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Joseph Caster, MD, PhD

Director of Brachytherapy
Assistant Professor of Radiation Oncology

Contact Information

01624 PFP
200 Hawkins Drive
Iowa City, IA 52242


BS, Biochemistry, Florida State University
PhD, Pharmacology, Duke University
MD, University of North Carolina School of Medicine
Internship, University of North Carolina Hospitals
Resident, Radiation Oncology, University of North Carolina Hospitals


Seyedin, S. N., Parekh, K. R., Ginader, T. & Caster, J. M. (2020). The Role of Definitive Radiation and Surgery in Metastatic Esophageal Cancer: A NCDB Investigation. The Annals of thoracic surgery. PMID: 33096068.

Seyedin, S. N., Gannon, M. K., Plichta, K. A., Abushahin, L., Berg, D. J., Arshava, E. V., Parekh, K. R., Keech, J. C., Caster, J. M., Welsh, J. W. & Allen, B. G. (2020). Safety and Efficacy of Stereotactic Body Radiation Therapy for Locoregional Recurrences After Prior Chemoradiation for Advanced Esophageal Carcinoma. Frontiers in oncology, 10, 1311. PMID: 32850412.

Hopfensperger, K. M., Adams, Q., Kim, Y., Wu, X., Xu, W., Patwardhan, K., Thammavong, B., Caster, J. & Flynn, R. T. (2020). Needle-Free Cervical Cancer Treatment Using Helical Multi-Shield Intracavitary Rotating Shield Brachytherapy with the 169 Yb Isotope. Medical physics. PMID: 32073669.

Seyedin, S. N., Hasibuzzaman, M. M., Pham, V., Petronek, M. S., Callaghan, C., Kalen, A. L., Mapuskar, K. A., Mott, S. L., Spitz, D. R., Allen, B. G. & Caster, J. M. (2020). Combination therapy with radiation and PARP inhibition enhances responsiveness to anti-PD-1 therapy in colorectal tumor models. International Journal of Radiation oncology, biology, physics. PMID: 32036006.

Sun, B., Hagan, 4th, C. T., Caster, J. M. & Wang, A. Z. (2019). Nanotechnology in Radiation Oncology. Hematology/Oncology clinics of North America, 33(6), 1071-1093. PMID: 31668207.

Allen, B. G., Bodeker, K. L., Smith, M. C., Monga, V., Sandhu, S., Hohl, R., Carlisle, T., Brown, H., Hollenbeck, N., Vollstedt, S., Greenlee, J. D., Howard, M. A., Mapuskar, K. A., Seyedin, S. N., Caster, J. M., Jones, K. A., Cullen, J. J., Berg, D., Wagner, B. A., Buettner, G. R., TenNapel, M. J., Smith, B. J., Spitz, D. R. & Buatti, J. M. (2019). First-in-Human Phase I Clinical Trial of Pharmacologic Ascorbate Combined with Radiation and Temozolomide for Newly Diagnosed Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 25(22), 6590-6597. PMID: 31427282.

Petronek, M. S., Wagner, B. A., Hollenbeck, N. J., Caster, J. M., Spitz, D. R., Cullen, J. J., Buettner, G. R. & Allen, B. G. (2019). Assessment of the Stability of Supraphysiological Ascorbate in Human Blood: Appropriate Handling of Samples from Clinical Trials for Measurements of Pharmacological Ascorbate. Radiation research, 191(6), 491-496. PMID: 31039080.

Caster, J. M., Callaghan, C., Seyedin, S. N., Henderson, K., Sun, B. & Wang, A. Z. (2019). Optimizing Advances in Nanoparticle Delivery for Cancer Immunotherapy. Advanced drug delivery reviews, 144, 3-15. PMID: 31330165.

Kaidar-Person, O., Eblan, M. J., Caster, J. M., Shan, A. R., Fried, D., Marks, L. B., Lee, C. N., Jones, E. L. & Jones, E. L. (2019). Effect of internal mammary vessels radiation dose on outcomes of free flap breast reconstruction. (Vols. 25). (2), pp. 286-289. Breast J. PMID: 30734417.

Adams, Q., Hopfensperger, K. M., Kim, Y., Wu, X., Xu, W., Shukla, H., McGee, J., Caster, J. M. & Flynn, R. T. (2018). Effectiveness of Rotating Shield Brachytherapy for Prostate Cancer Dose Escalation and Urethral Sparing. International journal of radiation oncology, biology, physics, 102(5), 1543-1550. PMID: 30092333.

Myung, J. H., Eblan, M. J., Caster, J. M., Park, S. J., Poellmann, M. J., Wang, K., Tam, K. A., Miller, S. M., Shen, C., Chen, R. C., Zhang, T., Tepper, J. E., Chera, B. S., Wang, A. Z. & Hong, S. (2018). Multivalent Binding and Biomimetic Cell Rolling improves the Sensitivity and Specificity of Circulating Tumor Cell Capture. Clin Cancer Res, 24(11), 2539-2547. PMID: 29545463.

Tian, X., Werner, M. E., Roche, K. C., Hanson, A. D., Foote, H. P., Yu, S. K., Warner, S. B., Copp, J. A., Lara, H., Wauthier, E. L., Caster, J. M., Herring, L. E., Zhang, L., Tepper, J. E., Hsu, D. S., Zhang, T., Reid, L. M. & Wang, A. Z. (2018). Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds. Nature biomedical engineering, 2(6), 443-452. PMID: 31011191.

Caster, J. M., Marks, L. B. (2018). Hypofractionation for lung tumors (Primary Malignant, Secondary Malignant). In O. Kaidar-Person , R. Chen (Eds.) Handbook of Hypofractionated Radiotherapy. pp. 207-236. New York NY: Chen RC and Marks LB (eds). DOI: 10.1007/978-3-319-92802-9.

Min, Y., Caster, J. M., Mi, Y., Wagner, K. T., Tian, X., Das, M. & Wang, A. Z. (2017). Use of antigen capturing nanoparticles to enhance the abscopal effect in mouse models of melanoma. Nature Nanotechnology, 12(9), 877-882. PMID: 28650437.

Min, Y., Roche, K. C., Tian, S., Eblan, M. J., McKinnon, K. P., Caster, J. M., Chai, S., Herring, L. E., Zhang, L., Zhang, T., DeSimone, J. M., Tepper, J. E., Vincent, B. G., Serody, J. S. & Wang, A. Z. (2017). Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy. Nature nanotechnology, 12(9), 877-882. PMID: 28650437.

Caster, J. M., Wang, A. Z. (2017). Applying nanotherapeutics to improve chemoradiotherapy treatment for cancer. Therapeutic delivery, 8(9), 791-803. PMID: 28825397.

Caster, J. M., Yu, S. K., Patel, A. N., Newman, N. J., Lee, Z. J., Warner, S. B., Wagner, K. T., Roche, K. C., Tian, X., Min, Y. & Wang, A. Z. (2017). Effect of particle size on the biodistribution, toxicity, and efficacy of drug-loaded polymeric nanoparticles in chemoradiotherapy. Nanomedicine, 13(5), 1673-1683. PMID: 28300658.

Tian, J., Min, Y., Rodgers, Z., Wan, X., Qiu, H., MI, Y., Tian, X., Wagner, K. T., Caster, J. M., Qi, Y., Roche, K., Zhang, T., Cheng, J. & Wang, A. Z. (2017). Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer. Nanomedicine, 13(3), 1301-1307. PMID: 27884641.

Tian, X., Nguyen, M., Foote, H. P., Caster, J. M., Roche, K. C., Peters, C. G., Wu, P., Jayaraman, L., Garmey, E. G., Tepper, J. E., Eliasof, S. & Wang, A. Z. (2017). CRLX101, a Nanoparticle-Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1a. Cancer Research, 77(1), 112-122. PMID: 27784746.

Caster, J. M., Patel, A. N., Zhang, T. & Wang, A. (2017). Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 9(1). PMID: 27312983.

Caster, J. M., Tepper, J. E. (2017). Adjuvant therapies for the management of gastric adenocarcinomas. In S. Rosso , S. Hoffe , E. Kim (Eds.) Gastrointestinal Malignancies -A Practical Guide on Treatment Techniques. pp. 53-94. New York NY: Russo S (ed) Gastrointestinal Malignancies. DOI: 10.1007/978-3-319-64900-9.

Caster, J. M., Wang, A. Z. (In Press). Nanotherapeutics in oncology. Princeton NJ: Goyal S and Haffty B (eds).

Tian, X., Warner, S. B., Wagner, K. T., Caster, J. M., Zhang, T., Ohana, P., Gabizon, A. A. & Wang, A. Z. (2016). Preclinical Evaluation of Promitil, a Radiation - Responsive Liposomal Formulation on Mitomycin C Prodrug, in Chemoradiotherapy. Int J Radiat Oncol Biol Phy, 96(3), 547-55. PMID: 27681751.

Au, K. M., Satterlee, A., Min, Y., Tian, X., Kim, Y. S., Caster, J. M., Zhang, L., Zhang, T., Huang, L. Z. & Wang, A. Z. (2016). Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic. Biomaterials, 82, 178-93. PMID: 26763733.

Caster, J. M., Patel, A., Wang, T. & Wang, A. Z. (2016). Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical investigation. WIRES Nanomed Nanobiotech. DOI: doi/j.ijrobp.2016.06.2457.

AU, K. M., Hyder, S. N., Wagner, K. T., Shi, C., Kim, Y. S., Caster, J. M., Tian, X., Min, Y. & Wang, A. W. (2015). Direct Observation of Early-Stage High-Dose Radiotherapy-Induced Vascular Injury via Basement Membrane-Targeting Nanoparticles. Small, 11(48), 6404-10. PMID: 26577747.

Tian, X., Lara, H., Wagner, K. T., Saripalli, S., Hyder, S. N., Foote, M., Sethi, M., Wang, E., Caster, J. M., Zhang, L. & Wang, A. Z. (2015). Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery. Nanoscale, 7(47), 20211-9.

Min, Y., Caster, J. M., Eblan, M. J. & Wang, A. Z. (2015). Clinical Translation of Nanomedicine. Chemical reviews, 115(19), 11147-90. PMID: 26088284.

Au, K. M., Min, Y., Tian, X., Zhang, L., Perello, V., Caster, J. M. & Wang, A. Z. (2015). Improving Cancer Chemoradiotherapy Treatment by Dual Controlled Release of Wortmannin and Docetaxel in Polymeric Nanoparticles. ACS Nano, 9(9), 8976-96. PMID: 26267360.

Caster, J. M., Falchook, A. D., Hendrix, L. H. & Chen, R. C. (2015). Risk of Pathologic Upgrading or Locally Advanced Disease in Early Prostate Cancer Patients Based on Biopsy Gleason Score and PSA: A Population-Based Study of Modern Patients. Int J Radiat Oncol Biol Phys, 92(2), 244-51. PMID: 25841621.

Wang, E. C., Min, Y., Palm, R. C., Fiordalisi, J. J., Wagner, K. T., Hyder, N., Cox, A. D., Caster, J. M., Tian, X. & Wang, A. Z. (2015). Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors. Biomaterials, 51, 208-15. PMID: 25771011.

Caster, J. M., Sethi, M., Kowalczyk, S., Wang, E., Tian, X., Hyder, S. N., Wagner, K. T., Zhang, Y. A., Kapadia, C., Man Au, K. & Wang, A. Z. (2015). Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity. Nanoscale, 7(6), 2805-11. PMID: 25584654.

Walker, Q. D., Johnson, M. L., Van Swearingen, A. E., Arrant, A. E., Caster, J. M. & Kuhn, C. M. (2012). Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy. Neuropharmacology, 62(7), 2267-77. PMID: 22342988.

Walker, Q. D., Morris, S. E., Arrant, A. E., Nagel, J. M., Parylak, S., Zhou, G., Caster, J. M. & Kuhn, C. M. (2010). Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats. The Journal of pharmacology and experimental therapeutics, 335(1), 124-32. PMID: 20605908.

Schramm-Sapyta, N. L., Walker, Q. D., Caster, J. M., Levin, E. D. & Kuhn, C. M. (2009). Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models. Psychopharmacology, 206(1), 1-21. PMID: 19547960.

Caster, J. M., Kuhn, C. M. (2009). Maturation of coordinated immediate early gene expression by cocaine during adolescence. Neuroscience, 160(1), 13-31. PMID: 19245875.

Walker, Q. D., Schramm-Sapyta, N. L., Caster, J. M., Waller, S. T., Brooks, M. P. & Kuhn, C. M. (2009). Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults. Pharmacology, biochemistry, and behavior, 91(3), 398-408. PMID: 18790706.

Parylak, S. L., Caster, J. M., Walker, Q. D. & Kuhn, C. M. (2008). Gonadal steroids mediate the opposite changes in cocaine-induced locomotion across adolescence in male and female rats. Pharmacology, biochemistry, and behavior, 89(3), 314-23. PMID: 18275993.

Caster, J. M., Walker, Q. D. & Kuhn, C. M. (2007). A single high dose of cocaine induces differential sensitization to specific behaviors across adolescence. Psychopharmacology, 193(2), 247-60. PMID: 17426961.

Caster, J. M., Walker, Q. D. & Kuhn, C. M. (2005). Enhanced behavioral response to repeated-dose cocaine in adolescent rats. Psychopharmacology, 183(2), 218-25. PMID: 16175404.