Ling Wang, MD, PhD
Introduction
Dr. Wang has joined the Department of Orthopedics and Rehabilitation since July 2021 from her prior position as a Research Assistant Professor in the Department of Medicine at University of Pittsburgh. Dr. Wang is currently a research faculty in Dr. Li’s lab. Dr. Wang has extensive basic research experience in cell and molecular biology and redox biology in vascular and pulmonary medicine. One of the major current focus of Dr. Wang’s research has been on the cellular and molecular mechanisms of nitrite mediated signaling pathway in the pathogenesis and treatment of muscular dystrophy. Dr. Wang is also actively investigating the molecular mechanisms that contribute to cardiovascular and musculoskeletal (osteoporosis and sarcopenia) complications in hemolytic anemias such as thalassemia and sickle cell disease. Dr. Wang enjoys cooking, hiking and watching movies with family in her spare time.
Current Positions
- Research Assistant Professor - Orthopedics and Rehabilitation
Education
- MD in Medicine, Fudan University, Shanghai, China
- PhD in Pulmonary Biology, Fudan University, Shanghai, China
- Resident in Internal Medicine, Shanghai Pulmonary Hospital, Shanghai, China
- Postdoctoral Fellow in Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee
- Postdoctoral Associate in Allergy, Pulmonary and Critical Care Medicine, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania
Selected Publications
- Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT. Reply: Better Studies Are Needed to Guide Treatment of Carbon Monoxide Poisoning. Am J Respir Crit Care Med. 2017;195(5):694-5. doi: 10.1164/rccm.201612-2463LE. PMID: 28248143. PMCID: PMC6850729. (Letter)
- Rose JJ, Xu Q, Wang L, Gladwin MT. Shining a Light on Carbon Monoxide Poisoning. Am J Respir Crit Care Med. 2015;192(10):1145-7. doi: 10.1164/rccm.201508-1579ED. PMID: 26568235. PMCID: PMC4731625. (Editorial)
- Wang L, Qian B, Mokhberian N, Li H. Activated satellite cells in dystrophic skeletal muscle secrete FGF21 to negatively regulate bone homeostasis.
- Wang L, Sun H, Xu J, Graham E, Sherrier M, Hogan M, Gladwin M, Li H. Splenectomy exaggerates bone loss in a thalassemia mouse model.
- Wang L, Hicks J, Qian B, Zhou S, LaBaze, Miller J, Hogan M, Li H. Sodium nitrite mitigates skeletal muscle and bone phenotypes in dystrophic mice.
- Zuchelkowski BE, Wang L, Gingras S, Xu Q, Yang M, Triulzi D, Page GP, Gordeuk VR, Kim-Shapiro DB, Lee JS, Gladwin MT. Brief Report: Hydroxychloroquine does not induce hemolytic anemia or organ damage in a "humanized" G6PD A- mouse model. PLoS One. 2020;15(10):e0240266. doi: 10.1371/journal.pone.0240266. PMID: 33007039. PMCID: PMC7531777.
- Li H, Sun H, Qian B, Feng W, Carney D, Miller J, Hogan MV, Wang L. Increased Expression of FGF-21 Negatively Affects Bone Homeostasis in Dystrophin/Utrophin Double Knockout Mice. J Bone Miner Res. 2020 Apr;35(4):738-752. doi: 10.1002/jbmr.3932. PMID: 31800971.
- Wang L*, Sparacino-Watkins CE*, Wang J, Wajih N, Varano P, Xu Q, Cecco E, Tejero J, Soleimani M, Kim-Shapiro DB, Gladwin MT. Carbonic anhydrase II does not regulate nitrite-dependent nitric oxide formation and vasodilation. Br J Pharmacol. 2020 Feb;177(4):898-911. doi: 10.1111/bph.14887. PMID: 31658361. PMCID: PMC7024708. (*co-corresponding author)
- Zhou S, Qian B, Wang L, Zhang C, Hogan MV, Li H. Altered bone-regulating myokine expression in skeletal muscle Of Duchenne muscular dystrophy mouse models. Muscle Nerve. 2018 Oct;58(4):573-582. doi: 10.1002/mus.26195. PMID: 30028902.
- Azarov I*, Wang L*, Rose JJ*, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Sci Transl Med. 2016 Dec 7;8(368):368ra173. doi: 10.1126/scitranslmed.aah6571. PMID: 27928027. PMCID: PMC5206801. (*co-first author)