Jessica C. Sieren, PhD
Associate Professor of Radiology-Division of Physiologic Imaging
Introduction
My research area of focus is the multimodal investigation of lung nodules, incorporating computed tomography, nuclear imaging, and histopathology. I have worked on developing and implementing methods for cross linking three-dimensional histopathology to non-destructive imaging methods. Current areas of focus include, dynamic perfusion computed tomography for nodule characterization and for early response to treatment monitoring, lobar co-localization between lung disease and cancer, and animal models for lung cancer evaluation and drug development.
Current Positions
- Associate Professor of Radiology - Division of Physiologic Imaging
- Associate Professor of Biomedical Engineering (BME)
Education
- Bachelor of Science, Flinders University of South Australia, Australia
- Bachelor of Engineering (with Honors), Flinders University of South Australia, Australia
- Doctor of Philosophy in Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States
Graduate Program Affiliations
Center, Program and Institute Affiliations
Selected Publications
- Kohlmeyer JL, Lingo JJ, Kaemmer CA, Scherer A, Warrier A, Voigt E, Raygoza Garay JA, McGivney GR, Brockman QR, Tang A, Calizo A, Pollard K, Zhang X, Hirbe AC, Pratilas CA, Leidinger M, Breheny P, Chimenti MS, Sieren JC, Monga V, Tanas MR, Meyerholz DK, Darbro BW, Dodd RD, Quelle DE. CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression. Clin Cancer Res. 2023 Sep 1;29(17):3484-3497. doi: 10.1158/1078-0432.CCR-23-0749. PMID: 37410426; PMCID: PMC10528807.
- Schroeder KE, Acharya L, Mani H, Furqan M, Sieren JC. Radiomic biomarkers from chest computed tomography are assistive in immunotherapy response prediction for non-small cell lung cancer. Transl Lung Cancer Res 2023;12(5):1023-1033. doi: 10.21037/tlcr-22-763
- Knoernschild K, Johnson HJ, Schroeder KE, Swier VJ, White KA, Sato TS, Rogers CS, Weimer JM, Sieren JC. Magnetic resonance brain volumetry biomarkers of CLN2 Batten disease identified with miniswine model. Sci Rep. 2023 Mar 29;13(1):5146. doi: 10.1038/s41598-023-32071-z. PMID: 36991106; PMCID: PMC10060411
- Bruz M, Knoernschild K, Sieren JC, Johnson HJ. PigSNIPE: Scalable Neuroimaging Processing Engine for Minipig MRI. Algorithms 2023, 16, 116. https://doi.org/10.3390/a16020116
- Swier VJ, White KA, Johnson TB, Sieren JC, Johnson HJ, Knoernschild K, Wang X, Rohret FA, Rogers CS, Pearce DA, Brudvig JJ, Weimer JM. A novel porcine model of CLN2 Batten disease that recapitulates patient phenotypes. Neurotherapeutics 2022 Oct;19(6):1905-1919. doi: 10.1007/s13311-022-01296-7. Epub 2022 Sep 13. PMID: 36100791; PMCID: PMC9723024.
- Shankar SS, Hoffman EA, Atha J, Sieren JC, Samei E, Abadi E. Inter- and intra-scan variability for lung imaging quantifications via CT. Proc SPIE Int Soc Opt Eng. 2022 Feb-Mar;12031:120312C. doi: 10.1117/12.2613191. Epub 2022 Apr 4. PMID: 35547179; PMCID: PMC9087481.
- Brzus M, Powers AB, Knoernschild KS, Sieren JC, Johnson HJ. Multi-agent reinforcement learning pipeline for anatomical landmark detection in minipigs, Proc. SPIE 12032, Medical Imaging 2022: Image Processing, 1203229 (4 April 2022); doi: 10.1117/12.2611008
- Shankar SS, Jadick GL, Hoffman EA, Atha J, Sieren JC, Samei E, Abadi E. Scanner-specific validation of a CT simulator using a COPD-emulated anthropomorphic phantom. Proc SPIE Int Soc Opt Eng. 2022 Feb-Mar;12031:120313R. doi: 10.1117/12.2613212. Epub 2022 Apr 4. PMID: 35547178; PMCID: PMC9087304.
- Fan L, Ma W, Ma J, Yang L, Wang Z, Xu K, Jia Y, Sun B, Sieren JC, Yang H, Yao F The improved success rate and reduced complications of a novel localization device vs. hookwire for thorascopic resection of small pulmonary nodules: a single-center, open- label, randomized clinical trial. TLCR. 2022 Aug 11: 11(8):1702-1712. doi: 10.21037/tlcr-22-555
- Shankar SS, Felice N, Hoffman EA, Atha J, Sieren JC, Samei E, Abadi E. Task‐based validation and application of a scanner‐specific CT simulator using an anthropomorphic phantom. Medical Physics. 2022 Dec;49(12):7447-7457. doi: 10.1002/mp.15967. Epub 2022 Nov 12. PMID: 36097259; PMCID: PMC9792443.