Andrew Russo, PhD
Introduction
My research interest is to understand how neurons respond to changes in their environment. We have focused on regulation of CGRP and its actions in the context of trigeminal-mediated disorders, especially migraine. A recent focus of the lab is a CGRP-sensitized transgenic mouse model we generated based on clinical reports that injection of CGRP is able to induce a migraine, but not in people who do not suffer from migraine. These sensitized mice overexpress the RAMP1 subunit of the CGRP receptor in the nervous system. The RAMP1 mice have elevated CGRP-induced neurogenic inflammation, mechanical allodynia, and light aversion analogous to photophobia. In collaborative projects, the lab is also studying the beneficial effects of CGRP and RAMP1 against hypertension and obesity, with overall goals to develop effective diagnostic and therapeutic strategies for neurovascular disorders.
Current Positions
- Professor of Molecular Physiology and Biophysics
- Professor of Neurology
- Research Health Science Specialist, Director of Animal Research
Education
- BA in Biology (concentrations in biochemistry and microbiology), University of California
- PhD in Biochemistry, University of California
- Postdoctoral Fellow in Molecular Neurobiology, Department of Medicine, UCSD
Graduate Program Affiliations
Center, Program and Institute Affiliations
Research Interests
- Molecular basis of migraine
Selected Publications
- VanPutte, C. L., Regan, J. L., Russo, A. F. & Seeley, R. R. (2008). Seeley's essentials of anatomy and physiology. (7th ed.) Dubuque: McGraw-Hill.