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Eric A. Hoffman, PhD

Director, Advanced Pulmonary Physiomic Imaging Laboratory: APPIL
Professor of Radiology - Division of Physiologic Imaging
Professor of Internal Medicine
Professor of Biomedical Engineering (BME)

Contact Information

Primary Office
C748 GH
Iowa City, IA 52242


BA, Physiological Psychology, Antioch College
PhD, Physiology, University of Minnesota / Mayo Graduate School of Medicine
Fellow, Physiology, Biodynamics Research Unit, Mayo Foundation, Rochester, MN
Fellow, Physiologic Imaging, Department of Physiology and Biophysics, Mayo Foundation, Rochester MN

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Informatics, Interdisciplinary Graduate Program in Translational Biomedicine, Medical Scientist Training Program

Center, Program and Institute Affiliations

Cardiovascular Research Center, Environmental Health Sciences Research Center, Institute for Clinical and Translational Science, Iowa Comprehensive Lung Imaging Center, Iowa Institute for Biomedical Imaging

Research Summary

Eric A. Hoffman, PhD is a professor of radiology, medicine and biomedical engineering at the University of Iowa. He is the director of the Advanced Pulmonary Physiomic Imaging Laboratory (APPIL) in the Department of Radiology and the director of the Iowa Comprehensive Lung Imaging Center (I-Clic) at the University of Iowa. He received his Ph.D. in Physiology from the University of Minnesota / Mayo Graduate School of Medicine in 1981 and remained on staff at the Mayo Clinic where he was a member of the team which Developed the Dynamic Spatial Reconstructor (DSR), a one of a kind CT scanner which was able to gather up to 240 contiguous CT sections of the body every 1/60 second. Throughout his career he has used advanced imaging methodologies to study basic respiratory physiology centered largely on mechanisms of ventilation and perfusion heterogeneity and regional lung mechanics. Dr. Hoffman moved from the Mayo Clinic in 1987 to head the Cardiothoracic Imaging Research Center in the Department of Radiology at the University of Pennsylvania and then moved in 1992 to his current position at the University of Iowa. Most recently, in addition to continuing basic physiologic research of the lung, he has established a combination of single and multi-spectral multidetector row spiral CT imaging methodology to objectively follow human lung pathology and pathophysiology with a particular emphasis on inflammatory lung diseases. The centerpiece of APPIL is a Siemens SOMATOM Force CT scanner. Dr. Hoffman is the author of more than 570 journal articles and 21 book chapters in the field of dynamic volumetric imaging of the lung and heart and served for 5 years as the founding chair of the Physiology and Function from Multidimensional Imaging sessions of the SPIE Medical Imaging conference. Dr. Hoffman was inducted into the college of fellows of the American Institute for Medical and Biological Engineering in March of 2000 and was elected into the Fleischner Society in May 2005 and named a Distinguished Investigator by The Academy for Radiology and Biomedical Imaging Research in 2018. He received the 2013 John West award for Outstanding Contributions to the Field of Functional Pulmonary Imaging from the IWPFI, the 2014 Joseph R Rodarte Award for Scientific Distinction from the Respiratory Structure and Function Assembly of the American Thoracic Society and the 2018 Alton Ochsner Award “relating smoking and disease.” He is a fellow of the European Respiratory Society and the American Thoracic Society. Dr. Hoffman’s laboratory is dedicated to the use of advanced imaging methodologies for the exploration of normal and pathologic physiology of the lung with specific areas of interest relating to inflammatory lung diseases including COPD, Astham and environmentally induced pathologies. APPIL serves as the Radiology Center for numerous large multi-center studies utilizing imaging to phenotype the lung as a component of the study (including SPIROMICS, MESA Lung, SARP, PreCISE, British Lung Foundation Early COPD).