W. S. Moye-Rowley, PhD

Portrait
Professor of Molecular Physiology and Biophysics
Professor of Internal Medicine

Contact Information

Primary Office
6-530 BSB
51 Newton Road
Iowa City, IA 52242
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Education

BS, Biochemistry, University of Illinois
PhD, Biochemistry, Purdue University

Education/Training Program Affiliations

Department of Molecular Physiology and Biophysics PhD, Interdisciplinary Graduate Program in Genetics, Interdisciplinary Graduate Program in Molecular Medicine, Medical Scientist Training Program

Research Summary

Our laboratory has two primary research interests centered on transcriptional control of gene expression. The first involves the study of the function of a yeast transcriptional regulatory protein. This yeast protein was designated Yap1p by virtue of its homology with a mammalian proto-oncoprotein, c-Jun. c-Jun is a component of a complex DNA binding activity present in animal cells referred to as AP-1. We have constructed yeast strains in which the normal YAP1 gene has been deleted. These yap1 mutant yeast cells were found to be hypersensitive to oxidative stress agents. Additionally, it has been found that transcriptional activity of Yap1p is stimulated by oxidative stress. We are dissecting the molecular events that lead to the activation of Yap1p function using a combination of genetics, molecular biology and biochemistry. The second area of investigation concerns the ability of particular mutant strains of yeast to simultaneously acquire resistance to several cytotoxic drugs with unrelated actions. This phenomenon, called pleiotropic drug resistance (Pdr) in yeast, is related to the multidrug resistance phenotype shown by mammalian tumor cells. Multidrug resistance is a major problem in chemotherapeutic treatment of cancer patients. We will use Pdr in yeast as a model for the mammalian phenotype to gain insight into the molecular events involved in eliciting multidrug resistance.

Publications

Khakhina, S., Johnson, S. S., Manoharlal, R., Russo, S. B., Blugeon, C., Lemoine, S., Sunshine, A. B., Dunham, M. J., Cowart, L. A., Devaux, F. & Moye-Rowley, W. S. (2015). Control of Plasma Membrane Permeability by ABC Transporters. Eukaryotic cell, 14(5), 442-53. PMID: 25724885.

Paul, S., Bair, T., McDonald, H. & Moye-Rowley, W. S. (2015). Function and regulation of the Candida glabrata Pdr1 transcription factor. Asilomar, CA: 28th Fungal Genetics Conference.

Paul, S., Doering, T. L. & Moye-Rowley, W. S. (2015). Cryptococcus neoformans Yap1 is required for normal fluconazole and oxidative stress resistance. Fungal Genet Biol, 74, 1-9. DOI: 10.1016/j.fgb.2014.10.015.

Moye-Rowley, W. S. (2015). Multiple mechanisms contribute to the development of clinically significant azole resistance in Aspergillus fumigatus. Front Microbiol, 6, 70. DOI: 10.3389/fmicb.2015.00070.

Paul, S., Bair, T. B. & Moye-Rowley, W. S. (2014). Identification of genomic binding sites for Candida glabrata Pdr1 transcription factor in wild-type and rho0 cells. Antimicrob Agents Chemother, 58(11), 6904-12. DOI: 10.1128/aac.03921-14.

Paul, S., Moye-Rowley, W. S. (2014). Multidrug resistance in fungi: regulation of transporter-encoding gene expression. Front Physiol, 5, 143. DOI: 10.3389/fphys.2014.00143.

Paul, S., Diekema, D. & Moye-Rowley, W. S. (2013). Contributions of Aspergillus fumigatus ATP-binding cassette transporter proteins to drug resistance and virulence. Eukaryot Cell, 12(12), 1619-28. DOI: 10.1128/ec.00171-13.

Paul, S., Moye-Rowley, W. S. (2013). Functional analysis of an ATP-binding cassette transporter protein from Aspergillus fumigatus by heterologous expression in Saccharomyces cerevisiae. Fungal Genet Biol, 57, 85-91. DOI: 10.1016/j.fgb.2013.06.004.

Kieler, J. B., Duong, K. L., Moye-Rowley, W. S. & Klutts, J. S. (2013). Targeted gene deletion in Aspergillus fumigatus using microbial machinery and a recyclable marker. J Microbiol Methods, 95(3), 373-8. DOI: 10.1016/j.mimet.2013.09.021.

Manoharlal, R., Johnson, S. S. & Moye-Rowley, W. S. (2012). Regulation of the Target of Rapamycin Complexes 1 and 2 (TORC1 and TORC2) by the plasma membrane ABC transporters Pdr5 and Yor1. Princeton, New Jersey: Yeast Genetics Meeting.

Paul, S., Klutts, J. S. & Moye-Rowley, W. S. (2012). Analysis of promoter function in Aspergillus fumigatus. Eukaryot Cell, 11(9), 1167-77. DOI: 10.1128/ec.00174-12.

Moye-Rowley, W. S., Paul, S. & Klutts, J. S. (2012). Differential oxidant tolerance determined by the key transcription factor Yap1 is controlled by levels of the Yap1-binding protein, Ybp1.

Moye-Rowley, W. S., Gulshan, K. & Thommandru, B. (2012). Proteolytic degradation of the Yap1 transcription factor is regulated by subcellular localization and the E3 ubiquitin ligase Not4. J Biol Chem., 287, 26796-26805.

Moye-Rowley, W. S., Morano, K. A. & Grant, C. M. (2012). The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae.

Moye-Rowley, W. S., Gulshan, K. & Lee, S. S. (2011). Differential oxidant tolerance determined by the key transcription factor Yap1 is controlled by levels of the Yap1-binding protein, Ybp1. J Biol Chem., 286, 340721-34081.

Moye-Rowley, W. S., Paul, S. & Schmidt, J. A. (2011). Regulation of the CgPdr1 transcription factor from the pathogen Candida glabrata.

Moye-Rowley, W. S., Gulshan, K. (2011). Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1.

Johnson, S. S., Hanson, P. K., Brice, S. E., Cowart, L. A. & Moye-Rowley, W. S. (2010). ABC transporters and a 7 transmembrane receptor-like protein control endocytosis of the Tat2 tryptophan permease. Vancouver, Canada: Yeast Genetics Meeting.

Paul, S., Schmidt, J. A. & Moye-Rowley, W. S. (2010). Control of drug resistance in Candida glabrata. Vancouver, Canada: Yeast Genetics Meeting.

Gulshan, K., Moye-Rowley, W. S. (2010). The vacuolar ABC transporter Ybt1 regulates phosphatidylcholine trafficking in yeast. Vancouver, Canada: Yeast Genetics Meeting.

Moye-Rowley, W. S., Gulshan, K. & Shahi, P. (2010). Compartment-specific synthesis of phosphatidylethanolamine is required for normal heavy metal resistance.

Moye-Rowley, W. S., Shahi, P., Gulshan, K. & Naar, A. M. (2010). Differential Roles of Transcriptional Mediator Subunits in Regulation of Multidrug Resistance Gene Expression in Saccharomyces cerevisiae.

Moye-Rowley, W. S., Johnson, S. S., Hanson, P. K., Manoharlal, R., Brice, S. E. & Cowart, L. A. (2010). Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven transmembrane protein, RSB1. J Biol Chem., 285(46), 35792-802.

Shahi, P., Moye-Rowley, W. S. (2009). Coordinate control of lipid composition and drug transport activities is required for normal multidrug resistance in fungi. Biochim Biophys Acta, 1794(5), 852-9. DOI: 10.1016/j.bbapap.2008.12.012.

Moye-Rowley, W. S., Shahi, P. (2009). Coordinate control of lipid composition and drug transport activities is required for normal multidrug resistance in fungi BBA.

Shahi, P., Moye-Rowley, W. S. (2008). Key role of mediator subunits module in retrograde signaling. Toronto, Canada: Yeast Genetics Meeting.

Lee, S., Moye-Rowley, W. S. (2008). The functional role of Ybp1p in Yap1p-mediated oxidative stress response. Toronto, Canada: Yeast Genetics Meeting.

Moye-Rowley, W. S., Thakur, J. K., Arthanari, H., Yang, F., Pan, S., Fan, X., Breger, J., Frueh, D. P., Gulshan, K., Li, D., Mylonakis, E., Struhl, K., Cormack, B. P., Wagner, G. & Naar, A. M. (2008). A nuclear receptor-like pathway regulating multidrug resistance in fungi.

Moye-Rowley, W. S., Kolaczkowska, A., Kolaczkowski, M. & Goffeau, A. (2008). Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae.

Moye-Rowley, W. S., Gulshan, K., Schmidt, J. A. & Shahi, P. (2008). Evidence for the bifunctional nature of mitochondrial phosphatidylserine decarboxylase: role in Pdr3-dependent retrograde regulation of PDR5 expression.

Riley, S., Moye-Rowley, W. S. (2007). A regulatory connection between genes involved in sphingolipid biosynthesis. Cold Spring Harbor, NY: Yeast Cell Biology Meeting.

Moye-Rowley, W. S., Gulshan, K. (2007). Multidrug resistance in fungi.

Moye-Rowley, W. S., Shahi, P. & Gulshan, K. (2007). Negative transcriptional regulation of multidrug resistance gene expression by an Hsp70 protein. J. Biol. Chem., 282, 26822-26831.

Gulshan, K., Schmidt, J. A., Shahi, P. & Moye-Rowley, W. S. (2007). Positive regulation of the pleiotropic drug resistance pathway by the bifunctional enzyme Psd1p. Cold Spring Harbor, NY: Yeast Cell Biology Meeting.

Gulshan, K., Moye-Rowley, W. S. (2006). Compartment-specific synthesis of phospholipids serves as a regulatory signal for expression of multidrug resistance genes. Princeton, New Jersey: Yeast Genetics Meeting.

Riley, S., Moye-Rowley, W. S. (2006). Coordinate control of multidrug resistance and sphingolipid biosynthesis. Princeton, New Jersey: Yeast Genetics Meeting.

Shahi, P., Moye-Rowley, W. S. (2006). Negative regulation of transcription factor Pdr3p activity by the Hsp70 protein Ssa1p. Princeton, New Jersey: Yeast Genetics Meeting.

Moye-Rowley, W. S., Panwar, S. L. (2006). Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria. J Biol Chem., 281, 6376-6384.

Moye-Rowley, W. S. (2006). Redox sensing and histidine oxidation: no longer PerR-fect strangers.

Moye-Rowley, W. S., Kraemer, S. M., Goldstrohm, D. A., Berger, A., Hankey, S., Rovinsky, S. A. & Stargell, L. A. (2006). TFIIA plays a role in the response to oxidative stress.

Moye-Rowley, W. S., Gulshan, K., Rovinsky, S. A. & Coleman, S. T. (2005). Oxidant-specific folding of YAP1P regulates both transcriptional activation and nuclear localization. J Biol Chem., 280, 40524-40533.

Moye-Rowley, W. S. (2005). Retrograde Regulation of Multidrug Resistance in Saccharomyces cerevisiae.

Moye-Rowley, W. S., Zhang, X., Kolaczkowska, A., Devaux, F., Panwar, S. L., Hallstrom, T. C. & Jacq, C. (2005). Transcriptional regulation by Lge1p requires a function independent of its role in H2B ubiquitination. J. Biol. Chem., 280, 2759-2770.

Gulshan, K., Rovinsky, S. & Moye-Rowley, W. S. (2004). Context-dependent oxidative stress inducibility of Yap1p-responsive genes. Seattle, Washington: Yeast Genetics Meeting.

Zhang, X., Kolaczkowska, A., Devaux, F., Panwar, S., Scoville, H., Hallstrom, T., Jacq, C. & Moye-Rowley, W. S. (2004). Retrograde regulation of the multidrug transporter gene PDR5 requires Lge1p, a multifunctional component of the histone H2B ubiquitinating complex. Seattle, Washington: Yeast Genetics Meeting.

Moye-Rowley, W. S., Kolaczkowski, M., Kolaczkowska, A., Gaigg, B. & Schneiter, R. (2004). Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae.

Moye-Rowley, W. S., Gulshan, K. & Rovinsky, S. A. (2004). YBP1 and its homologue YBP2/YBH1 influence oxidative stress tolerance by non-identical mechanisms in Saccharomyces cerevisiae.

Moye-Rowley, W. S. (2003). Regulation of the transcriptional response to oxidative stress response in fungi: similarities and differences.

Zhang, X., Kolaczkowska, A., Devaux, F., Hallstrom, T., Jacq, C. & Moye-Rowley, W. S. (2003). Retrograde regulation of the multidrug transporter gene PDR5 requires Lge1p, a multifunctional component of the histone H2B ubiquitinating complex. Cold Spring Harbor, NY: Yeast Cell Biology Meeting.

Moye-Rowley, W. S. (2003). Transcriptional control of multidrug resistance in the yeast Saccharomyces. In K. Moldave (Eds.) Progress in Nucleic Acid Research and Molecular Biology. pp. 251-279. Prog. Nucleic Acids Res. Mol. Biol..

Kolaczkowski, M., Zhang, X. & Moye-Rowley, W. S. (2002). Activation of LAC1, encoding ceramide synthase, by the yeast multidrug resistance regulator Pdr3p in response to mitochondrial dysfunction. Madison, Wisconsin: Yeast Genetics Meeting.

Rovinsky, S. A., Moye-Rowley, W. S. (2002). Genomic screen reveals genes required for normal Yap1p trafficking during oxidant challenge in S. cerevisiae. Madison, Wisconsin: Yeast Genetics Meeting.

Enriquez-Freire, E., Moye-Rowley, W. S. (2002). Genomic screen to recover negative regulators of pleiotropic drug resistance in Saccharomyces cerevisiae. Madison, Wisconsin: Yeast Genetics Meeting.

Zhang, X., Kolaczkowska, A., Tekippe, J. & Moye-Rowley, W. S. (2002). Ypl055cp functions downstream from Pdr3p during retrograde regulation of PDR5 transcription. Madison, Wisconsin: Yeast Genetics Meeting.

Moye-Rowley, W. S., Devaux, F., Carvajal, E. & Jacq, C. (2002). Genome-wide studies on the nuclear PDR3-controlled response to mitochondrial dysfunction in yeast.

Moye-Rowley, W. S., Epping, E. A. (2002). Identification of interdependent signals required for anterograde traffic of the ATP-binding cassette transporter protein Yor1p. J. Biol. Chem., 277, 38460-38469.

Moye-Rowley, W. S., LeCrom, S., Devaux, F., Marc, P., Zhang, X. & Jacq, C. (2002). New insights into the pleiotropic drug resisance network from genome-wide characterization of the YRR1 transcription factor. (Vols. 22). pp. 2642-2649. Mol. Cell. Biol..

Moye-Rowley, W. S. (2002). Transcription factors regulating the response to oxidative stress in yeast.

Moye-Rowley, W. S., Hallstrom, T. C., Lambert, L., Schorling, S., Balzi, E. & Goffeau, A. (2001). Coordinate control of sphingolipid biosynthesis and multidrug resistance in Saccharomyces cerevisiae. J. Biol. Chem., 276, 23674-23680.

Moye-Rowley, W. S., Zhang, X., Cui, Z. & Miyakawa, T. (2001). Crosstalk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae. J. Biol. Chem., 276, 8812-8819.

Moye-Rowley, W. S., Coleman, S. T., Fang, T. K., Rovinsky, S. A. & Turano, F. J. (2001). Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J. Biol. Chem., 276, 244-250.

Zhang, X., Hallstrom, T. C. & Moye-Rowley, W. S. (2001). Fo status regulates multidrug resistance in Saccharomyces cerevisiae. In Yeast Cell Biology Meeting. Cold Spring Harbor, NY.

Moye-Rowley, W. S., Zhang, X. (2001). Saccharomcyes cerevisiae multidrug resistance gene expression inversely correlates with the status of the Fo component of the mitochondrial ATPase. J. Biol. Chem., 276, 47844-47852.

Epping, E. A., Moye-Rowley, W. S. (2001). Structural determinants for localization of the ABC transporter Yor1p. Cold Spring Harbor, NY: Yeast Cell Biology Meeting.

Epping, E. A., Moye-Rowley, W. S. (2000). Intracellular trafficking of the ABC transporter Yor1p. Seattle, Washington: Yeast Genetics Meetingx.

Hallstrom, T. C., Moye-Rowley, W. S. (2000). Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. Seattle, Washington: Yeast Genetics Meeting.

Coleman, S. T., Rovinsky, S., Baxa, B. & Moye-Rowley, W. S. (2000). Oxidant-specific gene regulation by Yap1p. Seattle, Washington: Yeast Genetics Meeting.

Zhang, X., Cui, Z., Miyakawa, T. & Moye-Rowley, W. S. (2000). Regulation and function of the zinc cluster transcription factor Yrr1p. Seattle, Washington: Yeast Genetics Meeting.

Moye-Rowley, W. S., Zhang, X., de Micheli, M., Coleman, S. T. & Sanglard, D. (2000). Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p.

Moye-Rowley, W. S., 34. Hallstrom, T. C. (2000). Hyperactive forms of the Pdr1p transcription factor fail to respond to positive regulation by the Hsp70 protein Pdr13p.

Moye-Rowley, W. S., Hallstrom, T. C. (2000). Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. J. Biol. Chem., 275, 37347-37356.

Epping, E. A., Katzmann, D. J. & Moye-Rowley, W. S. (1999). Intracellular trafficking of the ABC transporter Yor1p. Cold Spring Harbor, NY: Yeast Cell Biology Meeting.

Moye-Rowley, W. S., Katzmann, D. J. & Epping, E. A. (1999). Mutational disruption of plasma membrane trafficking of Saccharomyces cerevisiae Yor1p, a homologue of mammalian multidrug resistance protein.

Moye-Rowley, W. S., Coleman, S. T., Epping, E. A. & Steggerda, S. M. (1999). Yap1p activates gene transcription in an oxidant-specific fashion.

Katzmann, D. J., Epping, E. A. & Moye-Rowley, W. S. (1998). Mutational disruption of plasma membrane trafficking of the Saccharomyces cerevisiae ABC transporter Yor1p. Ames, Iowa: Symposium on Endocytosis and Intracellular Trafficking.

Hallstrom, T. C., Max, S. & Moye-Rowley, W. S. (1998). Control of transcription factor Pdr1p function by a Hsp70 protein. College Park, Maryland: Yeast Genetics Meeting.

Coleman, S. T., Epping, E. A., Steggerda, S. M. & Moye-Rowley, W. S. (1998). Molecular mechanism of yAP-1-dependent oxidative stress tolerance. College Park, Maryland: Yeast Genetics Meeting.

Zhang, X., Cui, Z., Miyakawa, T. & Moye-Rowley, W. S. (1998). Multiple Cys6 zinc cluster transcription factors regulate multidrug resistance in Saccharomyces cerevisae. College Park, Maryland: Yeast Genetics Meeting.

Moye-Rowley, W. S., Hallstrom, T. C. (1998). Divergent transcriptional control of multidrug resistance genes in Saccharomyces cerevisiae. J. Biol. Chem., 273, 2098-2104.

Moye-Rowley, W. S., Hallstrom, T. C., Katzmann, D. J., Torres, R. J. & Sharp, W. J. (1998). Regulation of transcription factor Pdr1p function by a Hsp70 protein in Saccharomyces cerevisae.

Hallstrom, T. C., Katzmann, D. J., Sharp, W. J., Torres, R. J. & Moye-Rowley, W. S. (1997). Control of transcription factor function by a Hsp70 protein. Cold Spring Harbor, NY: Yeast Cell Biology Meeting.

Moye-Rowley, W. S., Wemmie, J. A. (1997). Mutational analysis of the Saccharomyces cerevisiae ATP-binding cassette transporter protein Ycf1p.

Moye-Rowley, W. S., Coleman, S. T. & Tseng, E. (1997). Saccharomyces cerevisiae basic region-leucine zipper protein regulatory networks converge at the ATR1 gene. J. Biol. Chem., 272, 23224-23230.

Moye-Rowley, W. S., Wemmie, J. A. & Steggerda, S. M. (1997). The Saccharomyces cerevisiae AP-1 protein discriminates between oxidative stress elicited by the oxidants H2O2 and diamide. J. Biol. Chem., 272, 7908-7914.

Hallstrom, T. C., Moye-Rowley, W. S. (1996). Control of YOR1 transcription by Pdr1p. Madison, WI: Yeast Genetics Meeting.

Katzmann, D. J., Moye-Rowley, W. S. (1996). The yeast ABC transporter YOR1 confers resistance to oligomycin. Madison, WI: Yeast Genetics Meeting.

Steggerda, S., Wemmie, J. A. & Moye-Rowley, W. S. (1996). Transcriptional control of the response to oxidative stress in S. cerevisiae by the yAP-1 protein. Madison, WI: Yeast Genetics Meeting.

Coleman, S. T., Tsung, E. & Moye-Rowley, W. S. (1996). YAP1-mediated transactivation of ATR1 confers resistance to cyytotoxic compounds 4-NQO and 3-AT. Madison, WI: Yeast Genetics Meeting.

Katzmann, D. J., Hallstrom, T. C. & Moye-Rowley, W. S. (1996). The yeast ABC transporter YOR1 confers resistance to oligomycin. Park City, UT: Keystone Symposium “The molecular basis for drug resistance in bacteria, parasites and fungi".

Moye-Rowley, W. S., Katzmann, D. J., Hallstrom, T. C. & Mahé, Y. (1996). Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5. J. Biol. Chem., 271, 23049-23054.

Moye-Rowley, W. S., Wu, A. & Hallstrom, T. C. (1996). ROD1, a novel gene conferring multiple resistance phenotypes in Saccharomyces cerevisiae. J. Biol. Chem, 271, 2914-2920.

Wemmie, J. A., Moye-Rowley, W. S. (1995). Function of a yeast vacuolar ABC transporter protein. Cold Spring Harbor, NY: Yeast Cell Biology.

Moye-Rowley, W. S., McGuire, T., Carvajal, E., Katzmann, D. J., Wagner, M., Goffeau, A. & Golin, J. (1995). Analysis of second site mutations that suppress the multiple drug resistance phenotype of the yeast PDR1-7 allele.

Moye-Rowley, W. S., Olson, A. L., Edgington, N. P. & Pessin, J. E. (1995). Characterization of 5'-heterogeneity of the rat GLUT4/muscle-adipose glucose transporter gene product.

Moye-Rowley, W. S., Katzmann, D. J., Hallstrom, T. C., Voet, M., Wysock, W., Golin, J. & Volckaert, G. (1995). Expression of an ATP-binding cassette transporter encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae.

Moye-Rowley, W. S., Decottignies, A., Lambert, L., Catty, P., Degand, H., Epping, E. A., Balzi, E. & Goffeau, A. (1995). Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. J. Biol. Chem., 270, 18150-18157.

Moye-Rowley, W. S., Liang, J. & Maurer, R. A. (1995). In vivo mutational analysis of the DNA binding domain of the tissue-specific transcription factor, Pit-1. J. Biol. Chem., 270, 25520-25525.

Wu, A. L., Moye-Rowley, W. S. (1994). Control of the o-dinitrobenzene resistance by yAP-1. Yeast Genetics Meeting.

Katzmann, D. J., Mahé, Y. & Moye-Rowley, W. S. (1994). Regulation of the PDR5 gene by the PDR1 and PDR3 gene products. Yeast Genetics Meeting.

Steggerda, S., Wemmie, J. A. & Moye-Rowley, W. S. (1994). YAP1 is a key mediator of oxidative stress tolerance. Yeast Genetics Meeting.

Wemmie, J. A., Moye-Rowley, W. S. (1994). Ycf1p, a yeast ABC transporter, confers resistance to diamide. Yeast Genetics Meeting.

Moye-Rowley, W. S., Szczypka, M. S., Wemmie, J. A. & Thiele, D. J. (1994). A yeast metal resistance protein similar to human CFTR and multidrug resistance-associated protein. J. Biol. Chem., 269, 22853-22857.

Moye-Rowley, W. S., Wu, A. (1994). GSH1, encoding ?-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation.

Moye-Rowley, W. S., Dexter, D., Wu, A. & Golin, J. (1994). Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic drug resistance loci affect the transcript level of an ABC transporter-encoding gene, PDR5.

Moye-Rowley, W. S., Liu, M., Olson, A. L., Edgington, N. P. & Pessin, J. E. (1994). Myocyte enhancer factor 2 (MEF2) binding site is essential for C2C12 myotube-specific expression of the rat GLUT4/muscle-fat facilitative glucose transporter gene. J. Biol. Chem., 269, 28514-28521.

Moye-Rowley, W. S., Holt, K. H., Olson, A. L. & Pessin, J. E. (1994). Phosphatidyinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits.

Moye-Rowley, W. S., Wemmie, J. A., Szczypka, M. S. & Thiele, D. J. (1994). The yeast AP-1 protein activates the expression of an ATP binding cassette transporter-encoding gene, YCF1. J. Biol. Chem., 269, 32592-32597.

Moye-Rowley, W. S., Wemmie, J., Wu, A., Harshman, K. & Parker, C. S. (1994). Transcriptional activation mediated by the yeast AP-1 protein is required for normal cadmium tolerance. J. Biol. Chem., 269, 14690-14697.

Moye-Rowley, W. S., Katzmann, D. J., Burnett, P. E., Golin, J. & Mahé, Y. (1994). Transcriptional control of the yeast PDR5 gene by the PDR3 gene product.

Wu, A., Moye-Rowley, W. S. (1993). Characterization of genes involved in heavy metal tolerance. Yeast Genetics Meeting.

Wemmie, J., Szczypka, M., Thiele, D. J. & Moye-Rowley, W. S. (1993). Transcriptional activation of an ABC transporter-encoding gene by the yeast AP-1 protein is required for normal cadmium tolerance. Yeast Genetics Meeting.

Burnett, P. E., Moye-Rowley, W. S. (1993). Transcriptional control of the pleiotropic drug resistance gene PDR5. Yeast Genetics Meeting.

Szczypka, M., Wemmie, J., Moye-Rowley, W. S. & Thiele, D. J. (1993). YCF1, a gene important for cadmium tolerance in S. cerevisiae. Yeast Genetics Meeting.

Moye-Rowley, W. S., Olson, A. L., Liu, M., Buse, J. B., Bell, G. I. & Pessin, J. E. (1993). Hormonal/Metabolic regulation of the human GLUT4/Muscle-Fat facilitative glucose thransporter gene in transgenic mice. J. Biol. Chem., 268, 9839-9846.

Moye-Rowley, W. S., Wu, A., Wemmie, J. A., Edgington, N., Guevara, J. C. & Goebl, M. (1993). Yeast bZip proteins mediate pleiotropic drug and metal resistance. J. Biol. Chem., 268, 18850-18858.

Olson, A. L., Edginton, N. P. & Moye-Rowley, W. S. (1992). Structure of the rat GLUT4 gene. American Diabetes Association Annual Meeting.

Moye-Rowley, W. S., Liu, M., Olson, A. L., Buse, J. B., Bell, G. I. & Pessin, J. E. (1992). Expression and regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice. J. Biol. Chem., 267, 11673-11676.

Moye-Rowley, W. S., Zhang-Keck, Z. Y., Kibbe, W. A. & Parker, C. S. (1991). The SV40 core sequence functions as a repressor element in yeast. J. Biol. Chem., 263, 21362-21367.

Moye-Rowley, W. S., Ding, Y., Lu, W., Roberson, M. S. & Maurer, R. A. (1991). The tissue-specific mammalian transcription factor, Pit-1, activates transcription in Saccharomyces cerevisiae.

Moye-Rowley, W. S., Harshman, K. D. & Parker, C. S. (1989). Yeast YAP1 encodes a novel form of the jun-family of transcriptional activator proteins.

Moye-Rowley, W. S., Harshman, K. D. & Parker, C. S. (1988). Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4.

Moye-Rowley, W. S., Harshman, K. D. & Parker, C. S. (1988). YAP1 encodes a yeast homolog of mammalian transcription factor AP-1.

Moye-Rowley, W. S., Zalkin, H. (1987). Roles of the TGACT repeat sequence in the yeast TRP5 promoter. J. Biol. Chem., 262, 3609-3614.

Moye-Rowley, W. S., Zalkin, H. (1985). Deletion mapping the yeast TRP5 control region. J. Biol. Chem., 260, 4718-4723.

Moye-Rowley, W. S., Amuro, N., Rao, J. & Zalkin, H. (1985). Nucleotide sequence of yeast GDH1 encoding NADP-dependent glutamate dehydrogenase. J. Biol. Chem., 260, 8502-8508.

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