopedics, 34(4), 274. PMID: 21469628.

Nguyen, M., Miller, B. J. & Buckwalter IV, J. A. (2011). Patterns of improvement following oncologic reconstruction compared to total knee arthroplasty and revision knee arthroplasty. Iowa Orthop J, 31, 160-5. PMID: 22096436.

Gitelis, S., Nicholson, G. P., Virkus, W. W., Malawer, M. M. & Miller, B. J. (2011). Proximal Humerus Resection with Allograft Prosthetic Composite. In S. W. Wiesel (Eds.) Operative Techniques in Orthopaedic Surgery. pp. 1786-92. Philadelphia: Lippincott Williams & Wilkins.

Virkus, W. W., Henshaw, R. M., Miller, B. J. & Gitelis, S. (2011). Use of Allografts and Segmental Prostheses for Reconstruction of Segmental Bone Defects. In S. W. Wiesel (Eds.) Operative Techniques in Orthopaedic Surgery. pp. 1982-90. Philadelphia: Lippincott Williams & Wilkins.

Miller, B. J., Virkus, W. W. (2010). Intercalary Allograft Reconstructions Using a Compressible Intramedullary Nail: A Preliminary Report. Clin Orthop Relat Res.,(468), 2507-13. PMID: 20146034.

Virkus, W. W., Miller, B. J., Chye, P. C. & Gitelis, S. (2008). The Use of Locking Plates in Orthopaedic Oncology Reconstructions. Orthopedics, 31(5), 438. PMID: 19292328.

Martin, J. A., Miller, B. J., Scherb, M. B., Lembke, L. A. & Buckwalter IV, J. A. (2002). Co-localization of Insulin-Like Growth Factor Binding Protein 3 and Fibronectin in Human Articular Cartilage. Osteoarthritis Cartilage, 10(7), 556-63. PMID: 12127836.

Miller, B., Nystrom, L. Benign tumors of bone and soft tissue for Orthopaedic Knowledge Update 12. - currently with editor.