The goal of the Welsh Lab is to explore problems at a fundamental level and carry the work to humans.  

Cystic fibrosis (CF) pathogenesis and therapies. 

Pseudomonas biofilm on mouse trachea

CF is a common, life-shortening genetic disease caused by mutations in the gene that encodes the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel.  We are learning how the CFTR anion channel is regulated and how mutations disrupt its function.  Lung disease is the major cause of morbidity and mortality in people who have CF.  We are working to understand the lung’s normal defense mechanisms and how loss of CFTR impairs those protective systems.  Our desire is to use this knowledge to develop novel treatments and assays for people who have CF. The results of our research also have implications for other lung diseases.

To appreciate the scope of our work and the tools we use, please see our publications.