Julien A. Sebag, PhD

Portrait
Assistant Professor of Molecular Physiology and Biophysics

Contact Information

Primary Office: 3330 PBDB
Iowa City, IA 52242
319-335-3270

Education

BS, Cellular Biology and Physiology, Université Paris XI
PhD, Pharmacology, University of Rochester School of Medicine and Dentistry

Internship, U99 INSERRML
Fellow, University of Rochester School of Medicine and Dentistry
Fellow, Molecular Physiology and Biophysics, Vanderbilt University

Education/Training Program Affiliations

Department of Molecular Physiology and Biophysics PhD

Center, Program and Institute Affiliations

Fraternal Order of Eagles Diabetes Research Center

Research Summary

Our laboratory focuses on identifying new pathways involved in the control of energy homeostasis and discovering novel targets for the treatment of obesity and diabetes. We recently identified the Melanocortin Receptor Accessory Protein 2 (MRAP2) as critical for the maintenance of proper energy balance. Indeed, the loss of MRAP2 in mice and humans results in severe obesity. Therefore, identifying the mechanisms by which MRAP2 regulates energy expenditure and the signaling pathways involved is a major goal of our laboratory. Using proteomic methods we have identified promising new targets for the treatment of obesity. In addition to studying the basic mechanisms through which those proteins contribute to the control of energy homeostasis, we are attempting to identify small molecule modulators using high throughput screening. Our goal is to select lead compounds that could become useful in the development of novel treatments for obesity and diabetes.