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Eric B. Taylor, PhD

Professor of Molecular Physiology and Biophysics

Introduction

The Taylor Lab investigates the molecular mechanisms regulating mitochondrial function and their relationship to disease. Our approach is multidisciplinary. We employ diverse experimental models as necessary to solve fundamental problems in metabolism. We have specific expertise in molecular genetics and metabolomics. We have ongoing projects on diabetes, cancer, and neuroscience.

Current Positions

  • Professor of Molecular Physiology and Biophysics
  • Director, Metabolomics Core Facility, F.O.E. Diabetes Research Center

Education

  • BS in Exercise Physiology, Brigham Young University, Provo, Utah, United States
  • PhD in Physiology/Biochemistry/Metabolism, Brigham Young University, Provo, Utah, United States
  • Postdoctoral Fellow in Skeletal Muscle Signaling, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, United States
  • Postdoctoral Fellow in Molecular Metabolism, University of Utah School of Medicine, Salt Lake City, Utah, United States

Graduate Program Affiliations

Center, Program and Institute Affiliations

Research Interests

  • Research

Selected Publications

  • Bartlett JA, Huntemann ED, Krishnamurthy S, Hartwig SM, Pewa A, Thurman AL, Chimenti MS, Taylor EB, Varga SM, McCray PB Jr. CF airway epithelia display exaggerated host defense responses and prolonged cilia loss during RSV infection. J Cyst Fibros. 2025 Feb 15:S1569-1993(25)00055-4. doi: 10.1016/j.jcf.2025.02.003. Epub ahead of print. PMID: 39956716.
  • Som R, Fink BD, Rauckhorst AJ, Taylor EB, Sivitz WI. Mitochondrial glutamic-oxaloacetic transaminase (GOT2) in the growth of C2C12 myoblasts. J Bioenerg Biomembr. 2025 Feb 15. doi: 10.1007/s10863-025-10053-2. Epub ahead of print. PMID: 39954225.
  • Kim BR, Rauckhorst AJ, Chimenti MS, Rehman T, Keen HL, Karp PH, Taylor EB, Welsh MJ. The oxygen level in air directs airway epithelial cell differentiation by controlling mitochondrial citrate export. Sci Adv. 2025 Jan 24;11(4):eadr2282. doi: 10.1126/sciadv.adr2282. Epub 2025 Jan 24. PMID: 39854459; PMCID: PMC11759043.
  • Guppy B, Mitchell C, Taylor EB. Parameter Estimation and Identifiability in Kinetic Flux Profiling Models of Metabolism. Bull Math Biol. 2024 Nov 27;87(1):7. doi: 10.1007/s11538-024-01386-x. PMID: 39601930; PMCID: PMC11602815.
  • Rauckhorst AJ, Sheldon RD, Pape DJ, Ahmed A, Falls-Hubert KC, Merrill RA, Brown RF, Deshmukh K, Vallim TA, Deja S, Burgess SC, Taylor EB. A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones. Cell Metab. 2025 Jan 7;37(1):255-273.e6. doi: 10.1016/j.cmet.2024.10.013. Epub 2024 Oct 28. PMID: 39471817.
  • Pape DJ, Falls-Hubert KC, Merrill RA, Ahmed A, Qian Q, McGivney GR, Sobieralski P, Rauckhorst AJ, Yang L, Taylor EB. The mitochondrial dicarboxylate carrier mediates in vivo hepatic gluconeogenesis. bioRxiv [Preprint]. 2024 Sep 13:2024.09.12.612761. doi: 10.1101/2024.09.12.612761. PMID: 39314408; PMCID: PMC11419125.
  • Guppy B, Mitchell C, Taylor EB. Parameter Estimation and Identifiability in Kinetic Flux Profiling Models of Metabolism. ArXiv [Preprint]. 2024 Jul 11:arXiv:2407.08844v1. Update in: Bull Math Biol. 2024 Nov 27;87(1):7. doi: 10.1007/s11538-024-01386-x. PMID: 39040651; PMCID: PMC11261987.
  • Siripoksup P, Cao G, Cluntun AA, Maschek JA, Pearce Q, Brothwell MJ, Jeong MY, Eshima H, Ferrara PJ, Opurum PC, Mahmassani ZS, Peterlin AD, Watanabe S, Walsh MA, Taylor EB, Cox JE, Drummond MJ, Rutter J, Funai K. Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism. J Clin Invest. 2024 Apr 23;134(11):e167371. doi: 10.1172/JCI167371. PMID: 38652544; PMCID: PMC11142742.
  • Riley MJ, Mitchell CC, Ernst SE, Taylor EB, Welsh MJ. A model for stimulation of enzyme activity by a competitive inhibitor based on the interaction of terazosin and phosphoglycerate kinase 1. Proc Natl Acad Sci U S A. 2024 Feb 27;121(9):e2318956121. doi: 10.1073/pnas.2318956121. Epub 2024 Feb 20. PMID: 38377207; PMCID: PMC10907273.
  • Rauckhorst AJ, Vasquez Martinez G, Mayoral Andrade G, Wen H, Kim JY, Simoni A, Robles-Planells C, Mapuskar KA, Rastogi P, Steinbach EJ, McCormick ML, Allen BG, Pabla NS, Jackson AR, Coleman MC, Spitz DR, Taylor EB, Zepeda-Orozco D. Tubular mitochondrial pyruvate carrier disruption elicits redox adaptations that protect from acute kidney injury. Mol Metab. 2024 Jan;79:101849. doi: 10.1016/j.molmet.2023.101849. Epub 2023 Dec 7. PMID: 38056691; PMCID: PMC10733108.