Andrew Russo, PhD
Introduction
My research interest is to understand how neurons respond to changes in their environment. We have focused on regulation of CGRP and its actions in the context of trigeminal-mediated disorders, especially migraine. A recent focus of the lab is a CGRP-sensitized transgenic mouse model we generated based on clinical reports that injection of CGRP is able to induce a migraine, but not in people who do not suffer from migraine. These sensitized mice overexpress the RAMP1 subunit of the CGRP receptor in the nervous system. The RAMP1 mice have elevated CGRP-induced neurogenic inflammation, mechanical allodynia, and light aversion analogous to photophobia. In collaborative projects, the lab is also studying the beneficial effects of CGRP and RAMP1 against hypertension and obesity, with overall goals to develop effective diagnostic and therapeutic strategies for neurovascular disorders.
Current Positions
- Professor of Molecular Physiology and Biophysics
- Professor of Neurology
- Research Health Science Specialist, Director of Animal Research
Education
- BA in Biology (concentrations in biochemistry and microbiology), University of California
- PhD in Biochemistry, University of California
- Postdoctoral Fellow in Molecular Neurobiology, Department of Medicine, UCSD
Graduate Program Affiliations
Center, Program and Institute Affiliations
Research Interests
- Molecular basis of migraine
Selected Publications
- Zorrilla E, Della Pietra A, Russo AF. Interplay between cannabinoids and the neuroimmune system in migraine. J Headache Pain. 2024 Oct 16;25(1):178. doi: 10.1186/s10194-024-01883-3. PMID: 39407099; PMCID: PMC11481476.
- Ashina H, Christensen RH, Hay DL, Pradhan AA, Hoffmann J, Reglodi D, Russo AF, Ashina M. Pituitary adenylate cyclase-activating polypeptide signalling as a therapeutic target in migraine. Nat Rev Neurol. 2024 Nov;20(11):660-670. doi: 10.1038/s41582-024-01011-4. Epub 2024 Sep 10. PMID: 39256637.
- Schwedt TJ, Pradhan AA, Oshinsky ML, Brin MF, Rosen H, Lalvani N, Charles A, Ashina M, Do TP, Burstein R, Gelfand AA, Dodick DW, Pozo-Rosich P, Lipton RB, Ailani J, Szperka CL, Charleston L 4th, Digre KB, Russo AF, Buse DC, Powers SW, Tassorelli C, Goadsby PJ; Headache Research Priorities Working Group Members. The headache research priorities: Research goals from the American Headache Society and an international multistakeholder expert group. Headache. 2024 Sep;64(8):912-930. doi: 10.1111/head.14797. Epub 2024 Aug 16. PMID: 39149968.
- Russo AF, Iliff JJ. A new path to migraine. Science. 2024 Jul 5;385(6704):28-29. doi: 10.1126/science.adq3498. Epub 2024 Jul 4. PMID: 38963860.
- Kuburas A, Russo AF. Shared and independent roles of CGRP and PACAP in migraine pathophysiology. J Headache Pain. 2023 Apr 3;24(1):34. doi: 10.1186/s10194-023-01569-2. PMID: 37009867; PMCID: PMC10069045.
- Hendrikse ER, Rees TA, Tasma Z, Garelja ML, Siow A, Harris PWR, Pawlak JB, Caron KM, Blakeney ES, Russo AF, Sowers LP, Lutz TA, Le Foll C, Walker CS, Hay DL. Characterization of Antibodies against Receptor Activity-Modifying Protein 1 (RAMP1): A Cautionary Tale. Int J Mol Sci. 2022 Dec 16;23(24):16035. doi: 10.3390/ijms232416035. PMID: 36555690; PMCID: PMC9787598.
- Russo AF, Hay DL. CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond. Physiol Rev. 2023 Apr 1;103(2):1565-1644. doi: 10.1152/physrev.00059.2021. Epub 2022 Dec 1. PMID: 36454715; PMCID: PMC9988538.
- Wang M, Tutt JO, Dorricott NO, Parker KL, Russo AF, Sowers LP. Involvement of the cerebellum in migraine. Front Syst Neurosci. 2022 Oct 13;16:984406. doi: 10.3389/fnsys.2022.984406. PMID: 36313527; PMCID: PMC9608746.
- Ailani J, Kaiser EA, Mathew PG, McAllister P, Russo AF, Vélez C, Ramajo AP, Abdrabboh A, Xu C, Rasmussen S, Tepper SJ. Role of Calcitonin Gene-Related Peptide on the Gastrointestinal Symptoms of Migraine-Clinical Considerations: A Narrative Review. Neurology. 2022 Nov 7;99(19):841-853. doi: 10.1212/WNL.0000000000201332. PMID: 36127137; PMCID: PMC9651456.
- Brain SD, Russo AF, Hay DL. Editorial: Calcitonin Gene-Related Peptide: Novel Biology and Treatments. Front Physiol. 2022 Jul 19;13:964568. doi: 10.3389/fphys.2022.964568. PMID: 35928563; PMCID: PMC9344364.