David W. Kaczka, MD, PhD

Portrait
Associate Professor of Anesthesia - Critical Care Medicine
Associate Professor of Radiology
Associate Professor of Biomedical Engineering (BME)

Contact Information

Primary Office
8483 John Colloton Pavilion
200 Hawkins Drive
Iowa City, IA 52242
319-356-2633

Fax
6546-1 John Colloton Pavilion
200 Hawkins Drive
Iowa City, IA 52242
319-356-2940

Education

BS, Biomedical Engineering, Boston University
MS, Biomedical Engineering, Boston University
MD, Medicine, Boston University School of Medicine
PhD, Biomedical Engineering, Boston University College of Engineering
Resident, Anesthesiology, Johns Hopkins University
Officer Training School (OTS), United States Air Force, Air University
Fellow, Obstetrical Anesthesia, Johns Hopkins University
Correspondence Program: Squadron Officer School (SOS), United States Air Force, Air University
Fellow, Critical Care Medicine, University of Iowa, Carver College of Medicine, Department of Anesthesia

Publications

Gerard, S. E., Herrmann, J., Kaczka, D. W., Musch, G., Fernandez-Bustamante, A. & Reinhardt, J. M. (2020). Multi-resolution convolutional neural networks for fully automated segmentation of acutely injured lungs in multiple species. Med Image Anal, 60, 101592. PMID: 31760194.

Kaczka, D. W., Chitilian, H. V. & Vidal Melo, M. F. (2020). Chapter 41: Respiratory Monitoring. In M. A. Gropper , L. I. Eriksson & L. A. Fleisher , J. P. Wiener-Kronish , N. H. Cohen , K. Leslie (Eds.) Miller's Anesthesia. (9), pp. 1298-1339. New York, NY: Elsevier.

King, G. G., Bates, J., Berger, K. I., Calverley, P., de Melo, P. L., Dellacà, R. L., Farré, R., Hall, G. L., Ioan, I., Irvin, C. G., Kaczka, D. W., Kaminsky, D. A., Kurosawa, H., Lombardi, E., Maksym, G. N., Marchal, F., Oppenheimer, B. W., Simpson, S. J., Thamrin, C., van den Berge, M. & Oostveen, E. (2019). Technical standards for respiratory oscillometry. Eur Respir J. PMID: 31772002.

Herrmann, J., Lilitwat, W., Tawhai, M. H. & Kaczka, D. W. (2019). High-frequency oscillatory ventilation and ventilator-induced lung injury: size does matter. Crit Care Med. PMID: 31634232.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2019). Strain, strain rate, and mechanical power: an optimization comparison for oscillatory ventilation. Int J Numer Method Biomed Eng, 35(10), e3238. PMID: 31318162.

Cereda, M., Xin, Y., Goffi, A., Herrmann, J., Kaczka, D. W., Kavanagh, B. P., Perchiazzi, G., Yoshida, T. & Rizi, R. R. (2019). Imaging the injured lung: mechanisms of action and clinical use. Anesthesiology, 131(3), 716-749. PMID: 30664057.

Motahari-Bidgoli, A., Liu, Y., Comellas, A. P., Kaczka, D. W., Gerke, A. K., Wilson, J. S. & Hoffman, E. A. (2019). Sildenafil-Based Reduction in Sub-Acinar Pulmonary Perfusion Heterogeneity Does Not Alter Acinar-Scale Histograms of V/Q Matching Derived from Dual Energy CT. (Vols. 199). pp. A3854. American Journal of Respiratory and Critical Care Medicine.

Liu, Y., Motahari-Bidgoli, A., Comellas, A. P., Kaczka, D. W., Gerke, A. K., Wilson, J. S. & Hoffman, E. A. (2019). Role of Sildenafil in Lowering Lung Inflammation During Smoking Cessation: A Multispectral CT Assessment of Lung Anatomy and Perfused Blood Volume. (Vols. 199). pp. A3853. American Journal of Respiratory and Critical Care Medicine.

Herrmann, J., Gerard, S. E., Shao, W., Reinhardt, J. M., Christensen, G. E., Hoffman, E. A., Hawley, M. L. & Kaczka, D. W. (2019). Multi-Frequency Oscillatory Ventilation Minimizes Spatial Gradients of Regional Strain Using 4D CT Image Registration in Porcine Lung Injury. (Vols. 199). pp. A7246. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W., Nieman, G. (2019). Designing Protective Mechanical Ventilation for the Injured Lung: Opportunities for the Engineer. (Vols. 2). (2), pp. 020201-020204. New York, NY: Journal of Engineering and Science in Medical Diagnostics and Therapy. DOI: 10.1115/1.4043220.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2019). Computational modeling of primary blast lung injury: implications for ventilator management. Mil Med, 184(Supplement_1), 273-281. PMID: 30901433.

Gerard, S. E., Herrmann, J., Kaczka, D. W. & Reinhardt, J. M. (2018). Transfer Learning for Segmentation of Injured Lungs Using Coarse-to-Fine Convolutional Neural Networks. In D. Stoyanov , Z. Taylor , B. Kainz & G. Maicas , R. Beichel , A. Martel , L. Maier-Hein , B. Kanwal , T. Vercauteren , O. Ozan , G. Carneiro , A. P. Bradley , J. Nascimento , H. Min , M. S. Brown , C. Jacobs , B. Lassen-Schmidt , K. Mori , J. Petersen , R. San Jose Estépar , A. Schmidt-Richberg , C. Veiga (Eds.) Image Analysis for Moving Organ, Breast, and Thoracic Images. pp. 191-201. Springer International Publishing. DOI: 10.1007/978-3-030-00946-5.

Mondoñedo, J. R., McNeil, J. S., Herrmann, J., Simon, B. A. & Kaczka, D. W. (2018). Targeted versus continuous delivery of volatile anesthetics during cholinergic bronchoconstriction. J Eng Sci Med Diagn Ther, 1(3). PMID: 31106293.

Kaczka, D. W. (2018). A lesson in uncertainty: how FAER helped an engineer find his calling. (Vols. 82). (5), pp. 62-3. ASA Monitor.

Taher, H., Bauer, C., Abston, E., Kaczka, D. W., Bhatt, S. P., Zabner, J., Brower, R. G., Beichel, R. R. & Eberlein, M. (2018). Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs. J Appl Physiol (1985), 124(5), 1186-1193. PMID: 29357485.

Herrmann, J., Shao, W., Gerard, S. E., Reinhardt, J. M., Hoffman, E. A., Christensen, G. E. & Kaczka, D. W. (2018). Time-varying regional aeration and strain in the acutely injured lung assessed with 4-D CT image registration. (Vols. 197). pp. A7227. American Journal of Respiratory and Critical Care Medicine.

Herrmann, J., Lilitwat, W., Tawhai, M. H. & Kaczka, D. W. (2018). Lung size and ventilation heterogeneity: a comparison of high-frequency oscillatory ventilation in neonates and adults. (Vols. 197). pp. A4663. American Journal of Respiratory and Critical Care Medicine.

Herrmann, J., Reinhardt, J. M., Hoffmann, E. A. & Kaczka, D. W. (2018). Xenon-enhanced CT for measurement of regional gas transport during oscillatory ventilation. (Vols. 197). pp. A4477. American Journal of Respiratory and Critical Care Medicine.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2018). Parenchymal strain heterogeneity during oscillatory ventilation: why two frequencies are better than one. J Appl Physiol (1985), 124(3), 653-63. PMID: 29051332.

Huhle, R., D'Antini, D., Herrmann, J., Raimondo, P., Mirabella, L., Hemmes, S. N., Schultz, M. J., Pelosi, P., Kaczka, D. W., Cinnella, G. & de Gama Abreu, M. (2018). Intratidal analysis of intraoperative respiratory system mechanics: keep it simple. (Vols. 126). (2), pp. 725-6. Anesth Analg. PMID: 29346212.

D'Antini, D., Huhle, R., Herrmann, J., Sulemanji, D. S., Oto, J., Raimondo, P., Mirabella, L., Hemmes, S. N., Schultz, M. J., Pelosi, P., Kaczka, D. W., Vidal Melo, M. F., de Gama Abreu, M. & Cinnella, G. (2018). Respiratory system mechanics during low versus high positive end-expiratory pressure in open abdominal surgery: a substudy of PROVHILO randomized controlled trial. Anesth Analg, 126(1), 143-9. PMID: 28632529.

Mondoñedo, J. R., Herrmann, J., McNeil, J. S. & Kaczka, D. W. (2017). Comparison of pneumotachography and anemometery for flow measurement during mechanical ventilation with volatile anesthetics. J Clin Monit Comput, 31(6), 1263-71. PMID: 27844299.

Herrmann, J., Hoffman, E. A. & Kaczka, D. W. (2017). Frequency-selective computed tomography: applications during periodic thoracic motion. IEEE Trans Med Imaging, 36(8), 1722-32. PMID: 28436852.

Herrmann, J., Hoffmann, E. A. & Kaczka, D. W. (2017). Temporally resolved CT imaging to assess high-frequency periodic deformation. (Vols. 195). pp. A6522. American Journal of Respiratory and Critical Care Medicine.

Huhle, R., Amini, R., Herrmann, J., Guldner, A., Gama De Abreu, M. & Kaczka, D. W. (2017). Stochastic resonance versus deterministic resonance during variable controlled ventilation: a numerical investigation. (Vols. 195). pp. A4433. American Journal of Respiratory and Critical Care Medicine.

Amini, R., Herrmann, J. & Kaczka, D. W. (2017). Intratidal overdistension and derecruitment in the injured lung: a simulation study. IEEE Trans Biomed Eng, 64(3), 681-9. PMID: 27244715.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2016). Regional gas transport in the heterogeneous lung during oscillatory ventilation. J Appl Physiol (1985), 121(6), 1306-18. PMID: 27763872.

Abston, E., Herrmann, J., Taft, P., Eberlein, M., Kaczka, D. W. & Stoltz, D. A. (2016). The effects of chest wall strapping in a porcine model of ARDS. (Vols. 193). pp. A4819. American Journal of Respiratory and Critical Care Medicine.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2016). Multi-frequency oscillatory ventilation (MFOV): impact on eucapnic ventilation distribution in simulated lung injury. (Vols. 193). pp. A4820. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W., Herrmann, J., Zonneveld, C. E., Tingay, D. G., Lavizzari, A., Noble, P. B. & Pillow, J. J. (2015). Multifrequency oscillatory ventilation in the premature lung: effects on gas exchange, mechanics, and ventilation distribution. Anesthesiology, 123(6), 1394-403. PMID: 26495977.

Mondoñedo, J. R., McNeil, J. S., Herrmann, J. & Kaczka, D. W. (2015). Comparison of flow measurements using a pneumotachograph and hot-wire anemometer during mechanical ventilation with volatile anesthetics. (Vols. 191). pp. A3168. American Journal of Respiratory and Critical Care Medicine.

Herrmann, J., Tawhai, M. H. & Kaczka, D. W. (2015). Computational modeling of gas transport during oscillatory ventilation. (Vols. 191). pp. A1217. American Journal of Respiratory and Critical Care Medicine.

Mondoñedo, J. R., McNeil, J. S., Amin, S. D., Herrmann, J., Simon, B. A. & Kaczka, D. W. (2015). Volatile anesthetics and the treatment of severe bronchoconstriction: a concept of targeted delivery. Drug Discov Today Dis Models, 15, 43-50. PMID: 26744597.

Bates, J. H., Kaczka, D. W. & Prisk, G. K. (2014). Chapter 17: Measurements in Pumonology. In J. G. Webster (Eds.) The Physiological Measurement Handbook. (1), pp. 419-52. Boca Raton, FL: CRC Press.

Chitillian, H. V., Kaczka, D. W. & Vidal Melo, M. F. (2014). Chapter 51: Respiratory Monitoring. In R. D. Miller , L. I. Eriksson & L. A. Fleisher , J. P. Wiener-Kronish , N. H. Cohen , W. L. Young (Eds.) Miller's Anesthesia. (8), pp. 1541-79. Elsevier.

Pratt, S. D., Kaczka, D. W. & Hess, P. E. (2014). In reply. (Vols. 23). (3), pp. 286-7. Int J Obstet Anesth. PMID: 24934309.

Pratt, S. D., Kaczka, D. W. & Hess, P. E. (2014). Observational study of changes in epidural pressure and elastance during epidural blood patch in obstetric patients. Int J Obstet Anesth, 23(2), 144-50. PMID: 24631062.

Kaczka, D. W., Herrmann, J., Zonneveld, C. E., Tingay, D., Lavizzari, A., Noble, P. B. & Pillow, J. J. (2014). Multi-frequency oscillation ventilation improves gas exchange and lung recruitment in preterm lambs. (Vols. 189). pp. A3567. American Journal of Respiratory and Critical Care Medicine.

Clark, A. R., Kaczka, D. W., Thompson, B. R. & Tawhai, M. H. (2014). Ventilation-perfusion matching in large and small animals. (Vols. 189). pp. A3568. American Journal of Respiratory and Critical Care Medicine.

Sulemanji, D. S., Oto, J., Herrmann, J., Kaczka, D. W. & Melo, M. F. (2014). High PEEP during major abdominal surgery improves intraoperative elastance and reduces lung recruitment. (Vols. 189). pp. A1179. American Journal of Respiratory and Critical Care Medicine.

Amini, R., Kaczka, D. W. (2013). Impact of ventilation frequency and parenchymal stiffness on flow and pressure distribution in a canine lung model. Ann Biomed Eng, 41(12), 2699-711. PMID: 23872936.

Kaczka, D. W., Mitzner, W. & Brown, R. H. (2013). Effects of lung inflation on airway heterogeneity during histaminergic bronchoconstriction. J Appl Physiol (1985), 115(5), 626-33. PMID: 23813528.

Fraser, 3rd, C. D., Brady, K. M., Rhee, C. J., Easley, R. B., Kibler, K., Smielewski, P., Czosnyka, M., Kaczka, D. W., Andropoulos, D. B. & Rusin, C. (2013). The frequency response of cerebral autoregulation. J Appl Physiol (1985), 115(1), 52-6. PMID: 23681909.

Herrmann, J., Talmor, D. S., Loring, S. H. & Kaczka, D. W. (2013). Nonlinear elastic distortion in acute lung injury: effects of ventilation strategy. (Vols. 187). pp. A1128. American Journal of Respiratory and Critical Care Medicine.

Colletti, A. A., Amini, R. & Kaczka, D. W. (2013). Simulating gas exchange in the canine lung using computational modeling. (Vols. 187). pp. A1965. American Journal of Respiratory and Critical Care Medicine.

Amini, R., Herrmann, J. & Kaczka, D. W. (2013). Impact of ventilation frequency and collateral ventilation on global mechanics and pressure/flow distribution in the canine lung. (Vols. 187). pp. A1966. American Journal of Respiratory and Critical Care Medicine.

Vidal Melo, M. F., Musch, G. & Kaczka, D. W. (2012). Pulmonary pathophysiology and lung mechanics in anesthesiology: a case-based overview. Anesthesiol Clin, 30(4), 759-84. PMID: 23089508.

Brady, K. M., Easley, R. B., Kibler, K., Kaczka, D. W., Andropoulos, D., Fraser III, C. D., Smielewski, P., Czosnyka, M., Adams, G. J., Rhee, C. J. & Rusin, C. G. (2012). Positive end-expiratory pressure oscillation facilitates brain vascular reactivity monitoring. J Appl Physiol (1985), 113(9), 1362-8. PMID: 22984248.

Kaczka, D. W., Smallwood, J. L. (2012). Constant-phase descriptions of canine lung, chest wall, and total respiratory system viscoelasticity: effects of distending pressure. Respir Physiol Neurobiol, 183(2), 75-84. PMID: 22691447.

Simon, B. A., Kaczka, D. W., Bankier, A. A. & Parraga, G. (2012). What can computed tomography and magnetic resonance imaging tell us about ventilation?. J Appl Physiol (1985), 113(4), 647-57. PMID: 22653989.

Amini, R., Amin, S. & Kaczka, D. W. (2012). Nonlinear time-dependent model of recruitment and derecruitment in canine lung injury. (Vols. 185). pp. A2047. American Journal of Respiratory and Critical Care Medicine.

Chon, D., Yin, Y., Hoffman, E. A., Amini, R., Simon, B. A. & Kaczka, D. W. (2012). High-resolution topographic distribution of regional inflation in healthy and injured canine lungs. (Vols. 185). pp. A2066. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W., Herrmann, J., Crowe, M. T. & Simon, B. A. (2012). Effects of high and low tidal volume ventilation on respiratory mechanics and systemic inflammation in canine acute lung injury. (Vols. 185). pp. A2046. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W., Simon, B. A. & Thompson, B. T. (2012). Regional lung strain and inflammation. (Vols. 185). (2), pp. 228-9; author reply 229-30. Am J Respir Crit Care Med. PMID: 22246708.

Custer, J. W., Watson, C. M., Dwyer, J., Kaczka, D. W., Simon, B. A. & Easley, R. B. (2011). Critical evaluation of emergency stockpile ventilators in an in vitro model of pediatric lung injury. Pediatr Crit Care Med, 12(6), e357-61. PMID: 21317679.

Colletti, A. A., Amini, R. & Kaczka, D. W. (2011). Simulating ventilation distribution in heterogenous lung injury using a binary tree data structure. Comput Biol Med, 41(10), 936-45. PMID: 21872852.

Custer, J. W., Ahmed, A., Kaczka, D. W., Mulreany, D. G., Hager, D. N., Simon, B. A. & Easley, R. B. (2011). In vitro performance comparison of the Sensormedics 3100A and B high-frequency oscillatory ventilators. Pediatr Crit Care Med, 12(4), e176-80. PMID: 21037502.

Kaczka, D. W., Lutchen, K. R. & Hantos, Z. (2011). Emergent behavior of regional heterogeneity in the lung and its effects on respiratory impedance. J Appl Physiol (1985), 110(5), 1473-81. PMID: 21292840.

Kaczka, D. W., Cao, K., Christensen, G. E., Bates, J. H. & Simon, B. A. (2011). Analysis of regional mechanics in canine lung injury using forced oscillations and 3D image registration. Ann Biomed Eng, 39(3), 1112-24. PMID: 21132371.

Brown, R. H., Kaczka, D. W., Fallano, K., Shapiro, S. & Mitzner, W. (2011). Individual canine airway response variability to a deep inspiration. Clin Med Insights Circ Respir Pulm Med, 5, 7-15. PMID: 21487453.

Kaczka, D. W., Dellacá, R. L. (2011). Oscillation mechanics of the respiratory system: applications to lung disease. Crit Rev Biomed Eng, 39(4), 337-59. PMID: 22011237.

Kaczka, D. W., Bates, J. H. (2011). Preface: Pulmonary physiology. (Vols. 39). (4), pp. 261-2. Crit Rev Biomed Eng. PMID: 22011232.

Kaczka, D. W., Chon, D., Yin, Y., Hoffman, E. A. & Simon, B. A. (2011). Regional expansion in canine lungs using CT image registration: a comparison of Jacobian determinant and density methods. (Vols. 183). pp. A3585. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W., Colletti, A. A., Tawhai, M. H. & Simon, B. A. (2010). Chapter 10: Computational Analyses of Lung Tissue and Airway Dynamics. In K. B. Chandran , H. S. Udaykumar , J. M. Reinhardt (Eds.) Image-Based Computational Modeling in the Human Circulatory and Pulmonary Systems. (2011), pp. 375-402. Norwell, MA: Springer. DOI: 10.1007/978-1-4419-7350-4_10.

Brown, R. H., Kaczka, D. W. & Mitzner, W. (2010). Effect of parenchymal stiffness on canine airway size with lung inflation. PLoS One, 5(4), e10332. PMID: 20436667.

Amini, R., Kaczka, D. W. (2010). Effect of parenchymal stiffness on regional flow and pressure distributions in the canine lung: a simulation study. (Vols. 181). pp. A1239. American Journal of Respiratory and Critical Care Medicine.

Smallwood, J. L., Simon, B. A. & Kaczka, D. W. (2010). Effects of distending pressure and canine lung, chest wall, and total respiratory system viscoelasticity. (Vols. 181). pp. A1238. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W., Brown, R. H. & Mitzner, W. (2009). Assessment of heterogeneous airway constriction in dogs: a structure-function analysis. J Appl Physiol (1985), 106(2), 520-30. PMID: 18927269.

Easley, R. B., Lancaster, C. T., Fuld, M. K., Custer, J. W., Hager, D. N., Kaczka, D. W. & Simon, B. A. (2009). Total and regional lung volume changes during high-frequency oscillatory ventilation (HFOV) of the normal lung. Respir Physiol Neurobiol, 165(1), 54-60. PMID: 18996228.

Custer, J. W., Dwyer, J., Watson, C. M., Kaczka, D. W., Simon, B. A. & Easley, R. B. (2009). Emergency ventilator performance characteristics under conditions of adult pediatric respiratory failure. (Vols. 179). pp. A3071. American Journal of Respiratory and Critical Care Medicine.

Ahmed, A., Custer, J. W., Mulreany, D. G., Kaczka, D. W., Simon, B. A. & Easley, R. B. (2009). The effect of piston position on tidal volume delivery during high-frequency oscillatory ventilation. (Vols. 179). pp. A5814. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W., Cao, K., Christensen, G. E., Bates, J. H. & Simon, B. A. (2009). Regional mechanics in acute lung injury: a comparison of Function and structure. (Vols. 179). pp. A3550. American Journal of Respiratory and Critical Care Medicine.

Bellardine Black, C. L., Hoffman, A. M., Tsai, L. W., Ingenito, E. P., Suki, B., Kaczka, D. W., Simon, B. A. & Lutchen, K. R. (2008). Impact of positive end-expiratory pressure during heterogeneous lung injury: insights from computed tomographic image functional modeling. Ann Biomed Eng, 36(6), 980-91. PMID: 18340535.

Brown, R. H., Kaczka, D. W., Fallano, K., Chen, S. & Mitzner, W. (2008). Temporal variability in the responses of individual canine airways to methacholine. J Appl Physiol (1985), 104(5), 1381-6. PMID: 18309091.

Pauldine, R., Beck, G., Salinas, J. & Kaczka, D. W. (2008). Closed-loop strategies for patient care systems. J Trauma, 64(4 Suppl), S289-94. PMID: 18385581.

Brown, R. H., Kaczka, D. W., Fallano, K. & Mitzner, W. (2008). Individual airway size variability. (Vols. 177). pp. A547. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W., Brown, R. H. & Mitzner, W. (2008). Assessment of heterogeneous airway constriction: an inverse model analysis. (Vols. 177). pp. A514. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W. (2007). Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease. (Vols. 103). (5), pp. 1907; author reply 1909-10. Bethesda, MD: J Appl Physiol (1985). PMID: 18098391.

Kaczka, D. W., Massa, C. B. & Simon, B. A. (2007). Reliability of estimating stochastic lung tissue heterogeneity from pulmonary impedance spectra: a forward-inverse modeling study. Ann Biomed Eng, 35(10), 1722-38. PMID: 17558554.

Bellardine Black, C., Hoffman, A. M., Tsai, L. W., Ingenito, E. P., Suki, B., Kaczka, D. W., Simon, B. A. & Lutchen, K. R. (2007). In reply: Dynamic respiratory mechanics measurements for optimization of ventilator settings in acute lung injury. (Vols. 35). (7), pp. 1807-1808. Critical Care Medicine. DOI: 10.1097/01.CCM.0000269350.98447.E3.

Hager, D. N., Fessler, H. E., Kaczka, D. W., Shanholtz, C. B., Fuld, M. K., Simon, B. A. & Brower, R. G. (2007). Tidal volume delivery during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome. Crit Care Med, 35(6), 1522-9. PMID: 17440422.

Bellardine Black, C. L., Hoffman, A. M., Tsai, L. W., Ingenito, E. P., Suki, B., Kaczka, D. W., Simon, B. A. & Lutchen, K. R. (2007). Relationship between dynamic respiratory mechanics and disease heterogeneity in sheep lavage injury. Crit Care Med, 35(3), 870-8. PMID: 17255854.

Hager, D. N., Fuld, M., Kaczka, D. W., Fessler, H. E., Brower, R. G. & Simon, B. A. (2006). Four methods of measuring tidal volume during high-frequency oscillatory ventilation. Crit Care Med, 34(3), 751-7. PMID: 16505661.

Kaczka, D. W., Massa, C. B. & Simon, B. A. (2006). Reliability of estimating stochastic lung tissue heterogeneity with inverse modeling. (Vols. 3). pp. A876. Proceedings of the American Thoracic Society.

Kaczka, D. W., Kumar, D., Christensen, G. E., Massa, C. B. & Simon, B. A. (2006). Assessment of regional mechanics in acute lung injury using 3D image registration. (Vols. 3). pp. A788. Proceedings of the American Thoracic Society.

Kaczka, D. W., Hager, D. N., Hawley, M. L. & Simon, B. A. (2005). Quantifying mechanical heterogeneity in canine acute lung injury: impact of mean airway pressure. Anesthesiology, 103(2), 306-17. PMID: 16052113.

Kaczka, D. W., Beck, G. (2004). Mechanical ventilation in orbit: emphasis on closed-loop ventilation. Respir Care Clin N Am, 10(3), 369-400, vii. PMID: 15458734.

Kaczka, D. W., Lutchen, K. R. (2004). Servo-controlled pneumatic pressure oscillator for respiratory impedance measurements and high-frequency ventilation. Ann Biomed Eng, 32(4), 596-608. PMID: 15117033.

Hager, D. N., Kaczka, D. W., Fuld, M. K., Fessler, H. E., Brower, R. G. & Simon, B. A. (2004). Tidal volume measurement during simulated high frequency oscillatory ventilation (HFOV). (Vols. 169). (7), pp. A348. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W., Hager, D. N. & Simon, B. A. (2004). Quantifying mechanical heterogeneity in canine acute lung injury (ALI). (Vols. 169). (7), pp. A785. American Journal of Respiratory and Critical Care Medicine.

Lutchen, K. R., Jensen, A., Atileh, H., Kaczka, D. W., Israel, E., Suki, B. & Ingenito, E. P. (2001). Airway constriction pattern is a central component of asthma severity: the role of deep inspirations. Am J Respir Crit Care Med, 164(2), 207-15. PMID: 11463589.

Kaczka, D. W., Ingenito, E. P., Body, S. C., Duffy, S. E., Mentzer, S. J., DeCamp, M. M. & Lutchen, K. R. (2001). Inspiratory lung impedance in COPD: effects of PEEP and immediate impact of lung volume reduction surgery. J Appl Physiol (1985), 90(5), 1833-41. PMID: 11299274.

Kaczka, D. W., Ingenito, E. P. & Lutchen, K. R. (1999). Technique to determine inspiratory impedance during mechanical ventilation: implications for flow limited patients. Ann Biomed Eng, 27(3), 340-55. PMID: 10374726.

Kaczka, D. W., Ingenito, E. P., Israel, E. & Lutchen, K. R. (1999). Airway and lung tissue mechanics in asthma. Effects of albuterol. Am J Respir Crit Care Med, 159(1), 169-78. PMID: 9872836.

Ingenito, E. P., Evans, R. B., Loring, S. H., Kaczka, D. W., Rodenhouse, J. D., Body, S. C., Sugarbaker, D. J., Mentzer, S. J., DeCamp, M. M. & Reilly, Jr, J. J. (1998). Relation between preoperative inspiratory lung resistance and the outcome of lung-volume-reduction surgery for emphysema. N Engl J Med, 338(17), 1181-5. PMID: 9554858.

Kaczka, D. W., Ingenito, E. P., Body, S., Loring, S. H. & Lutchen, K. R. (1998). Lung resistance and elastance spectra in flow-limited, intubated patients. (Vols. 157). (3), pp. A82. American Journal of Respiratory and Critical Care Medicine.

Lutchen, K. R., Ingenito, E. P. & Kaczka, D. W. (1998). Impact of deep inspiration on induced versus spontaneous airway constriction. (Vols. 157). (3), pp. A517. American Journal of Respiratory and Critical Care Medicine.

Lutchen, K. R., Gillis, H., Kaczka, D. W., Israel, E. & Ingenito, E. P. (1998). Does airway inflammation enable heterogeneous airway closure that amplifies acute asthma?. (Vols. 26). (Suppl. 1), pp. S-46. Annals of Biomedical Engineering.

Kaczka, D. W., Ingenito, E. P., Suki, B. & Lutchen, K. R. (1997). Partitioning airway and lung tissue resistances in humans: effects of bronchoconstriction. J Appl Physiol (1985), 82(5), 1531-41. PMID: 9134903.

Lutchen, K. R., Gillis, H. & Kaczka, D. W. (1997). On the relation between heterogeneous changes in airway morphometry and important changes in lung mechanical properties. (Vols. 155). (4), pp. A744. American Journal of Respiratory and Critical Care Medicine.

Ingenito, E. P., Evans, R. B., Loring, S. H., Kaczka, D. W., Reilly, J. J., Mentzer, S. J., DeCamp, M. M. & Sugarbaker, D. J. (1997). Preoperative inspiratory resistance: a predictor of clinical response volume reduction surgery. (Vols. 155). (4), pp. A794. American Journal of Respiratory and Critical Care Medicine.

Kaczka, D. W., Ingenito, E. P., Israel, E., Suki, B. & Lutchen, K. R. (1997). Effect of beta agonist-induced bronchodilation airway and lung tissue resistances in asthmatic subjects. (Vols. 155). (4), pp. A859. American Journal of Respiratory and Critical Care Medicine.

MacLeod, D., Kaczka, D. W., Krishna, M., Scott, R., Grant, L., Frew, A. (1997). Effect of short-term ozone exposure on human input impedance (Zin) behavior in healthy subjects between 5-4 Hz. (Vols. 10). (Suppl. 25), pp. 329S. European Respiratory Journal.

Kaczka, D. W., Ingenito, E. P., Suki, B. & Lutchen, K. R. (1996). Separation of airway and lung tissue resistance in healthy humans using an optimal ventilator waveform. (Vols. 153). (4), pp. A745. American Journal of Critical Care Medicine.

Kaczka, D. W., Ingenito, E. P., Body, S., Suki, B. & Lutchen, K. R. (1996). Partitioning airway and lung tissue resistance in unhealthy human lungs. (Vols. 24). (Suppl. 1), pp. S-12. Annals of Biomedical Engineering.

Kaczka, D. W., Barnas, G. M., Suki, B. & Lutchen, K. R. (1995). Assessment of time-domain analyses for estimation of low-frequency respiratory mechanical properties and impedance spectra. Ann Biomed Eng, 23(2), 135-51. PMID: 7605051.

Barnas, G. M., Harinath, P., Green, M. D., Suki, B., Kaczka, D. W. & Lutchen, K. R. (1994). Influence of waveform and analysis technique on lung and chest wall properties. Respir Physiol, 96(2-3), 331-44. PMID: 8059094.

Lutchen, K. R., Suki, B., Kaczka, D. W., Zhang, O., Hantos, Z., Daroczy, B. & Petak, F. (1994). Direct use of mechanical ventilation to measure respiratory mechanics associated with physiological breathing. European Respiratory Review, 4(19), 198-202.

Lutchen, K. R., Kaczka, D. W., Suki, B., Barnas, G., Cevenini, G. & Barbini, P. (1993). Low-frequency respiratory mechanics using ventilator-driven forced oscillations. J Appl Physiol (1985), 75(6), 2549-60. PMID: 8125874.

Lutchen, K. R., Yang, K., Kaczka, D. W. & Suki, B. (1993). Optimal ventilation waveforms for estimating low-frequency respiratory impedance. J Appl Physiol (1985), 75(1), 478-88. PMID: 8376299.

Bamas, G. M., Harinath, P., Green, M. D., Suki, B., Kaczka, D. W. & Lutchen, K. R. (1993). Measurement of respiratory system properties in the physiologic range. (Vols. 7). pp. A9. FASEB Journal.

Kaczka, D. W., Suki, B. & Lutchen, K. R. (1993). Time- vs. frequency-domain analysis of respiratory mechanics at low frequencies: impact of waveform. (Vols. 21). (Suppl 1), pp. 6. Annals of Biomedical Engineering.

Yutchen, K. R., Yang, K., Kaczka, D. W. & Suki, B. (1992). Optimal ventilator waveform design for estimating respiratory impedance at low frequencies. (Vols. 6). pp. A1480. FASEB Journal.

Lutchen, K. R., Kaczka, D. W., Suki, B., Yang, K., Cevinini, G., Ursino, M. & Barbini, P. (1992). Estimating low frequency respiratory impedance in humans and dogs using ventilator step and optimally designed waveforms. (Vols. 5). (Suppl 15), pp. 122s. European Respiratory Journal.

Kaczka, D. W., Yang, K., Bamas, G. M. & Lutchen, K. R. (1991). Identification of human respiratory mechanics using ventilator-driven forced oscillations at low frequencies. (Vols. 19). (5), pp. 585. Annals of Biomedical Engineering.