Joseph Caster

Assistant Professor
Assistant Professor of Radiation Oncology

Contact Information

Clinic: 01624 PFP
200 Hawkins Drive
Iowa City, IA 52242


BS, Biochemistry, Florida State University
PhD, Pharmacology, Duke University
MD/PhD, University of North Carolina School of Medicine

University of North Carolina SOM
Internship, University of North Carolina
Chief Resident, University of North Carolina
Resident, University of North Carolina
Resident, Radiation Oncology, University of North Carolina


Caster, J. M., Patel, A. N., Zhang, T. & Wang, A. (2017). Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical trials. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 9(1). PMID: 27312983.

Caster, J. M., Wang, A. Z. (2017). Applying nanotherapeutics to improve chemoradiotherapy treatment for cancer. pp. 791-803. Ther Deliv.

Caster, J. M., Tepper, J. E. (In Press). Adjuvant therapies for the management of gastric adenocarcinomas. New York NY: Russo S (ed) Gastrointestinal Malignancies.

Caster, J. M., Marks, L. B. (In Press). Hypofractionation for lung malignancies. In Handbook of Hypofractionated Radiotherapy. New York NY: Chen RC and Marks LB (eds).

Caster, J. M., Wang, A. Z. (In Press). Nanotherapeutics in oncology. Princeton NJ: Goyal S and Haffty B (eds).

Min, Y., Caster, J. M., Mi, Y., Wagner, K. T., Tian, X., Das, M. & Wang, A. Z. (In Press). Use of antigen capturing nanoparticles to enhance the abscopal effect in moues models of melanoma. Nature Nanotechnology.

Caster, J. M., Wang, A. Z. (2017). Applying nanotherapeutics to improve chemoradiotherapy treatment for cancer. Therapeutic delivery, 8(9), 791-803. PMID: 28825397.

Tian, X., Nguyen, M., Foote, H. P., Caster, J. M., Roche, K. C., Peters, C. G., Wu, P., Jayaraman, L., Garmey, E. G., Tepper, J. E., Eliasof, S. & Wang, A. Z. (2017). CRLX101, a Nanoparticle-Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherap by Inhibiting DNA Repair and HIF1a. Cancer Research, 77(1), 112-122. PMID: 27784746.

Min, Y., Roche, K. C., Tian, S., Eblan, M. J., McKinnon, K. P., Caster, J. M., Chai, S., Herring, L. E., Zhang, L., Zhang, T., DeSimone, J. M., Tepper, J. E., Vincent, B. G., Serody, J. S. & Wang, A. Z. (2017). Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy. Nature nanotechnology, 12(9), 877-882. PMID: 28650437.

Caster, J. M., Yu, S. K., Patel, A. N., Newman, N. J., Lee, Z. J., Warner, S. B., Wagner, K. T., Roche, K. C., Tian, X., Min, Y. & Wang, A. Z. (2017). Effect of particle size o the biodistribution, toxicity, and efficacy of drug-loaded polymeric nanoparticles in chemoradiotherapy. Nanomedicine, 13(5), 1673-1683. PMID: 28300658.

Tian, J., Min, Y., Rodgers, Z., Wan, X., Qiu, H., MI, Y., Tian, X., Wagner, K. T., Caster, J. M., Qi, Y., Roche, K., Zhang, T., Cheng, J. & Wang, A. Z. (2017). Nanoparticle delivery of chemotherapy combination regimen improves the therapeutic efficacy in mouse models of lung cancer. Nanomedicine, 13(3), 1301-1307. PMID: 27884641.

Caster, J. M., Patel, A., Wang, T. & Wang, A. Z. (2016). Investigational nanomedicines in 2016: a review of nanotherapeutics currently undergoing clinical investigation. WIRES Nanomed Nanobiotech. DOI: doi/j.ijrobp.2016.06.2457.

Tian, X., Warner, S. B., Wagner, K. T., Caster, J. M., Zhang, T., Ohana, P., Gabizon, A. A. & Wang, A. Z. (2016). Preclinical Evaluation of Promitil, a Radiation - Responsive Liposomal Formulation on Mitomycin C Prodrug, in Chemoradiotherapy. Int J Radiat Oncol Biol Phy, 96(3), 547-55.

Au, K. M., Satterlee, A., Min, Y., Tian, X., Kim, Y. S., Caster, J. M., Zhang, L., Zhang, T., Huang, L. Z. & Wang, A. Z. (2016). Folate-targeted pH-responsive calcium zoledronate nanoscale metal-organic frameworks: Turning a bone antiresorptive agent into an anticancer therapeutic. Biomaterials, 28, 178-93. PMID: 26763733.

Au, K. M., Hyder, S. N., Wagner, K., Shi, C., Kim, Y. S., Caster, J. M., Tian, X., Min, Y., Wang, A. Z. (Eds.) (2015). Direct Observation of Early-Stage High-Dose Radiotherapy-Induced Vascular Injury via Basement Membrane-Targeting Nanoparticles. Small, 11(48), 6404-10. PMID: 26577747.

Wang, E. C., Min, Y., Palm, R. C., Fiordalisi, J. J., Wagner, K. T., Hyder, N., Cox, A. D., Caster, J. M., Tian, X. & Wang, A. Z. (2015). Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors. Biomaterials, 51, 208-15. PMID: 25771011.

Tian, X., Lara, H., Wagner, K. T., Saripalli, S., Hyder, S. N., Foote, M., Sethi, M., Wang, E., Caster, J. M., Zhang, L. & Wang, A. Z. (2015). Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery. Nanoscale, 7(47), 20211-9.

Caster, J. M., Sethi, M., Kowalczyk, S., Wang, E., Tian, X., Hyder, S. N., Wagner, K. T., Zhang, Y. A., Kapadia, C., Man Au, K. & Wang, A. Z. (2015). Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity. Nanoscale, 7(6), 2805-11. PMID: 25584654.

Caster, J. M., Falchook, A. D., Hendrix, L. H. & Chen, R. C. (2015). Risk of Pathologic Upgrading or Locally Advanced Disease in Early Prostate Cancer Patients Based on Biopsy Gleason Score and PSA: A Population-Based Study of Modern Patients. Int J Radiat Oncol Biol Phys, 92(2), 244-51. PMID: 25841621.

Min, Y., Caster, J. M., Eblan, M. J. & Wang, A. Z. (2015). Clinical Translation of Nanomedicine. Chemical reviews, 115(19), 11147-90. PMID: 26088284.

Au, K. M., Min, Y., Tian, X., Zhang, L., Perello, V., Caster, J. M. & Wang, A. Z. (2015). Improving Cancer Chemoradiotherapy Treatment by Dual Controlled Release of Wortmannin and Docetaxel in Polymeric Nanoparticles. ACS Nano, 9(9), 8976-96. PMID: 26267360.

Walker, Q. D., Johnson, M. L., Van Swearingen, A. E., Arrant, A. E., Caster, J. M. & Kuhn, C. M. (2012). Individual differences in psychostimulant responses of female rats are associated with ovarian hormones and dopamine neuroanatomy. Neuropharmacology, 62(7), 2267-77. PMID: 22342988.

Walker, Q. D., Morris, S. E., Arrant, A. E., Nagel, J. M., Parylak, S., Zhou, G., Caster, J. M. & Kuhn, C. M. (2010). Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats. The Journal of pharmacology and experimental therapeutics, 335(1), 124-32. PMID: 20605908.

Walker, Q. D., Schramm-Sapyta, N. L., Caster, J. M., Waller, S. T., Brooks, M. P. & Kuhn, C. M. (2009). Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults. Pharmacology, biochemistry, and behavior, 91(3), 398-408. PMID: 18790706.

Schramm-Sapyta, N. L., Walker, Q. D., Caster, J. M., Levin, E. D. & Kuhn, C. M. (2009). Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models. Psychopharmacology, 206(1), 1-21. PMID: 19547960.

Caster, J. M., Kuhn, C. M. (2009). Maturation of coordinated immediate early gene expression by cocaine during adolescence. Neuroscience, 160(1), 13-31. PMID: 19245875.

Parylak, S. L., Caster, J. M., Walker, Q. D. & Kuhn, C. M. (2008). Gonadal steroids mediate the opposite changes in cocaine-induced locomotion across adolescence in male and female rats. Pharmacology, biochemistry, and behavior, 89(3), 314-23. PMID: 18275993.

Caster, J. M., Walker, Q. D. & Kuhn, C. M. (2007). A single high dose of cocaine induces differential sensitization to specific behaviors across adolescence. Psychopharmacology, 193(2), 247-60. PMID: 17426961.

Caster, J. M., Walker, Q. D. & Kuhn, C. M. (2005). Enhanced behavioral response to repeated-dose cocaine in adolescent rats. Psychopharmacology, 183(2), 218-25. PMID: 16175404.